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| 1 | Upregulation of annexin A5 affects the biological behaviors of lung squamous carcinoma cells in vitro显示文摘Annexin A5 is a Ca2?-dependent phospholipidbinding protein and protein kinase C inhibitory protein. It has a potential role in cellular signal transduction, inflammation, growth and differentiation. In this study, we evaluated the expression of this protein in lung tumor tissues and subsequently established a NCI-H520 cell line that stably expresses the wild-type ANXA5 gene to determine the effects of annexin A5 upregulation on the cell morphology, proliferation and metastasis potential in vitro.The effects of annexin A5 on NCI-H520 cells were tested by crystal violet staining, CCK-8 assay, scratch wound assay, and Transwell assay. The expressions of Akt,PCNA, vimentin, and E-cadherin were examined by Western blot assay. In this study, we demonstrated that annexin A5 is expressed at lower levels in tumor tissues compared with normal tissues. Additionally, the upregulation of this protein may inhibit the proliferation, migration, and invasion abilities of NCI-H520 cells in vitro. The transfected cells were arrested in the G1/S phase of the cell cycle, and the expression levels of Akt, PCNA and Vimentin were downregulated, while E-cadherin was upregulated. | Linlin Gong Haoqi Zhao Lan Wang Bing Sun Lijun Yu Xiaoyu Qi Xin Zhou Liyuan Zhang Hongwei Guan Shujuan Shao | 2014 | Chinese Science Bulletin2014，59，28： | 6 |
| 2 | Ultrafast control of fractional orbital angular momentum of microlaser emissions显示文摘On-chip integrated laser sources of structured light carrying fractional orbital angular momentum(FOAM)are highly desirable for the forefront development of optical communication and quantum information-processing technologies.While integrated vortex beam generators have been previously demonstrated in different optical settings,ultrafast control and sweep of FOAM light with low-power control,suitable for high-speed optical communication and computing,remains challenging.Here we demonstrate fast control of the FOAM from a vortex semiconductor microlaser based on fast transient mixing of integer laser vorticities induced by a control pulse.A continuous FOAM sweep between charge 0 and charge+2 is demonstrated in a 100 ps time window,with the ultimate speed limit being established by the carrier recombination time in the gain medium.Our results provide a new route to generating vortex microlasers carrying FOAM that are switchable at GHz frequencies by an ultrafast control pulse. | Zhifeng Zhang Haoqi Zhao Danilo Gomes Pires Xingdu Qiao Zihe Gao Josep M.Jornet Stefano Longhi Natalia M.Litchinitser Liang Feng | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 3 | Surface Doping vs.Bulk Doping of Cathode Materials for Lithium-Ion Batteries:A Review显示文摘To address the capacity degradation,voltage fading,structural instability and adverse interface reactions in cathode materi-als of lithium-ion batteries(LIBs),numerous modification strategies have been developed,mainly including coating and doping.In particular,the important strategy of doping(surface doping and bulk doping)has been considered an effective strategy to modulate the crystal lattice structure of cathode materials.However,special insights into the mechanisms and effectiveness of the doping strategy,especially comparisons between surface doping and bulk doping in cathode materials,are still lacking.In this review,recent significant progress in surface doping and bulk doping strategies is demonstrated in detail by focusing on their inherent differences as well as effects on the structural stability,lithium-ion(Li-ion)diffusion and electrochemical properties of cathode materials from the following mechanistic insights:preventing the exposure of reactive Ni on the surface,stabilizing the Li slabs,mitigating the migration of transition metal(TM)ions,alleviating unde-sired structural transformations and adverse interface issues,enlarging the Li interslab spacing,forming three-dimensional(3D)Li-ion diffusion channels,and providing more active sites for the charge-transfer process.Moreover,insights into the correlation between the mechanisms of hybrid surface engineering strategies(doping and coating)and their influences on the electrochemical performance of cathode materials are provided by emphasizing the stabilization of the Li slabs,the enhancement of the surface chemical stability,and the alleviation of TM ion migration.Furthermore,the existing challenges and future perspectives in this promising field are indicated. | Huaming Qian Haoqi Ren Ying Zhang Xianfeng He Wenbin Li Jingjing Wang Junhua Hu Hong Yang Hirbod Maleki Kheimeh Sari Yu Chen Xifei Li | 2022 | Electrochemical Energy Reviews2022，5，4： | 2 |
| 4 | Experimental investigation on single person's jumping load model显示文摘This paper presents a modified half-sine-squared load model of the jumping impulses for a single person. The model is based on a database of 22,921 experimentally measured single jumping load cycles from 100 test subjects. Threedimensional motion capture technology in conjunction with force plates was employed in the experiment to record jumping loads. The variation range and probability distribution of the controlling parameters for the load model such as the impact factor, jumping frequency and contact ratio, are discussed using the experimental data. Correlation relationships between the three parameters are investigated. The contact ratio and jumping frequency are identified as independent model parameters, and an empirical frequency-dependent function is derived for the impact factor. The feasibility of the proposed load model is established by comparing the simulated load curves with measured ones, and by comparing the acceleration responses of a single-degree-of-freedom system to the simulated and measured jumping loads. The results show that a realistic individual jumping load can be generated by the proposed method. This can then be used to assess the dynamic response of assembly structures. | Chen Jun Wang Haoqi Wang Ling | 2015 | Earthquake Engineering and Engineering Vibration2015，14，4： | 1 |
| 5 | Detecting Noncommutative Phase Space by Aharonov-Bohm Effect显示文摘 | Liang Shi-Dong Li Haoqi Huang Guang-Yao | 2015 | Phys Rev A2015，90，18： | 1 |
| 6 | Adaptive Consensus Quantized Control for a Class of High-Order Nonlinear Multi-Agent Systems With Input Hysteresis and Full State Constraints显示文摘For a class of high-order nonlinear multi-agent systems with input hysteresis,an adaptive consensus output-feedback quantized control scheme with full state constraints is investigated.The major properties of the proposed control scheme are:1)According to the different hysteresis input characteristics of each agent in the multi-agent system,a hysteresis quantization inverse compensator is designed to eliminate the influence of hysteresis characteristics on the system while ensuring that the quantized signal maintains the desired value.2)A barrier Lyapunov function is introduced for the first time in the hysteretic multi-agent system.By constructing state constraint control strategy for the hysteretic multi-agent system,it ensures that all the states of the system are always maintained within a predetermined range.3)The designed adaptive consensus output-feedback quantization control scheme allows the hysteretic system to have unknown parameters and unknown disturbance,and ensures that the input signal transmitted between agents is the quantization value,and the introduced quantizer is implemented under the condition that only its sector bound property is required.The stability analysis has proved that all signals of the closed-loop are semi-globally uniformly bounded.The Star Sim hardware-in-the-loop simulation certificates the effectiveness of the proposed adaptive quantized control scheme. | Guoqiang Zhu Haoqi Li Xiuyu Zhang Chenliang Wang Chun-Yi Su Jiangping Hu | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，9： | 1 |
| 7 | Ethylene Polymeri- zation Using a Novel MgCl2/SiO2-Supported Ziegler-Natta Catalyst 显示文摘 | Wang Jianfeng Wang Li Gao Haoqi | 2006 | Polym lnt2006，55，3： | 1 |
| 8 | Advancing the experiment to reality: Perspectives on Shanghai pilot carbon emissions trading scheme显示文摘 | Libo Wu Haoqi Qian Jin Li | 2014 | Energy Policy2014，，： | 1 |
| 9 | GelNB molecular coating as a biophysical barrier to isolate intestinal irritating metabolites and regulate intestinal microbial homeostasis in the treatment of inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)is a chronic,immune-mediated inflammatory disease characterized by the destruction of the structure and function of the intestinal epithelial barrier.Due to the poor remission effect and severe adverse events associated with current clinical medications,IBD remains an incurable disease.Here,we demonstrated a novel treatment strategy with high safety and effective inflammation remission via tissue-adhesive molecular coating.The molecular coating is composed of o-nitrobenzaldehyde(NB)-modified Gelatin(GelNB),which can strongly bond with-NH_(2)on the intestinal surface of tissue to form a thin biophysical barrier.We found that this molecular coating was able to stay on the surface of the intestine for long periods of time,effectively protecting the damaged intestinal epithelium from irritations of external intestinal metabolites and harmful flora.In addition,our results showed that this coating not only provided a beneficial environment for cell migration and proliferation to promote intestinal repair and regeneration,but also achieved a better outcome of IBD by reducing intestinal inflammation.Moreover,the in vivo experiments showed that the GelNB was better than the classic clinical medication-mesalazine.Therefore,our molecular coating showed potential as a promising strategy for the prevention and treatment of IBD. | Qijiang Mao Haoqi Pan Yiyin Zhang Yi Zhang Qiuwen Zhu Yi Hong Zhengze Huang Yang Li Xu Feng Yifeng Fang WenChao Chen Pengfei Chen Bo Shen Hongwei Ouyang Yuelong Liang | 2023 | Bioactive Materials2023，，1： | 1 |
| 10 | Ethylene Polymeriza- tion Using a Novel MgC12/SiO2-Supported Ziegler-Natta Catalyst显示文摘 | Wang Jianfen Wang Li Gao Haoqi | 2006 | Polym lnt2006，55，3： | 1 |
| 11 | Phylogeny,molecular evolution,and dating of divergences in Lagerstroemia using plastome sequences显示文摘Lagerstroemia L.(Lythraceae)is a widely distributed genus of trees and shrubs native to tropical and subtropical environments from Southeast Asia to Australia,with numerous species highly valued as ornamentals.Although the plastomes of many species in this genus have been sequenced,the rates of functional gene evolution and their effect on phylogenetic analyses have not been thoroughly examined.We compared three plastome sequence matrices to elucidate how differences in these datasets affected phylogenetic analyses.Robust phylogenetic relationships for Lagerstroemia species were reconstructed based on different plastome sequence partitions and multiple phylogenetic methods.Identification of single-nucleotide variants within different genes also provides basic data on the patterns of functional gene evolution in Lagerstroemia and may provide insights into how those mutations affect protein structure and potentially drive divergence via cytonuclear incompatibility.These results as well as analyses of non-synonymous and synonymous mutations,indicate that heterotachic modes of evolution are present in functional plastome genes and should be accounted for in the analyses of molecular evolution.In addition,divergence events within the Lagerstroemia were dated for the first time.Several of the divergence estimates corresponded to well-known Earth history events,such as the reduction in global temperatures at the Eocene/Oligocene boundary.Our analyses conducted in Lagerstroemia here dissects the various patterns in the divergence of Lagerstroemia and may provide a useful guide to help plant breeders,as well as the necessity of using plastomic data and as possible as to combine evidence from morphological characteristics to investigate the complicated interspecies relationship and the evolutionary dynamics of species. | Jie Wang Wenchuang He Xuezhu Liao Jin Ma Wei Gao Haoqi Wang Dili Wu Luke R.Tembrock Zhiqiang Wu Cuihua Gu | 2023 | Horticultural Plant Journal2023，9，2： | 1 |
| 12 | Robustactivestereovisionusingkullback-leiblerdivergence显示文摘 | WangYongchang LiuKai HaoQi etal | 2012 | IEEETransonPatternAnalysisandMachineIntelligence2012，34，3： | 1 |
| 13 | Broadband continuous supersymmetric transformation:a new paradigm for transformation optics显示文摘Transformation optics has formulated a versatile framework to mold the flow of light and tailor its spatial characteristics at will.Despite its huge success in bringing scientific fiction(such as invisibility cloaking)into reality,the coordinate transformation often yields extreme material parameters unfeasible even with metamaterials.Here,we demonstrate a new transformation paradigm based upon the invariance of the eigenspectra of the Hamiltonian of a physical system,enabled by supersymmetry.By creating a gradient-index metamaterial to control the local index variation in a family of isospectral optical potentials,we demonstrate broadband continuous supersymmetric transformation in optics,on a silicon chip,to simultaneously transform the transverse spatial characteristics of multiple optical states for arbitrary steering and switching of light flows.Through a novel synergy of symmetry physics and metamaterials,our work provides an adaptable strategy to conveniently tame the flow of light with full exploitation of its spatial degree of freedom. | Jieun Yim Nitish Chandra Xilin Feng Zihe Gao Shuang Wu Tianwei Wu Haoqi Zhao Natalia M.Litchinitser Liang Feng | 2022 | eLight2022，2，1： | 1 |
| 14 | 显示文摘 | Liu Qinglin Gao Haoqi | 2003 | Journal of Membrane Science2003，214，： | 1 |
| 15 | Adsorption kinetics and thermodynamics of water-insoluble crosslinked β -cyclodextrin polymer for phenol in aqueous solution显示文摘 | Hui Huang Yifan Fan Junwei Wang Haoqi Gao Shiying Tao | 2013 | Macromolecular Research2013，，7： | 1 |
| 16 | Electricity Carbon Quota Trading Scheme based on Certificateless Signature and Blockchain显示文摘The carbon tradingmarket can promote“carbon peaking”and“carbon neutrality”at low cost,but carbon emission quotas face attacks such as data forgery,tampering,counterfeiting,and replay in the electricity trading market.Certificateless signatures are a new cryptographic technology that can address traditional cryptography’s general essential certificate requirements and avoid the problem of crucial escrowbased on identity cryptography.However,most certificateless signatures still suffer fromvarious security flaws.We present a secure and efficient certificateless signing scheme by examining the security of existing certificateless signature schemes.To ensure the integrity and verifiability of electricity carbon quota trading,we propose an electricity carbon quota trading scheme based on a certificateless signature and blockchain.Our scheme utilizes certificateless signatures to ensure the validity and nonrepudiation of transactions and adopts blockchain technology to achieve immutability and traceability in electricity carbon quota transactions.In addition,validating electricity carbon quota transactions does not require time-consuming bilinear pairing operations.The results of the analysis indicate that our scheme meets existential unforgeability under adaptive selective message attacks,offers conditional identity privacy protection,resists replay attacks,and demonstrates high computing and communication performance. | Xiaodong Yang Runze Diao Tao Liu Haoqi Wen Caifen Wang | 2024 | Computer Modeling in Engineering & Sciences2024，138，2： | 0 |
| 17 | LncRNA-m18as1 competitively binds with miR-18a-5p to regulate follicle-stimulating hormone secretion through the Smad2/3 pathway in rat primary pituitary cells显示文摘Long noncoding RNAs(lncRNAs)are expressed in different species and different tissues,and perform different functions,but little is known about their involvement in the synthesis or secretion of follicle-stimulating hormone(FSH).In general,we have revealed lnc RNA-micro RNA(mi RNA)-messenger RNA(m RNA)interactions that may play important roles in rat primary pituitary cells.In this study,a new lncRNA was identified for the first time.First,we analyzed the gene expression of lncRNA-m18as1 in different tissues and different stages by reverse transcription-quantitative polymerase chain reaction(RT-qPCR)and observed the localization of lncRNA-m18as1 with fluorescence in situ hybridization,which indicated that this lncRNA was distributed mainly in the cytoplasm.Next,we used RT-qPCR and enzyme-linked immunosorbent assay(ELISA)to analyze the regulation of FSH synthesis and secretion after overexpression or knockdown of lncRNA-m18as1 and found that lncRNA-m18as1 was positively correlated with FSH synthesis and secretion.In addition,mothers against decapentaplegic homolog 2(Smad2)was highly expressed in our sequencing results.We also screened miR-18a-5p from our sequencing results as a miRNA that may bind to lncRNA-m18as1 and Smad2.We used RNA immunoprecipitation-qPCR(RIP-qPCR)and/or dual luciferase assays to confirm that lncRNA-m18as1 interacted with miR-18a-5p and miR-18a-5p interacted with Smad2.Fluorescence in situ hybridization(FISH)showed that lncRNA-m18as1 and miR-18a-5p were localized mainly in the cytoplasm.Finally,we determined the relationship among lncRNA-m18as1,miR-18a-5p,and the Smad2/3 pathway.Overall,we found that lncRNA-m18as1 acts as a molecular sponge of miR-18a-5p to regulate the synthesis and secretion of FSH through the Smad2/3 pathway. | Weidi ZHANG Wenzhi REN Dongxu HAN Guokun ZHAO Haoqi WANG Haixiang GUO Yi ZHENG Zhonghao JI Wei GAO Bao YUAN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，6： | 0 |
| 18 | High-Throughput Powder Diffraction Using White X-Ray Beam and a Simulated Energy-Dispersive Array Detector显示文摘High-throughput powder X-ray diffraction(XRD)with white X-ray beam and an energy-dispersive detector array is demonstrated in this work on a CeO;powder sample on a bending magnet synchrotron beamline at the Shanghai Synchrotron Radiation Facility(SSRF),using a simulated energy-dispersive array detector consisting of a spatially scanning silicon-drift detector(SDD).Careful analysis and corrections are applied to account for various experimental hardware-related and diffraction angle-related factors.The resulting diffraction patterns show that the relative strength between different diffraction peaks from energy-dispersive XRD(EDXRD)spectra is consistent with that from angle-resolved XRD(ARXRD),which is necessary for analyzing crystal structures for unknown samples.The X-ray fluorescence(XRF)signal is collected simultaneously.XRF counts from all pixels are integrated directly by energy,while the diffraction spectra are integrated by d-spacing,resulting in a much improved peak strength and signal-to-noise(S/N)ratio for the array detector.In comparison with ARXRD,the diffraction signal generated by a white X-ray beam over monochromic light under the experimental conditions is about 104 times higher.The full width at half maximum(FWHM)of the peaks in q-space is found to be dependent on the energy resolution of the detector,the angle span of the detector,and the diffraction angle.It is possible for EDXRD to achieve the same or even smaller FWHM as ARXRD under the energy resolution of the current detector if the experimental parameters are properly chosen. | Xiaoping Wang Weiwei Dong Peng Zhang Haoqi Tang Lanting Zhang Tieying Yang Peng Liu Hong Wang X.-D.Xiang | 2022 | Engineering2022，8，3： | 0 |
| 19 | Enlisting a Traditional Chinese Medicine to tune the gelation kinetics of a bioactive tissue adhesive for fast hemostasis or minimally invasive therapy显示文摘Gelation kinetics is important in tailoring chemically crosslinked hydrogel-based injectable adhesives for different applications.However,the regulation of gelation rate is usually limited to varying the gel precursor and/or crosslinker concentration,which cannot reach a fine level and inevitably alters the physical properties of hydrogels.Amidation reactions are widely used to synthesize hydrogel adhesives.In this work,we propose a traditional Chinese medicine(Borax)-input strategy to tune the gelation rate of amidation reaction triggered systems.Borax provides an initial basic buffer environment to promote the deprotonation process of amino groups and accelerate this reaction.By using a tissue adhesive model PEG-lysozyme(PEG-LZM),the gelation time can be modulated from seconds to minutes with varying Borax concentrations,while the physical properties remain constant.Moreover,the antibacterial ability can be improved due to the bioactivity of Borax.The hydrogel precursors can be regulated to solidify instantly to close the bleeding wound at emergency.Meanwhile,they can also be customized to match the flowing time in the catheter,thereby facilitating minimally invasive tissue sealing.Because this method is easily operated,we envision Borax adjusted amidation-type hydrogel has a promising prospect in clinical application. | Haoqi Tan Dawei Jin Junjie Sun Jialin Song Yao Lu Meng Yin Xin Chen Xue Qu Changsheng Liu | 2021 | Bioactive Materials2021，6，3： | 0 |
| 20 | Potential factors and mechanism of particulate matters explosive increase induced by free radicals oxidation显示文摘Atmospheric particulate pollution in China has attracted much public attention.Occasionally, the particle number concentration increases sharply in a short time period,which is defined as a 'particulate matter explosive increase'. Heavy particulate matter pollution not only reduces visibility but also has an adverse effect on human health. Hence,there is an urgent need to discover the causes of particulate matter explosive increase.During this campaign, the particle number concentration and free radicals were measured at a tall building on the campus of Lanzhou University of Technology. Additionally, we examined a series of chemicals to reproduce the observed particulate matter explosive increase in a smog chamber to determine its potential factors. Then, we analyzed the mechanism of particulate matter explosive increase in the presence of free radicals. We found that, among the potential inorganic and organic sources analyzed, a mixture of organic and SO_2 in the research region had a major effect on particulate matter explosive increase. Moreover, free radical oxidation has a large effect, especially in the formation of organic particulates. | Guoying Wang Shiming Jia Xiuli Niu Haoqi Tian Yanrong Liu Zhong Xie Chao Liu Yucan Dong Ying Su Jianglei Yu Gaofeng Shi Xuefu Chen Lan Li Peng Zhang | 2019 | Journal of Environmental Sciences2019，31，7： | 0 |
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