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| 1 | Nodular regenerative hyperplasia:Evolving concepts on underdiagnosed cause of portal hypertension显示文摘Nodular regenerative hyperplasia(NRH)is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules.NRH may lead to the development of non-cirrhotic portal hypertension.There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series.NRH may develop via autoimmune,hematological,infectious,neoplastic,or drug-related causes.The disease is usually asymptomatic,slowly or nonprogressive unless complications of portal hypertension develop.Accurate diagnosis is made by histopathology,which demonstrates diffuse micronodular transformation without fibrous septa.Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver.While the initial treatment is to address the underlying disease,ultimately the therapy is directed to the management of portal hypertension.The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension.In this review we detail the epidemiology,pathogenesis,diagnosis,management,and prognosis of NRH. | Marek Hartleb Krzysztof Gutkowski Piotr Milkiewicz | 2011 | World Journal of Gastroenterology2011，17，11： | 16 |
| 2 | Serum adipokines in inflammatory bowel disease显示文摘AIM:To investigate serum adipokine levels in inflammatory bowel disease(IBD)patients before treatment and after achieving clinical remission.METHODS:Serum concentrations of six adipokines(tissue growth factor-β1,adiponectin,leptin,chemerin,resistin,and visfatin)were studied in 40 subjects with active IBD[24 subjects with Crohn’s disease(CD)and in 16 subjects with ulcerative colitis(UC)]before and after three months of therapy with corticosteroids and/or azathioprine.Clinical diagnoses were based on ileocolonoscopy,computed tomography or magnetic resonance enterography and histological examination of mucosal biopsies sampled during endoscopy.Serum levels of adipokines were assessed by an indirect enzyme-linked immunosorbent assay.The control group was comprised of 16 age-and sex-matched healthyvolunteers.RESULTS:Baseline leptin concentrations were significantly decreased in both types of IBD compared to controls(8.0±9.1 in CD and 8.6±6.3 in UC vs 16.5±10.1 ng/mL in controls;P<0.05),and significantly increased after treatment only in subjects with CD(14.9±15.1 ng/mL;P<0.05).Baseline serum resistin concentrations were significantly higher in CD(19.3±12.5ng/mL;P<0.05)and UC subjects(23.2±11.0 ng/mL;P<0.05)than in healthy controls(10.7±1.1 ng/mL).Treatment induced a decrease in the serum resistin concentration only in UC subjects(14.5±4.0 ng/mL;P<0.05).Baseline serum concentrations of visfatin were significantly higher in subjects with CD(23.2±3.2ng/mL;P<0.05)and UC(18.8±5.3 ng/mL;P<0.05)than in healthy controls(14.1±5.3 ng/mL).Treatment induced a decrease in the serum visfatin concentrations only in CD subjects(20.4±4.8 ng/mL;P<0.05).Serum levels of adiponectin,chemerin and tissue growth factor-β1 did not differ between CD and UC subjects compared to healthy controls and also were not altered by anti-inflammatory therapy.Clinical indices of IBD activity did not correlate with adipokine levels.CONCLUSION:IBD modulates serum adipokine levels by increasing resistin and visfatin release and suppressing leptin production. | Marek Waluga Marek Hartleb Grzegorz Boryczka Micha Kukla Krystyna Zwirska-Korczala | 2014 | World Journal of Gastroenterology2014，20，22： | 11 |
| 3 | Kidneys in chronic liver diseases显示文摘Acute kidney injury(AKI),defined as an abrupt increase in the serum creatinine level by at least 0.3 mg/dL,occurs in about 20% of patients hospitalized for decompensating liver cirrhosis.Patients with cirrhosis are susceptible to developing AKI because of the progressive vasodilatory state,reduced effective blood volume and stimulation of vasoconstrictor hormones.The most common causes of AKI in cirrhosis are pre-renal azotemia,hepatorenal syndrome and acute tubular necrosis.Differential diagnosis is based on analysis of circumstances of AKI development,natriuresis,urine osmolality,response to withdrawal of diuretics and volume repletion,and rarely on renal biopsy.Chronic glomerulonephritis and obstructive uropathy are rare causes of azotemia in cirrhotic patients.AKI is one of the last events in the natural history of chronic liver disease,therefore,such patients should have an expedited referral for liver transplantation.Hepatorenal syndrome(HRS) is initiated by progressive portal hypertension,and may be prematurely triggered by bacterial infections,nonbacterial systemic inflammatory reactions,excessive diuresis,gastrointestinal hemorrhage,diarrhea or nephrotoxic agents.Each type of renal disease has a specific treatment approach ranging from repletion of the vascular system to renal replacement therapy.The treatment of choice in type 1 hepatorenal syndrome is a combination of vasoconstrictor with albumin infusion,which is effective in about 50% of patients.The second-line treatment of HRS involves a transjugular intrahepatic portosystemic shunt,renal vasoprotection or systems of artificial liver support. | Marek Hartleb Krzysztof Gutkowski | 2012 | World Journal of Gastroenterology2012，18，24： | 8 |
| 4 | Simultaneous liver mucinous cystic and intraductal papillary mucinous neoplasms of the bile duct:A case report显示文摘Cystic hepatic neoplasms are rare tumors,and are classified into two separate entities:mucinous cystic neoplasms(MCNs)and intraductal papillary mucinous neoplasms of the bile duct(IPMN-B).We report the case of a 56-year-old woman who presented with abdominal pain and jaundice due to the presence of a large hepatic multilocular cystic tumor associated with an intraductal tumor.Partial hepatectomy with resection of extrahepatic bile ducts demonstrated an intrahepatic MCN and an intraductal IPMN-B.This is the first report of the simultaneous occurrence of these two histologically distinct entities in the liver. | Agnieszka Budzynska Marek Hartleb Ewa Nowakowska-Dulawa Robert Krol Piotr Remiszewski Michal Mazurkiewicz | 2014 | World Journal of Gastroenterology2014，20，14： | 2 |
| 5 | Hepatic angiogenesis and fibrosis are common features in morbidly obese patients显示文摘 | Monika Ciupińska-Kajor Marek Hartleb Maciej Kajor Micha? Kukla Mariusz Wyle?o? Dariusz Lange ?ukasz Liszka | 2013 | Hepatology International2013，，1： | 1 |
| 6 | Procalci-tonin and macrophage inflammatory protein -1 beta ( MIP -1p) in serum and peritoneal fluid of patients with decompen-sated cirrhosis and spontaneous bacterial peritonitis显示文摘 | LESINSKA M HARTLEB M GUTKOWSKI K etal | 2014 | AdvMed Sci2014，59，1： | 1 |
| 7 | Serological prevalence of hepatitis B virus and hepatitis C virus infection in the elderly population: Polish nationwide survey – PolSenior显示文摘 | Marek Hartleb Krzysztof Gutkowski Jan E. Zejda Jerzy Chudek Andrzej Wi?cek | 2012 | European Journal of Gastroenterology & Hepatology2012，，11： | 1 |
| 8 | Alcoholic liver disease 显示文摘 | Waluga M Hartleb M | 2003 | Wiad Lek2003，56，12： | 1 |
| 9 | Coagu- lopathy in liver diseases显示文摘 | PLUTA A GUTKOWSKI K HARTLEB M | 2010 | Advances in Medical Sci- ences2010，55，： | 1 |
| 10 | Procalcitonin and macrophage inflammatory protein-1 beta (MIP-113) in serum and peritoneal fluid of patients with decompensated cirrhosis and spontaneous bacterial peritonitis显示文摘 | Lesi fi ska M Hartleb M Gutkowski K | 2014 | Adv Med Sci2014，59，1： | 1 |
| 11 | Drug-induced liver damage-a three-year study of patients from one gastroenterological department显示文摘 | Hartleb M Biernat L Kochel A | 2002 | Med Sci Monit2002，8，4： | 1 |
| 12 | Vascular hyproresponsiveness to endothelin- 1 in rats with cirrhosis显示文摘 | Hartleb M Moreau R Cailmail S | 1994 | Gastroenterology1994，107，4： | 1 |
| 13 | Alcoholic liver disease显示文摘 | Waluga M Hartleb M | 2003 | W iadLek2003，56，12： | 1 |
| 14 | Vasculor hy- poresponsiveness to endothelin-1 in rats with cirrhosis显示文摘 | HARTLEB M MOREAU R CAILMAIL S | 1994 | Gas- troenterology1994，107，4： | 1 |
| 15 | Coagulopathy in liver diseases 显示文摘 | Pluta A Gutkowski K Hartleb M | 2010 | Adv Med Sci2010，55，1： | 1 |
| 16 | Neurogenic tumors of the digestive tract:report of two cases 显示文摘 | Rymarczyk G Hartleb M Boldys H | 2000 | Med Sci Monit2000，6，2： | 1 |
| 17 | Coagulopathy in liver diseases显示文摘 | Pluta A Gutkowski K Hartleb M | | 0，，01： | 1 |
| 18 | Vascular hyporesponsiveness to endothelin-1 in rats with cirrhosis 显示文摘 | 14,Hartleb M Moreau K Cailmail S | 1994 | Gastroenterology1994，107，4： | 1 |
| 19 | Vascular hyporeponsiveness to endothelin in rats with cirrhosis显示文摘 | Moreau R Caimail S | 1994 | Gastroenterology1994，107，： | 1 |
| 20 | Coagulopathy in liver diseases显示文摘 | A Pluta K Gutkowski M Hartleb | 2010 | Advances in Medical Sciences2010，，1： | 1 |
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