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| 1 | Clinical outcomes of self-expandable stent placement for benign esophageal diseases: A pooled analysis of the literature显示文摘AIM: To analyze the outcomes of self-expandable stent placement for benign esophageal strictures and benign esophageal leaks in the literature.METHODS: The Pub Med, Embase and Cochrane databases were searched for relevant articles published between January 2000 and July 2014. Eight prospective studies were identified that analyzed the outcomes of stent placement for refractory benign esophageal strictures. The outcomes of stent placement for benign esophageal leaks, perforations and fistulae were extracted from 20 retrospective studies that were published after the inclusion period of a recent systematic review. Data were pooled and analyzed using descriptive statistics.RESULTS: Fully covered self-expandable metal stents(FC SEMS)(n = 85), biodegradable(BD) stents(n = 77) and self-expandable plastic stents(SEPS)(n = 70) were inserted in 232 patients with refractory benign esophageal strictures. The overall clinical success rate was 24.2% and according to stent type 14.1% for FC SEMS, 32.9% for BD stents and 27.1% for SEPS. Stent migration occurred in 24.6% of cases. The overall complication rate was 31.0%, including major(17.7%) and minor(13.4%) complications. A total of 643 patients were treated with self-expandable stents mainly for postsurgical leaks(64.5%), iatrogenic perforations(19.6%), Boerhaave's syndrome(7.8%) and fistulae(3.7%). FC SEMS and partially covered SEMS were used in the majority of patients. Successful closure of the defect was achieved in 76.8% of patients and according to etiology in 81.4% for postsurgical leaks, 86.0% for perforations and 64.7% for fistulae. The pooled stent migration rate was 16.5%. Stent-related complications occurred in 13.4% of patients, including major(7.8%) and minor(5.5%) complications.CONCLUSION: The outcomes of stent placement for refractory benign esophageal strictures were poor. However, randomized trials are needed to put this into perspective. The evidence on successful stent placement for benign esophageal leaks, perforationsand fistulae is promising. | Emo E van Halsema Jeanin E van Hooft | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，2： | 10 |
| 2 | Self-expandable metal stents for malignant gastric outlet obstruction: A pooled analysis of prospective literature显示文摘AIM: To provide an overview of the clinical outcomes of self-expandable metal stent(SEMS) placement for malignant gastric outlet obstruction(MGOO).METHODS: A systematic literature search was performed in Pub Med of the literature published between January 2009 and March 2015. Only prospective studies that reported on the clinical success of stent placement for MGOO were included. The primary endpoint was clinical success,defined according to the definition used in the original article. Data were pooled and analyzed using descriptive statistics. Subgroup analyses were performed for partially covered SEMSs(PCSEMSs) and uncovered SEMSs(UCSEMSs) using Fisher's exact test.RESULTS: A total of 19 studies,including 1281 patients,were included in the final analysis. Gastric(42%) and pancreatic(37%) cancer were the main causes of MGOO. UCSEMSs were used in 76% of patients and PCSEMSs in 24%. The overall pooled technical success rate was 97.3% and the clinical success rate was 85.7%. Stent dysfunction occurred in 19.6% of patients,mainly caused by re-obstruction(12.6%) and stent migration(4.3%),and was comparable between PCSEMSs and UCSEMSs(21.2% vs 19.1%,respectively,P = 0.412). Re-obstruction was more common with UCSEMSs(14.9% vs 5.1%,P < 0.001) and stent migration was more frequent after PCSEMS placement(10.9% vs 2.2%,P < 0.001). The overall perforation rate was 1.2%. Bleeding was reported in 4.1% of patients,including major bleeding in 0.8%. The median stent patency ranged from 68 to 307 d in five studies. The median overall survival ranged from 49 to 183 d in 13 studies.CONCLUSION: The clinical outcomes in this large population showed that enteral stent placement was feasible,effective and safe. Therefore,stent placement is a valid treatment option for the palliation of MGOO. | Emo E van Halsema Erik AJ Rauws Paul Fockens Jeanin E van Hooft | 2015 | World Journal of Gastroenterology2015，21，43： | 5 |
| 3 | Efficiency and productivity terms for water management:a matter of contextual relativism versus general absolutism显示文摘 | Van Halsema G E Vincent L | 2012 | Agricultural Water Management2012，108，： | 1 |
| 4 | Perforation in colorectal stenting: a meta-analysis and a search for risk factors显示文摘 | Emo E. van Halsema Jeanin E. van Hooft Aaron J. Small Todd H. Baron Jesús García-Cano Jae Hee Cheon Moon Sung Lee Se Hwan Kwon Stéphanie Mucci-Hennekinne Paul Fockens Marcel G.W. Dijkgraaf Alessandro Repici | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 5 | MINISAR:一种体积小、重量轻、成本低、可扩展的合成孔径系统显示文摘TNO-FEL正在开发一种称作“MiniSAR”的体积小、重量轻、成本低、可扩展的SAR/MTI系统。该小型合成孔径系统的体积和构造都很独特。最初,要将验证系统安装在一个两座滑翔机平台上。该雷达将尽可能使用商用货架产品(COTS)。本文阐述了TNO-FEL及其合作者在2002年制造的小型合成孔径雷达样机的概念和设计。
前端是一个有源相控阵天线。该天线由三堤含有波束形成网络、T/R模块和天线单元的平板组成。平板是一块将所有功能都集成在一块板上的多层微波板。每块平板集成有8个T/R模块。T/R模块的基础是TNO-FEL(TNO物理与电子实验室)开发的单片微波集成电路。天线结构大小可变,可扩展至在MiniSAR系统中安装更大的天线或多个天线。
该系统将安装在滑翔机平台机翼下的一个COTS吊舱中。TNO-FEL开发的这一平台既用于遥感,也用作无人机工作时的TNO—FEL教练台。该平台将在运行调试中为检验新概念和各项技术提供极好的机会。
雷达工作在X波段,中心频率约为9.75GHz。样机系统的设计目标是达到500MHz的带宽。系统将在高分辨率模式下覆盖至少1千米的地带,而在条带图像模式下覆盖大约4千米的地带。此外,MiniSAR将有一个三通道动目标显示模式。为了机上质量控制和运行支持,将为系统开发一种快视合成孔径雷达处理器。近期,有望扩展MiniSAR系统,使其包含交叉轨迹干涉仪和极化测定仪的更多能力。这个MiniSAR系统是TNO-FEL及其合作伙伴联合设计的。 | Philippe Steeghs Erik van Halsema 刘建忠(译) 雷庚(校) | 2006 | 空载雷达2006，，4： | 1 |
| 6 | Brief report: the effect of antiretroviral therapy and CIM count on marke of infectiousness in HIV-associated tuberculosis 显示文摘 | van Halsema CL Fielding KL Chihota VN | 2015 | J Acquit Immune Defic Syndr2015，70，1： | 1 |
| 7 | Safety of endoscopic removal of self-expandable stents after treatment of benign esophageal diseases显示文摘 | VAN HALSEMA E E WONG KEE SONG L M BARON T H | 2013 | Gastrointestinal Endoscopy2013，77，1： | 1 |
| 8 | Flow regimes in centrifugal partition chromatography 显示文摘 | VAN BUEL M J VAN HALSEMA F E D VAN DER WIELEN L A M | 1998 | AIChE1998，10，9： | 1 |
| 9 | Gost-effictiveness of extraperitoneal laparosopic inguinal hemia repair:a rancomized comperison with conventional hemiorrhaphy显示文摘 | Liem MSL Halsema JAM Van Der Graf Y | 1997 | Ann Surg1997，226，： | 1 |
| 10 | Self- expandable metal stents for malignant gastric outlet obstruction: A pooled a- nalysis of prospective literature显示文摘 | van Halsema EE Rauws EAJ Fockens P | 2015 | World J Gastroenterol2015，21，12： | 1 |
| 11 | Genetic influences in respiratory distress syndrome:a twin study显示文摘 | van Sonderen L Halsema EF Spiering EJ | | 0，，： | 1 |
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