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| 1 | Inhibition of lipid oxidation in foods and feeds and hydroxyl radical-treated fish erythrocytes:A comparative study of Ginkgo biloba leaves extracts and synthetic antioxidants显示文摘This study explored the effects of butylated hydroxytoluene(BHT) and ethoxyquin(EQ) and ethyl ether extracts, ethyl acetate extracts(EAE), acetone extracts, ethanol extracts and aqueous extracts of Ginkgo biloba leaves(EGbs) on lipid oxidation in a linoleic acid emulsion, fish flesh and fish feed and in hydroxyl radical(·OH)-treated carp erythrocytes. The linoleic acid, fish flesh and fish feed were incubated with BHT,EQ and EGbs at 45℃ for 8 d, respectively, except for the control group. The lipid oxidation in the linoleic acid emulsion, fish flesh and fish feed was then measured by the ferric thiocyanate method or thiobarbituric acid method. The carp erythrocytes were treated with BHT, EQ. or EGbs in the presence of40 μmol/L FeSO_4 and 20 μmol/L H_2 O_2 at 37℃ for 6 h,except for the control group. Oxidative stress and apoptosis parameters in carp erythrocytes were then evaluated by the commercial kit. The results showed that BHT, EQ and EGbs inhibited lipid oxidation in the linoleic acid emulsion, fish flesh and fish feed and·OH-induced phosphatidylserine exposure and DNA fragmentation(the biomarkers of apoptosis) in carp erythrocytes. Furthermore, BHT, EQ and EGbs decreased the generation of reactive oxygen species(ROS),inhibited the oxidation of cellular components and restored the activities of enzymatic antioxidants in·OH-treated carp erythrocytes. Of all examined EGbs, EAE showed the strongest effects. The effects of EAE on lipid oxidation in the linoleic acid emulsion and on superoxide anion and malonaldehyde levels,catalase activity and apoptosis in. OH-treated carp erythrocytes were equivalent to or stronger than those of BHT. Moreover, these results indicated that the inhibition order of EGbs on the generation of ROS and oxidation of cellular components in fish erythrocytes approximately agreed with that for the food and feed materials tested above. And, the antioxidative and anti-apoptotic effects of EGbs were positively correlated with their flavonoid content. Taken together, these results revealed that the fish erythrocyte system can be used as an experimental model to evaluate lipid oxidation in food and feed ingredients. The EAE can be used as a potential natural antioxidant or apoptosis inhibitor. The inhibition effects of EGbs on lipid oxidation and apoptosis may be due to the presence of flavonoid compounds. | Huatao Li Xiaoqiu Zhou Ping Gao Qiuyue Li Hansi Li Rong Huang Min Wu | 2016 | Animal Nutrition2016，，3： | 6 |
| 2 | Influence of size and distribution of W phase on strength and ductility of high strength Mg-5.1Zn-3.2Y-0.4Zr-0.4Ca alloy processed by indirect extrusion显示文摘A high strength Mg-5.1Zn-3.2Y-0.4Zr-0.4Ca(wt%) alloy containing W phase(Mg_3Y_2Zn_3) prepared by permanent mold direct-chill casting is indirectly extruded at 350?C and 400?C, respectively. The extruded alloys show bimodal grain structure consisting of fine dynamic recrystallized(DRXed) grains and unrecrystallized coarse regions containing fine W phase and β2' precipitates. The fragmented W phase particles induced by extrusion stimulate nucleation of DRXed grains, leading to the formation of fine DRXed grains, which are mainly distributed near the W particle bands along the extrusion direction. The alloy extruded at 350?C exhibits yield strength of 373 MPa, ultimate tensile strength of 403 MPa and elongation to failure of 5.1%. While the alloy extruded at 400?C shows lower yield strength of 332 MPa,ultimate tensile strength of 352 MPa and higher elongation to failure of 12%. The mechanical properties of the as-extruded alloys vary with the distribution and size of W phase. A higher fraction of DRXed grains is obtained due to the homogeneous distribution of micron-scale broken W phase particles in the alloy extruded at 400?C, which can lead to higher ductility. In addition, the nano-scale dynamic W phase precipitates distributed in the un DRXed regions are refined at lower extrusion temperature. The smaller size of nano-scale W phase precipitates leads to a higher fraction of un DRXed regions which contributes to higher strength of the alloy extruded at 350?C. | Hansi Jiang Xiaoguang Qiao Chao Xu Shigeharu Kamado Kun Wu Mingyi Zheng | 2018 | Journal of Materials Science & Technology2018，34，2： | 2 |
| 3 | iRGD decorated liposomes:A novel actively penetrating topical ocular drug delivery strategy显示文摘Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation,resulting in low ocular bioavailability(<5%).Worse still,the most convenient and safe route of ocular drug administration,topical administration results in a drug bioavailability of less than 1%.iRGD modified drug delivery strategies have been developed for cancer therapy,however active targeting iRGD platforms for ocular drug delivery have yet to be explored.Herein,an iRGD modified liposomes was developed for ocular drug delivery via topical administration.The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance corneal permeability in an iRGD receptor mediated manner.These findings provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases. | Hai Huang Xiaorong Yang Huili Li Hansi Lu James Oswald Yongmei Liu Jun Zeng Chaohui Jin Xingchen Peng Jiyan Liu Xiangrong Song | 2020 | Nano Research2020，13，11： | 2 |
| 4 | Totipotency, cell differentiation and reprogramming in humans 显示文摘 | Hansis C | 2006 | Reprod Biomed Online2006，13，4： | 1 |
| 5 | Nuclear Reprogramming of Human Somatic Cells by Xenopus Egg Extract Requires BRG1显示文摘 | Christoph Hansis Guillermo Barreto Nicole Maltry Christof Niehrs | 2004 | Current Biology2004，，16： | 1 |
| 6 | Analysis of Oct-4 expression and ploidy in individual human blastomeres 显示文摘 | Hansis C Tang YX Grifo JA | 2001 | Mol Hum Repred2001，7，2： | 1 |
| 7 | Differences of platelet adhesion and thrombus activation on am-orphous silicon carbide, magnesium alloy, stain-less steel, and cobalt chromium stent surfaces显示文摘 | Hansi C Arab A Rzany A | 2009 | Catheter Cardiovasc In terv2009，73，4： | 1 |
| 8 | Totipotency, cell differentiation and reprogramming in humans 显示文摘 | Hansis C | 2006 | Reprod Biomed Online2006，13，4： | 1 |
| 9 | Differences of platelet adhesion and thrombus activation on amorphous silicon carbide, magnesiumalloy, stainless steel, and cobalt chromium stent surfaces 显示文摘 | Hansi C Arab A Rzany A | 2009 | Catheter Cardio Inte2009，73，4： | 1 |
| 10 | Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRGI显示文摘 | HANSIS C BARRETO G MALTRY N | 2004 | Curr Biol2004，14，16： | 1 |
| 11 | A Political Ecology of Picking: Non-Timber Forest Products in the Pacific Northwest显示文摘 | Richard Hansis | 1998 | Human Ecology1998，，1： | 1 |
| 12 | Analysis of Oct-4 expression and ploidy in individual human blastomeres显示文摘 | Hansis C Tang YX Grifo JA | 2001 | Mol Hum Reprod2001，7，2： | 1 |
| 13 | Long-term quality of life and uncertainty in patients living with an implantable car- dioverter defibrillator显示文摘 | INGER F NILS E HANSI H | 2005 | Heart Lung2005，34，： | 1 |
| 14 | Vacuum pyrolysis of intruder plant biomass 显示文摘 | De Jongh Willem A Carrier Marion Knoetze J H (Hansie) | 2011 | Journal of Analytical and Applied Pyrolysis2011，92，1： | 1 |
| 15 | Plasma Fired cupolda promises melting economies显示文摘 | Hansi Heine | 1986 | Founder M & T1986，114，3： | 1 |
| 16 | From bacterial genomics to metagenomics: concept, tools and recent advances显示文摘 | Pooja Sharma Hansi Kumari Mukesh Kumar Mansi Verma Kirti Kumari Shweta Malhotra Jitendra Khurana Rup Lal | 2008 | Indian Journal of Microbiology2008，，2： | 1 |
| 17 | Vacuum Pyrolysis of Intruder Plant Biomasses显示文摘 | de Jongh W A Carrier M (Hansie) Knoetze J H | 2011 | Journal of Analytical and Applied Pyrolysis2011，92，1： | 1 |
| 18 | Oct4 expression in inner cell mass and trophectoderm of human blastocysts显示文摘 | Hansis C Grifo J Krey L | 2000 | Mol Hum Reprod2000，6，： | 1 |
| 19 | Analysis of Oct4 expression and ploid in individual human blastomeres显示文摘 | Hansis C Tang Y Grifo J | 2001 | Mol Hum Reprod2001，7，： | 1 |
| 20 | OCT4 expression in inner cell mass and trophectoderm of human blastocysts 显示文摘 | HANSIS C GRIFO J A KREY L C | 2000 | Mol Hum Reprod2000，6，： | 1 |
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