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| 1 | Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis显示文摘AIM: Cyclooxygenase (COX)-2 is over expressed ingastrointestinal neoplasm. Helicobacter pylori ( H pylon)infection is causally linked to gastric cancer. However, theexpression of COX-2 in various stages of Hpylori-associatedgastric carcinogenesis pathway has not been elucidated.Therefore, the aim of this study was to clarify the role ofH pyloriinduced COX-2 expression during carcinogenesisin the stomach.METHODS: Gastric biopsies from 138 subjects [30 casesof chronic superficial gastritis (CSG), 28 cases of gastricglandular atrophy (GA), 45 cases of gastric mucosal intestinalmetaplasia (IM), 12 cases of moderate gastric epithelialdysplasia and 23 cases of gastric cancer] were enrolled.Hpyloriinfection was assessed by a rapid urease test andhistological examination (modified Giemsa staining). Theexpression of COX-1 and COX-2 in human gastric mucosawas detected by immunohistochemical staining.I^7~I_~: Hpyloriinfeddon rate was 64.3% in GA and 69.5%in gastric cancer, which was significantly higher than that(36.7%) in CSG (P<0.05). The positive expression rates ofCOX-2 were 10.0%, 35.7%, 37.8%, 41.7% and 69.5% inCSG, GA, IM, dysplasia and gastric cancer, respectively.From CSG to GA, IM, dysplasia and finally to gastric cancer,expression of COX-2 showed an ascending tendency, whereasCOX-1 expression did not change significantly in the gastricmucosa. The level of COX-2 expression in IM and dysplasiawas significantly higher in H pylon:positive than in H pylor/-negative subjects (P<0.01). | Wei-HaoSun QianYu HongShen Xi-LongOu Da-ZhongCao TingYu ChengQian FengZhu Yun-UangSun Xi-UngFu HanSu | 2004 | World Journal of Gastroenterology2004，10，19： | 21 |
| 2 | Efficacy of omeprazole and amoxicillin with either clarithromycin or metronidazole on eradication of Helicobacter pylori in Chinese peptic ulcer patients显示文摘AIM: One-week triple therapy with proton pump inhibitors, clarithromycin and amoxicillin has recently been proposed as the first-line treatment for Helicobacter pylori(H pylori) infection; however, data regarding the effects of this regimen in China are scarce. The aim of this prospective and randomized study was to compare the efficacy of clarithromycin and metronidazole when they were combined with omeprazole and amoxicillin on eradication of H pylori and ulcer healing in Chinese peptic ulcer patients.METHODS: A total of 103 subjects with H pylori-positive peptic ulcer were randomly divided into two groups, and accepted triple therapy with omeprazole 20 mg, amoxicillin 1 000 mg and either clarithromycin 500 mg (OAC group,n = 58) or metronidazole 400 mg (OAM group, n = 45).All drugs were given twice daily for 7 d. Patients with active peptic ulcer were treated with omeprazole 20 mg daily for 2-4 wk after anti-H pylori therapy. Six to eight weeks after omeprazole therapy, all patients underwent endoscopies and four biopsies (two from the antrum and two others from the corpus of stomach) were taken for rapid urease test and histological analysis (with modified Giemsa staining) to examine H pylori. Successful eradication was defined as negative results from both examination methods.RESULTS: One hundred patients completed the entire course of therapy and returned for follow-up. The eradication rate of H pylori for the per-protocol analysis was 89.3% (50/56) in OAC group and 84.1% (37/44) in OAM group. Based on the intention-to-treat analysis, the eradication rate of H pylori was 86.2% (50/58) in OAC group and 82.2% (37/45) in OAM group. There were no significant differences in eradication rates between the two groups on either analysis. The active ulcer-healing rate was 96.7% (29/30) in OAC group and 100% (21/21)in OAM group (per-protocol analysis, P>0.05). Six patients in OAC group (10.3%) and five in OAM group (11.1%)reported adverse events (P>0.05).CONCLUSION: One-week triple therapy with omeprazole and amoxicillin in combination with either clarithromycin or metronidazole is effective for the eradication of H pylori. The therapeutic regimen comprising metronidazole with low cost, good compliance and mild adverse events may offer a good choice for the treatment of peptic ulcers associated with H pylori infection in China. | Wei-HaoSun Xi-LongOu Da-ZhongCao QianYu TingYu Jin-MingHu FengZhu Yun-LiangSun Xi-LingFu HanSu | 2005 | World Journal of Gastroenterology2005，11，16： | 3 |
| 3 | Detection of scab in wheat ears using in situ hyperspectral data and support vector machine optimized by genetic algorithm显示文摘A new method was proposed to extract sensitive features and to construct a monitoring model for wheat scab based on in situ hyperspectral data of wheat ears to achieve effective prevention and control and provide theoretical support for its large-scale monitoring.Eight sensitive features were selected through correlation analysis and wavelet transform.These features were as follows:three original bands of 350-400 nm,500-600 nm,and 720-1000 nm;three vegetation indices of modified simple ratio(MSR),normalized difference vegetation index,and structural independent pigment index;and two wavelet features of WF01 and WF02.By combining the selected sensitive features with support vector machine(SVM)and SVM optimized by genetic algorithm(GASVM),a total of 16 monitoring models were built,and the monitoring accuracies of the two types of models were compared.The ability of the monitoring models built by GASVM to identify scab was better than that of SVM algorithm under the same characteristic variables.Among the 16 models,MSR combined with GASVM had an overall accuracy of 75%and a Kappa coefficient of 0.47.GASVM can be used to monitor wheat scab and its application can improve the accuracy of disease monitoring. | Linsheng Huang Hansu Zhang Chao Ruan Wenjiang Huang Tingguang Hu Jinling Zhao | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 2 |
| 4 | 显示文摘 | Sukeun Yoon Cheolmin Park Hansu Kim Hunjoon Sohn | 2007 | Power Sources2007，167，2007： | 1 |
| 5 | Development of metal-based electrodes for non-aqueous redox flow batteries显示文摘 | Kim Jae Hun Kim Ki Jae Park Min Sik Lee Nam Jin Hwang Uk Kim Hansu Kim Young Jun | 2011 | Electrochemistry Communications2011，13，9： | 1 |
| 6 | Conditioning technique:A general anti-windup and bumpless transfer method 显示文摘 | Hansu R Kinnaert M Henrotte J L | 1987 | Automatica1987，23，6： | 1 |
| 7 | Automatic generation of transducer models for bus-based MPSoC design 显示文摘 | Hansu Cho Lochi Yu Samar Abdi | 2013 | IEEE Transactions on Computers2013，62，2： | 1 |
| 8 | Progress in bleaching to top brightenss with low reservision显示文摘 | HansU Sulse ChreesonMoodley | 2005 | TAPPSA Journal2005，，3： | 1 |
| 9 | Enhancement of electrochemical and thermal properties of polyethylene separators coated with polyvinylidene fluoride–hexafluoropropylene co-polymer for Li-ion batteries显示文摘 | Ki Jae Kim Jae-Hun Kim Min-Sik Park Hyuk Kwon Kwon Hansu Kim Young-Jun Kim | 2011 | Journal of Power Sources2011，，： | 1 |
| 10 | Preparation and characterization of (K 0.5 Na 0.5 )NbO 3 ceramics显示文摘 | Hansu Birol Dragan Damjanovic Nava Setter | 2004 | Journal of the European Ceramic Society2004，，： | 1 |
| 11 | Contouring accuracy improvement using cross-coupled control and position error compensator显示文摘 | KE Hansu MING Yancheng | 2008 | International Journal of Machine Tools & Manufacture2008，48，： | 1 |
| 12 | Polymer mi-crosphere embedded Si/ graphite composite anode material for lithium rechargeable battery显示文摘 | Seung Sik Hwang Chang Gi Cho- Hansu Kim | 2010 | Electrochim Acta2010，55，： | 1 |
| 13 | Preparation of carbon-coated TiO 2 nanostructures for lithium-ion batteries显示文摘 | Sang-Jun Park Hansu Kim Young-Jun Kim Hyukjae Lee | 2011 | Electrochimica Acta2011，，15： | 1 |
| 14 | Significant corregulation between serum level of hepatocyte growth factor and progression of gastric carcinoma显示文摘 | HanSU LeeJH KimWH | 2000 | World J Surg2000，23，： | 1 |
| 15 | Risk Factors for Progression of background retinopathy in long-standing IDDM显示文摘 | Hansu UJ James HW Lawrence IR | 1989 | Diabetes1989，38，： | 1 |
| 16 | Electrochemical Characteristics of Mg-Ni Alloys as Anode Materials for Secondary Li Batteries显示文摘 | Hansu Kim Byungwoo Park Hun-Joon Sohn | 2000 | JPower Sources2000，90，： | 1 |
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