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535篇 您的检索式:作者名="Handelsman"
    题名 作者 年代 出处 被引量
1Afterword to Semen Analysis in 21st Century Medicine special issue in Asian Journal of Andrology显示文摘David J. Handelsman Trevor G. Cooper 2010Asian Journal of Andrology2010,12,1:6
2Foreword to Semen Analysis in 21st Century Medicine special issue in Asian Journal of Andrology显示文摘David J. Handelsman Trevor G. Cooper 2010Asian Journal of Andrology2010,12,1:3
3Androgen abuse in sports显示文摘雄激素在运动仍然是最有效、广泛地滥用的因此遗传因子的药。尽管雄激素做为超过 3 被禁止了,有一个禁令的十年由质量强制了度谱(MS ) 基于尿为合成、外长的自然雄激素测试,尝试继续开发逐渐地复杂的计划围绕禁令。一条突出的最近的途径是设计者雄激素的发展。因为集体 spectrometry 依靠识别要求化学结构的优先的知识的典型化学签名,如此的从未出售的雄激素躲避察觉。尽管曾经知道,设计者雄激素乐意地被检测并且增加了禁止的表。然而,被阐明直到他们的结构,设计者雄激素能在雄激素做上围绕禁令。与这作斗争,在 vitro,雄激素生物鉴定为未辩别出的简历的通用察觉提供强大的新可能性活跃雄激素,不管他们的化学结构。在雄激素做上围绕禁令的另一条途径是间接雄激素做的发展,外长的药到的使用在内长的睾丸激素(T) 产生持续增加生产。然而,除了雌激素堵住 ers 活跃的药主要提供的如此的 neuroendocrine 血 T 的仅仅短暂的增加。最后,雄激素做上的禁令必须与偶然的、证明雄激素缺乏为稀罕运动员允许预备要求 T 代替治疗。治疗学的使用解脱机制为如此的必要医疗做预备,题目到为为 T 表明真进行中的需要并且 T 剂量监视的严密标准。做的运动的有效挽留的事物要求校准打败这些挑战,没有,在运动的公平是 tarnished 和聚会和贬值的冒险冠军的健康理想化的新奇、逐渐地复杂的察觉选择。David J. Handelsman Alison Heather 2008Asian Journal of Andrology2008,10,3:3
4Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate显示文摘疼痛追随者仓库肌内(IM ) 油的注射基于车辆的药是学习的很少。这研究试图有希望地在 4-mL 海狸油车辆在 1 000 mg 睾丸激素 undecanoate (TU ) 的 IM 注射以后在这个星期期间决定流行,决定因素,严厉和疼痛的功能的后果。在一个学术 andrology 诊所收到常规 T 代替治疗的雄激素缺乏的人被招募在深 IM 臀的注射以后在第一天和日报在七次用有色的视觉线性类似物规模报导疼痛分数一个星期。时间功课和 covariables 影响疼痛分数被变化(ANOVA ) 的混合模型分析分析。在 125 个人,的追随者 168 注射疼痛被 80% 人报导,在注射以后立即达到顶点,到达仅仅中等的严厉,持续 1 鈥?天并且在白天回到基线 4。疼痛几乎没要求很少止痛使用并且在每日的活动生产了最小的干扰。疼痛分数的时间功课在经历了二连续注射的 43 个人是可再现的。疼痛在有更早痛苦的注射,而是在严重的更少的人是更严重的更旧并且更多的肥胖的人。根据在管理注射的富有经验的护士之间的注射以后的疼痛经验有可以忽略的差别。在 4-mL 海狸油的仓库 TU 的深 IM 臀的注射很好被容忍,注射以后的疼痛被更早痛苦的注射经验,以及年龄和肥胖影响。Gideon Sartorius Carolyn Fennell Sasa Spasevska Leo Turner Ann J. Conway David J. Handelsman 2010Asian Journal of Andrology2010,12,2:3
5An old emperor finds new clothing: rejuvenation in our time显示文摘David J Handelsman 2011Asian Journal of Andrology2011,13,1:3
6Early infant male circumcision:Systematic review,risk-benefit analysis,and progress in policy显示文摘AIM To determine whether recent evidence-based United States polices on male circumcision(MC) apply to comparable Anglophone countries,Australia and New Zealand.METHODS Articles in 2005 through 2015 were retrieved from PubM ed using the keyword 'circumcision' together with 36 relevant subtopics.A further PubM ed search was performed for articles published in 2016.Searches of the EMBASE and Cochrane databases did not yield additional citable articles.Articles were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied further.The most relevant andrepresentative of the topic were included.Bibliographies were examined to retrieve further key references.Randomized controlled trials,recent high quality systematic reviews or meta-analyses(level 1++ or 1+ evidence) were prioritized for inclusion.A risk-benefit analysis of articles rated for quality was performed.For efficiency and reliability,recent randomized controlled trials,metaanalyses,high quality systematic reviews and large welldesigned studies were used if available.Internet searches were conducted for other relevant information,including policies and Australian data on claims under Medicare for MC.RESULTS Evidence-based policy statements by the American Academy of Pediatrics(AAP) and the Centers for Disease Control and Prevention(CDC) support infant and later age male circumcision(MC) as a desirable public health measure.Our systematic review of relevant literature over the past decade yielded 140 journal articles that met our inclusion criteria.Together,these showed that early infant MC confers immediate and lifelong benefits by protecting against urinary tract infections having potential adverse long-term renal effects,phimosis that causes difficult and painful erections and 'ballooning' during urination,inflammatory skin conditions,inferior penile hygiene,candidiasis,various sexually transmissible infections in both sexes,genital ulcers,and penile,prostate and cervical cancer.Our risk-benefit analysis showed that benefits exceeded procedural risks,which are predominantly minor,by up to 200 to 1.We estimated that more than 1 in 2 uncircumcised males will experience an adverse foreskin-related medical condition over their lifetime.Wide-ranging evidence from surveys,physiological measurements,and the anatomical location of penile sensory receptors responsible for sexual sensation strongly and consistently suggested that MC has no detrimental effect on sexual function,sensitivity or pleasure.United States studies showed that early infant MC is cost saving.The evidence supporting early infant MC has further strengthened since the positive AAP and CDC reviews.CONCLUSION Affirmative MC policies are needed in Australia and New Zealand.Routine provision of accurate,unbiased education,and access in public hospitals,will maximize health and financial benefits.Brian J Morris Sean E Kennedy Alex D Wodak Adrian Mindel David Golovsky Leslie Schrieber Eugenie R Lumbers David J Handelsman John B Ziegler 2017World Journal of Clinical Pediatrics2017,6,1:2
7Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products显示文摘Jo Handelsman Michelle R. Rondon Sean F. Brady Jon Clardy Robert M. Goodman 1998Chemistry & Biology1998,,10:2
8Falling sperm counts and global oestrogenic pollution:postscript显示文摘Trevor G Cooper David J Handelsman 2013Asian Journal of Andrology2013,15,2:2
9Molecular biological access to the chemistry of unknown soil microbes:a new frontier for natural products显示文摘Handelsman J Rondon M R Brady S P 1998Chem Biol1998,5,10:1
10Does combination anti- microbial therapy reduce mortality in Gram-negative bacterae- mia? A meta-analysis显示文摘Safdar N Handelsman J Maki DG 2004Lancet Infect Dis2004,4,8:1
11Molecular biolo- gical access to the chemistry of unknown soil microbes: a new frontier for natural products显示文摘Handelsman J Rondon MR Brady SF 1998Chemistry Biology1998,5,10:1
12American Association of Clinical Endocrinologists medical guidelines for clinical practice for developing a diabetes mellitus comprehensive care plan显示文摘Handelsman Y Mechanick JI Blonde L 2011Endocr Pract2011,17,2:1
13Biocontrol of soilborne plant pathoens显示文摘Handelsman J Stabb E V 1996The Plant Cell1996,8,:1
14Molecular biological access to the chemistry of unknown soil microbes : a new frontier for natural products 显示文摘Handelsman J Rondon MR Brady SF 1998Chem Biol1998,5,10:1
15Rodent models for human polycystic ovary syndrome显示文摘Walters KA Allan CM Handelsman DJ 2012Biol Reprod2012,86,5:1
16Biocontrol of plant disease:a (Gram-) positive perspective显示文摘Elizabeth A B E Handelsman J O 1999FEMS Microbiology Letters1999,171,:1
17Zwittermycin A-producing sWain of Bacillus cereus from diverse soils 显示文摘Stabb E Jacobson V G Handelsman L M 1994Applied and Environmental Microbiology1994,60,12:1
18Hormonal therapy of cryptorchidism: A randomized, double - blind study comparing human chorionic gonadotropin and gonadotropin - releasing hormone显示文摘Rajfer J Handelsman DJ Swerdloff RS 1986N Engl J Med1986,314,8:1
19Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA显示文摘Brady S F Chao C J Handelsman J 2001Org Lett2001,3,13:1
20American association of clinical endocrinologists and american college of endocrinology-clinical practice guidelines for developing a diabetes mellitus comprehensive care plan-2015 显示文摘Handelsman Y Bloomgarden ZT Grunberger G et aI 2015Endocr Pract2015,21,1:1
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