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| 1 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 2 | Ambient UVB radiation causes deformities in amphibian embryos 显示文摘 | Blaustein A R Kiesecker J M Chivers D P | 1997 | Proc Nat Acad Sci USA1997，94，13： | 1 |
| 3 | Easy removal of pressure sensitive adhesives for skin applications显示文摘 | CHIVERS R A | 2001 | International Journal of Adhesion & Adhesives2001，21，： | 1 |
| 4 | Fretting fatigue and contact condition: a rational explanation of palliative behaviour显示文摘 | Chivers T C Gordelier S C | 1985 | Imech E1985，199，： | 1 |
| 5 | Studying primate carpal kinematics in three dimensions using a computed - tomography - based markerless registration method显示文摘 | Orr CM Leventhal EL Chivers SF | 2010 | Anat Rec (Hoboken)2010，293，4： | 1 |
| 6 | Chemical alarm signalling in aquatic predator-prey systems:A review and prospectus显示文摘 | CHIVERS D P SMITH R J F | 1998 | Ecoscience1998，，： | 1 |
| 7 | Characterization of the trisulfur radical anionS3- in blue solutions of alkali polysulfides in hexamethylphosphoramide显示文摘 | Chivers T Drummond I | 1972 | Inorg Chem1972，11，25： | 1 |
| 8 | Raman spectroscopic identification of theS4N– and S3- ions in blue solutions of sulfur in liquid ammonia显示文摘 | Chivers T Lau C | 1982 | Inorg Chem1982，21，45： | 1 |
| 9 | An intact urease assembly pathway is re-quired to compete with NikR for nickel ions in Helicobacter pylori显示文摘 | BENANTI E L CHIVERS P T | 2009 | JBacteriol2009，191，7： | 1 |
| 10 | Complex transcriptional control links NikABCDE-dependent nickel transport with hydrogenase expression in Escherichia coli显示文摘 | Rowe J L Starnes G L Chivers PT | 2005 | Journal of Bacteriology2005，187，7： | 1 |
| 11 | The effect of videl-based perceptual training on the tennis return of serve显示文摘 | Farrow D Chivers P Hardingham C & Sachse S | 1998 | International Journal of Sport Psychology1998，29，3： | 1 |
| 12 | The effect of video-based perceptual training on the tennis return of serve显示文摘 | Farrow D Chivers P Hardingham C | 1998 | International Journal of Sport Psychology1998，29，： | 1 |
| 13 | Mucosal disease of cattle显示文摘 | Ramsey F K Chivers W H | 1953 | North Am Vet1953，34，： | 1 |
| 14 | Mucosal disease of cattle显示文摘 | Ramsey FK Chivers WH | 1953 | North Americ Veterinary1953，34，4： | 1 |
| 15 | The sonocrystallisation of ice in sucrose solutions: primary and secondary nucleation显示文摘 | Rachel Chow Renoo Blindt Robert Chivers Malcolm Povey | 2003 | Ultrasonics2003，41，： | 1 |
| 16 | A study on the primary and secondary nucleation of ice by power ultrasound显示文摘 | Chow R Blindt R Chivers R | 2005 | Ultra- sonics2005，43，4： | 1 |
| 17 | The siamang in Malaya: a field study of a primate in a tropical forest 显示文摘 | Chivers D J | 1974 | Contr Primatol1974，4，： | 1 |
| 18 | The microscopic visualization of the sonocrystallisation of ice using a novel ultrasonic cold stage显示文摘 | Rachel Chow Renoo Blindt Arnold Kamp Peter Grocutt Robert Chivers | 2004 | Ultrasonics Sonochemistry2004，11，： | 1 |
| 19 | The effect of video- based perceptual training on the tennis return of serve 显示文摘 | Farrow D Chivers P Hardingham C | 1998 | Inter- national Journal of Sport Psychology1998，29，3： | 1 |
| 20 | Morphlogy of the gastroinlestinal tract in primates:comparision with the mammals in relation to diet显示文摘 | Chivers D J Hladic C M | 1980 | J Morpha1980，166，： | 1 |
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