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| 1 | Polyoxometalate-based nanozyme: Design of a multifunctional enzyme for multi-faceted treatment of Alzheimer's disease显示文摘 | Nan Gao Kai Dong Andong Zhao Hanjun Sun Ying Wang Jinsong Ren Xiaogang Qu | 2016 | Nano Research2016，9，4： | 7 |
| 2 | Visible-light-driven enhanced antibacterial and biofilm elimination activity of graphitic carbon nitride by embedded Ag nanoparticles显示文摘有 photocatalytic 活动的半导体 nanomaterials 为许多应用有潜力。支持 photocatalytic 活动的一个有效方法在一个半导体上正在扔高贵金属 nanoparticles (NP ) ,自从 NP 作为禁止 photoexcited 电子洞对的快再结合并且从而提高反应的氧种类(ROS ) 的产生的优秀电子领受人扮演的高贵金属。此处,一个高度有效的平台, graphitic 碳氮化物( g-C <潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”>有嵌入的 Ag nanoparticles 的 4 ) nanosheets ( Ag/g-C <潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 ),被综合由一灵巧的线路。在可见轻照耀下面, Ag/g-C 的 ROS 生产<潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 nanohybrids 极大地与太古的 g-C 相比被改进<潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 nanosheets ,并且而且, nanohybrids 显示出驱散细菌的 biofilms 的提高的抗菌剂功效和能力。我们第一次证明 Ag/g-C < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 nanohybrids 是在可见的光下面的有效杀菌代理人照耀,和罐头也为 biofilm 提供一个新方法消除。Ag/g-C 的提高的抗菌剂性质和破坏 biofilm 能力 < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 nanohybrids 可以为许多提供生物医学的应用。 | Wei Bing Zhaowei Chen Hanjun Sun Peng Shi Nao Gao Jinsong Ren Xiaogang Qu | 2015 | Nano Research2015，8，5： | 7 |
| 3 | Staged angioplasty versus regular carotid artery stenting in patients with carotid artery stenosis at high risk of hyperperfusion:a randomised clinical trial显示文摘Background and purpose Hyperperfusion(HP)is a devastating complication associated with carotid artery stenting(CAS)or endarterectomy.The efficacy and safety of staged angioplasty(SAP)in patients with CAS at high risk of HP remains unclear.We sought to determine whether SAP is superior to regular CAS in patients with high risk of HP.Methods A randomised,multicentre open-label clinical trial with blinded outcome assessment(STEP)was conducted.Patients with severe carotid stenosis at high risk of HP were randomly assigned(1:1)to the SAP or regular CAS group.The primary endpoint was hyperperfusion syndrome(HPS)and intracerebral haemorrhage(ICH)within 30 days after the procedure.Results From November 2014 to January 2017,a total of 64 patients were enrolled in 11 centres.33 patients were allocated to the SAP group and 31 to the regular CAS group.At 30 days,the rate of primary endpoint was 0.0%(0/33)in the SAP group and 9.7%(3/31)in the regular CAS group(absolute risk reduction(ARR),9.7%;95%CI−20.1% to 0.7%;p=0.11).As one of the secondary endpoints,the incidence of HP phenomenon(HPP)was lower in the SAP group than the regular CAS group(0.0%vs 22.6%,ARR,−22.6%;95% CI−36.8%to−10.2%;p=0.04).Conclusion The rate of HPS and ICH was not significantly lower in SAP group;the extended secondary endpoint of HPP,however,significantly reduced,which suggested that SAP may be a safe and effective carotid revascularisation procedure to prevent HP. | Dapeng Mo Baixue Jia Huaizhang Shi Yaxuan Sun Qingan Liu Chengzhe Fan Jianping Deng Jinglin Yuan Wei Wu Changchun Jiang Guilian Zhang Hanjun Du Ning Ma Feng Gao Xuan Sun Ligang Song Lian Liu Guangge Peng Yongjun Wang Yilong Wang Zhongrong Miao the STEP Study Group | 2021 | Stroke & Vascular Neurology2021，6，1： | 3 |
| 4 | Temperature-sensitive and solvent-resistance hydrogel sensor for ambulatory signal acquisition in“moist/hot environment”显示文摘To realize continuously and stably work in a“moist/hot environment”,flexible electronics with excellent humid resistance,antiswelling,and detection sensitivity are demanding.Herein,a solvent-resistant and temperature-ultrasensitive hydrogel sensor was prepared by combining MXene and quaternized chitosan(QCS)with the binary polymer chain.The strong electrostatic interaction between the QCS chain and the poly(acrylic acid)(PAA)network endows the hydrogel stability against solvent erosion,high temperature,and high humidity.The strong dynamic interaction between MXene and polymer matrix significantly improves the mechanical properties and sensing(strain and temperature)sensitivity of the hydrogel.The hydrogel strain sensor exhibits a high gauge factor(5.53),temperature/humidity tolerance(equilibrium swelling ratio of 2.5%at 80℃),and excellent cycle stability,which could achieve a remote and accurate perception of complex human motion and environment fluctuation under aquatic conditions.Moreover,the hydrogel sensor exhibits impressive thermal response sensitivity(-3.183%/℃),ultrashort response time(<2.53 s),and a low detection limit(<0.5℃)in a wide temperature range,which is applied as an indicator of the body surface and ambient temperature.In short,this study broadens the application scenarios of hydrogels in persistent extreme thermal and wet environments. | Xinyu Qu Hanjun Sun Xiaolong Kan Bing Lei Jinjun Shao Qian Wang Wenjun Wang Zhenhua Ni Xiaochen Dong | 2023 | Nano Research2023，16，7： | 0 |
| 5 | The protection of CoronaVac against the infection of wild-type SARS-CoV-2(WH-09)or Omicron variant in nude-hACE2 mice显示文摘Background:Immunocompromised individuals have an increased risk of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and severe outcomes,but we pay less attention to these people.Athymic nude mice are a murine strain with a spontaneous deficiency of the Foxn1 gene,which can result in thymic degeneration or its absence,leading to immunosuppression and a decrease in the number of T cells,and are widely used in preclinical evaluations of disease in immunocompromised populations.Methods:We investigated the protection of the coronavirus disease 2019(COVID-19)inactivated vaccine(CoronaVac)against the infection of wild-type SARS-CoV-2(WH-09)or Omicron variant utilizing a hybrid-type nude-hACE2 mouse model.Results:Compared with nude-hACE2/W mice,the viral load in the brain and lung tissue of nude-hACE2 mice(nude-hACE2/WV)infected with WH-09 after vaccination significantly decreased,and the histopathological changes were also reduced.The viral load in the brain and lung tissue of nude-hACE2 mice(nude-hACE2/OV)infected with the Omicron variant after vaccination was lower than that in nude-hACE2/O,but histopathological symptoms did not improve significantly.Conclusion:CoronaVac provides some protection against infection of both WH-09 and the Omicron variant in the nude-hACE2 mice.Our findings aimed to provide a reference for vaccination against SARS-CoV-2 in immunocompromised populations. | Kaili Lin Meixuan Liu Lu Sun Hanjun Fu Hongwei Qiao Shunyi Wang Sidan Pan Hong Gao | 2023 | Animal Models and Experimental Medicine2023，6，4： | 0 |
| 6 | Soft Site Swap and Cutover in WCDMA Network显示文摘Traditionally,when a radio network site is swapped,it is necessary to interrupt existing services and perform a step-by-step serial cutover,which involves complex arrangements and huge resource investments.Therefore,there is an urgent need to discuss a fast and low-risk solution for site moving and cutover.ZTE Base Band Unit and Remote Radio Unit(BBU+RRU)Node B adopts distributed structure and combines full frequency reuse of the WCDMA system to conveniently implement soft site moving and cutover.The solution is to build an overlay network and make a one-time cutover without any impact on the operation of the existing network.Moreover,it supports timely fallback,and can considerably simplify the site moving and cutover operation and lower the network risk. | Lei Zengping Shi Hanjun Sun Yi(ZTE Corporation,Shanghai 201203,China) | 2007 | ZTE Communications2007，5，4： | 0 |
| 7 | Renal Effects of Prosthetic Abdominal Aortic Aneurysm in Dogs显示文摘To provide experimental model for abdominal aortic aneurysm research and to optimize design of stent-graft,the authors established an animal models of prosthetic abdominal aortic aneurysm (PAAA) in dogs,evaluated its biofunction,biocompatibility and renal effect.The PAAA was sutured using aneurysm neck (Φ 6 mm artificial blood vessel) and aneurysm body (Φ 29 and 31mm artificial blood vessel,respectively). Sixteen healthy adult dogs,with weight of 13. 5 ± 0. 66 kg,were randomly divided into 2 groups: group 29 mm and group 31 mm,8 in each group. Infrarenal aortic artery was reconstructed with PAAA to establish abdominal aortic aneurysm (AAA) animal model. Blood coagulation index such as prothrombin time (PT),activated partial thromboplatin time (APTT),thrombin time (TT) and Fibrinogen (Fbg) were detected pre-operation,1,7 and 14 days post-operation,respectively. Blood routine parameters were detected pre-operation 11,3 and 7 days post-operation. Renal function parameters such as blood urea nitrogen (BUN),creatinine (CREA),urea acid (UA) and urea/ creatinine (BU/CREA) were evaluated pre-operation and 30,90,150 days post-operation,respectively. PAAA were removed en bloc to determinine its biofuction and biocompatibility after 5 months of surgery. Kidneys were fixed in neutral buffered formalin solution,pathological slice were conducted to observate pathological changes of kidneys by HE stain.The results are as follows:1. Animal model: The PAAA was implanted to the infrarenal abdominal aortic artery without extensive bleeding after anastomosis. One dog died 2,25 and 127 days post-operation in group 31 mm,respectively,and the overall success rate was 62. 5%. One dog died 7 days post-operation in group 29 mm,the overall success rate was 87. 5%.2. Biofunction and biocompatibility of PAAA: Autopsy showed that there were no abdominal adhesions around the PAAAs,the lumen was patent without blood clots,there were no bleeding in PAAAs in two groups. Biocompatibility was poor because the outer layer of PAAA was enclosed by tissues,which was easy to strip,in group 31 mm. Excellent biocompatibility was proved by vascular endothelial cells growth in the inner layer of PAAA in group 29 mm.3. Coagulation examination: ATPP reduced significantly 1 day post-operation,and returned to normal after 7 days;there was no significant difference on TT in two groups. Fbg increased significantly 1 day post-operation (3. 16 ± 0. 56g/L,P<0. 05),and returned to normal after 7 days; PT and INR have no significant difference in group 29 mm. Value of PT and INR was 7. 92 ± 0. 57s and 0. 655 ± 0. 49,respectively,which reduced significantly compared with base value (P<0. 05),and returned to normal after 7 days; Fbg increased extremely 1 day post-operation (3. 28 ± 0. 49 g /L) (P<0. 01),which still increased significantly after 7 and 14 days in group 31 mm.4. Blood routine examination: Red blood cell count (RBC) and hemoglobin (HGB) reduced significantly 1 and 3days post-operation (P<0. 05); white blood cell count (WBC) and intermediate cell rate (MID%) increased extremely 1 day post-operation; there was no significant change in platelet count in group 29 mm. Mean corpuscular volume (MCV),RBC,HGB reduced significantly 1 and 3 days post-operation; WBC and MID% increased extremely 1 day after surgery; platelet (PLT),thrombocytocrit (PCT%) and platelet distribution width (PDW%) increased significantly1 day post-operation in group 31 mm.5. Renal function: BUN was 3. 995 ± 0. 36 mmol/L,which reduced extremely (P<0. 01),CREA was 104. 5 ±13. 85 μmol/L,which increased significantly (P<0. 05) after 150 days. BU/CREA reduced 90 and 150 days post-operation; UA reduced significantly or extremely 30,90 and 150 days post-operation (P<0. 05,P<0. 01),Its' values were 309. 61 ± 40. 8 μmol/L,160. 26 ± 28. 73 μmol/L and 23. 69 ± 12. 66 μmol/L,respectively in group 29 mm.In group 31 mm,BUN were 5. 51 ± 0. 43 mmol/L and 5. 36 ± 0. 32 mmol/L,which reduced significantly (P <0. 05); BU/CREA reduced significantly (P<0. 05),CREA were 106. 83 ± 7. 0 μmol/L、113. 17 ± 9. 79 μmol/L (P< 0. 05),which increased significantly compared with base values (P<0. 05) 90 and 150 days post-operation. UA reduced significantly or extremely 30,90 and 150 days post-operation (P<0. 05,P<0. 01),its' values were 303. 17 ±39. 2 μmol/L,144. 17. 26 ± 31. 06 μmol/L and 20. 83 ± 11. 52 μmol/L,respectively.6. Pathologic observation of kidney: Glomerular atrophy and granular degeneration in renal tubule with luminal narrowing was observed under microscope. Red thrombosis could be seen in part of renal tubule and renal glomerulus.Animal model of PAAA in dogs was successfully established. Biofunction and biocompatibility of PAAA in group 29mm is better than that of group 31mm. There were great changes in renal function,and obvious pathological changes appeared on kidney post-operation. | LV Yu-huan XU Zai-pin XU Wanli MA Zhe PENG Yao DU Peihang SUN Anqiang Deng Xiaoyan LOU Hanjun | 2012 | 畜牧与兽医2012，44，S2： | 0 |
| 8 | The gut microbiome and microbial metabolites in acute myocardial infarction显示文摘Emerging evidence has highlighted the role of gut microbiome in human health.However,the integrative role of gut microbiome and microbial metabolites in acute myocardial infarction(AMI)remains unclear.The current study profiles the microbial community through 16S rRNA gene sequencing and shotgun metagenomic sequencing and measures fecal short-chain fatty acids and circulating choline pathway metabolites among 117 new-onset AMI cases and 78 controls.Significant microbial alternations are observed in AMI patients compared with controls(P=0.001).The abundances of nine species(e.g.,Streptococcus salivarius and Klebsiella pneumoniae)are positively associated,and one species(Roseburia hominis)is inversely associated with AMI status and severity.A gut microbial score at disease onset is associated with the risk of major adverse cardiovascular events in 3.2 years(hazard ratio[95%CI]:2.01[1.04-4.24])in AMI patients.The molar proportions of fecal acetate and butyrate are higher,and the circulating levels of choline and carnitine are lower in AMI patients than in controls.In addition,disease classifiers show that AMI cases and controls have a more distinct pattern in taxonomical composition than in pathways or metabolites.Our findings suggest that microbial composition and functional potentials are associated with AMI status and severity. | Chenglin Liu Zhonghan Sun Shalaimaiti Shali Zhendong Mei Shufu Chang Hanjun Mo Lili Xu Yanni Pu Huihui Guan Guo-Chong Chen Qibin Qi Zhexue Quan Ji Qi Kang Yao Yuxiang Dai Yan Zheng Junbo Ge | 2022 | Journal of Genetics and Genomics2022，49，6： | 0 |
| 9 | The effects of inactivated SARS-CoV-2 vaccination and subsequent infection of pregnant mice on the behaviors of offspring显示文摘The mass inoculation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines to induce herd immunity is one of the most effective measures we can deploy in the fight against coronavirus disease 2019(COVID-19).Pregnant women are prone to a higher risk of COVID-19,and maternal infection is a risk fac-tor for a range of neurological disorders leading to abnormal behavior in adulthood.However,there are limited clinical data to support whether vaccination or infection post-immunization in pregnant women can affect the behavioral cognition of fetuses in adulthood.In this study,human angiotensin-converting enzyme 2 pregnant mice(F0 generation)were immunized with CoronaVac and then infected with SARS-CoV-2.Subsequently,we analyzed the behavioral cognition of their adult offspring(F1 gen-eration)using the open-field test and Morris water maze test.The adult F1 generation did not exhibit any impairments in spontaneous locomotor activity or spatial refer-ence memory. | Kaili Lin Meixuan Liu Lu Sun Hongwei Qiao Shunyi Wang Sidan Pan Hanjun Fu Jingzhu Wang Qiang Wei Hong Gao | 2022 | Animal Models and Experimental Medicine2022，5，5： | 0 |
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