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| 1 | Characterisation and risk assessment of venous thromboembolism in gastrointestinal cancers显示文摘AIM To characterise venous thromboembolism(VTE) in gastrointestinal cancer and assess the clinical utility of risk stratification scoring. METHODS We performed a retrospective analysis using electronic patient records of 910 gastro-oesophageal(GO) cancer and 1299 colorectal cancer(CRC) patients referred to a tertiary cancer centre to identify the incidence of VTE, its relationship to chemotherapy and impact on survival.VTE risk scores were calculated using the Khorana index. Patients were classified as low risk(0 points), intermediate risk(1 to 2 points) or high risk(3 points). Data was analysed to determine the sensitivity of the Khorana score to predict VTE. RESULTS The incidence of VTE was 8.9% for CRC patients and 9.7% for GO cancer patients. Pulmonary emboli(PE) were more common in advanced than in localised CRC(50% vs 21% of events respectively) and lower limb deep vein thrombosis(DVT) were more common in localised than in advanced CRC(62% vs 39% of events respectively). The median time to VTE from cancer diagnosis was 8.3 mo for CRC patients compared to 6.7 mo in GO cancer. In localised CRC median time to VTE was 7.1 mo compared with 10.1 mo in advanced CRC. In contrast in GO cancer, the median time to VTE was 12.5 mo in localised disease and 6.8 mo in advanced disease. No survival difference was seen between patients with and without VTE in this cohort. The majority of patients with CRC in whom VTE was diagnosed had low or intermediate Khorana risk score(94% for localised and 97% in advanced CRC). In GO cancer, all patients scored either intermediate or high risk due to the primary site demonstrating a limitation of the risk assessment score in discriminating high and low risk patients with GO cancers. Additional risk factors were identified in this cohort including surgery, chemotherapy or hospital admission. Overall, 81% of patients with CRC and 77% of patients with GO cancer had one or more of these factors within 4 wk prior to diagnosis VTE. These should be factored into clinical risk assessment scores. CONCLUSION The Khorana score has low sensitivity for thrombotic events in CRC and cannot discriminate low risk patients in high risk cancer sites such as GO cancer. | Robert L Metcalf Eamon Al-Hadithi Nicholas Hopley Thomas Henry Clare Hodgson Antony McGurk Wasat Mansoor Jurjees Hasan | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 10 |
| 2 | Stress analysis of functionally graded rotating discs: analytical and numerical solutions显示文摘This study deals with stress analysis of annular rotating discs made of functionally graded materials(FGMs).Elasticity modulus and density of the discs are assumed to vary radially according to a power law function,but the material is of constant Poisson's ratio.A gradient parameter n is chosen between 0 and 1.0.When n = 0,the disc becomes a homogeneous isotropic material.Tangential and radial stress distributions and displacements on the disc are investigated for various gradient parameters n by means of the diverse elasticity modulus and density by using analytical and numerical solutions.Finally,a homogenous tangential stress distribution and the lowest radial stresses along the radius of a rotating disc are approximately obtained for the gradient parameter n = 1.0 compared with the homogeneous,isotropic case n = 0.This means that a disc made of FGMs has the capability of higher angular rotations compared with the homogeneous isotropic disc. | Hasan Callioglu Numan Behll Bektas Metin Sayer | 2011 | Acta Mechanica Sinica2011，27，6： | 3 |
| 3 | Food impaction in older age:Think about an eosinophilic esophagitis显示文摘Eosinophilic esophagitis is an inflammatory condition of esophagus.It is generally seen in childhood and young population.Men are more commonly affected than women.However,it is not common in an advanced age.Eosinophilic esophagitis decreases the ability of the esophagus to stretch and accommodation against foods.Therefore,the major symptom in adults with eosinophilic esophagitis is difficulty in swallowing solid food(dysphagia).Specifically,the food gets stuck in the esophagus after it is swallowed.Less common symptoms include heartburn and chest pain.Because of this,it may be incorrectly diagnosed as a gastroesophageal reflux disease.Here,we reported a case presented with food impaction at advanced age.As a conclusion,eosinophilic esophagitis is a rare entity that must be remembered in advance aged patients presenting with food impaction. | Umit Akyüz Filiz Akyüz Kamil zdil Hasan Altun Ahmet Faruk Agan Aysegül Agan | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，2： | 2 |
| 4 | Low-Temperature Synthesis of Hausmannite Mn3O4显示文摘 | Sagheer F A Hasan M A Pasupulety L | 1999 | Journal of Materials Science Letters1999，18，3： | 1 |
| 5 | Complete spontaneous regression of an extrahepatic portal vein aneurysm显示文摘 | Purandath L Lohith P Hasan H D | 2011 | J Vasc Surg2011，53，1： | 1 |
| 6 | Coupled turbulent flow, heat and solute transport in continuous casting processes 显示文摘 | ABOULALEBI M R HASAN M GULHRIE R L | 1995 | Metall Mater Trans1995，26，4： | 1 |
| 7 | A geometric analysis of diffusion tensor measurements of the human brain显示文摘 | Alexander A L Hasan K Kindlmann G | 2000 | Magn Reson Med2000，44，： | 1 |
| 8 | A new genetic algorithm with lamarckian individual learning for generation scheduling显示文摘 | Habib R M Hasan M S Caro L | 2003 | IEEE Transactions on Power Systems2003，18，3： | 1 |
| 9 | Further Evidence on the Link Between Finance and Growth: An International Analysis of Community Banking and Economic Performance 显示文摘 | Berger A N Hasan I Klapper L | 2004 | Journal of fi- nancial Services Research2004，，25： | 1 |
| 10 | Further Evidence on the Link Between Finance and Growth: An International Analysis of Community Banking and Economic Performance 显示文摘 | BERGER A N HASAN I KLAPPER L F | 2004 | Journal of Financial Services Research2004，25，： | 1 |
| 11 | Colloquium: topological insulators 显示文摘 | Hasan M Z Kane C L | 2010 | Reviews of Modern Physics2010，82，4： | 1 |
| 12 | Genetic polymorphisms and drug interactions leading to clopidogrel resistance:why the Asian population requires special attention显示文摘 | HASAN M S BASRI H B HIN L P | 2013 | Int J Neurosci2013，123，3： | 1 |
| 13 | Assessing the quality of Web sites 显示文摘 | Hasan L Abuelrub E | 2011 | Applied Computing and Informatics2011，9，1： | 1 |
| 14 | Coupled Turbulent Flow, Heat, and Solute Transport in Continuous Casting Process显示文摘 | Aboutalebi M R Hasan M Guthrie R I L | 1995 | Metall Mater Trans1995，26，4： | 1 |
| 15 | Effect of materialvariation on the biomechanical behaviour of orthodontic fixed appliances: a finite element analysis显示文摘 | Papageorgiou SN Keilig L Hasan I | 2015 | Eur J Orthod2015，14，3： | 1 |
| 16 | Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell 显示文摘 | MacDonald MJ Smith AD Hasan NM l | 2007 | The Journal of Biological Chemistry2007，282，30： | 1 |
| 17 | Push-over analysis for performance-based seismic design显示文摘 | XU L GRIERSON D E | 2002 | Computers and Structures2002，80，31： | 1 |
| 18 | Low-temperature synthesis of nanominite Mn3O4显示文摘 | F A Hasan M A Pasupuletv | 1999 | Journal of materials Science Letters1999，18，3： | 1 |
| 19 | The use of Fh3 as adjuvant for hepatitis B vaccination of healthy adults显示文摘 | Evans TG Hasan M Galibert L | 2002 | Vaccine2002，21，34： | 1 |
| 20 | Returns to retail banking and payments显示文摘 | Hasan I Schmiedel H Song L | 2012 | Journal of Financial Services Research2012，41，3： | 1 |
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