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| 1 | Pioneer of prostate cancer: past, present and the future of FOXA1显示文摘Prostate cancer is the most commonly diagnosed noncutaneous cancers in North American men.While androgen deprivation has remained as the cornerstone of prostate cancer treatment,resistance ensues leading to lethal disease.Forkhead box A1(FOXA1)encodes a pioneer factor that induces open chromatin conformation to allow the binding of other transcription factors.Through direct interactions with the Androgen Receptor(AR),FOXA1 helps to shape AR signaling that drives the growth and survival of normal prostate and prostate cancer cells.FOXA1 also possesses an AR-independent role of regulating epithelial-to-mesenchymal transition(EMT).In prostate cancer,mutations converge onto the coding sequence and c/s-regulatory elements(CREs)of FOXA1,leading to functional alterations.In addition,FOXA1 activity in prostate cancer can be modulated post-translationally through various mechanisms such as LSD1-mediated protein demethylation.In this review,we describe the latest discoveries related to the function and regulation of FOXA1 in prostate cancer,pointing to their relevance to guide future clinical interventions. | Mona Teng Stanley Zhou Changmeng Cai Mathieu Lupien Housheng Hansen He | 2021 | Protein & Cell2021，12，1： | 12 |
| 2 | Forkhead domain mutations in FOXA1 drive prostate cancer progression显示文摘Dear Editor,F0XA1 (Forkhead Box Protein A1)is a pioneer transcription factor (TF) that functions to loosen the compact chromatin structure to facilitate binding of other TFs such as estrogen receptor and androgen receptor (AR).1,2 AR is a nuclear receptor functioning as a ligand-dependent TF that plays a pivotal role in driving the initiation of prostate cancer (Pca) and the development of castration-resistant Pca (CRPC). | Shuai Gao Sujun Chen Dong Han David Barrett Wanting Han Musaddeque Ahmed Susan Patalano Jill A. Macoska Housheng Hansen He Changmeng Cai | 2019 | Cell Research2019，29，9： | 3 |
| 3 | Laser-induced oxidation assisted micro milling of high aspect ratio microgroove on WC-Co cemented carbide显示文摘Severe tool wear and poor surface quality are the main problems during micro machining of cemented carbide.In this work,an innovative hybrid process of laser-induced oxidation assisted micro milling(LOMM)was proposed to solve the problems.A nanosecond laser was utilized to induce oxidation of the WC-20%Co material,producing loose oxide which was easy to remove.The micro machinability of the material was improved by laser-induced oxidation.The oxidation mechanisms of cemented carbide were studied.A microgroove with a depth of 2.5 mm and aspect ratio of 5 was fabricated successfully.The milling force,surface quality and tool wear mechanisms were investigated.For comparison,a microgroove was also fabricated with conventional micro milling(COMM)using identical milling parameters.Results revealed that in LOMM the milling force and tool wear rate were extremely low during removing the oxide.The machined surface quality and dimensional accuracy achieved by LOMM were superior to those obtained by COMM.The surface roughness Saof the microgroove bottom reached 88 nm in LOMM,while the cross-sectional geometry of the microgroove was a trapezoid.Perpendicularity of the microgroove sidewall machined by LOMM was better than that by COMM.The tool wear forms in LOMM were coating spalling and slight tool nose breakage.Compared with COMM,the tool life in LOMM was prolonged significantly.It indicates that the proposed hybrid process is an effective and efficient way to fabricate high aspect ratio micro-features with high dimensional accuracy. | Guolong ZHAO Hongjun XIA Yang ZHANG Liang LI Ning HE Hans Nφrgaard HANSEN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 3 |
| 4 | Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice显示文摘Dear Editor,Hypercholesterolemia is the leading risk factor for cardiovascular diseases.Current evidence suggests that the heritability for blood cholesterol levels is high,with 40%-60%in different cohorts.1,2 Genome-wide association study(GWAS)is a powerful tool to ascertain the contribution of common genetic variants in population-wide disease variability.It has been performed extensively on blood lipids traits and hundreds of genome variants are associated with dyslipidemia.However,approximately 95%of these variants are located in genome noncoding regions and cluster in more than 300 loci in different populations. | Fangfang Han Xiao Liu Chuanfang Chen Yinan Liu Mingkun Du Yu Zhou Yong Liu Bao-Liang Song Housheng Hansen He Yan Wang | 2020 | Cell Research2020，30，4： | 2 |
| 5 | Renal biopsy finding in long term cyclosporin treatment of psoriasis显示文摘 | Zachariae H Kragballe K Hansen HE | 1997 | Br J Dermatol1997，136，： | 1 |
| 6 | Different membrane expression of CD11b and CD14 on blood neutrophils following in vivo administration of myeloid growth factors显示文摘 | Hansen PB Kjarsgaard E Johnsen HE | 1994 | Br J Haematol1994，86，1： | 1 |
| 7 | Acute tubulointerstitial nephritis:phenotype of infiltrating cells and prognostic impact tubulitis显示文摘 | Ivanyi B Hamilton-Dutoit SJ Hansen HE | 1996 | Virchows Arch1996，428，1： | 1 |
| 8 | Hematopoietic growthfactors fur the treatment of myelodysplastic syndromes显示文摘 | Penkowa M Johnsen HE | 1998 | Leuk Lymphoma1998，28，56： | 1 |
| 9 | The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family 显示文摘 | van War HE Birkedal Hansen H | 1990 | Proc Natl Acad Sci USA1990，87，14： | 1 |
| 10 | Increased serum erythropoietin level during azathioprine treatment in renal transplant recipients显示文摘 | Jensen JD Hansen HE Pedersen EB | | 0，，： | 1 |
| 11 | Difference in family caregiver outcomes by their level of involvement in discharge planning显示文摘 | Bull MJ Hansen HE Gross CR | 2000 | Applied Nursing Research2000，18，2： | 1 |
| 12 | The eysteine switch:a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metallopro- teinase gene family 显示文摘 | Vanwart HE Birkedal Hansen H | 1990 | Proceedings of the National Acade- my of Sciences1990，87，14： | 1 |
| 13 | Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic β-cells显示文摘 | Friedriehsen BN Richter HE Hansen JA | 2003 | Mol Endocrinol2003，17，： | 1 |
| 14 | Stones in ureter显示文摘 | Carstensen HE Hansen TS | 1973 | Acta Chir Stand1973，433，1： | 1 |
| 15 | Cutting force model and damage formation mechanism in milling of 70wt%Si/Al composite显示文摘High-mass fraction silicon aluminium composite(Si/Al composite) has unique properties of high specific strength, low thermal expansion coefficient, excellent wear resistance and weldability. It has attracted many applications in terms of radar communication, aerospace and automobile industry. However, rapid tool wear resulted from high cutting force and hard abrasion, and damaged machined surfaces are the main problem in machining Si/Al composite. This work aims to reveal the mechanisms of milling-induced damages of 70wt% Si/Al composites. A cutting force analytical model considering the characteristics of both the primary silicon particles and the cutting-edge radius was established. Milling experiments were conducted to verify the validity of the model. The results show that the analytical model exhibits a good consistency with the experimental results, and the error is about 10%. The cutting-edge radius has significant effects on the cutting force, surface roughness and damage formation. With the increase in the cutting-edge radius, both the cutting force and the surface roughness decrease firstly and then increase. When the cutting-edge radius is 27 μm, the surface roughness(Sa) reaches the minimum of 2.3 μm.Milling-induced surface damages mainly contain cracks, pits, scratches, matrix coating and burrs.The damage formation is dominated by the failure mode of primary silicon particles, which includes compressive breakage, intragranular fracture, particle pull-out, and interface debonding. In addition, the high ductility of aluminium matrix leads to matrix coating. This work provides guidance for tool selection and damage inhibition in high-efficiency and high-precision machining of high mass fraction Si/Al composites. | Guolong ZHAO Lianjia XIN Liang LI Yang ZHANG Ning HE Hans Nørgaard HANSEN | 2023 | Chinese Journal of Aeronautics2023，36，7： | 1 |
| 16 | Differences in family caregiver outcomes by their level of involvement in discharge planning显示文摘 | Bull MJ Hansen HE Gross CR | 2000 | Applied Nursing Research2000，13，2： | 1 |
| 17 | A professional- patient partnership model of discharge planning with elders hospitalized with heart failure 显示文摘 | Bull M J Hansen HE Gross CR | 2000 | Appl Nurs Res2000，13，1： | 1 |
| 18 | Managers, leadership andcritical care nurses,intent to stay显示文摘 | Boyle DK Bott MJ Hansen HE | 1999 | Am J Crit Care1999，8，6： | 1 |
| 19 | Differences in family caregiver outcomes by their level of involvement in discharge planning显示文摘 | Bull MJ Hansen HE Gross CR | 2000 | Applied Nursing Research2000，13，2： | 1 |
| 20 | Differences in family caregiver outcomes by their level of involvement in discharge planning显示文摘 | Bull MJ Hansen HE Gross CR | 2000 | Applied Nursing Research2000，13，2： | 1 |
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