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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | A sampling method for measurement of large root systems with scanner based image analysis显示文摘 | Costa C Dwyer L M Hamilton R I | 2000 | Agronomy Journal2000，92，： | 1 |
| 3 | Efficient attribute-oriented generalization for knowledge discovery from large databases 显示文摘 | Carter C L Hamilton H J | 1998 | IEEE Transactions on Knowledge and Data Engineering1998，10，2： | 1 |
| 4 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 5 | Acousticand other physical properties of shallow-water sediments offSan Diego显示文摘 | HAMILTON E L MENARD H W SHIPEX C J 1956 | 1956 | The Journal of the Acoustical Society ofAmerica1956，28，： | 1 |
| 6 | Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia显示文摘 | Kamdem LK Hamilton L Cheng C | 2008 | Pharmacogenet Genomics2008，18，6： | 1 |
| 7 | Dislocation nucleation and defect structure during surface indentation 显示文摘 | Kelchner C L Plimpton S J Hamilton J C | 1998 | Phys Rev B1998，58，11： | 1 |
| 8 | Component inertial effects on transmission Design显示文摘 | SEAMAN R L JOHNSON C E HAMILTON R F | 1984 | SAE Paper1984，，： | 1 |
| 9 | Protein kinase C beta II mRNA levels decrease in the striatum and cortex of transgenic Huntington's disease mice 显示文摘 | Harris A S Denovan-Wright E M Hamilton L C | 2001 | J Psychiatry Neurosci2001，26，： | 1 |
| 10 | A Numerical Simulation of the Role of Zooplankton in C, N and P Cycling in Lake Kinneret, Israel 显示文摘 | BRUCE L C HAMILTON D IMBERGER J | 2006 | Ecological Modelling2006，193，34： | 1 |
| 11 | A sampling method form easurement of large root systems with scanner based image analysis显示文摘 | Costa C Dwy er L M Hamilton R I | 2000 | Agronomy Journal2000，92，： | 1 |
| 12 | A fast, on-line generalization algorithm for knowledge discovery显示文摘 | Carter C L Hamilton H J | 1995 | Applied Math Letters1995，8，2： | 1 |
| 13 | Adding Hydrocarbons in Row Mix to Reduce NOx Emission Iron Ore Sintering Process 显示文摘 | Mo C L Teo C S Hamilton I | 1997 | ISIJ International1997，37，4： | 1 |
| 14 | Early, single ehlorhexidine application reduces ventilator-associated pneumonia in trauma patients显示文摘 | Grap M J Munro C L Hamilton V A | 2011 | Heart Lung2011，40，5： | 1 |
| 15 | Rapid analysis of genetic variation in Atlantic salmon ( Salmo salar) by PCR multiplexing of dinucleotide and tetranucleotide microsatellites 显示文摘 | O' Reilly P T Hamilton L C McConnell S K | 1996 | Can J Fish Aquat Sci1996，53，10： | 1 |
| 16 | Essential fatty acid deficiency in human adults during parenteral nutrition显示文摘 | HAMILTON C AUSTIN T SEIDNER D L | 2006 | Nutr Clin Pract2006，21，4： | 1 |
| 17 | The Sar Cheshmeh porphyry copper deposit显示文摘 | Waterman G C Hamilton R L | 1975 | Economic Geology1975，70，： | 1 |
| 18 | Intrathecal sufentanil for labor analgesia does not cause a sympathectomy显示文摘 | RILEY E T WALKERD HAMILTON C L | | 0，，04： | 1 |
| 19 | Disloea tion nucleation and defect structure during surface indentation 显示文摘 | KELCHNER C L PLIMPTON S J HAMILTON J C | 1998 | Physical Review B1998，58，11： | 1 |
| 20 | Contemporary advances and classic advice for analyzing mediating and moderating variables 显示文摘 | Dearing E Hamilton L C | 2006 | Monographs of the Society for Research in Child Development2006，71，： | 1 |
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