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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | 全球溺水负担:GBD 2017全球疾病负担死亡率的估计研究显示文摘世界卫生组织已将溺水确定为公共卫生优先事项。溺水指因淹没或者浸没于液体中而出现呼吸障碍的过程,其结果分为死亡、受伤和不受伤。致命性溺水是世界范围内导致非故意伤害相关死亡的主要原因,全球每年约有30万人溺水死亡。中低收入国家非故意溺水发生尤为严重。此外,男性和儿童是非故意溺水的高危人群。伤害预防工作者掌握准确和及时的数据将有助于合理分配公共卫生资源和评价干预措施的效果。 | 黄锦裕 佘宇航(摘译) 李丽萍(审校) Franklin R C Peden A E Hamilton E B | 2020 | 伤害医学(电子版)2020，9，4： | 6 |
| 3 | 激活β_3肾上腺素能受体恢复一氧化氮/氧化还原平衡,增强高血糖患者的内皮功能显示文摘一氧化氮与O_2^-之间的平衡紊乱(即一氧化氮/氧化还原失衡)是糖尿病引起的血管功能障碍的中心病理环节。该研究目的为在高血糖动物模型中探索β_3肾上腺素能受体(β_3adrenergic receptor,β3AR)激活能否耦合激活内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)。 | 刘莉 叶鹏 Karimi Galougahi K Liu CC Garcia A Gentile C Fry NA Hamilton EJ Hawkins CL Figtree GA | 2016 | 中华高血压杂志2016，24，3： | 2 |
| 4 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 5 | Do inflammatory processes contribute to radiation-induced erythema observed in the skin of humans? 显示文摘 | Simonen P Hamilton C Ferguson S | 1998 | Radiother Oncol J1998，46，1： | 1 |
| 6 | The Uniform Data System for Medical Rehabilitation Report of First Admissions for 1990显示文摘 | Granger C V Hamilton B B | 1992 | Am J Phys Med Rehabil1992，71，2： | 1 |
| 7 | An integrated anal ytical approach for determining the origin of solid bitumens in the McArthur Basin,Northern Australia显示文摘 | George S C Llorca S M Hamilton P J | 1994 | Org Geochem1994，21，： | 1 |
| 8 | Phytoremediation of soil contaminated with low concentrations of radionuclides显示文摘 | Entry J A Vance N C Hamilton M A | 1996 | Water Air Soil Pollution1996，88，： | 1 |
| 9 | C-2 neurec-tomy during atlantoaxial instrumented fusion in the elderly: patient satisfaction and surgical outcome 显示文摘 | Hamilton D K Smith J S Sansur C A | 2011 | J Neurosurg Spine2011，15，1： | 1 |
| 10 | Effect of pH on glucose and starch fermentation in batch and sequenced batch mode with a recently isolated strain of hydrogen-producing Clostridium butyricum CWBI1009 显示文摘 | Masset J Hiligsmann S Hamilton C | 2010 | International Journal of Hydrogen Energy2010，35，8： | 1 |
| 11 | A sampling method for measurement of large root systems with scanner based image analysis显示文摘 | Costa C Dwyer L M Hamilton R I | 2000 | Agronomy Journal2000，92，： | 1 |
| 12 | Evidence for a male-produced sex pheromone in the western flower thrips Frankliniella occidentals显示文摘 | Kirk W D J Hamilton J G C | | 0，，01： | 1 |
| 13 | Simulating the distribution effects of Canadian carbon taxes 显示文摘 | Hamilton K Grant C | 1994 | Canadian Public Policy1994，20，4： | 1 |
| 14 | A species of small antisense RNA in post transcriptional gene silencing in plants显示文摘 | HAMILTON A J BAULCOMBE D C | 1999 | Science1999，286，5441： | 1 |
| 15 | The nitrogen budget of a pine forest under free air CO2 enrichment显示文摘 | Delucia E H Hamilton J G | 2002 | Oecologia2002，132，： | 1 |
| 16 | An investigation of the route and progression of encephalitozoon cuniculi infection in adult rabbits显示文摘 | Cox J C Hamilton R C Attwood H D | 1979 | J Protozool1979，26，1： | 1 |
| 17 | Efficient attribute-oriented generalization for knowledge discovery from large databases 显示文摘 | Carter C L Hamilton H J | 1998 | IEEE Transactions on Knowledge and Data Engineering1998，10，2： | 1 |
| 18 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 19 | The production and emission of nitrous oxide from headwater streams in the midwestern United States显示文摘 | Beaulieu J J Arango C P Hamilton S K | 2008 | Global Change Biology2008，14，4： | 1 |
| 20 | Organic polymer thin-film transistor photosensors 显示文摘 | Hamilton M C Kanicki J | 2004 | IEEE J Sel Top Quantum Electron2004，10，4： | 1 |
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