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| 1 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 2 | Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury 显示文摘 | Zhang PL Rothblum LI Han WK | 2008 | Kidney International2008，73，5： | 1 |
| 3 | Depression and the risk of pso- riasis in US women显示文摘 | Dominguez PL Han J Li T | 2013 | J Eur Acad Dermatol Venereol2013，27，： | 1 |
| 4 | Ethyl pyruvate amelio- rates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers显示文摘 | Sappington PL Han X Yang R | 2003 | J Pharmaeol Exp Ther2003，304，1： | 1 |
| 5 | Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult 显示文摘 | Piao CS Kim JB Han PL Lee JK | 2003 | J Neurosci Res2003，73，： | 1 |
| 6 | Work-up of the diabetic foot显示文摘 | William BM Hans PL | 2002 | Radio Clin Nor Am2002，40，5： | 1 |
| 7 | Antimicrobial effects ofcorn zein films impregnated with nisin, lauric acid,and EDTA显示文摘 | HOFFMAN KL’HAN IY DAWSON PL | 2001 | J Food Protect2001，64，6： | 1 |
| 8 | Modified technique for kidney transplantation in mice显示文摘 | Han WR Murray-Segal L J Mottram PL | 1999 | Microsurgery1999，19，6： | 1 |
| 9 | Pelvic heterotopic ossification:MRimaging 显示文摘 | Hans PL Mark ES WilliamSM | 2002 | Radiology2002，222，1： | 1 |
| 10 | An update of animal models of Alzheimer disease with a reevaluation of plaque depositions显示文摘 | Lee JE Han PL | | 0，，02： | 1 |
| 11 | Administration of the p38MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemie insult显示文摘 | Piao CS Kim JB Han PL | 2003 | J Neurosci Res2003，73，4： | 1 |
| 12 | Increased ex- pression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy显示文摘 | MOTTRAM PL HAN WR PURCELL LJ | 1995 | Transplantation1995，59，4： | 1 |
| 13 | Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell inj ury显示文摘 | Zhang PL Rothblum LI Han WK | 2008 | Kidney Int2008，73，5： | 1 |
| 14 | Imaging in spinal vascular disease显示文摘 | Krings T Lasjaunias PL Hans FJ | 2007 | Neuroimaging Clin N Am2007，17，1： | 1 |
| 15 | Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury显示文摘 | Rothblum LI Han WK | 2008 | Kidney Int2008，73，： | 1 |
| 16 | The Drosophila learning and memory gene rutabaga encodesa Ca2+/Calmodulin-responsive adenyl cyciase显示文摘 | Levin LR Han PL Hwang PM | 1996 | Cell1996，68，： | 1 |
| 17 | Ethyl pyruvateameliorates intestinal epithelial barrier dysfunction inendotoxemic mice and immunostimulated caco-2 enterocyticmonolayers 显示文摘 | SAPPINGTON PL HAN X YANG R | 2003 | J Pharmacol Exp Ther2003，304，1： | 1 |
| 18 | Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers 显示文摘 | Sappington PL Han X Yang R | 2003 | J Pharmacol Exp Ther2003，304，1： | 1 |
| 19 | Imaging in spinal vascular disease显示文摘 | Krings T Lasjaunias PL Hans FJ | 2007 | Neuroimaging Clin N Am2007，17，1： | 1 |
| 20 | Human papillomavirus is more prevalent in first trimester spontaneously aborted products of conception compared to elective specimens显示文摘 | Hermonat PL Han L Wendel PJ | 1997 | Virus Genes1997，14，1： | 1 |
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