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| 1 | Mapping QTL associated with Verticillium dahliae resistance in the cultivated strawberry(Fragaria×ananassa)显示文摘A biparental cross of octoploid strawberry segregating for resistance to Verticillium dahliae,the causative agent of Verticillium wilt,was screened under field conditions for three seasons.Average wilt scores were significantly associated with multiple QTL,which were mostly significant across all years.Markers significantly associated with the traits were used to screen material with known wilt resistance and susceptibility phenotypes.A clear and statistically significant relationship was observed between resistant,tolerant and susceptible material and the total number of markers present in the different resistance classes.In field situations resistance QTL appear to behave in an additive manner.These markers are abundant in the cultivated strawberry germplasm indicating that,despite the large number of markers,clear genetic gain is possible through marker-assisted breeding. | L Antanaviciute NŠurbanovski N Harrison K J McLeary D W Simpson F Wilson D J Sargent R J Harrison | 2015 | Horticulture Research2015，2，1： | 5 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | Evaluating distributed generation impacts with a multiobjective index显示文摘 | Ochoa L F Padilha-Feltrin A Harrison G | 2006 | IEEE Trans on Power Del2006，21，3： | 1 |
| 4 | Observations on gray leaf spot of maize in Virginia显示文摘 | Roane C W Harrison R I Center C F | 1974 | Plant Disease Report1974，58，： | 1 |
| 5 | Motor evoked potential monitoring during spinal surgery: responses of distal limb muscles to transcranial cortical stimulation with pulse trains 显示文摘 | Jones S J Harrison R Koh K F | 1996 | Electroencephalogr Clin Neurophysiol1996，100，5： | 1 |
| 6 | Time-series-based prediction of complex oscillator networks via compressive sensing显示文摘 | Wang W X Yang R Lai Y C Kovanis V Harrison M A F | 2011 | EPL2011，94，48： | 1 |
| 7 | The value of lesion cross sectional area determined by quantitative coronary angiography in assessing the physiologic significance of proximal left anterior descending coronary arterial stenoses 显示文摘 | Harrison D G White C W Hiratzka L F | 1984 | Circulation1984，69，6： | 1 |
| 8 | Cost-effectiveness in diagnosing infantile hypertrophic pyloric stenosis 显示文摘 | Hulka F Campell JR Harrison MW | 1997 | J Pediatr Surg1997，32，： | 1 |
| 9 | Technology, standards, and real- world deployments of the EPC network 显示文摘 | Thieseh F Floerkemeier C Harrison M | 2009 | IEEE Internet Computing2009，13，2： | 1 |
| 10 | Effect of spacing and age on nitrogen and phosphorus distribution in biomass of Eucalyptus camaldulensis,Eucalyptus pellita and Eucalyptus urophylla plantations in southeastern Brazil显示文摘 | Harrison R B Reis G G Reis M D G F | 2000 | Forest Ecology and Management2000，133，3： | 1 |
| 11 | Clouds and the Earth's Radiant Energy System (CERES): An earth observing system experiment 显示文摘 | Wielicki B A Barkstrom B R Harrison E F | 1996 | Bulletin of American Meteorological Society1996，77，： | 1 |
| 12 | Hawthorn: an overview of chemical, pharmacological and clinical studies显示文摘 | CHANG Q ZUO Z HARRISON F | 2002 | Journal of Clinical Pharmacology2002，42，6： | 1 |
| 13 | Ordered mesoporous Fe2O3 with crystalline walls显示文摘 | Jiao F Harrison A Jumas J C | 2006 | Journal of the American Chemical Society2006，128，16： | 1 |
| 14 | Use of immunochemical techniques for the analysis of pesticides 显示文摘 | Jung F Gee S J Harrison R 0 | 1989 | Pestic Sci1989，26，： | 1 |
| 15 | Effects of climate change on nitrogen dynamics in upland soils ( 1 ) : A transplant approach 显示文摘 | Ineson P Taylor K Harrison A F | 1998 | Global Change Biology1998，4，2： | 1 |
| 16 | Optical and Radio Observations of the Afterglow from GRB 990510: Evidence for a Jet显示文摘 | Harrison F A Bloom J S Frail D A | 1999 | APJ1999，523，： | 1 |
| 17 | 显示文摘 | Harrison DJ Candy AM Rae F | 1997 | Hum Exp Toxicol1997，17，： | 1 |
| 18 | Development of a novel 3D simulation modelling system for distributed manufacturing显示文摘 | Qin S F Harrison R West A A | 2004 | Computers in Industry2004，54，1： | 1 |
| 19 | Cloud radiative forcing and climate: results from the Earth radiation budget experiment 显示文摘 | Ramanathan V Cess R D Harrison E F | 1989 | Sci- ence1989，243，4887： | 1 |
| 20 | Removal of domestic airborne dust particles by naturally charged liquid sprays 显示文摘 | Gaunt L F Hughes J F Harrison N M | 2003 | Journal of Electrostatics2003，58，15： | 1 |
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