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| 1 | Non-genetic mechanisms of diabetic nephropathy显示文摘 | Qiuxia Han Hanyu Zhu Xiangmei Chen Zhangsuo Liu | 2017 | Frontiers of Medicine2017，11，3： | 29 |
| 2 | Modified bottleneck-based heuristic for large-scale job-shop scheduling problems with a single bottleneck显示文摘A modified bottleneck-based (MB) heuristic for large-scale job-shop scheduling problems with a well- defined bottleneck is suggested,which is simpler but more tailored than the shifting bottleneck (SB) procedure. In this algorithm,the bottleneck is first scheduled optimally while the non-bottleneck machines are subordinated around the solutions of the bottleneck schedule by some effective dispatching rules.Computational results indicate that the MB heuristic can achieve a better tradeoff between solution quality and computational time compared to SB procedure for medium-size problems.Furthermore,it can obtain a good solution in a short time for large-scale job- shop scheduling problems. | Zuo Yan Gu Hanyu Xi Yugeng | 2007 | Journal of Systems Engineering and Electronics2007，18，3： | 20 |
| 3 | Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment显示文摘Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components.Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, wesummarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent. | Xu Wu Wei Hu Lan Lu Yueshui Zhao Yejiang Zhou Zhangang Xiao Lin Zhang Hanyu Zhang Xiaobing Li Wanping Li Shengpeng Wang Chi Hin Cho Jing Shen Mingxing Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 20 |
| 4 | Type 1 regulatory T cells: a new mechanism of periphera immune tolerance显示文摘对抗原的有免疫力的反应的缺乏,作为有免疫力的忍耐知道的一个过程,为有免疫力的动态平衡的保藏是必要的。迄今为止,驾驶有免疫力的忍耐的二机制广泛地被描述了:中央忍耐和外部忍耐。在新名称下面,导出胸腺的规章的 T (tT reg ) 房间是中央有免疫力的忍耐的主要调停人,而外围地发源规章的 T (磅 reg ) 房间工作调整外部有免疫力的忍耐。T reg 房间,称为它 reg , 仅仅代表在里面导致 vitro 的 T reg 房间 1 。取决于房间是否稳定地表示 Foxp3,磅 reg , 和它 reg 房间可以被划分成二个子集:古典 CD4 + Foxp3 + T reg 房间和 CD4 + Foxp3 − 类型 1 规章的 T (Tr1 ) 房间 2 。这评论集中于发现,联系 biomarkers,规章的功能,正式就职的方法,有疾病的协会,和 Tr1 房间的临床的试用。 | Hanyu Zeng Rong Zhang Boquan Jin Lihua Chen | 2015 | Cellular & Molecular Immunology2015，12，5： | 19 |
| 5 | The Influence of Transgenic cry1Ab/cry1Ac,cry1C and cry2A Rice on Non-Target Planthoppers and Their Main Predators Under Field Conditions显示文摘Transgenic Bt rice has been shown to be an effective means of controlling Lepidoptera pests of rice.However,the potential roles of transgenic rice on planthoppers and their predators need to be investigated before its commercialization.Population density,species dominance and population dynamics are important parameters of arthropods populations in field.So the impacts of three transgenic Bt rice strains expressing cry1Ab/cry1Ac,cry1C and cry2A on population density,species dominance and population dynamics of three species of planthoppers(Nilaparvata lugens,Sogatella furcifera and Laodelphax striatellus) and their three main predators(Cyrtorhinus lividipennis,Pirata subpiraticus and Theridium octomaculatum) were evaluated at three sites in Hubei Province,China,in the current study.The results showed that among three species of planthoppers,both in transgenic and non-transgenic rice field,the predominant species of planthoppers within phytophagous guild was S.furcifera at any site either growing season(46-50%).Significantly higher population density of N.lugens was observed in T2A-1 field relative to Minghui 63 field at Wuxue in 2010.The species dominance of predator,P.subpiraticus,in TT51 field was significantly higher than that in T1C-19 and T2A-1 fields in 2009 at Xiaogan site.Sampling date significantly influenced six arthropods except for P.subpiraticus in 2010.The interaction between rice strain×sampling date had no significant adverse effects on the population dynamics of three species of planthoppers and their predators,except for several individual species in 2009.The interaction among rice strain×sampling date×sampling site also had no significant effect on six arthropods except for S.furcifera in 2009.The results indicated that transgenic Bt rice expressing cry1Ab/cry1Ac,cry2A and cry1C had no significant adverse effects on the population dynamics of three planthoppers and their predators in most investigated data and sampling site. | HANYu XU Xue-liang MA Wei-hua YUAN Ben-qi WANG Hui LIU Fang-zhou WANG Man-qun WU Gang HUA Hong-xia | 2011 | Agricultural Sciences in China2011，10，11： | 14 |
| 6 | Value of diffusion-weighted imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis: a meta-analysis显示文摘 | Niu Xiangke Sushant Kumar Das Anup Bhetuwal Xiao Yingquan Sun Feng Zeng Lichuan Wang Wenxuan Yang Hanfeng Yang Hanyu | 2014 | Chinese Medical Journal2014，，19： | 11 |
| 7 | Texture analysis on gadoxetic acid enhanced-MRI for predicting Ki-67 status in hepatocellular carcinoma: A prospective study显示文摘Objective: To investigate the value of whole-lesion texture analysis on preoperative gadoxetic acid enhanced magnetic resonance imaging(MRI) for predicting tumor Ki-67 status after curative resection in patients with hepatocellular carcinoma(HCC).Methods: This study consisted of 89 consecutive patients with surgically confirmed HCC. Texture features were extracted from multiparametric MRI based on whole-lesion regions of interest. The Ki-67 status was immunohistochemical determined and classified into low Ki-67(labeling index ≤15%) and high Ki-67(labeling index >15%) groups. Least absolute shrinkage and selection operator(LASSO) and multivariate logistic regression were applied for generating the texture signature, clinical nomogram and combined nomogram. The discrimination power, calibration and clinical usefulness of the three models were evaluated accordingly. Recurrence-free survival(RFS) rates after curative hepatectomy were also compared between groups.Results: A total of 13 texture features were selected to construct a texture signature for predicting Ki-67 status in HCC patients(C-index: 0.878, 95% confidence interval: 0.791-0.937). After incorporating texture signature to the clinical nomogram which included significant clinical variates(AFP, BCLC-stage, capsule integrity, tumor margin,enhancing capsule), the combined nomogram showed higher discrimination ability(C-index: 0.936 vs. 0.795,P<0.001), good calibration(P>0.05 in Hosmer-Lemeshow test) and higher clinical usefulness by decision curve analysis. RFS rate was significantly lower in the high Ki-67 group compared with the low Ki-67 group after curative surgery(63.27% vs. 85.00%, P<0.05).Conclusions: Texture analysis on gadoxetic acid enhanced MRI can serve as a noninvasive approach to preoperatively predict Ki-67 status of HCC after curative resection. The combination of texture signature and clinical factors demonstrated the potential to further improve the prediction performance. | Zheng Ye Hanyu Jiang Jie Chen Xijiao Liu Yi Wei Chunchao Xia Ting Duan Likun Cao Zhen Zhang Bin Song | 2019 | Chinese Journal of Cancer Research2019，31，5： | 11 |
| 8 | Applications of Lithium-Ion Batteries in Grid-Scale Energy Storage Systems显示文摘In the electrical energy transformation process,the grid-level energy storage system plays an essential role in balancing power generation and utilization.Batteries have considerable potential for application to grid-level energy storage systems because of their rapid response,modularization,and flexible installation.Among several battery technologies,lithium-ion batteries(LIBs)exhibit high energy efficiency,long cycle life,and relatively high energy density.In this perspective,the properties of LIBs,including their operation mechanism,battery design and construction,and advantages and disadvantages,have been analyzed in detail.Moreover,the performance of LIBs applied to grid-level energy storage systems is analyzed in terms of the following grid services:(1)frequency regulation;(2)peak shifting;(3)integration with renewable energy sources;and(4)power management.In addition,the challenges encountered in the application of LIBs are discussed and possible research directions aimed at overcoming these challenges are proposed to provide insight into the development of grid-level energy storage systems. | Tianmei Chen Yi Jin Hanyu Lv Antao Yang Meiyi Liu Bing Chen Ying Xie Qiang Chen | 2020 | Transactions of Tianjin University2020，26，3： | 9 |
| 9 | Effects of acupuncture treatment on natural killer cell activity,pulse rate,and pain reduction for older adults:an uncontrolled,observational study显示文摘OBJECTIVE: The aim of this study was to examine the changes in natural killer (NK) cell activity, pulse rate, and pain intensity among older adults before and after acupuncture treatment. METHODS: Fifty-six individuals (16 males and 40 females), aged 60 to 82 years (mean age 72.4 ± 5.0), who were experiencing pain in the shoulder, low back, or knee, participated in the study. NK cell activity, leukocyte differentiation (granulocytes and lymphocytes), pulse rate, and blood pressure values were obtained. Pain intensity was evaluated by using the visual analog scale (VAS). The Wilcoxon test was used to analyze NK cell activity, leukocytes (granulocyte counts and granulocyte-to-lymphocyte ratio), and the VAS score in accordance with the location of pain complaints before and after acupuncture treatment. RESULTS: NK cell activity decreased after acupuncture treatment for pain in the shoulder-pain and knee-pain groups. Further, the lymphocyte and granulocyte counts increased after acupuncture treatment for the shoulder-pain group. Pulse rate decreased for the shoulder-pain, low-back-pain, and knee-pain groups after acupuncture treatment. The VAS score decreased after acupuncture treatment for the shoulder-pain, low-back-pain, and knee-pain groups. CONCLUSION: This study showed that in older adults, acupuncture treatment decreases pulse rate, relieves pain in the shoulder, low back, and knee, and reduces NK-cell activity. | Hidetoshi Mori Hiroshi Kuge Tim Hideaki Tanaka Eiichi Taniwaki Kazuyo Hanyu Tateyuki Morisawa | 2013 | Journal of Integrative Medicine2013，11，2： | 9 |
| 10 | Nonlinear optical selection rule based on valley-exciton locking in monolayer ws2显示文摘Optical selection rules fundamentally determine the optical transitions between energy states in a variety of physical systems,from hydrogen atoms to bulk crystals such as gallium arsenide.These rules are important for optoelectronic applications such as lasers,energy-dispersive X-ray spectroscopy,and quantum computation.Recently,single-layer transition metal dichalcogenides have been found to exhibit valleys in momentum space with nontrivial Berry curvature and excitons with large binding energy.However,there has been little study of how the unique valley degree of freedom combined with the strong excitonic effect influences the nonlinear optical excitation.Here,we report the discovery of nonlinear optical selection rules in monolayer WS2,an important candidate for visible 2D optoelectronics because of its high quantum yield and large direct bandgap.We experimentally demonstrated this principle for second-harmonic generation and two-photon luminescence(TPL).Moreover,the circularly polarized TPL and the study of its dynamics evince a sub-ps interexciton relaxation(2p R 1s).The discovery of this new optical selection rule in a valleytronic 2D system not only considerably enhances knowledge in this area but also establishes a foundation for the control of optical transitions that will be crucial for valley optoelectronic device applications such as 2D valley-polarized THz sources with 2p–1s transitions,optical switches,and coherent control for quantum computing. | Jun Xiao Ziliang Ye Ying Wang Hanyu Zhu Yuan Wang Xiang Zhang | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 11 | Effect of wet flue gas desulfurization(WFGD) on fine particle(PM_(2.5)) emission from coal-fired boilers显示文摘In this study, the characteristics of fine particles before and after wet flue gas desulfurization(WFGD) in three coal-fired heating boilers in northern China were investigated by using a dilution-based emission sampling experimental system. The influences of the WFGD process on the mass and number concentrations as well as the chemical composition of fine particles were analyzed. The removal efficiency of desulfurization processes on particulate matter mass was 30.06%–56.25% for the three study units. The WFGD had a great influence on the size distributions of particle mass concentration and number concentration. A significant increase in the number and mass concentration of particles in the size range of 0.094–0.946 μm was observed. The watersoluble ion content accounted for a very large proportion of PM_(2.5) mass, and its proportion in PM_(2.5) increased from 28.39%–41.08% to 48.96%–61.21% after the WFGD process for the three units. The desulfurizing process also drastically increased the proportion of cation component(Ca^(2+) for unit A, Mg^(2+) for unit B, and Na+for unit C) and the proportion of SO_4^(2-) in PM_(2.5), and it increased the CE/AE values of PM_(2.5) from 0.82–0.98 to 0.93–1.27 for the three study units. | Sen Yao Shuiyuan Cheng Jianbing Li Hanyu Zhang Jia Jia Xiaowei Sun | 2019 | Journal of Environmental Sciences2019，31，3： | 8 |
| 12 | Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease显示文摘Netrin-1,an axon guidance factor,and its receptor UNC5B play important roles in axonal development and angiogenesis.This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated their roles in angiogenesis.Netrin-1 and UNC5B were upregulated in streptozotocininduced DKD Wistar rats,and their expression was compared with that in healthy controls.However,exogenous netrin-1 in UNC5B-depleted human renal glomerular endothelial cells (HRGECs) inhibited cell migration and tubulogenesis.This effect was likely associated with SRC pathway deactivation.Netrin-1 treatment also eliminated the pro-angiogenic effects of exogenous VEGF-165 on UNC5B-silenced HRGECs.These results indicate that UNC5B antagonizes netrin-1 and that UNC5B upregulation contributes partly to enhancing angiogenesis in DKD.Therefore,introducing exogenous netrin-1 and depleting endogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney injury in DKD. | Xiaojing Jiao Dong Zhang Quan Hong Lei Yan Qiuxia Han Fengmin Shao Guangyan Cai Xiangmei Chen Hanyu Zhu | 2020 | Frontiers of Medicine2020，14，3： | 7 |
| 13 | Endobronchial metastasis from adenocarcinoma of gastric cardia 7 years after potentially curable resection显示文摘Endobronchial metastasis(EBM) is a rare form of metas-tasis from extrapulmonary malignant tumors,although there are few reports of EBM from gastric cancer specifically.We report the case of a 51-year-old woman who had undergone gastrectomy for advanced gastric cancer seven years previously but was diagnosed with a solitary lung tumor by follow-up computed tomography.On diagnosis of primary lung cancer,she underwent pulmonary lobectomy,but immunohistochemical examination confirmed the resected tumor to be an EBM from the gastric cancer.Six months later,she was diagnosed with peritoneal metastases and underwent chemotherapy with gastric cancer regimen.She is still alive at 33 mo after the lobectomy.Generally,the prognosis for EBM is poor although multidisciplinary treatment can lead to long-term survival.Precise diagnosis on the basis of detailed pathological and immunohistochemical evaluation can contribute to deciding the most effective treatment and improving prognosis. | Takaaki Hanyu Tatsuo Kanda Atsushi Matsuki Go Hasegawa Kazuhito Yajima Masanori Tsuchida Shin-ichi Kosugi Makoto Naito Katsuyoshi Hatakeyama | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 7 |
| 14 | Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn 1^-/- mice显示文摘 | Guangyang Liu Lihua Wang Tianxiang Pang Delin Zhu Yi Xu Hanyu Wang Xiuli Cong Yongjun Liu | 2014 | Cellular & Molecular Immunology2014，11，3： | 6 |
| 15 | Functional assembly of root-associated microbial consortia improves nutrient efficiency and yield in soybean显示文摘Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated microbes or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that rootassociated microbes are critical influencers of host plant growth and nutrient acquisition. Three synthetic communities(SynComs) were constructed based on functional screening of 1,893 microbial strains isolated from root-associated compartments of soybean plants. Functional assemblage of SynComs promoted significant plant growth and nutrient acquisition under both N/P nutrient deficiency and sufficiency conditions.Field trials further revealed that application of SynComs stably and significantly promoted plant growth, facilitated N and P acquisition, and subsequently increased soybean yield. Among the tested communities, SynCom1 exhibited the greatest promotion effect, with yield increases of up to 36.1% observed in two field sites. Further RNA-seq implied that SynCom application systemically regulates N and P signaling networks at the transcriptional level, which leads to increased representation of important growth pathways, especially those related to auxin responses. Overall,this study details a promising strategy for constructing SynComs based on functional screening,which are capable of enhancing nutrient acquisition and crop yield through the activities of beneficial root-associated microbes. | Cunhu Wang Yanjun Li Mingjia Li Kefei Zhang Wenjing Ma Lei Zheng Hanyu Xu Baofeng Cui Ran Liu Yongqing Yang Yongjia Zhong Hong Liao | 2021 | Journal of Integrative Plant Biology2021，63，6： | 5 |
| 16 | Intelligent Detection and Identification in Fiber-Optical Perimeter Intrusion Monitoring System Based on the FBG Sensor Network显示文摘一个即时聪明的光纤的周界侵入察觉系统(PIDS ) 基于纤维布拉格栅栏(FBG ) ,传感器网络在这份报纸被介绍。区分不同侵入事件的效果,一个新奇即时行为影响分类方法在时间域基于信号侧面的必要统计特征被建议。特征被主要部件分析(PCA ) 提取,它然后被用来与一个 K 近邻居分类器识别事件。模拟和地测试两个都被执行验证它的有效性。为在模拟测试的五个样品信号的平均鉴定率(红外) 象 96.67% 一样高,并且为在域测试的八个典型信号的识别率能也被完成直到 96.52% ,它包括两个装篱笆并且埋葬地面的察觉到信号。而且,极其高的察觉率(医生) 和低虚惊评价(远) 能同时基于自相关特征分析和层次察觉和鉴定流动被获得。 | Huijuan WU Ya QIAN Wei ZHANG Hanyu LI Xin XIE | 2015 | Photonic Sensors2015，5，4： | 4 |
| 17 | Multifunctional metaoptics based on bilayer metasurfaces显示文摘Optical metasurfaces have become versatile platforms for manipulating the phase,amplitude,and polarization of light.A platform for achieving independent control over each of these properties,however,remains elusive due to the limited engineering space available when using a single-layer metasurface.For instance,multiwavelength metasurfaces suffer from performance limitations due to space filling constraints,while control over phase and amplitude can be achieved,but only for a single polarization.Here,we explore bilayer dielectric metasurfaces to expand the design space for metaoptics.The ability to independently control the geometry and function of each layer enables the development of multifunctional metaoptics in which two or more optical properties are independently designed.As a proof of concept,we demonstrate multiwavelength holograms,multiwavelength waveplates,and polarization-insensitive 3D holograms based on phase and amplitude masks.The proposed architecture opens a new avenue for designing complex flat optics with a wide variety of functionalities. | You Zhou Ivan I.Kravchenko Hao Wang Hanyu Zheng Gong Gu Jason Valentine | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 18 | Theory-orientated discovery of high-temperature superconductors in superhydrides stabilized under high pressure显示文摘A dream long held by physicists has been to raise the critical temperature(Tc)—the temperature below which the material exhibits no electrical resistance—of a superconductor to room temperature.The most recent excitement in that regard has centered on rare-earth superhydrides,of which LaH10 at 190 GPa has a remarkably high Tc of 260 K. | Jian Lv Ying Sun Hanyu Liu Yanming Ma | 2020 | Matter and Radiation at Extremes2020，5，6： | 4 |
| 19 | Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model显示文摘Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related deaths were reported(Rudd et al.,2020).Inflammation,oxidative stress,and apoptosis are the most common pathologies seen in sepsis.Liensinine(LIE)is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera.Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects.It can exert anti-carcinogenicactivityby regulating cell. | HANYU WANG YUANHAO YANG XIAO ZHANG YAN WANG HUI FAN JINFENG SHI XUELIAN TAN BAOSHI XU JINGCHAO QIANG ENZHUANG PAN MINGYI CHU ZIBO DONG JINGQUAN DONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 4 |
| 20 | 3D printing biomimeticmaterials and structures for biomedical applications显示文摘Over millions of years of evolution,nature has created organisms with overwhelming performances due to their unique materials and structures,providing us with valuable inspirations for the development of next-generation biomedical devices.As a promising new technology,3D printing enables the fabrication of multiscale,multi-material,and multi-functional threedimensional(3D)biomimetic materials and structures with high precision and great flexibility.The manufacturing challenges of biomedical devices with advanced biomimetic materials and structures for various applications were overcome with the flourishing development of 3D printing technologies.In this paper,the state-of-the-art additive manufacturing of biomimetic materials and structures in the field of biomedical engineering were overviewed.Various kinds of biomedical applications,including implants,lab-on-chip,medicine,microvascular network,and artificial organs and tissues,were respectively discussed.The technical challenges and limitations of biomimetic additive manufacturing in biomedical applications were further investigated,and the potential solutions and intriguing future technological developments of biomimetic 3D printing of biomedical devices were highlighted. | Yizhen Zhu Dylan Joralmon Weitong Shan Yiyu Chen Jiahui Rong Hanyu Zhao Siqi Xiao Xiangjia Li | 2021 | Bio-Design and Manufacturing2021，4，2： | 3 |
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