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| 1 | 早期胃癌内镜下切除日本指南的历史和未来展望显示文摘日本胃癌治疗指南首次发表于2001年,其目的是为了明确不同治疗方案的适应证,从而减少不同医疗机构间治疗方式的差异。随着病例的积累及内镜黏膜下剥离术(ESD)的发展,早期胃癌(EGC)内镜下切除(ER)的适应证和治愈性范围有所扩大,但是,仍有部分问题亟待解决。使用风险评分系统(eCura system)评估淋巴结转移(LNM)的情况,可能有助于确定不符合内镜切除标准的EGC患者的治疗方案。对于不符合内镜切除标准的EGC患者,即最新指南中的eCura C-2分期的患者,尽管他们的LNM风险较高,但对于很多患者来说,追加胃切除联合淋巴结清扫术仍然是过度的治疗。而保留功能的低侵入性手术,如内镜下非开放式胃壁反转切除术联合腹腔镜前哨淋巴结活检,有可能会解决该问题。此外,对于拒绝追加胃切除术的患者,可采取更多的低侵入性治疗方式,如ER联合化疗。 | Waku Hatta Takuji Gotoda Tomoyuki Koike Atsushi Masamune 丁士刚(译) 张冬雪(译) 乌雅罕(译) | 2020 | 中华胃肠内镜电子杂志2020，7，1： | 22 |
| 2 | The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury显示文摘Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host defense.However,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of inflammation.Recent studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung injury.However,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain unclear.In this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model mice.Furthermore,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing CXCR4.Sulfatide,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface CXCR4.Our findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of L-selectin.The CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death. | Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku | 2011 | Cellular & Molecular Immunology2011，8，4： | 6 |
| 3 | lnterleukin-6 and interleukin-10 plasma levels and mRNA expression in polytrauma patients显示文摘 | Heber B. Sapan Idrus Paturusi Andi Asadul Islam Irawan Yusuf Ilhamjaya Patellongi Muhammmad Nasrum Massi Aryono D. Pusponegoro Syafrie K. Arief Ibrahim Labeda Leo Rendy Mochammad Hatta | 2017 | Chinese Journal of Traumatology2017，20，6： | 6 |
| 4 | Long-Range Displacement Sensor Based on SMS Fiber Structure and OTDR显示文摘这份报纸由使用 single-multi-single 模式 SMS 纤维结构论述一个远程的排水量测量方法,属于在二永久的杆和光时间领域反射计之间的一个灵活盘子基于 OTDR 的讯问者。SMS 纤维结构传感器与二种不同配置被准备,即直并且正弦曲线配置。排水量传感器能与 0.159 公里的一个决定从 0 公里与一个范围执行排水量大小到 150 公里,这被表明。正弦曲线配置比直配置提供更好的敏感。建议传感器提议低费用,和它能为对民用的结构监视合适的伪分布式的排水量测量被实现。 | A. ARIFIN A. M. HATTA SEKARTEDJO M. S. MUNTINI A. RUBIYANTO | 2015 | Photonic Sensors2015，5，2： | 5 |
| 5 | Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients显示文摘AIM: To clarify the pathogenesis of gastroesophageal reflux disease symptoms in non-erosive reflux disease(NERD) patients.METHODS: Thirty-five NERD patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily for at least 8 wk, were included in this study. All patients underwent 24 h combined impedance- p H on rabeprazole. The symptom index(SI) was considered to be positive if ≥ 50%, and proximal reflux episodes were determined when reflux reached 15 cm above the proximal margin of the lower esophageal sphincter.RESULTS: In 14(40%) SI-positive patients, with liquid weakly acid reflux, the occurrence rate of reflux symptoms was significantly more frequent in proximal reflux episodes(46.7%) than in distal ones(5.7%)(P < 0.001). With liquid acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes(38.5%) and distal ones(20.5%)(NS). With mixed liquid-gas weakly acid reflux, the occurrence rate of reflux symptoms in proximal reflux episodes was significantly more frequent(31.0%) than in distal reflux ones(3.3%)(P < 0.001). With mixed liquid-gas acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes(29.4%) and distal ones(14.3%)(NS).CONCLUSION: The proximal extent of weakly acidic liquid and mixed liquid-gas reflux is a major factor associated with reflux perception in SI-positive patients on proton pump inhibitor therapy. | Kenichiro Nakagawa Tomoyuki Koike Katsunori Iijima Masahiro Saito Hiroki Kikuchi Waku Hatta Nobuyuki Ara Kaname Uno Naoki Asano Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，47： | 4 |
| 6 | Finite-element analysis of the formability of a magnesium-based alloy AZ31 sheet显示文摘 | H Takuda T Yoshii N Hatta | 1999 | Journal of Materials Processing Tech1999，，： | 2 |
| 7 | Is segmentectomy with lymph node assessment an alternative to lobectomy for non–small cell lung cancer of 2 cm or smaller?显示文摘 | Morihito Okada Koichi Yoshikawa Takeshi Hatta Noriaki Tsubota | 2001 | The Annals of Thoracic Surgery2001，，3： | 2 |
| 8 | Graphene-and Multi-Walled Carbon Nanotubes-Coated Tapered Plastic Optical Fiber for Detection of Lard Adulteration in Olive Oil显示文摘A rapid and high-performance sensor for lard adulterant in edible oil was developed using the tapered plastic optical fiber(POF)coated with graphene and multi-walled carbon nanotubes.The coating material was deposited onto a tapered POF with a taper waist diameter and a taper length of 0.45 mm and 1 cm,respectively.The addition of the coating material was used to increase the sensitivity and selectivity coefficient of the tapered POF toward the lard substance.The sensing mechanism is based on a simultaneous interaction of lard substance and an evanescent wave of tapered POF with the coating layers.The results showed that graphene coating on the tapered POF increased the selectivity coefficient of the tapered POF towards lard substance from 33.54 to 324.19,and it gave a sensitivity of 0.427 dBm/%.In comparison,multi-walled carbon nanotubes coating increased the selectivity coefficient to 71.65 and increased its sensitivity to 1.189 dBm/%.Thus,the proposed configuration of the tapered POF with the coating material offered a simple configuration for a rapid,high sensitivity and selectivity detection of lard adulterant in edible oils. | Ika PUSPITA Ninik IRAWATI Kartika Anoraga MADURANI Fredy KURNIAWAN Sekartedjo KOENTJORO Agus Muhamad HATTA | 2022 | Photonic Sensors2022，12，4： | 2 |
| 9 | A prospective comparative study of optical coherence tomography and EUS for tumor staging of superficial esophageal squamous cell carcinoma显示文摘 | Waku Hatta Kaname Uno Tomoyuki Koike Katsunori Iijima Naoki Asano Akira Imatani Tooru Shimosegawa | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 10 | Finite-element analysis of the formability of a magnesium-based alloy AZ31 sheet显示文摘 | Takuda H Yoshii T Hatta N | 1999 | Journal of Materials Processing Technology1999，89，10： | 1 |
| 11 | Effect of temperature and layer thickness on these strengths of carbon bonding for carbon/carbon composites显示文摘 | Koyama M Hatta H Fukuda H | 2005 | Carbon2005，43，： | 1 |
| 12 | A case of curatively resected AFP producing gastric cancer that responded remarkably to 1 course of TS-1 and showed complete loss of multiple liver metastatic tumors显示文摘 | Hatta W Kumagai S Imamura J | 2005 | Gan To Kagaku Ryoho2005，32，6： | 1 |
| 13 | Is posterior spinal cord shifting by extensive posterior decompression clinically significant for multiseg- mental cervical spondylotic myelopathy 显示文摘 | Hatta Y Shiraishi T Hase H | 2005 | Spine2005，30，： | 1 |
| 14 | Comparison of 2D and 3D carbon/carbon com- posites with respect to damage and fracture re- sistance 显示文摘 | Mohamed S Aly - Hassana Hiroshi Hatta | 2003 | Carbon2003，41，： | 1 |
| 15 | A novel isolation method for egg yolk antibody, “IgY”显示文摘 | Hajime Hatta Mujokim | 1990 | Agric Biol Chem1990，54，10： | 1 |
| 16 | Physiological involvement of placental endothelin-1 and prostaglandin F2 alpha in uteroplacental circulatory disturbance in pregnant rats exposed to heat stress显示文摘 | Nakamura H Matsuzaki I Hatta K | 2004 | Can J Physiol Pharmacol2004，82，4： | 1 |
| 17 | Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos显示文摘 | Hatta K | 1987 | Dev Biol1987，120，： | 1 |
| 18 | Numerical simulation of convective heat transfer to a radial free surface jet impinging on a hot solid显示文摘 | H. Fujimoto N. Hatta R. Viskanta | 1999 | Heat and Mass Transfer1999，，4： | 1 |
| 19 | Tensile strength and fiber/matrix interfacial properties of 2D and 3D carbon/carbon composites 显示文摘 | Hatta H Goto K Ikegaki S | 2005 | Journal of theEuropean ceramic Soeieyt2005，25，4： | 1 |
| 20 | Concurrent chemo-radiotherapy for nasopharyngeal carcinoma显示文摘 | Okita J Hatta C Terada T | 2004 | Auris Nasus Larynx2004，31，1： | 1 |
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