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| 1 | Nab-paclitaxel(abraxane)-based chemotherapy to treat elderly patients with advanced non-small-cell lung cancer:a single center,randomized and open-label clinical trial显示文摘Background:The purpose of this study is to evaluate the clinical efficacy and safety of abraxane-based chemotherapy with/without nedaplatin in elderly patients with non-small-cell lung cancer(NSCLC).Materials and methods:From October 2009 to January 2013,48 elderly patients(>65 years) with NSCLC were investigated in this clinical trial.The patients were randomized and equally allocated into arms A and AP:(A) abraxane(130 mg/m^2,days 1,8);(B) abraxane + nedaplatin(20 mg/m^2 days 1-3,q3w).The parameters of objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),overall survival(OS) and side effects were evaluated between two arms.Results:Over 80%of the patients completed four cycles of chemotherapy.The total ORR was 21.3%,DCR was 55.3%,PFS 4.5 months and OS 12.6 months.No significant difference was found between arms A and AP in terms of ORR(16.7%vs.26.1%,P=0.665) or DCR(55.3%vs.56.5%,P=0.871).The median PFS in arm A was 3.3 months[25-75%confidence interval(CI):3.1-7.2]and 5.5 months(25-75%CI:3.2-7.0) in arm AP with no statistical significance(P=0.640).The median OS in arm A was 12.6 months(25-75%CI:5.7-26.2) and 15.1 months(25-75%CI:6.4-35.3) in arm AP with no statistical significance(P=0.770).The side effects were mainly grade 1-2.The incidence of grade 3-4 toxicities was 29.1%in arm A and 62.5%in arm AP with a statistical significance(P=0.020).Conclusions:Compared with combined therapy,abraxane alone chemotherapy was beneficial for elderly NSCLC patients with better tolerability and less adverse events,whereas did not significantly differ in terms of ORR,DCR,PFS or OS. | Hanrui Chen Xuewu Huang Shutang Wang Xinting Zheng Jietao Lin Peng Li Lizhu Lin | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 2 | Drop-coating produces efficient CsPbI_(2) Br solar cells显示文摘Inorganic perovskites (CsPbX_3, X=halide anion), containing no volatile organic cations, exhibit better thermal stability than organic–inorganic hybrid perovskites~([1, 2]). Among inorganic perovskites,α-Cs Pb I3(cubic phase) possesses a relatively suitable bandgap of~1.7 eV. CsPbI_3 perovskite solar cells (PSCs) have demonstrated power conversion efficiencies (PCEs) over 20%~([3-5]). | Hanrui Xiao Chuantian Zuo Fangyang Liu Liming Ding | 2021 | Journal of Semiconductors2021，42，5： | 3 |
| 3 | CGR-QV: A Virtual Topology DTN Routing Algorithm Based on Queue Scheduling显示文摘In this paper,we proposed a CGR-QV algorithm in order to solve the problems of low message delivery rate and low throughput problems in deep space communication networks,which are caused by the high delay,asymmetric data transmission rate,and frequent topology switching characteristics.The proposed method separate different message types in the queues,establish the relationship between TTL,wait time and Hurst to prevent the phenomenon of'starvation'and redundancy.In view of the impact of congestion on the network,improved algorithm use the Elastic load balancing strategy establish the relationship between optimal thresholdsαand network performance reliability.Simulation result show that the algorithm has improved in throughput as about 19%,message delivery rate improved as about 7.5%and bandwidth rejection rate decreased as about 4.7%,the algorithm can balance the impact of topology updates and resource consumption better in space communication networks. | Yaowen Qi Li Yang Chengsheng Pan Hanrui Li | 2020 | China Communications2020，17，7： | 3 |
| 4 | adipokines 的新兴的角色作为在动脉粥样硬化的调停人显示文摘Atherosclerotic cardiovascular disease is a major health problem around the world.Obesity is a primary risk factor for atherosclerosis and is associated with increased morbidity and mortality of cardiovascular diseases.However,the precise molecular pathways underlying this close association remain poorly understood.Adipokines are cytokines,chemokines and hormones secreted by adipose tissue that couple the regulation of lipid accumulation,inflammation,and atherogenesis,and therefore serve to link obesity with cardiovascular disorders.Obesity-related disorders including metabolic syndrome,diabetes,atherosclerosis,hypertension,and coronary artery disease are associated with dysregulated adipokine(s) expression.Recent studies demonstrate the proinflammatory effects as well as atherogenic properties of adipokines.Adipokines also participate in the regulation of endothelial function,which is an early event in atherosclerosis.By contrast,adiponectin,an adipocyte-derived hormone,exerts anti-inflammatory,anti-atherogenic and vascular protective effects.Furthermore,there is an interactive association among adipokines,by which adipokines reciprocally regulate each other’s expression.Understanding this interplay may reveal plausible mechanisms for treating atherosclerosis and coronary heart disease by modulating adipokine(s) expression.In this review,we discuss insights into the role and the therapeutic potential of adipokines as mediators of atherosclerosis. | Hanrui Zhang Jian Cui Cuihua Zhang | 2010 | World Journal of Cardiology2010，2，11： | 2 |
| 5 | Mechanistic investigation of the field-activated combustion synthesis of tungsten carbide with or without cobalt added显示文摘 | Jiang Guojian Zhuang Hanrui Li Wenlan | 2003 | Combustion and Flame2003，135，12： | 1 |
| 6 | 显示文摘 | BaiLinshan(白林山) HanRui(韩睿) LvDandan(吕丹丹) | | 安徽工业大学学报:自然科学版0，，： | 1 |
| 7 | Electroless silver coating on fine copper powder and its effects on oxidation resistance 显示文摘 | Xu Xinrui Luo Xiaojun Zhuang Hanrui | 2003 | Materials Letters2003，57，： | 1 |
| 8 | Preparation and sintering of Ni-coated Si3N4 composite powders显示文摘 | He Wanbao Zhang Baolin Zhuang Hanrui | | 0，，： | 1 |
| 9 | Synthesis and characterization of nano crystalline BaFe12O19 powders by low temperature combustion 显示文摘 | Huang Jianguo Zhuang Hanrui Li WenLan | 2003 | J Mater Res2003，，38： | 1 |
| 10 | 显示文摘 | Xu Xinrui Luo Xiaojun Zhuang Hanrui | 2003 | Materials Letters2003，57，： | 1 |
| 11 | 显示文摘 | He Wanbao Zhang Baolin Zhuang Hanrui | 2004 | Ceram Inter2004，30，： | 1 |
| 12 | Role of TNF-α in vascular dysfunction显示文摘 | Hanrui Zhang Yoonjung Park Junxi Wu | | 0，，3： | 1 |
| 13 | Eleetroless silver coating on fine copper powder and its effects on oxidation resistance 显示文摘 | Xinrui Xu Xiaojun Luo Hanrui Zhuang | 2003 | Materials Letters2003，57，： | 1 |
| 14 | Electroless silver coating on fine copper powder and its effects on oxidation resistance显示文摘 | Xu Xinrui Xiao Junluo Zhuang Hanrui | 2003 | Mater Lett2003，57，： | 1 |
| 15 | Electroless silver coating on fine copper powder and its effects on oxidation resistance显示文摘 | Xu Xinrui Luo Xiaojun Zhuang Hanrui | 2003 | Mater Lett2003，57，2425： | 1 |
| 16 | Preparation and sintering of Ni - coated Si3N4 composite powders 显示文摘 | HE WANBAO ZHANG BAOLIN ZHUANG HANRUI | 2005 | Ceramics International2005，，5： | 1 |
| 17 | Electroless silver coating on fine copper powder and its effects on oxidation resistance显示文摘 | Xu Xinrui Luo Xiaojun Zhuang Hanrui | 2003 | Materials Letters2003，57，： | 1 |
| 18 | Combustion synthesis of Si 3 N 4 –TiN composite powders显示文摘 | He Wanbao Zhang Baolin Zhuang Hanrui Li Wenlan | 2004 | Ceramics International2004，，8： | 1 |
| 19 | Role of inflammation in the regulation of coronary blood flow in ischemia and reperfusion: Mechanisms and therapeutic implications显示文摘 | Jun Li Hanrui Zhang Cuihua Zhang | 2011 | Journal of Molecular and Cellular Cardiology2011，，4： | 1 |
| 20 | Electroless silver coating on fine copper powder and its effects on oxidation resistance显示文摘 | Xinrui Xu Xiao jun Luo Hanrui Zhuang | 2003 | Materials Letters2003，57，： | 1 |
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