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| 1 | Hepatocellular carcinoma surveillance:An evidence-based approach显示文摘Hepatocellular carcinoma(HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. All patients with cirrhosis and high-risk hepatitis B patients are at risk for HCC and should undergo surveillance. The recommended surveillance modality is abdominal ultrasound(US) given that it is cost effective and noninvasive with good sensitivity. However, US is limited in obese patients and those with non-alcoholic fatty liver disease(NAFLD). With the current obesity epidemic and rise in the prevalence of NAFLD, abdominal computed tomography or magnetic resonance imaging may be indicated as the primary screening modality in these patients. The addition of alpha-fetoprotein to a surveillance regimen is thought to improve the sensitivity of HCC detection.Further investigation of serum biomarkers is needed. Semiannual screening is the suggested surveillance interval. Surveillance for HCC is underutilized and low adherence disproportionately affects certain demographics such as nonCaucasian race and low socioeconomic status. | Patrick S Harris Ross M Hansen Meagan E Gray Omar I Massoud Brendan M McGuire Mohamed G Shoreibah | 2019 | World Journal of Gastroenterology2019，25，13： | 31 |
| 2 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 3 | Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin显示文摘瞄准:Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物,但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的形成上估计免费细胞的牛的血红素的效果。方法:在尖锐胰腺炎 Wistar 老鼠的正式就职以后的十五分钟收到了任何一个 0.8 mL 牛的血红素(HBOC-200 ) , hydroxyethyl 淀粉(HES ) 或保证血量正常替换的生理盐水的 2.4 mL。在检查的 6 h 以后,胰每氧化产品 malondialdehyde (MDA ) 为类脂化合物的间接测量被切除并且很快处理了并且在胰腺的织物减少了谷胱甘肽(GSH ) 。结果:HBOC-200 的单个申请改进了胰腺的微循环并且显著地减少了组织病理学说的织物损坏。MDA 的织物集中没在这些组之间不同。另外,在 GSH 层次的差别都没被检测。结论:不过 HBOC-200 和 HES 的单个申请改进胰腺的微循环,在类脂化合物的没有差别每氧化,产品被检测。另外的氧供应(HBOC-200 ) 的有益的效果不每氧化导致提高的类脂化合物。 | Helge Kleinhans Oliver Mann Paulus G Schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki Tim Strate | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 4 | Sperm chromatin structure integrity in liquid stored boar semen and its relationships with field fertility 显示文摘 | BOE HANSEN G B CHRISTENSEN P VIVJERG D | 2008 | Theriogenology2008，69，6： | 1 |
| 5 | Priority setting for existing chemicals : The European Union risk ranking method 显示文摘 | HANSEN B J VAN HAELST A G VAN LEEUWEN K | 1999 | Environ Toxicol Chem1999，18，： | 1 |
| 6 | Removal of heavy metals from mine waters by natural zeolite 显示文摘 | Wingenfelder U Hansen C Furrer G | 2005 | Environment Science and Technology2005，39，12： | 1 |
| 7 | Pregnancy outcorne after loop electrosurgical excision procedure for the management of cervical intraepithelial neoplasia显示文摘 | Acharya G Kjeldberg I Hansen SM | 2005 | Arch Gynecol Obstet2005，272，1： | 1 |
| 8 | Analysis of orbital T cells in thyroid-asssociated ophthalmopathy显示文摘 | Forster G Otto E Hansen C | 1998 | Clin Exp Imunol1998，11，2： | 1 |
| 9 | The first X-ray structural evidence demonstrating thiolate coordination in an organocobalt B12 model complex:implications for methionine syntheses显示文摘 | Polson S M Hansen L Marzilli L G | 1997 | Inorg Chem1997，36，2： | 1 |
| 10 | Conjugation of an anti-B-cell lymphoma monoclonal antibody, LL2, to long- circulating drug-carrier lipid emulsions 显示文摘 | Lundberg BB Griffiths G Hansen HJ | 1999 | J Pharm Pharmacol1999，51，10： | 1 |
| 11 | Enforced mobilization,early oral feeding, and balanced analgesia improve convalescence after colorectal surgery 显示文摘 | Henriksen M G Jensen M B Hansen H V | 2002 | Nutrition2002，18，2： | 1 |
| 12 | Bacterial interactions in early life stage of marine cold water fish显示文摘 | Hansen G H Olafsen J A | 1999 | Microbial Ecology1999，38，： | 1 |
| 13 | De Novo Biosynthesis of Vanillin in Fission Yeast (Schizosaccharomyces i?ombe) and Bakers Yeast (Saccharomyces cerevisiae)显示文摘 | Hansen E H Moiler B L Koek G R | 2009 | Applied md Environmentalmicrobiology2009，75，9： | 1 |
| 14 | Allergen-specific Thl cells fail to counterbalance Th2 cellqnduced airway hyperreactivity but cause severe airway inflammation显示文摘 | Hansen G Berry G DeKruyff RH | 1999 | J Clin Invest1999，103，2： | 1 |
| 15 | Pharmacokinetics of mycophenolatemofetil for autoimmune disease in children显示文摘 | FILLER G HANSEN M LEBLANC C | 2003 | Pediatr Nephrol2003，18，5： | 1 |
| 16 | Fault ride-through capability of DFIG wind turbines显示文摘 | HANSEN A D MICHALKE G | 2007 | Renewable Energy2007，32，1： | 1 |
| 17 | Effect of different holding regimens on the intestinal microfora of herring (Clupea harengus) larvae显示文摘 | HANSEN G H STREM E OLAFSEN H A | 1992 | Appl Environ Microbial1992，58，： | 1 |
| 18 | Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration显示文摘 | Weibrich G Hansen T Kleis W | 2004 | Bone2004，34，4： | 1 |
| 19 | Molecular phylogenetic evidence for a reversible morphogenetic switch controlling the gross morphology of two common genera of green seaweeds, Ulva and Enteromorpha 显示文摘 | TAN I H BLOMS3'FA J HANSEN G | 1999 | Molecular Biology Evolution1999，16，8： | 1 |
| 20 | Benzene exposure and the effect of traffic pollution in Copenhagen, Denmark 显示文摘 | SKOV H HANSEN A B LORENZEN G | 2001 | Atmos Environ2001，35，14： | 1 |
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