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| 1 | Roles of Fas signaling pathway in vitamin E succinateinduced apoptosis in human gastric cancer SGC-7901 cells显示文摘AIM: To investigate the roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.METHODS: Human gastric cancer SGC-7901 cells were treated with VES at 5, 10, 20 mg@L-1, succinic acid and vitamin E as vehicle control and condition media only as untreated (UT) control. Apoptotic morphology was observed by DAPI staining. Western blot analysis was applied to measure the expression of Fas, FADD and caspase-8 proteins. After the cells were transiently transfected with Fas and FADD antisense oligonucleotides, respectively, caspase-8 activity was determined by flurometric method.RESULTS: The morphologically apoptotic changes were observed after VES treatment by DAPI staining. 23.7 % and 89.6 % apoptosis occurred after 24 h and 48 h of 20 mg@L-1 VES treatment, respectively. The protein levels of Fas, FADD and caspase-8 were evidently increased in a dose-dependent manner after 24 h of VES treatment. The blockage of Fas by transfection with Fas antisense oligonucleotides obviously inhibited the expression of FADD protein. After SGC-7901 cells were transfected with Fas and FADD antisense oligonucleotides, caspase-8 activity was obviously decreased (P<0.01), whereas Fas blocked more than FADD.CONCLUSION: VES-induced apoptosis in human gastric cancer SGC-7901 cells involves Fas signaling pathway including the interaction of Fas, FADD and caspase-8. | Kun Wu Yao Li Yan Zhao Yu-Juan Shah Wei Xia Lan Zhao,Department of Nutrition and Food Hygiene,Public Health School,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Wei-Ping Yu,Genetics Institute,Texas University of USA,Austin,USA | 2002 | World Journal of Gastroenterology2002，8，6： | 30 |
| 2 | Enhanced anaerobic biodegradability of real coal gasification wastewater with methanol addition显示文摘Coal gasification effluent is a typical refractory industrial wastewater with a very poor anaerobic biodegradability due to its toxicity.Methanol was introduced to improve anaerobic biodegradability of real coal gasification wastewater,and the effect of methanol addition on the performance was investigated in a mesophilic upflow anaerobic sludge bed reactor with a hydraulic retention time of 24 hr.Experimental results indicated that anaerobic treatment of coal gasification wastewater was feasible with the addition of methanol.The corresponding maximum COD and phenol removal rates were 71% and 75%,respectively,with methanol concentration of 500 mg COD/L for a total organic loading rate of 3.5 kg COD/(m3 ·day) and a phenol loading rate of 0.6 kg/(m3 ·day).The phenol removal rate was not improved with a higher methanol concentration of 1000 mg COD/L.Substrate utilization rate (SUR) tests indicated that the SURs of phenol were 106,132,and 83 mg phenol/(g VSS·day) at methanol concentrations of 250,500,and 1000 mg COD/L,respectively,and only 45 mg phenol/(g VSS·day) in the control reactor.The presence of methanol could reduce the toxicity of coal gasification wastewater and increase the biodegradation of phenolic compounds. | Wei Wang,Hongjun Han,Min Yuan,Huiqiang Li State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology,Harbin 150090,China | 2010 | Journal of Environmental Sciences2010，22，12： | 25 |
| 3 | Effect of cis-9,trans-11-conjugated linoleic acid on cell cycle of gastric adenocarcinoma cell line(SGC-7901)显示文摘AIM: To determine the effect of cis-9, trans-1l-conjugated linoleic acid ( c9, tl 1-CLA) on the cell cycle of gastric cancer cells( SGC-7901 ) and its possible mechanism in inhibition cancer growth.METHODS: Using cell culture and immunocytochemicaltechniques, we examined the cell growth, DNA synthesis,expression of PCNA, cyclin A, B1, D1, pl6nink4a and p21clp/wafl ofSGC-7901 cells which were heated with various c9, tll-CLAconcentrations (25,50,100 and 200μnol@L-1)of c9, tll-CLA for 24and 48 h, with a negative control (0.1% ethane).RESULTS: The cell growth and DNA synthesis of SGC-7901cells were inhibited by c9, tll-CLA. SGC-7901 cells. Eightday after treatment with various concentrations of c9, tl1-CLA mentioned above, the inhibition rates were 5.92 % ,20.15 % ,75.61% and 82.44 % ,respectively and inhibitory effeotof c9, tll-CLA on DNA synthesis (except for 25 tmol/L,24h) showed significantly less 3H-TdR incorporation than thatin the negative controls (P < 0. 05 and P < 0. 01).Immunocytochemical staining demonstrated that SGC-7901cells preincubated in media supplemented with different c9,tl1-CLA concentrations at various times significantlydecreased the expressions of PCNA (the expression rateswere7.2-3.0 %,24 h and 9.1-0.9 % at 48 h, respectively),Cyclin A (l1.0-2.3 %, 24 h and 8.5-0.5 % ,48 h), B1 (4.8-1.8% at 24 h and 5.5-0.6 % at 48 h)and D1 (3.6-1.4 % at 24 hand 3.7 %-0 at 48 h) as compared with those in the negativecontrols(the expressions of PCNA, Cyclin A, B1 and D1were 6.5 % at 24h and 9.0 % at 48 h, 4.2% at 24h and5.1% at 48 h, 9.5 % at 24h and 6.0 % at 48 h,respectively)(P< 0.01), whereas the expressions of p16ink4a and p21clp/waf1,cyclin-dependent kinases inhibltors(CDKI), were increased.CONCLUSION: The cell growth and proliferation of SGC-7901cell is inhibited by c9, tll-CLA via blocking the cell cycle,with reduced expressions of cyclin A, B1 and D1 andenhanced expressions of CDKI( p16ink4a and p21cip/waf1). | Jia-Ren Liu Bai-Xiang Li Bing-Qing Chen Ying-ben Xue Yan-Mei Yang Yu-Mei Zheng,Department of Toxicological Health,Public Health College,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Xiao-Hui Han ICU of Cardiological Surgery,The Second Hospital,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Rui-Hai Liu,Food Science and Toxicology,Department of Food Science,Cornell University,Ithaca,NY 14853-7201,USA | 2002 | World Journal of Gastroenterology2002，8，2： | 26 |
| 4 | COMPUTERIZED SIMULATION AND EXPERIMENTAL RESEARCH ON SOFT-SWITCHING ARC WELDING INVERTER POWER SOURCE显示文摘Based on the existing component models in the Pspice software package, a combined model for Insulat- ed the Bipolar Transistor (IGBT) is established, in which a non - linear is introduced to represent the parasitic capacitance. Using this model, computerized simulation is conducted for the FB - ZVZCS - PWM soft - ewitching converter,the switching and energy-transferring characteristics of the components are analyzed.The simulation results are testified by experiments.It is proved that by abopting appropriate models,computerized simulation becomes an effective tool for investigation of arc welding inverter power source. | S. J. Chen S. Y. Yin L. Feng and L. Y. Li( 1) School of Materials Science and Engineering, Beijing Polytechnic University, Beijing 100022, China 2)National Key Laboratory of Advanced Welding Production Technology, HIT, Harbin 150001, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 24 |
| 5 | Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats显示文摘AIM:To determine whether mitochondrial dysfunction resulting from high-fat diet is related to impairment of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt,also known as PKB) pathway. METHODS:Rat models of nonalcoholic fatty liver were established by high-fat diet feeding. The expression of total and phosphorylated P13K and Akt proteins in hepatocytes was determined by Western blotting. Degree of fat accumulation in liver was measured by hepatic triglyceride. Mitochondrial number and size were determined using quantitative morphometric analysis under transmission electron microscope. The permeability of the outer mitochondrial membrane was assessed by determining the potential gradient across this membrane.RESULTS:After Wistar rats were fed with high-fat diet for 16 wk,their hepatocytes displayed an accumulation of fat (103.1 ± 12.6 vs 421.5 ± 19.7,P < 0.01),deformed mitochondria (9.0% ± 4.3% vs 83.0% ± 10.9%,P < 0.05),and a reduction in the mitochondrial membrane potential (389.385% ± 18.612% vs 249.121% ± 13.526%,P < 0.05). In addition,the expression of the phosphorylated P13K and Akt proteins in hepatocytes was reduced,as was the expression of the anti-apoptotic protein Bcl-2,while expression of the pro-apoptotic protein caspase-3 was increased. When animals were treated with pharmacological inhibitors of P13K or Akt,instead of high-fat diet,a similar pattern of hepatocellular fat accumulation,mitochondrial impairment,and change in the levels of PI3K,Akt,Bcl-2 was observed. CONCLUSION:High-fat diet appears to inhibit the PI3K/Akt signaling pathway,which may lead to hepa-tocellular injury through activation of the mitochondrial membrane pathway of apoptosis. | Ji-Wu Han,Department of Gastroenterology,The 4th Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China Xiao-Rong Zhan,Xin-Yu Li,Bing Xia,Yue-Ying Wang,Jing Zhang,Department of Endocrinology,First Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China Bao-Xin Li,Department of Pharmacology,State Key Laboratory of Biomedicine and Pharmacology,Harbin Medical University,Harbin 150001,Heilongjiang Province,China | 2010 | World Journal of Gastroenterology2010，16，48： | 22 |
| 6 | Assessment of tumor vascularization with functional computed tomography perfusion imaging in patients with cirrhotic liver disease显示文摘BACKGROUND:Hepatocellular carcinoma(HCC)is a common malignant tumor in China,and early diagnosis is critical for patient outcome.In patients with HCC,it is mostly based on liver cirrhosis,developing from benign regenerative nodules and dysplastic nodules to HCC lesions,and a better understanding of its vascular supply and the hemodynamic changes may lead to early tumor detection.Angiogenesis is essential for the growth of primary and metastatic tumors due to changes in vascular perfusion,blood volume and permeability.These hemodynamic and physiological properties can be measured serially using functional computed tomography perfusion(CTP)imaging and can be used to assess the growth of HCC.This study aimed to clarify the physiological characteristics of tumor angiogenesis in cirrhotic liver disease by this fast imaging method. METHODS:CTP was performed in 30 volunteers without liver disease(control subjects)and 49 patients with liver disease (experimental subjects:27 with HCC and 22 with cirrhosis). All subjects were also evaluated by physical examination, laboratory screening and Doppler ultrasonography of the liver. The diagnosis of HCC was made according to the EASL criteria. All patients underwent contrast-enhanced ultrasonography, pre-and post-contrast triple-phase CT and CTP study.A mathematical deconvolution model was applied to provide hepatic blood flow(HBF),hepatic blood volume(HBV), mean transit time(MTT),permeability of capillary vessel surface(PS),hepatic arterial index(HAI),hepatic arterial perfusion(HAP)and hepatic portal perfusion(HPP)data. The Mann-Whitney U test was used to determine differences in perfusion parameters between the background cirrhotic liver parenchyma and HCC and between the cirrhotic liver parenchyma with HCC and that without HCC.RESULTS:In normal liver,the HAP/HVP ratio was about 1/4. HCC had significantly higher HAP and HAI and lower HPP than background liver parenchyma adjacent to the HCC.The value of HBF at the tumor rim was significantly higher than that in the controls.HBF,HBV,HAI,HAP and HPP,but not MTT and PS,were significantly higher in the cirrhotic liver parenchyma involved with HCC than those of the controls. Perfusion parameters were not significantly different between the controls and the cirrhotic liver parenchyma not involved with HCC. CONCLUSIONS:CTP can clearly distinguish tumor from cirrhotic liver parenchyma and controls and can provide quantitative information about tumor-related angiogenesis, which can be used to assess tumor vascularization in cirrhotic liver disease. | Jin-Ping Li,De-Li Zhao,Hui-Jie Jiang,Ya-Hua Huang,Da-Qing Li,Yong Wan, Xin-Ding Liu and Jin-E Wang Department of Radiology,Second Affiliated Hospital,Harbin Medical University,Harbin150086,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，1： | 21 |
| 7 | Chebyshev Fitting Way and Error Analysis for Propeller Atlas across Four Quadrants显示文摘A Chebyshev fitting way for a propeller atlas across four quadrants is discussed. As an example, Chebyshev polynomialfitting results and its error analysis are given. Because it’s difficult generally to get a propeller atlas across four quadrants,a wayis used to construct an alternative with higher accuracy based on the properties. As an application example, an alternative forthe propeller property of a Deep Submergence Vebicle across four quadrants is given practically and a simulation model of | LI Dian-pu, WANG Zong-yi, CHI Hai-hong College of Automation , Harbin Engineering University, Harbin 150001, China | 2002 | Journal of Marine Science and Application2002，1，1： | 20 |
| 8 | Monitoring microbial community structure and succession of an A/O SBR during start-up period using PCR-DGGE显示文摘Polymerase chain reaction(PCR)-denaturing gradient gel electrophoresis(DGGE) protocol was employed for revealing microbial community structure and succession in a sequential anaerobic and aerobic reactor performing enhanced biological phosphorus removal(EBPR) during start-up period.High phosphorus removal was achieved after 15 d.On day 30,phosphorus removal effciency reached to 83.2% and the start-up was finished.DGGE profiles of periodical sludge samples showed that dominant microbial species were 19 OTUs(operational taxonomy units).Unweighted pair-group method using arithmetic averages(UPGMA) clustering analysis revealed that rapid community succession correlated to low phosphorus removal rate and high phosphorus removal effciency reflected on steady community structure.Sequencing results indicated that determined sequences(12 OTUs) belonged to Proteobacterium,Actinobacteria,Gemmatimonadales and unaffiliate group.Proteobacterium,Tetrasphaera elongate and Gemmatimonas aurantiaca may act important roles in phosphorus removal.With little amount as known glycogen accumulating organisms,Candidatus Competibacter phosphatis still at accumulating-phase had limited effect on microbial community structure.When climax community was obtained,dominant microbes were 14 OTUs.Microbes in a large amount were uncultured bacterium Thauera sp.,uncultured γ-Proteobacterium and Tetrasphaera elongata. | WANG Xiuheng,ZHANG Kun,REN Nanqi,LI Nan,REN Lijiao State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology,Harbin 150090,China. | 2009 | Journal of Environmental Sciences2009，21，2： | 17 |
| 9 | An Anthropomorphic Robot Hand Developed Based on Underactuated Mechanism and Controlled by EMG Signals显示文摘When developing a humanoid myo-control hand,not only the mechanical structure should be considered to afford a highdexterity,but also the myoelectric (electromyography,EMG) control capability should be taken into account to fully accomplishthe actuation tasks.This paper presents a novel humanoid robotic myocontrol hand (AR hand Ⅲ) which adopted an underac-tuated mechanism and a forearm myocontrol EMG method.The AR hand Ⅲ has five fingers and 15 joints,and actuated by threeembedded motors.Underactuation can be found within each finger and between the rest three fingers (the middle finger,the ringfinger and the little finger) when the hand is grasping objects.For the EMG control,two specific methods are proposed:thethree-fingered hand gesture configuration of the AR hand Ⅲ and a pattern classification method of EMG signals based on astatistical learning algorithm-Support Vector Machine (SVM).Eighteen active hand gestures of a testee are recognized ef-fectively,which can be directly mapped into the motions of AR hand Ⅲ.An on-line EMG control scheme is established basedon two different decision functions:one is for the discrimination between the idle and active modes,the other is for the recog-nition of the active modes.As a result,the AR hand Ⅲ can swiftly follow the gesture instructions of the testee with a time delayless than 100 ms. | Da-peng Yang~1 Jing-dong Zhao~1 Yi-kun Gu~1 Xin-qing Wang~1 Nan Li~1 Li Jiang~1Hong Liu~(1,2) Hai Huang~3 Da-wei Zhao~41.State Key Laboratory of Robotics and System,Harbin Institute of Technology,Harbin 150001,P.R.China2.Institute of Robotics and Mechatronics,German Aerospace Center,Munich 82230,Germany3.College of Shipbuilding Engineering,Harbin Engineering University,Harbin 150001,P.R.China4.College of Automation,Harbin Engineering University,Harbin 150001,P.R.China | 2009 | Journal of Bionic Engineering2009，6，3： | 16 |
| 10 | Factors predisposing to severe acute pancreatitis:evaluation and prevention显示文摘AIM: To analyze factors predisposing to the infections associated with severe acute pancreatitis (SAP) and to work out ways for its prevention.METHODS: Total 208 cases of SAP treated in this hospital from Jan. 1980 to Dec. 2001 were retrospectively analyzed.RESULTS: Statistical difference in the incidence of the aforementioned infections was found between the following pairs: between the groups of bloody or non-bloody ascites,paralytic ileus lasting shorter or longer than 5 days, Ranson scores lower or higher than 5, hematocrit lower or higher than 45 %, CT Balthazar scores lower or higher than 7 and between 1980.1-1992.6 or 1992.7-2001.12 admissions (χ2>3.84, P<0.05), while no statistical difference was established between the groups of biliogenic and nonbiliogenic pancreatitis, serum amylase <200 U/L and ≥200U/L, serum calcium <2 mmol/L and ≥ 2 mmol/L or groups of total parenteral nutrition shorter or longer than 7 days (χ2<3.84, P>0.05).CONCLUSION: Occurrence of infection in patients with SAP is closely related with bloody ascites, paralytic ileus ≥5 days, Ranson scores ≥5, hematocrit ≥45 % and CT Balthazar Scores ≥7, but not with pathogens, serum calcium and total parenteral nutrition (TPN). Comprehensive prevention of pancreatic infection and practice of individualized therapy contribute to reducing the incidence of infection. | Bei Sun Ha-Li Li Yue Gao Jun Xu Hong-Chi Jiang Department of General Surgery,First Clinical Hospital,Harbin Medical University,Harbin 150001,China | 2003 | World Journal of Gastroenterology2003，9，5： | 14 |
| 11 | Performance-based methodology for assessing seismic vulnerability and capacity of buildings显示文摘This paper presents a performance-based methodology for the assessment of seismic vulnerability and capacity of buildings. The vulnerability assessment methodology is based on the HAZUS methodology and the improved capacity- demand-diagram method. The spectral displacement (Sd) of performance points on a capacity curve is used to estimate the damage level of a building. The relationship between Sd and peak ground acceleration (PGA) is established, and then a new vulnerability function is expressed in terms of PGA. Furthermore, the expected value of the seismic capacity index (SCev) is provided to estimate the seismic capacity of buildings based on the probability distribution of damage levels and the corresponding seismic capacity index. The results indicate that the proposed vulnerability methodology is able to assess seismic damage of a large number of building stock directly and quickly following an earthquake. The SCev provides an effective index to measure the seismic capacity of buildings and illustrate the relationship between the seismic capacity of buildings and seismic action. The estimated result is compared with damage surveys of the cities of Dujiangyan and Jiangyou in the M8.0 Wenchuan earthquake, revealing that the methodology is acceptable for seismic risk assessment and decision making. The primary reasons for discrepancies between the estimated results and the damage surveys are discussed. | Lin Shibin1, Xie Lili1, 2,Gong Maosheng1,2 and Li Ming1,3 1.Institute of Engineering Mechanics,China Earthquake Administration, Harbin 150080, China 2.School of Civil Engineering,Harbin Institute of Technology,Harbin 150090, China 3.School of Civil Engineering,Shenyang Jianzhu University,Shenyang 11016, China | 2010 | Earthquake Engineering and Engineering Vibration2010，9，2： | 12 |
| 12 | HEAT TRANSFER BEHAVIOR OF SUPERALLOY DROPLETS DURING SPRAY FORMING显示文摘Based on the Newtonian heat transfer formulation and classical heterogeneous nucleation theory, a mathematical model has been established to predict the profile of flight velocity, heat transfer coefficient, temperature, solid fraction and cooling rate of atomizing droplets for a superalloy. The results indicated that above parameters change with different droplet size and flight distance. The changing trend as well as the mechanism for the change are described and discussed. | J.F. Sun, J. Shen, Z. Y. Li, J. Jia and Q.C. Li National Key Laboratory of Metal Precision Hot Processing, Harbin Institute of Technology, Harbin 150001, China | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 11 |
| 13 | Preliminary analysis of the hanging wall effect and velocity pulse of the 5.12 Wenchuan earthquake显示文摘A preliminary study of the PGA attenuation, hanging wall effect and velocity pulse characteristics from the 2008 Wenchuan earthquake of Ms =8.0 is described in this paper. The study was carried out through analyses in the time and frequency domains of main earthquake records. In the PGA attenuation study, records from 316 stations less than 1000 km from the surface rupture of the fault were used as a database and attenuation relationships were developed and compared with some existing relationships that are widely used in China's Mainland, Chinese Taiwan and the US. At the same time, records from 28 stations less than 100 km from the fault were used to study the hanging wall effect and velocity pulse characteristics of this earthquake based on the distribution of PGA, PGV, spectral acceleration, and the velocity pulse peak, and the results are compared with the 1999 Chi-Chi earthquake. In addition, the large PGAs of the UD components observed in this event are also discussed in this paper. From the results of the preliminary study, some conclusions are developed and suggestions for further research are proposed. | Liu Qifang and Li Xiaojun Institute of Engineering Mechanics, China Earthquake Administration, Harbin 150080, China Associate Professor Professor | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 11 |
| 14 | Arsenic trioxide promotes mitochondrial DNA mutation and cell apoptosis in primary APL cells and NB4 cell lines显示文摘This study aimed to investigate the effects of arsenic trioxide(As2O3) on the mitochondrial DNA(mtDNA) of acute promyelocytic leukemia(APL) cells.The NB4 cell line was treated with 2.0 μmol/L As2O3 in vitro,and the primary APL cells were treated with 2.0 μmol/L As2O3 in vitro and 0.16 mg kg-1 d-1 As2O3 in vivo.The mitochondrial DNA of all the cells above was amplified by PCR,directly sequenced and analyzed by Sequence Navigatore and Factura software.The apoptosis rates were assayed by flow cytometry.Mitochondrial DNA mutation in the D-loop region was found in NB4 and APL cells before As2O3 use,but the mutation spots were remarkably increased after As2O3 treatment,which was positively correlated to the rates of cellular apoptosis,the correlation coefficient:rNB4-As2O3=0.973818,and rAPL-As2O3=0.934703.The mutation types include transition,transversion,codon insertion or deletion,and the mutation spots in all samples were not constant and regular.It is revealed that As2O3 aggravates mtDNA mutation in the D-loop region of acute promyelocytic leukemia cells both in vitro and in vivo.Mitochondrial DNA might be one of the targets of As2O3 in APL treatment. | MENG Ran1,ZHOU Jin2,SUI Meng3,LI ZhiYong4,FENG GuoSheng1 & YANG BaoFeng2 1 Division of Neurology,the Ninth Clinical Medical College of Beijing University(Shijitan Hospital),Beijing 100038,China 2 The First Hospital of Harbin Medical University,Harbin 150001,China 3 Management Information System,University of International Business and Economics,Beijing 100029,China 4 Department of Radiology,Cambridge University Hospitals NHS Foundation Trust Box 219 Level 5,Addenbrooke’s Hospital Cambridge CB2 0QQ,UK | 2010 | Science China(Life Sciences)2010，53，1： | 10 |
| 15 | Adaptive inverse control of random vibration based on the filtered-X LMS algorithm显示文摘随机的颤动控制针对复制力量光谱在指定控制的密度(PSD ) 指。古典频率光谱均等算法需要计算多重频率反应函数(FRF ) 的一般水准,它变长在均等进程的控制循环时间。同样,反馈控制算法让很慢的集中由于反馈获得参数的小价值评价保证系统的稳定性。克服这些限制,随机的颤动的适应反的控制基于 filtered-X 最不吝啬平方(LMS ) 算法被建议。根据描述和频率领域的随机的颤动测试的重复特征,而且,频率领域 LMS 算法被采用精制 FRF 的反的特征而不是传统的时间领域 LMS 算法。这个反的特征,在控制下面被称为系统的阻抗函数,被用来直接更新驱动器 PSD。测试结果显示除了成功地避免发生在重复过程期间的不稳定性问题,适应控制策略最小化需要获得一个短控制环并且完成均等的时间的数量。关键词随机的颤动 - 力量光谱密度 - 频率反应功能 - 适应反的控制 - filtered-X LMS 算法旁边支持了:不在资助下面在大学里为新世纪优秀才能编程序。 | Yang Zhidong,Huang Qitao~(++),Han Junwei~§and Li Hongren~§National Key Laboratory of Robots Technique and System,Harbin Institute of Technology,Harbin 150080,China PhD Candidate ~++ PhD ~§Professor | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 10 |
| 16 | The single nucleotide polymorphisms of the chicken myostatin gene are associated with skeletal muscle and adipose growth显示文摘Myostatin, a new member of the TGF-β superfamily, is predominantly expressed in skeletal muscle cells and functions as a negative regulator of skeletal muscle growth in animals. Recently, we have reported three single nucleotide polymorphisms (SNPs) in the chicken myostatin gene. Herein, we investigate the association of those SNPs with the production traits in a F2 chicken line derived from Broilers crossing to Silky with the least square analysis. The results show that the BB and AA genotypes are strongly associated with abdominal fat weight (AFW), abdominal fat percentage (AFP), and birth weight (BW) (P < 0.05). Breast muscle percentage (BMP) of the AA type is higher than that of the AB type. The breast muscle weight and breast muscle percentages of F2 individuals have significant difference between CC and DD genotypes (P < 0.05). Breast muscle weight (BMW) of EF birds is higher than that of EE birds (P < 0.05). In this report, we present the first genetic evidence to show that chicken myostatin not only plays an important role in controlling skeletal muscle growth and differentiation, but also may be involved in regulation of adipose growth in chicken. | GU Zhiliang, ZHU Dahai, LI Ming, LI Hui, DENG Xuemei & WU ChangxinMolecular and Cellular Developmental Biology Laboratory, Harbin Institute of Technology, Harbin 150001, China College of Animal Science & Technology, Northeast Agricultural University, Harbin 150030, China National Laboratories for Agribiotechnology, China Agricultural University, Beijing 100094, China College of Animal Science & Technology, China Agricultural University, Beijing 100094, China Department of Life Science and Technology, Changshu Institute of Technology, Changshu 215500, China Department of Biochemistry and Molecular Biology, National Laboratory of Medical Molecular Biology, Peking Union Medical College, Beijing 100005, China | 2004 | Science China(Life Sciences)2004，47，1： | 9 |
| 17 | 大兴安岭呼中林区狍冬季卧息生境的选择显示文摘大兴安岭呼中林区狍冬季卧息生境的选择关键词狍子,卧息点选择,大兴安岭WINTERRESTINGSITESELECTIONBYROEDEERATHUZHONG,DAXINGANLINGMOUNTAINSNORTHEASTERNCHINA￥JiangZh... | Jiang Zhaowen Xu Li(Institute of Natural Resources,Heilongjang Academy of Sciences Harbin 150040)Wang Yongqing(Daxinganling District Forestry Resource and Policy Administrative Bureau)Jiao Peirong Liu Hongfa(Resouce Management Section,Huzhong,Daxingonling | 1996 | Zoological Research1996，17，2： | 8 |
| 18 | SURFACE ROUGHNESS PREDICTION MODEL FOR ULTRAPRECISION TURNING ALUMINIUM ALLOY WITH A SINGLE CRYSTAL DIAMOND TOOL显示文摘A surface roughness model utilizing regression analysis method is developed for predicting roughness of ultraprecision machined surface with a single crystal diamond tool. The effects of the main variables,such as cutting speed,feed,and depth of cut on surface roughness are also analyzed in diamond turning aluminum alloy. In order to predict and control the surface roughness before ultraprecision machining,constrained variable metric method is used to select the optimum cutting conditions during process planning. A lot of experimental results show that the model can predict the surface roughness effectively under a certain cutting conditions . | Wang Hongxiang Li Dan Dong shen Precision Engineering Research Institute, Harbin Institute of Technology, Harbin 150001, China | 2002 | Chinese Journal of Mechanical Engineering2002，15，2： | 8 |
| 19 | Early changes of hepatic hemodynamics measured by functional CT perfusion in a rabbit model of liver tumor显示文摘BACKGROUND:Early detection and treatment of hepatocellular carcinoma is crucial to improving the patients' survival.The hemodynamic changes caused by tumors can be serially measured using CT perfusion.In this study,we used a CT perfusion technique to demonstrate the changes of hepatic hemodynamics in early tumor growth,as a proof-of-concept study for human early hepatocellular carcinoma.METHODS:VX2 tumors were implanted in the liver of ten New Zealand rabbits.CT perfusion scans were made 1 week(early) and 2 weeks(late) after tumor implantation.Ten normal rabbits served as controls.CT perfusion parameters were obtained at the tumor rim,normal tissue surrounding the tumor,and control liver;the parameters were hepatic blood flow,hepatic blood volume,mean transit time,permeability of capillary vessel surface,hepatic arterial index,hepatic arterial perfusion and hepatic portal perfusion.Microvessel density and vascular endothelial growth factor were correlated.RESULTS:At the tumor rim,compared to the controls,hepatic blood flow,hepatic blood volume,permeability of capillary vessel surface,hepatic arterial index,and hepatic arterial perfusion increased,while mean transit time and hepatic portal perfusion decreased on both early and late scans(P<0.05).Hepatic arterial index increased(135%,P<0.05),combined with a sharp increase in hepatic arterial perfusion(182%,P<0.05) and a marked decrease in hepatic portal perfusion(-76%,P<0.05) at 2 weeks rather than at 1 week(P<0.05).Microvessel density and vascular endothelial growth factor showed significant linear correlations with hepatic blood flow,permeability of capillary vessel surface and hepatic arterial index,but not with hepatic blood volume or mean transit time.CONCLUSION:The CT perfusion technique demonstrated early changes of hepatic hemodynamics in this tumor model as proof-of-concept for early hepatocellular carcinoma detection in humans. | Guo-Lin Ma,Rong-Jie Bai,Hui-Jie Jiang,Xue-Jia Hao,Xu-Peng Dong,Da-Qing Li,Xin-Ding Liu and Lai Wei Department of Radiology,China-Japan Friendship Hospital,Beijing 100029,China Department of Radiology,Beijing Jishuitan Hospital,Beijing 100035,China Department of Radiology,Second Affiliated Hospital,Harbin Medical University,Harbin 150086,China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 8 |
| 20 | Changes in soluble interleukin-2 receptor level in serum and Na^+ -K^+ -exchanging ATPase activity in semen of infertile men caused by antisperm antibody显示文摘Aim: To explore the possible mechanisms of male infertility caused by antisperm antibody (AsAb). Methods: The soluble interleukin-2 receptor (sIL-2R) level in serum was analyzed by ELISA and Na^+ -K^+ -exchanging ATPase activity in semen by phosphorus (Pi) assay. Results: The sIL-2R level in serum was significantly higher and the Na^+-K^+- exchanging ATPase activity in semen significantly lower in AsAb positive infertile men when compared with the controls. Conclusion: The AsAb titer varies with the sIL-2R level in serum. A decrease in Na^+-K^+-exchanging ATPase activity in semen may play a role in male infertility caused by AsAb. | Jiang NI Qing-Lei LI Wei ZHANG Jian-Song XIE Shu-Ling BIAN Department of Physiology, Harbin Medical University, Harbin 150086, China | 2000 | Asian Journal of Andrology2000，2，2： | 8 |
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