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| 1 | Nodular regenerative hyperplasia:Evolving concepts on underdiagnosed cause of portal hypertension显示文摘Nodular regenerative hyperplasia(NRH)is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules.NRH may lead to the development of non-cirrhotic portal hypertension.There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series.NRH may develop via autoimmune,hematological,infectious,neoplastic,or drug-related causes.The disease is usually asymptomatic,slowly or nonprogressive unless complications of portal hypertension develop.Accurate diagnosis is made by histopathology,which demonstrates diffuse micronodular transformation without fibrous septa.Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver.While the initial treatment is to address the underlying disease,ultimately the therapy is directed to the management of portal hypertension.The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension.In this review we detail the epidemiology,pathogenesis,diagnosis,management,and prognosis of NRH. | Marek Hartleb Krzysztof Gutkowski Piotr Milkiewicz | 2011 | World Journal of Gastroenterology2011，17，11： | 16 |
| 2 | Kidneys in chronic liver diseases显示文摘Acute kidney injury(AKI),defined as an abrupt increase in the serum creatinine level by at least 0.3 mg/dL,occurs in about 20% of patients hospitalized for decompensating liver cirrhosis.Patients with cirrhosis are susceptible to developing AKI because of the progressive vasodilatory state,reduced effective blood volume and stimulation of vasoconstrictor hormones.The most common causes of AKI in cirrhosis are pre-renal azotemia,hepatorenal syndrome and acute tubular necrosis.Differential diagnosis is based on analysis of circumstances of AKI development,natriuresis,urine osmolality,response to withdrawal of diuretics and volume repletion,and rarely on renal biopsy.Chronic glomerulonephritis and obstructive uropathy are rare causes of azotemia in cirrhotic patients.AKI is one of the last events in the natural history of chronic liver disease,therefore,such patients should have an expedited referral for liver transplantation.Hepatorenal syndrome(HRS) is initiated by progressive portal hypertension,and may be prematurely triggered by bacterial infections,nonbacterial systemic inflammatory reactions,excessive diuresis,gastrointestinal hemorrhage,diarrhea or nephrotoxic agents.Each type of renal disease has a specific treatment approach ranging from repletion of the vascular system to renal replacement therapy.The treatment of choice in type 1 hepatorenal syndrome is a combination of vasoconstrictor with albumin infusion,which is effective in about 50% of patients.The second-line treatment of HRS involves a transjugular intrahepatic portosystemic shunt,renal vasoprotection or systems of artificial liver support. | Marek Hartleb Krzysztof Gutkowski | 2012 | World Journal of Gastroenterology2012，18，24： | 8 |
| 3 | Load-independent control of a hydraulic excavator显示文摘 | Eugeniusz Budny Miroslaw Chlosta Witold Gutkowski | 2003 | Automationin Construction2003，2003，12： | 1 |
| 4 | Procalci-tonin and macrophage inflammatory protein -1 beta ( MIP -1p) in serum and peritoneal fluid of patients with decompen-sated cirrhosis and spontaneous bacterial peritonitis显示文摘 | LESINSKA M HARTLEB M GUTKOWSKI K etal | 2014 | AdvMed Sci2014，59，1： | 1 |
| 5 | Field Load Tests of an Anisotropic - grid Timber Bridge 显示文摘 | GUTKOWSKI R M NATTERER J FAVRE P A | 2006 | Construction and Building Materials2006，，9： | 1 |
| 6 | Stereopsis and monovision in the contact lens management of presbyopia显示文摘 | Gutkowski M Cassir B | 1991 | Int Ophthalmol Clin1991，31，1： | 1 |
| 7 | Serological prevalence of hepatitis B virus and hepatitis C virus infection in the elderly population: Polish nationwide survey – PolSenior显示文摘 | Marek Hartleb Krzysztof Gutkowski Jan E. Zejda Jerzy Chudek Andrzej Wi?cek | 2012 | European Journal of Gastroenterology & Hepatology2012，，11： | 1 |
| 8 | High-pressure phase behavior of the binary ionic liquid system 1-octyl-3-methylimidazolium tetrafluoroborate+carbon dioxide显示文摘 | Gutkowski K I Shariati A Peters C J | 2006 | Journal of Supercritical Fluids2006，39，： | 1 |
| 9 | Acute coronary syndrome following massive pulmonary embolism in a 81-year-old woman with thrombophilia 显示文摘 | Wozakowska-KatAon B Bzymek RM Gutkowski W | 2008 | Kardiol Pol2008，66，5： | 1 |
| 10 | Acute my- ocardial infarction due to left main coronary artery disease in men and women:does ST-segment elevation matter? 显示文摘 | Sadowski M Gutkowski W Raczyhski G | 2015 | Arch Med Sci2015，11，6： | 1 |
| 11 | Coagu- lopathy in liver diseases显示文摘 | PLUTA A GUTKOWSKI K HARTLEB M | 2010 | Advances in Medical Sci- ences2010，55，： | 1 |
| 12 | Optimal design of a truss configuration under multiloading conditions 显示文摘 | Dems K Gutkowski W | 1995 | Structural Optimization1995，9，： | 1 |
| 13 | Procalcitonin and macrophage inflammatory protein-1 beta (MIP-113) in serum and peritoneal fluid of patients with decompensated cirrhosis and spontaneous bacterial peritonitis显示文摘 | Lesi fi ska M Hartleb M Gutkowski K | 2014 | Adv Med Sci2014，59，1： | 1 |
| 14 | Composite repair of timber structures 显示文摘 | Radford D Van Goethem D Gutkowski R | 2002 | Construction and Building Materials2002，16，7： | 1 |
| 15 | Algorithm for retrieval and verification of personal identity using bimodal biometrics显示文摘 | Gutkowski P | 2004 | Information Fusion2004，5，1： | 1 |
| 16 | Investigation o显示文摘 | Gutkowski R M Brown IK Shigidi A | 2004 | Journal of Structural Engineering2004，130，10： | 1 |
| 17 | Load-independent control of a hydraulic excavator 显示文摘 | BUDNY E CHLOSTA M GUTKOWSKI W | 2003 | Journal of Automation in Construction2003，12，3： | 1 |
| 18 | Social determinants of loneliness among older Americans 显示文摘 | Mullins LC Elston CH Gutkowski SM | 1996 | Genet Soc Gen Psychol Monogr1996，122，4： | 1 |
| 19 | High-pressure phase behavior of the binary ionic liquid system 1-octyl- 3-methylimidazolium tetrafluoroborate+carbon dioxide 显示文摘 | GUTKOWSKI K I SHARIATI A PETERS C J | 2006 | J Supercrit Fluid2006，39，： | 1 |
| 20 | Coagulopathy in liver diseases 显示文摘 | Pluta A Gutkowski K Hartleb M | 2010 | Adv Med Sci2010，55，1： | 1 |
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