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| 1 | Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms显示文摘Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow diverters.Glycoprotein IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications afterwards.We sought to determine the safety of tirofiban and DAPT in these cases.Methods We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow diversion.The tirofiban-DAPT protocol used is described.Data regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and analysed.results One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 electively.Minor and major haemorrhagic events were recognised in 20%(30/148)aneurysms.Only 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 EVD-related.The average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were symptomatic.Most haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was documented.Concomitant administration of heparin did not increase haemorrhagic events.Conclusion The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was safe.Tirofiban and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications. | Edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez Mario Zanaty Jorge A Roa Pascal Jabbour David M Hasan | 2019 | Stroke & Vascular Neurology2019，4，1： | 17 |
| 2 | Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis. | Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira | 2019 | Stroke & Vascular Neurology2019，4，4： | 10 |
| 3 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 4 | Tea beverage in chemoprevention and chemotherapy of prostate cancer显示文摘前列腺癌症(PCa ) 是最经常诊断的恶意和在有在存在的许多 westerncountries.The 的类似的趋势的美国男性的癌症相关的死亡的第二个领先的原因治疗途径和外科的干预一直不能有效地应付这畏惧的疾病。为这些原因,为它的预防和治疗为疾病过程的更好的理解并且为新奇途径的发展加强我们的努力是必要的。从在 vivo 并且在 vitrodata 和流行病学的研究基于可观的证据,在饮料茶获得了为减少几癌症的风险的可观的注意的最近的年里。许多茶的癌症预防措施效果,特别绿的茶看起来被在那里在场的多酚调停。地理证据建议 PCa 的发生和出现在消费茶 regularly.Thisevidence 的人口是更低的建议茶多酚能被外推对 PCa.PCa 优化他们的 chemopreventiveproperties 因为它典型地超过 50 岁并且因此在人被诊断,为 chemoprevention 代表优秀候选人疾病,甚至在通过药理学或营养的干预完成的肿瘤的开发的谦虚延期能在临床上可检测的疾病的发生导致实质的减小。在这评论,我们处理茶的可能的使用的问题,特别绿的茶,为象治疗 ofPCa 一样的预防。 | Imtiaz A SIDDIQUI Mohammad SALEEM Vaqar M ADHAMI Mohammad ASIM Hasan MUKHTAR | 2007 | Acta Pharmacologica Sinica2007，28，9： | 4 |
| 5 | Intussusception in adults: an unusual and challenging condition for surgeons显示文摘 | Nazif Erkan Mehmet Hac?yanl? Mehmet Y?ld?r?m Hasan Sayhan Enver Vardar Alper F?rat Polat | 2005 | International Journal of Colorectal Disease2005，，5： | 3 |
| 6 | Biomechanical and Macroscopic Evaluations of the Effects of 5-Fluorouracil on Partially Divided Flexor Tendon Injuries in Rabbits显示文摘 | Shkelzen B Duci Hysni M Arifi Hasan R Ahmeti Suzana Manxhuka-Kerliu Burim Neziri Agon Y Mekaj Shpetim Lajqi Labinot Shahini | 2015 | Chinese Medical Journal2015，，12： | 3 |
| 7 | Antimicrobial Agents from Selected Medicinal Plants in Libya显示文摘Objective:To test the in vitro antimicrobial efficacy of water and methanol extracts of 23 plan species that are commonly used in Libyan folk medicine.Methods:The antimicrobial activity was determinec using the well-diffusion method.Four test microorganisms were used namely,Escherichia coli,Salmonella species,Staphylococcus aureus and Bacillus subtilis.The minimum inhibitory concentration(MIC) was determined for the high biologically active crude plant extracts.Results:Among 23 medicinal plants used in the study,only 5 methanolic extracts[Rosmarinus offcinalis L,Carduus marianium L.,Lantana camara L.,Rhus tripartite(ueria) Grande,and Thymus capitatus(L.) Hoffm(link)]showed the highest antimicrobial activity againsl Staphylococcus aureus,Bacillus subtilis and Salmonella species,while 22 methanolic and aqueous extracts showed moderate to weak antimicrobial activity on all tested organisms.However 19 of the extracts showed no activity at all against Gram-ve and Gram +ve microorganisms.MIC was found to be 1.25 mg/mL(Thymus capitatus),3 mg/mL(Rhus tripartite),4 mg/mL(Carduus marianium),5 mg/mL(Rosamarinus officinalis) and5 mg/mL(Lantana camara),respectively.Conclnsions:The present results revealed that,crude methanolic extracts of the investigated Libyan folk medicinal plants exhibited mild to high in vitro antibacterial activities against Gram-positive and Gram-negative microorganisms. | Hasan MH Muhaisen Miftah Mailoud Ab-Mous Fadel A Ddeeb Aboclaid All Rtemi Omer M Taba Mehtab Parveen | 2016 | Chinese Journal of Integrative Medicine2016，22，3： | 2 |
| 8 | Atmospheric pressure gliding arc discharge plasma treatments for improving germination, growth and yield of wheat显示文摘Wheat(Triticum aestivum) seeds were treated with atmospheric pressure gliding arc discharge plasmas to investigate the effects on water absorption, seed germination rate, seedling growth and yield in wheat. The surface architectures and functionalities of the seeds were found to modify due to plasma treatments. 6 min treatment was provided 95%–100% germination rate.For the treatment duration of 3 and 9 min the growth activity, dry matter accumulation, leaves chlorophyll contents, longest spikes, number of spikes/spikelet and total soluble protein content in shoots were improved. The grain yield of wheat was increased ~20% by 6 min treatment with H_2O/O_2 plasma with respect to control. | N C ROY M M HASAN A H KABIR M A REZA M R TALUKDER A N CHOWDHURY | 2018 | Plasma Science and Technology2018，20，11： | 2 |
| 9 | Acute ischaemic stroke interventions: large vessel occlusion and beyond显示文摘Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical thrombectomy.Large vessel occlusion(LVO)accounts for up to 38%of acute ischaemic stroke and comes with devastating outcomes for patients,families and society in the pre-intervention era.A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke;this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming benefits.This review article will present a comprehensive overview of LVO management,techniques and devices used,and the future of stroke therapy.In addition,we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion. | Ahmad Sweid Batoul Hammoud Sunidhi Ramesh Daniella Wong Tyler D Alexander Joshua Harrison Weinberg Maureen Deprince Jaime Dougherty Dimitri Jean-Mickael Maamari Stavropoula Tjoumakaris Hekmat Zarzour Michael R Gooch Nabeel Herial Victor Romo David M Hasan Robert H Rosenwasser Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 2 |
| 10 | 用PDE-5抑制剂治疗勃起功能障碍的男性患者中前列腺癌的发生率:回顾性研究显示文摘本研究比较了用PDE-5抑制剂治疗勃起功能障碍(ED)7年的男性患者和与这些患者年龄及各种风险因素相似的7年内不使用PDE一5抑制剂治疗ED的男性患者中前列腺癌发生率的情况。通过分析2000年到2006年的电子病例和数据库,以年龄在50至69岁,2000年前无前列腺癌病史的ED患者作为研究对象。这些患者被分为两组:2362名曾用PDE-5抑制剂治疗的男性和2612名不曾使用过该药物的男性。比较每组的人口数据。在研究期内:97名(4.1%)接受过PDE-5抑制剂治疗的ED患者被诊断出患了前列腺癌,在非PDE-5抑制剂治疗组中,258名(9.9%)被诊断出患了前列腺癌(P〈O.0001)。在非洲裔美国人中,接受PDE-5抑制剂治疗的比例比不用的比例高(10.5%VS.7.1%,P〈0.0001)。接受过PDE-5治疗的患者,其前列腺特异性抗原增高的比例比较低(10.0%vs.13.1%,P=0.0008),但良性前列腺增生的比例比较高(38.4%vs.35.1%,P=0.0149)。接受PDE-5抑制剂治疗ED的男性不易患前列腺癌(调整后的优势比为0.4,95%CI:0.3—0.5,P〈0.0001)。我们的研究数据表明:用PDE-5抑制剂治疗ED的男性倾向于不易患前列腺癌。还需要进行更多的研究。 | Anthony H Chavez K Scott Coffield M Hasan Rajab Chanhee Joe | 2013 | Asian Journal of Andrology2013，15，2： | 2 |
| 11 | Acute toxicity of ammonia to commoncarp fry显示文摘 | HASAN M R MACINTOSH D J | 1986 | Aquaculture1986，54，12： | 1 |
| 12 | High enzyme concentration model for the kinetics of hydrolysis of oils by lipase 显示文摘 | AL - ZUHAtR S HASAN M RAMACHANDRAN K B | 2004 | Chem Eng2004，103，13： | 1 |
| 13 | Synthesis of Hybrid Dendritic-Linear Block Copolymers with Dendritic Initiators Prepared by Convergent Living Anionic Polymerization显示文摘 | Hasan A Muallem A Knauss N M | 2001 | Journal of Polymer Science Part A: Polymer Chemistry2001，39，： | 1 |
| 14 | Inhibition of NFkappa B activity by a membrane-transducing mutant of I Kappa B alpha显示文摘 | Kabouridis DS Hasan M Newson J etal | 2002 | J Immunol2002，169，5： | 1 |
| 15 | Bio-electrochemical removal of nitrate from water and wastewater: A review显示文摘 | Ghafari S Hasan M Aroua M K | 2008 | Bioresource Technology2008，99，39： | 1 |
| 16 | Bio-eletroehemical re- moval of nitrate from water and wastewater-A review 显示文摘 | Ghafari S Hasan M Aroua M K | 2008 | Bioresource Technology2008，99，10： | 1 |
| 17 | Removal of Cr(VI) from aqueous solutions using wheat bran 显示文摘 | Singh K K Hasan S H Talat M | 2009 | ChemEngJ2009，151，123： | 1 |
| 18 | Low-Temperature Synthesis of Hausmannite Mn3O4显示文摘 | Sagheer F A Hasan M A Pasupulety L | 1999 | Journal of Materials Science Letters1999，18，3： | 1 |
| 19 | Can firms learn by observing? Evidence from cross-border M&As 显示文摘 | Francis B B Hasan I Sun X Waisman M | 2014 | Journal of Corporate Finance2014，25，： | 1 |
| 20 | Investigation of local- ized dryout versus CHF in saturated flow boiling显示文摘 | Konishi C Mudawar I Hasan M M | 2013 | Inter- national Journal of Heat and Mass Transfer2013，67，： | 1 |
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