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| 1 | Unexpected guests in the tumor microenvironment:microbiome in cancer显示文摘Although intestinal microbiome have been established as an important biomarker and regulator of cancer development and therapeutic response, less is known about the role of microbiome at other body sites in cancer. Emerging evidence has revealed that the local microbiota make up an important part of the tumor microenvironment across many types of cancer, especially in cancers arising from mucosal sites, including the lung, skin and gastrointestinal tract. The populations of bacteria that reside specifically within tumors have been found to be tumor-type specific, and mechanistic studies have demonstrated that tumor-associated microbiota may directly regulate cancer initiation, progression and responses to chemo- or immuno-therapies. This review aims to provide a comprehensive review of the important literature on the microbiota in the cancerous tissue, and their function and mechanism of action in cancer development and treatment. | Abigail Wong-Rolle Haohan Karen Wei Chen Zhao Chengcheng Jin | 2021 | Protein & Cell2021，12，5： | 16 |
| 2 | Adaptive decision-level fusion strategy for the fault diagnosis of axial piston pumps using multiple channels of vibration signals显示文摘An axial piston pump is a key component that plays the role of the 'heart' in hydraulic systems. The pump failure will lead to an unexpected breakdown of the entire hydraulic system or even economic loss and catastrophic safety consequences. Several vibration-based machine learning methods have been developed to detect and diagnose faults of axial piston pumps. However,most of these intelligent diagnosis methods use single-sensor vibration data to monitor the pump health states. Additionally, the diagnostic accuracy is unacceptable in most situations due to the complex pump structure and limited sensor information.Therefore, this study proposes a multi-sensor fusion method to improve the fault diagnosis performance of axial piston pumps.The convolutional neural network receives three channels of vibration data and makes the final diagnosis through information fusion at the decision level. The proposed decision fusion method is evaluated on the classification task of leakage levels of an actual axial piston pump. The experimental results show that the proposed method improves the classification accuracy by adjusting the probability distribution of classification according to the learned weight matrix. | CHAO Qun GAO HaoHan TAO JianFeng WANG YuanHang ZHOU Jian LIU ChengLiang | 2022 | Science China(Technological Sciences)2022，65，2： | 2 |
| 3 | Fault diagnosis of axial piston pumps with multi-sensor data and convolutional neural network显示文摘Axial piston pumps have wide applications in hydraulic systems for power transmission.Their condition monitoring and fault diagnosis are essential in ensuring the safety and reliability of the entire hydraulic system.Vibration and discharge pressure signals are two common signals used for the fault diagnosis of axial piston pumps because of their sensitivity to pump health conditions.However,most of the previous fault diagnosis methods only used vibration or pressure signal,and literatures related to multi-sensor data fusion for the pump fault diagnosis are limited.This paper presents an end-to-end multi-sensor data fusion method for the fault diagnosis of axial piston pumps.The vibration and pressure signals under different pump health conditions are fused into RGB images and then recognized by a convolutional neural network.Experiments were performed on an axial piston pump to confirm the effectiveness of the proposed method.Results show that the proposed multi-sensor data fusion method greatly improves the fault diagnosis of axial piston pumps in terms of accuracy and robustness and has better diagnostic performance than other existing diagnosis methods. | Qun CHAO Haohan GAO Jianfeng TAO Chengliang LIU Yuanhang WANG Jian ZHOU | 2022 | Frontiers of Mechanical Engineering2022，17，3： | 2 |
| 4 | Production characteristics and the key factors in high-rank coalbed methane fields: A case study on the Fanzhuang Block, Southern Qinshui Basin, China显示文摘 | Yumin Lv Dazhen Tang Hao Xu Haohan Luo | 2012 | International Journal of Coal Geology2012，，： | 2 |
| 5 | Study of multi-roll stretch forming process using different clamps显示文摘 | Zhang Haohan Li Mingzhe Fu Wenzhi | 2011 | Applied Mechanics and Materials2011，4447，： | 1 |
| 6 | Numerical simulation of muhi-roll stretch forming process with different lubrication and rollers显示文摘 | Zhang Haohan Li Mingzhe Fu Wenzhi | 2011 | Applied Mechanics and Materials2011，，： | 1 |
| 7 | Thermo-responsive imprinted hydrogel with switchable sialic acid recognition for selective cancer cell isolation from blood显示文摘In this work,a sialic acid(SA)-imprinted thermo-responsive hydrogel layer was prepared for selective capture and release of cancer cells.The SA-imprinting process was performed at 37℃ using thermo-responsive functional monomer,thus generating switchable SA-recognition sites with potent SA binding at 37℃and weak binding at a lower temperature(e.g.,25℃).Since SA is often overexpressed at the glycan terminals of cell membrane proteins or lipids,the SA-imprinted hydrogel layer could be used for selective cancer cell recognition.Our results confirmed that the hydrogel layer could efficiently capture cancer cells from not only the culture medium but also the real blood samples.In addition,the captured cells could be non-invasively released by lowing the temperature.Considering the non-invasive processing mode,considerable capture efficiency,good cell selectivity,as well as the more stable and durable SA-imprinted sites compared to natural antibodies or receptors,this thermo-responsive hydrogel layer could be used as a promising and general platform for cell-based cancer diagnosis. | Yue Ma Yimei Yin Li Ni Haohan Miao Yingjia Wang Cheng Pan Xiaohua Tian Jianming Pan Tianyan You Bin Li Guoqing Pan | 2021 | Bioactive Materials2021，6，5： | 1 |
| 8 | SVR Recommendation Algorithm of Civil Aviation Auxiliary Service Based on Context-Awareness显示文摘Analysis of the particularity of the civil aviation passenger auxiliary service recommendation scenario.As application of the traditional recommendation algorithm has certain limitation in civil aviation auxiliary services recommendation,a SVR recommendation algorithm of auxiliary service of civil aviation based on context-awareness was proposed.Analysis of the civil aviation passenger travel data,construct the civil aviation passenger preference model,then recommend auxiliary service for passengers.Based on the traditional two-dimensional user-item recommendation,considering the user characteristics,item attributes and user contextual information in the process of recommendation,which can effectively reduce the data sparseness in some degree.In addition,when there is a new user or a new item,whose similar users or items can be found according to the user or item attributes,to some extent,which can solve the problem of cold start.The experimental results show that the algorithm can recommend auxiliary service for passengers more accurately,which can provide convenience for passengers as well as increase the quality of airlines’services. | Haohan Liu Hongli Zhang Kanghua Hui Huaiqing He | 2015 | 国际计算机前沿大会会议论文集2015，，B12： | 0 |
| 9 | Systematic Study of Experimental Fusion Barrier Based on Wong Formula显示文摘Coulomb barrier is the critical point between repulsive Coulomb potential and attractive nuclear potential in central collisions.Nuclear force plays the decisive role in inner barrier region,and the external barrier region is dominated by the Coulomb force.This barrier is usually named as fusion barrier(for light and medium mass heavyion systems)or capture barrier(heavy systems)when taking into account other effects,such as the quasi-fission or fission. | WEN Peiwei LIN Chengjian JIA Huiming CUI Danteng YANG Feng MA Nanru SUN Lijie WANG Dongxi ZHONG Fupeng SUN Haohan YANG Lei XU Xinxing | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 10 | MUSTA:MUltilayer Silicon Telescope Array for Study of Elastic Scattering and Breakup Reaction of Weakly Bound Nuclei at Energy near Coulomb Barrier显示文摘Nowadays the reaction mechanism study of weakly bound nuclei has been one of the frontier problems of nuclear physics.For weakly bound nucleus,the nuclear force and Coulomb force is so weak that in the process of interaction with target nucleus,weakly bound nucleus may breakup into small pieces easily,and such breakup effect can bring some unconventional physical phenomena to weakly bound nucleus near the drip line:such as halo/skin structure,the disappearance of old magic number and the appearance of new magic number,etc. | MA Nanru LIN Chengjian JIA Huiming CUI Danteng YANG Feng WEN Peiwei WANG Dongxi SUN Lijie ZHONG Fupeng SUN Haohan YANG Lei XU Xinxing | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 11 | The Current Status of Regulations for Industrial Cannabis and Its Research and Application in Cosmetics显示文摘Cannabis sativa has a long history of medication,which is often medicated with seeds.Moreover,cannabidiol(CBD),the active ingredient extracted from the flowers and leaves of industrial hemp,has high medicinal value.With the acceptance of CBD by the World Health Organization(WHO)in 2017 and being in the international list as a non-controlled substance,the international strict policy on industrial hemp has been slowly liberalized.It has been proved that the industrial hemp has great economic value and application potential in many aspects.In order to make better use of the unique efficacy of industrial hemp,the definition of industrial hemp and its current laws in the domestic and overseas are systematically studied and summarized in this paper.At the same time,the research status of hemp seed oil and hemp leaves extractive in cosmetics is expounded,which is helpful to the comprehensive development and application of industrial hemp. | Chen Laicheng Huang Haohan Yang Zhanhong Song Xiangzhi He Qiuxing | 2020 | China Detergent & Cosmetics2020，5，2： | 0 |
| 12 | Divergent chondro/osteogenic transduction laws of fibrocartilage stem cell drive temporomandibular joint osteoarthritis in growing mice显示文摘The anterior disc displacement(ADD)leads to temporomandibular joint osteoarthritis(TMJOA)and mandibular growth retardation in adolescents.To investigate the potential functional role of fibrocartilage stem cells(FCSCs)during the process,a surgical ADDTMJOA mouse model was established.From 1 week after model generation,ADD mice exhibited aggravated mandibular growth retardation with osteoarthritis(OA)-like joint cartilage degeneration,manifesting with impaired chondrogenic differentiation and loss of subchondral bone homeostasis.Lineage tracing using Gli1^(-)CreER^(+);Tm^(fl/-)mice and Sox9-CreER^(+);Tm^(fl/-)mice showed that ADD interfered with the chondrogenic capacity of Gli1+FCSCs as well as osteogenic differentiation of Sox9+lineage,mainly in the middle zone of TMJ cartilage.Then,a surgically induced disc reposition(DR)mouse model was generated.The inhibited FCSCs capacity was significantly alleviated by DR treatment in ADD mice.And both the ADD mice and adolescent ADD patients had significantly relieved OA phenotype and improved condylar growth after DR treatment.In conclusion,ADD-TMJOA leads to impaired chondrogenic progenitor capacity and osteogenesis differentiation of FCSCs lineage,resulting in cartilage degeneration and loss of subchondral bone homeostasis,finally causing TMJ growth retardation.DR at an early stage could significantly alleviate cartilage degeneration and restore TMJ cartilage growth potential. | Ruiye Bi Qianli Li Haohan Li Peng Wang Han Fang Xianni Yang Yiru Wang Yi Hou Binbin Ying Songsong Zhu | 2023 | International Journal of Oral Science2023，15，3： | 0 |
| 13 | Microstructure and nanomechanical properties of foreleg surface of the prayingmantis(Mantis religiosa Linnaeus)显示文摘Detailed investigations on the microstructure and mechanical properties of the surface of the praying mantis'foreleg were carried out in this work since the microstructure and mechanical properties of insect organisms surfaceare well adjusted to their functions.Scanning electron microscopy revealed the surface microstructures of the tibia andfemur were composed of squamous fibre and the spine surfaces on these two parts are arris.A nanoindenter wasused to investigate the mechanical properties of the praying mantis's foreleg,including the mean Young's modulusand hardness of the femur cuticle,tibia cuticle and the apical claw.The test results on these parts were E=5.533 GPa,H=0.239 GPa,E=3.471GPa,H=0.186 GPa,E=2.232GPa,H=0.449 GPa,respectively.The variation of mechanicalproperties agreed with the analysis of microstructure. | Hongliang Sun Zhang Haohan Mo Li | 2018 | Biosurface and Biotribology2018，4，4： | 0 |
| 14 | Research on Soil Conservation and Improvement Technology in Zhaoyang District显示文摘The environment of tobacco-growing soil directly affects the yield and quality of tobacco leaves.In order to solve problems of tobacco-growing soil degradation,low organic matter content and unbalanced soil nutrient supply and promote sustainable and healthy development of tobacco production,this paper comprehensively discussed conservation and improvement techniques of tobacco-growing soil based on existing problems in Zhaoyang District,aiming to provide reference for tobacco-growing soil conservation. | Jing YANG Shifu ZHONG Liting FANG Wei YAN Shixian PU Dianli MA Wenkai XIA Haohan GONG Mengsheng ZHANG Yeming FU Xia NI | 2024 | Agricultural Biotechnology2024，13，1： | 0 |
| 15 | Chiral self-assembly of terminal alkyne and selenium clusters organic–inorganic hybrid显示文摘The on-surface self-assembly of inorganic atomic clusters and organic molecules offers significant opportunities to design novel hybrid materials with tailored functionalities.By adopting the advantages from both inorganic and organic components,the hybrid self-assembly molecules have shown great potential in future optoelectrical devices.Herein,we report the co-deposition of 4,8-diethynylbenzo[1,2-d-4,5-d0]bisoxazole(DEBBA)and Se atoms to produce a motif-adjustable organic–inorganic hybrid self-assembly system via the non-covalent interactions.By controlling the coverage of Se atoms,various chiral molecular networks containing Se,Se_(6),Se_(8),and terminal alkynes evolved on the Ag(111)surface.In particular,with the highest coverage of Se atoms,phase segregation into alternating one-dimensional chains of non-covalently bonded Se_(8) clusters and organic ligands has been noticed.The atom-coverage dependent evolution of self-assembly structures reflects the remarkable structural adaptability of Se clusters as building blocks based on the spontaneous resize to reach the maximum non-covalent interactions.This work has significantly extended the possibilities of flexible control in self-assembly nanostructures to enable more potential functions for broad applications. | Zhi Chen Tao Lin Haohan Li Mingzi Sun Chenliang Su Bolong Huang Kian Ping Loh | 2022 | Nano Research2022，15，3： | 0 |
| 16 | Comparative metabolomics provides novel insights into the basis of petiole color differences in celery(Apium graveolens L.)显示文摘Plant metabolites are important for plant development and human health.Plants of celery(Apium graveolens L.)with different-colored petioles have been formed in the course of long-term evolution.However,the composition,content distribution,and mechanisms of accumulation of metabolites in different-colored petioles remain elusive.Using ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS),1159 metabolites,including 100 lipids,72 organic acids and derivatives,83 phenylpropanoids and polyketides,and several alkaloids and terpenoids,were quantified in four celery cultivars,each with a different petiole color.There were significant differences in the types and contents of metabolites in celery with different-colored petioles,with the most striking difference between green celery and purple celery,followed by white celery and green celery.Annotated analysis of metabolic pathways showed that the metabolites of the different-colored petioles were significantly enriched in biosynthetic pathways such as anthocyanin,flavonoid,and chlorophyll pathways,suggesting that these metabolic pathways may play a key role in determining petiole color in celery.The content of chlorophyll in green celery was significantly higher than that in other celery cultivars,yellow celery was rich in carotenoids,and the content of anthocyanin in purple celery was significantly higher than that in the other celery cultivars.The color of the celery petioles was significantly correlated with the content of related metabolites.Among the four celery cultivars,the metabolites of the anthocyanin biosynthesis pathway were enriched in purple celery.The results of quantitative real-time polymerase chain reaction(q RT-PCR)suggested that the differential expression of the chalcone synthase(CHS)gene in the anthocyanin biosynthesis pathway might affect the biosynthesis of anthocyanin in celery.In addition,HPLC analysis revealed that cyanidin is the main pigment in purple celery.This study explored the differences in the types and contents of metabolites in celery cultivars with different-colored petioles and identified key substances for color formation.The results provide a theoretical basis and technical support for genetic improvement of celery petiole color. | Mengyao LI Jie LI Haohan TAN Ya LUO Yong ZHANG Qing CHEN Yan WANG Yuanxiu LIN Yunting ZHANG Xiaorong WANG Haoru TANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 0 |
| 17 | Preparation of Quaternary FeCoMoCu Metal Oxides for Oxygen Evolution Reaction显示文摘Molybdenum doping is an effective way to improve the oxygen evolution reaction(OER)properties of catalysts,which can efficiently improve the electronic conductivity,mass transport process,and intrinsic activity of transition metal oxides or hydroxides,especially for those multi-component oxides with more abundant active sites.Herein,we have prepared a quaternary FeCoMoCu metal oxide on Cu foam(FeCoMoCuO_(x)@Cu)as an efficient OER catalyst.As expected,FeCoMoCuO_(x)@Cu could exhibit a low overpotential(252 mV at the current density of 10 mA/cm^(2))and exceptional stability(10000 cycles of CV scans or constant electrolysis for 48 h). | HAO Zhimin LIU Dapeng GE Huaiyun ZUO Xintao FENG Xilan SHAO Mingzhe YU Haohan YUAN Guobao ZHANG Yu | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
| 18 | Effects of Microbial Fertilizers in Improving Acidic Tobacco-planting Soil and Tobacco Leaf Quality显示文摘[Objectives]This study was conducted to improve acidic soil and enhance the quality of tobacco leaves.[Methods]The effects of different microbial fertilizers on improving acidic tobacco-planting soil and tobacco leaf quality were investigated through plot experiments.[Results]The application of microbial fertilizers could improve the pH value of acidic soil,and composite microbial agent A showed the best application effect.The application of bio-organic fertilizer was beneficial to improving the contents of available phosphorus and available boron in acidic soil.The application of composite microbial agent A was beneficial to improving the contents of available phosphorus and available potassium in acidic soil,and could promote the growth of tobacco plants and improve the economic traits of flue-cured tobacco and the coordination of chemical components in tobacco leaves.The application of composite microbial agent B led to a downward trend in the content of available boron in acidic soil.The application of composite microbial agent B could promote the absorption of nutrients by tobacco plants,and improve their disease resistance and the quality of tobacco leaves.Due to the differences in functional microorganisms contained,the application effects of different microbial fertilizers in improving acidic tobacco-planting soil and improving tobacco leaf quality varied.Overall,the application of microbial fertilizers could increase soil pH,activate soil nutrients,promote tobacco growth,enhance disease resistance,increase tobacco output value,and improve tobacco quality.Microbial fertilizers have good application prospects in improving acidic soil and improving tobacco quality.[Conclusions]The application of microbial fertilizers to improve acidic tobacco-planting soil can ensure the normal growth and development of tobacco plants and the improvement of tobacco leaf quality,achieving high-quality and sustainable development of Zhaotong tobacco. | Xia NI Shungang SHEN Xianyi ZENG Dewen LI Yeming FU Min CHEN Chaokai YU Libing QI Ying-guo RUAN Changchong ZI Haohan GONG Guangjun HU Mengsheng ZHANG Xu ZHANG Shu PENG Hongbing LI | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
| 19 | A Five-Point TENO Scheme with Adaptive Dissipation Based on a New Scale Sensor显示文摘In this paper,a new five-point targeted essentially non-oscillatory(TENO)scheme with adaptive dissipation is proposed.With the standard TENO weighting strategy,the cut-off parameter C_(T) determines the nonlinear numerical dissipation of the resultant TENO scheme.Moreover,according to the dissipation-adaptive TENO5-A scheme,the choice of the cut-off parameter C_(T) highly depends on the effective scale sensor.However,the scale sensor in TENO5-A can only roughly detect the discontinuity locations instead of evaluating the local flow wavenumber as desired.In this work,a new five-point scale sensor,which can estimate the local flow wavenumber accurately,is proposed to further improve the performance of TENO5-A.In combination with a hyperbolic tangent function,the new scale sensor is deployed to the TENO5-A framework for adapting the cut-off parameter C_(T),i.e.,the local nonlinear dissipation,according to the local flow wavenumber.Overall,sufficient numerical dissipation is generated to capture discontinuities,whereas a minimum amount of dissipation is delivered for better resolving the smooth flows.A set of benchmark cases is simulated to demonstrate the performance of the new TENO5-A scheme. | Haohan Huang Tian Liang Lin Fu | 2023 | Communications in Computational Physics2023，33，4： | 0 |
| 20 | Analysis of Autocorrelation Associated with Spatial Sampling Estimation on Urban Greenland Coverage显示文摘By taking the urban greenland as testing objective,the GeoEye-1 fusion image as background, and using Moran’s index,the correlativity of greenland units has been measured.Then,the presampling was conducted based on the measured correlativity,the systematic sampling design has been carried out at the precision 95%and 85%.By using of Kriging interpolation method,the weight of different type of greenland has been divided into the stratifications.Through the stratified sampling,the estimation of greenland coverage has been obtained. The results show that the urban greenland coverage area is 14.81 km^2,accounting for 27.73%of all urban land areas.Compared with the common sampling method,the precision of that increased about 3%. This method can also be utilized in monitoring dynamic variation of urban greenland with the real time images. | Sun Haohan She Guanghui Wen Xiaorong Lin Guozhong | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
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