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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | Molecular mechanisms of phenotypic plasticity in smooth muscle cells显示文摘 | Andrew J Halayko Julian Solway | 2001 | J Ap-pl Physiol2001，90，： | 1 |
| 3 | 13-Catenin signaling is required for TGF-131-induced extracellular matrix production by airway smooth muscle cells显示文摘 | Baarsma HA Menzen MH Halayko AJ | 2011 | Am J PhysioI Lung Cell Mol Physiol2011，301，6： | 1 |
| 4 | Transcriptional regulation of smooth muscle contractile apparatus expression显示文摘 | So/way J Forsythe S M Halayko A J | 1998 | Am J Respir Crit Care Med1998，158，53： | 1 |
| 5 | Marker of airway smooth muscle cell phenotype显示文摘 | Halayko A J Salari H MA X | 1996 | Am J Physiol1996，270，6： | 1 |
| 6 | Essential role of NF-kappa B and AP-1 transcription factors in TNF-alpha-induced TSLP expression in human airway smooth muscle cells显示文摘 | Redhu NS Saleh A Halayko AJ | | 0，，： | 1 |
| 7 | Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins显示文摘 | Halayko AJ Tran T Gosens R | 2008 | Proc Am Thorac Soc2008，5，1： | 1 |
| 8 | Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes显示文摘 | HALAYKO A J CAMORETT-MERCADO B FORSYTHE S M | 1999 | Am J Physiol1999，276，1： | 1 |
| 9 | Phenotype and functional plasticity of airway smooth muscle显示文摘 | Halayko A J Tran T Gosens R | 2008 | Proc Am Thorac Soc2008，5，： | 1 |
| 10 | S100A8/A9: a mediator of severe asth- ma pathogenesis and morbidity? 显示文摘 | Halayko A J Ghavami S | 2009 | Can J Physiol Pharmacol2009，87，10： | 1 |
| 11 | The RhoA/Rho Kinase pathway regulates nuclear localization of serum response factor显示文摘 | Halayko AJ Fernandes DJ | 2003 | Am J Respir Cell Mol Biol2003，29，1： | 1 |
| 12 | Markers of airway smooth muscle cell phenotype显示文摘 | Halayko A J Salari H MA X | 1996 | Am J Physiol1996，270，61： | 1 |
| 13 | Potential role for phenotypic modulationof brochial smooth muscle cells in chronic asthma显示文摘 | Halayko AJ Stephens NL | 1994 | Can J Physiol Pharrnacol1994，71，11： | 1 |
| 14 | S100A8/ A9:a mediator of severe asthma pathogenesis and morbidity? 显示文摘 | Halayko AJ Ghavami S | 2009 | Can J Physiol Pharmacol2009，87，10： | 1 |
| 15 | Sustained suppression of IL- l3 by a vaccine attenuates airway inflammation and remodeling in mice 显示文摘 | Ma Y Halayko AJ Basu S | 2013 | Am J Respir Cell Mol Biol2013，48，5： | 1 |
| 16 | Molecular mechanisms of phenotypic plasticity in smooth muscle cells显示文摘 | Halayko AJ Solway J | 2001 | J Appl Physiol2001，，： | 1 |
| 17 | Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthma显示文摘 | Halayko AJ Amrani Y | 2003 | Respir Physiol Neurobiol2003，137，23： | 1 |
| 18 | Cell-Specific Dual Role of Caveolin-1 in Pulmonary Hypertension显示文摘 | Rajamma Mathew Andrew J. Halayko | 2011 | Pulmonary Medicine2011，，： | 1 |
| 19 | Phenotype and functional plasticity of airway smooth muscle:role of caveolae and caveolins显示文摘 | Halayko AJ Tran T Gosens R | 2008 | Proc Am Thorac Soc2008，5，1： | 1 |
| 20 | Hypoxia induces hypersensi- tivity and hyperreactivity to thromboxane receptor agonist in neonatal pulmonary arterial myocytes显示文摘 | Hinton M Mellow L Halayko AJ | 2006 | Am J Physiol Lung Cell Mol Physiol2006，290，2： | 1 |
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