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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Developing a low-cost milliliter-scale chemostat array for precise control of cellular growth显示文摘 | David Skelding Samuel F M Hart Thejas Vidyasagar Alexander E Pozhitkov Wenying Shou | 2018 | Frontiers of Electrical and Electronic Engineering in China2018，6，2： | 2 |
| 3 | Identification of candidate molecu- lar markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection 显示文摘 | Huang F Reeves K Hart X | 2007 | Cancer Res2007，67，5： | 1 |
| 4 | GDF5 SNP rs143383 is as-sociated with lumbar disc disease in northern European women显示文摘 | Williams F Popham M Hart D | 2011 | Arthritis Rheum2011，3，： | 1 |
| 5 | Evalution of the airtraq and macintosh laryngoscopes in patients at increased risk for difficult tracheal intubation 显示文摘 | MAHARAJ C H COSTELLO J F HARTE B H | 2008 | Anaesthesia2008，63，2： | 1 |
| 6 | Medical treatment of Rasmussen' s syndrome( chronic encephalitis and epilepsy)显示文摘 | Hart YM Cortez M Andermann F | 1994 | Neuralogy1994，44，6： | 1 |
| 7 | High salt intake accelerated cardiac remodeling in spontaneously hypertensive rats : time window of left ventficular functional transition and its relation to salt-loading doses显示文摘 | Gao F Hart ZQ Zhou X | 2011 | Clin Exp Hypertens2011，2，： | 1 |
| 8 | Analysis of eighty-one cases with breast lesions using automated breast volume scanner and comparison with handheld ultrasound 显示文摘 | Lin X Wang J Hart F | 2012 | Eur J Radiol2012，81，5： | 1 |
| 9 | The relation of temperature to oxygen consumption in the goldfish显示文摘 | FRY F &Hart JS | 1948 | The Biological Bulletin1948，94，1： | 1 |
| 10 | Soil carbon sequestrations by nitrogen fertilizer application, straw return and no-tillage in China's cropland 显示文摘 | Lu F Wang X K Hart B | 2009 | Global Change Biology2009，15，2： | 1 |
| 11 | Carbon nitride: Ab initio investigation of carbon-rich phases 显示文摘 | HART J N CLEAYSSENS F ALLAN N L | 2009 | Phys Rev B2009，80，17： | 1 |
| 12 | Lung cancer in railroad work- ers exposed to diesel exhaust显示文摘 | Garshick E Laden F Hart JE | 2004 | Environ Health Perspect2004，112，15： | 1 |
| 13 | Effects of apocynin, a drug isolated from the roots of Pierorhiza kurroa, on arachidonie acid metabolism 显示文摘 | Engels F Renirie BF Hart BA | 1992 | FEBS Lett1992，305，3： | 1 |
| 14 | Pulmonary passage is a major obstacle for intravenous stem cell delivery:the pulmonary first-pass effect显示文摘 | Fischer UM Harting MT Jimenez F | | 0，，05： | 1 |
| 15 | Power flow solutions by Newton's method显示文摘 | Tinney W F Hart C E | | 0，，11： | 1 |
| 16 | Ankylosing spondylitis andHLA-B27显示文摘 | Brewerton D A Caffrey M Hart F D | 1973 | Lancet1973，1，7809： | 1 |
| 17 | From bijels to picketing emulsions: a lattice Boltzmann study显示文摘 | Jansen F Harting J | 2011 | Phys Rev E2011，83，04： | 1 |
| 18 | Guaranteed Cost Control of Affine Nonlinear Systems via Partition of Unity Method 显示文摘 | Hart D F Shi L | 2013 | Automatica2013，49，2： | 1 |
| 19 | Stroke in the people's republic of China显示文摘 | Shi F L Hart RG Shemam DG | 1989 | Stroke1989，20，11： | 1 |
| 20 | A comparison or PCR with am in fectivity assay for HIV-1 titration during virus inactivation of blood products显示文摘 | Mcomish F Hart WG | 1993 | Transfusion1993，33，10： | 1 |
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