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| 1 | Osteoarthritis:toward a comprehensive understanding of pathological mechanism显示文摘Osteoarthritis(OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently,there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes. | Di Chen Jie Shen Weiwei Zhao Tingyu Wang Lin Han John L Hamilton Hee-Jeong Im | 2017 | Bone Research2017，5，1： | 121 |
| 2 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 3 | A series of normal stages in the development of the chick embryo 显示文摘 | Hamburger V Hamilton H L | 1951 | Morph1951，88，： | 1 |
| 4 | Risk-based evaluation of different postmortem inspection procedures for pigs in Australia显示文摘 | Hamilton D R Gallas P Lyall L | 2002 | The Veterinary Record2002，151，4： | 1 |
| 5 | Laparoscopic adrena lectomy: th e preferred choice? A comparison to open adrenalectomy显示文摘 | HAMILTON B D BRAVO E L | 1998 | J Urol1998，160，： | 1 |
| 6 | Chemical characteristics of fluid phase from a subducted lithosphere and origin of arc magmas: Evidence from high-pressure experiments and natural rocks 显示文摘 | Tatsumi Y Hamilton D L Nesbitt R W | 1986 | Journal of Velcanology and Geothermal Research1986，29，： | 1 |
| 7 | Ritual-enema-induced colitis显示文摘 | Segal I Tim L O Hamilton D G | 1979 | Dis Colon Rectum1979，22，3： | 1 |
| 8 | Physical modeling of the step recovery diode for pulse and harmonic generation circuits显示文摘 | Moll J L Hamilton S A | 1969 | Proc of the IEEE1969，57，7： | 1 |
| 9 | Life-history concepts andthepopulation biology of clonal organisms 显示文摘 | Saekvilh Hamilton N R Schmid B Harper J L | 1987 | Proceeding of Royal Society London B1987，232，： | 1 |
| 10 | A series of normal stages in the development of the chicken 显示文摘 | Hamburger V Hamilton H L | 1951 | Morphol1951，88，1： | 1 |
| 11 | Simulation of flexible-link manipulators applying sequential integration method 显示文摘 | Chang L W Hamilton J F | 1991 | Journal of dynamic systems measurement and control1991，113，： | 1 |
| 12 | A sampling method for measurement of large root systems with scanner based image analysis显示文摘 | Costa C Dwyer L M Hamilton R I | 2000 | Agronomy Journal2000，92，： | 1 |
| 13 | Mierofibrillated cellulose : morphology and accessibility 显示文摘 | Herrick F W Casebier R L Hamilton J K | 1983 | Journal of Applied Poly- mer Science1983，37，2： | 1 |
| 14 | Optical propertiesof cubic SiC:luminescence of nitrogen-exciton complexes,and interband absorption显示文摘 | Choyke W J Hamilton D R Patrick L | 1964 | Physical Review1964，133，4： | 1 |
| 15 | Efficient attribute-oriented generalization for knowledge discovery from large databases 显示文摘 | Carter C L Hamilton H J | 1998 | IEEE Transactions on Knowledge and Data Engineering1998，10，2： | 1 |
| 16 | First Paper:Measurementof the Oil-film Thickness between the Piston Ringsand Liner of a Small Diesel Engine显示文摘 | Hamilton G M Moore S L | 1974 | Proceedings ofthe Institution of Mechanical Engineering1974，188，1： | 1 |
| 17 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 18 | Prediction of in-situ acoustic and elastic properties of marine sediments显示文摘 | Hamilton E L | 1971 | Geophysics1971，36，2： | 1 |
| 19 | Feline ilial fractures:a prospective study of dorsal plating and comparisonwith lateral plating显示文摘 | Langley-Hobbs S J Meeson R L Hamilton M H | 2009 | Vet Surg2009，38，： | 1 |
| 20 | Acousticand other physical properties of shallow-water sediments offSan Diego显示文摘 | HAMILTON E L MENARD H W SHIPEX C J 1956 | 1956 | The Journal of the Acoustical Society ofAmerica1956，28，： | 1 |
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