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| 1 | Type 1 diabetes and polyglandular autoimmune syndrome: A review显示文摘Type 1 diabetes(T1D) is an autoimmune disorder caused by inflammatory destruction of the pancreatic tissue. The etiopathogenesis and characteristics of the pathologic process of pancreatic destruction are well described. In addition, the putative susceptibility genes for T1 D as a monoglandular disease and the relation to polyglandular autoimmune syndrome(PAS) have also been wellexplored. The incidence of T1 D has steadily increased in most parts of the world, especially in industrialized nations. T1 D is frequently associated with autoimmune endocrine and non-endocrine diseases and patients with T1 D are at a higher risk for developing several glandular autoimmune diseases. Familial clustering is observed, which suggests that there is a genetic predisposition. Various hypotheses pertaining to viral- and bacterialinduced pancreatic autoimmunity have been proposed, however a definitive delineation of the autoimmune pathomechanism is still lacking. In patients with PAS, pancreatic and endocrine autoantigens either colocalize on one antigen-presenting cell or are expressed on two/various target cells sharing a common amino acid, which facilitates binding to and activation of T cells. The most prevalent PAS phenotype is the adult type 3 variant or PAS type Ⅲ, which encompasses T1 D and autoimmune thyroid disease. This review discusses the findings of recent studies showing noticeable differences in the genetic background and clinical phenotype of T1 D either as an isolated autoimmune endocrinopathy or within the scope of polyglandular autoimmune syndrome. | Martin P Hansen Nina Matheis George J Kahaly | 2015 | World Journal of Diabetes2015，6，1： | 7 |
| 2 | Metabolic and hepatic effects of liraglutide,obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis(NASH) in obese mouse models of biopsy-confirmedNASH.METHODS Male wild-type C57 BL/6 J mice(DIO-NASH) and Lep^(ob/ob)(ob/ob-NASH) mice were fed a diet high in trans-fat(40%), fructose(20%) and cholesterol(2%) for 30 and 21 wk, respectively. Prior to treatment, all mice underwent liver biopsy for confirmation and stratification of liver steatosis and fibrosis, using the nonalcoholic fatty liver disease activity score(NAS) and fibrosis staging system. The mice were kept on the diet and received vehicle, liraglutide(0.2 mg/kg, SC, BID), obeticholic acid(OCA, 30 mg/kg PO, QD), or elafibranor(30 mg/kg PO, QD) for eight weeks. Within-subject comparisons were performed on changes in steatosis, inflammation, ballooning degeneration, and fibrosis scores. In addition, compound effects were evaluated by quantitative liver histology, including percent fractional area of liver fat, galectin-3, and collagen 1 a1.RESULTS Liraglutide and elafibranor, but not OCA, reduced body weight in both models. Liraglutide improved steatosis scores in DIO-NASH mice only. Elafibranor and OCA reduced histopathological scores of hepatic steatosis and inflammation in both models, but only elafibranor reduced fibrosis severity. Liraglutide and OCA reduced total liver fat, collagen 1 a1, and galectin-3 content, driven by significant reductions in liver weight. The individual drug effects on NASH histological endpoints were supported by global gene expression(RNA sequencing) and liver lipid biochemistry.CONCLUSION DIO-NASH and ob/ob-NASH mouse models show distinct treatment effects of liraglutide, OCA, and elafibranor, being in general agreement with corresponding findings in clinical trials for NASH. The present data therefore further supports the clinical translatability and utility of DIO-NASH and ob/ob-NASH mouse models of NASH for probing the therapeutic efficacy of compounds in preclinical drug development for NASH. | Kirstine S Tolbol Maria NB Kristiansen Henrik H Hansen Sanne S Veidal Kristoffer TG Rigbolt Matthew P Gillum Jacob Jelsing Niels Vrang Michael Feigh | 2018 | World Journal of Gastroenterology2018，24，2： | 5 |
| 3 | Reflectance measurement of canopy biomass and nitrogen status in wheat crops using normalized difference vegetation indices and partial least squares regression显示文摘 | HANSEN P M SCHJOERRING J K | 2003 | Remote Sensing of Environment2003，86，： | 2 |
| 4 | 西双版纳傣族及上海汉族群体HLA-DR2相关的DR/DQ单倍型分析显示文摘对44名西双版纳傣族和9名上海地区汉族DK2阳性个体进行了与其相关的DR/DQ单倍型组合的分析。傣族群体中DRBI-DR2亚型分布以*1602与*1502为最常见,其等位基因频率分别为43.6%与,40.0%和汉族群体中以*1501为主明显不同。傣族群体中共检出10种与DR2相关联的DR/DQ单倍型;最常见的是DRB1*1602、DRB5*0101、DQA1*0102、DQB1*0502(34.5%)与汉族及其他群体明显不同,本研究表明傣族不仅具有高频率的DR2,而且与DR2相关联的DRB1、DRB5、DQA1、DQB1单倍型组合有其独特性。 | 范丽安 杨珏琴 姚芳娟 董建中 许玲娣 陈仁彪 M Sirkong R Vongrathna P Longta S Lekmak D Chandanayingyong A Smith J Hansen | 1995 | 中华医学遗传学杂志1995，12，3： | 2 |
| 5 | Finite sample properties of some alternative GMM estimators 显示文摘 | Hansen L P Heaton J Yaron A | 1996 | Journal of Business & Economic Statistics1996，14，3： | 1 |
| 6 | Collaborative information retrieval in an information-intensive domain显示文摘 | Hansen P Javelin K | 2005 | Information Processing & Management2005，41，5： | 1 |
| 7 | Sperm chromatin structure integrity in liquid stored boar semen and its relationships with field fertility 显示文摘 | BOE HANSEN G B CHRISTENSEN P VIVJERG D | 2008 | Theriogenology2008，69，6： | 1 |
| 8 | Investigation of precipitation in an Al-Zn-Mg alloy after twostep ageing treatment at 100 ℃ and 150 ℃显示文摘 | Warren P J Hansen V | 1999 | Material Science and Engineering A1999，270，： | 1 |
| 9 | Neural networks ensembles显示文摘 | Hansen L K Salamon P | 1990 | IEEE Trans Pattern Analysis and Machine intelligence1990，12，10： | 1 |
| 10 | Effect of high pH on the growth and survival of marine phytoplankton: implications for species succession显示文摘 | HANSEN P J | 2002 | Aquat Microb Ecol2002，28，3： | 1 |
| 11 | Cluster analysis and mathematical programming 显示文摘 | Hansen P Jaumard B | 1997 | Mathematical Programming1997，79，13： | 1 |
| 12 | Investigation of precipitation in an Al-Zn-Mg alloy after two-step aging treatment at 100℃ and 150 ℃显示文摘 | Stiller K Warren P J Hansen V | 1999 | Mater Sci Eng A1999，270，： | 1 |
| 13 | Regularization Tools: A Matlab Package for Analysis and Solution of Discrete Ill-posed Problems 显示文摘 | Hansen P C | 1994 | Numerical Algorithms1994，6，： | 1 |
| 14 | Virtual-flux-based direct power control of three-phase PWM rectifier显示文摘 | Aalinowski M Kazmierkowski M P Hansen S | 2001 | IEEE Transaction on Industry Applications2001，37，： | 1 |
| 15 | Movement of foliar boron out of leaves and accumulation in flower buds and flower parts of Italion prune显示文摘 | HANSEN M H CHAPLIN P J | 1985 | HortScience1985，20，： | 1 |
| 16 | Reflectance measurement of canopy biomass and nitrogen statue in wheat crops using normalized difference vegetation indices and partial least squares regression显示文摘 | HANSEN P M Schjoerring J K | 2003 | Remote Sensing Environment2003，86，4： | 1 |
| 17 | Consistent ranking ofvolafilitymo dels显示文摘 | Hansen P R Lunde A | 2006 | Journal of Econometrics2006，，6： | 1 |
| 18 | New steel framing system promises major savings in high-rise apartment显示文摘 | Hansen R J Leuessurier W J Pahl P J Pel-letier R J | 1966 | Architecture Record1966，139，6： | 1 |
| 19 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 20 | Effect of Deletion of Chitin Synthase Genes on Mycelial Morphology and Culture Viscosity in Aspergillus oryzae显示文摘 | M tiller C Hansen K Szabo P | 2003 | Biotechnology and Bioengineering2003，81，5： | 1 |
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