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| 1 | Relationship between vitamin D and IL-23,IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians显示文摘AIM:To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). METHODS:The study was conducted on 50 Egyptian hepatitis C virus (HCV) genotype number IV-infected patients and 25 ageand gender-matched healthy subjects. Venous blood samples were obtained. Samples were allowed to clot and sera were separated by centrifugation and stored at -20 ℃. A 25 hydroxy vitamin D assay was carried out using solid phase RIA. A 1,25 dihydroxy vitamin D assay was carried out using a commercial kit purchased from Incstar Corporation. IL-17 and -23 and MCP-1 were assayed by an enzyme immunoassay. Quantitative and qualitative polymerase chain reaction for HCV virus were done by TaqMan technology. Only HCV genotype IV-infected subjectswere included in the study. The mean ± SD were determined, a t-test for comparison of means of different parameters was used. Correlation analysis was done using Pearson's correlation. Differences among different groups were determined using the Kruskal-Wallis test. RESULTS:The mean vitamin D level in HCV patients (groupⅠ) was 15 ± 5.2 ng/mL while in control (group Ⅱ) was 39.7 ± 10.8. For active vitamin D in groupⅠas 16.6 ± 4.8 ng/mL while in group Ⅱ was 41.9 ± 7.9. IL-23 was 154 ± 97.8 in group Ⅰ and 6.7 ± 2.17 in group Ⅱ. IL-17 was 70.7 ± 72.5 in cases and 1.2 ± 0.4 in control. MCP-1 was 1582 ± 794.4 in group Ⅰand 216.1 ± 5.38 in group Ⅱ. Vitamin D deficiency affected 72% of HCV-infected patients and 0% of the control group. Vitamin D insufficiency existed in 28% of HCV-in-fected patients and 12% of the control group. One hundred percent of the cirrhotic patients and 40% of non cirrhotic HCV-infected patients had vitamin D deficiency. IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and-23 and MCP-1 was detected. HCV-infected males and females showed no differences with respect to viral load, vitamin D levels, IL-17, IL-23 and MCP-1. The viral load was negatively correlated with vitamin D and active vitamin D (P = 0.0001 and P = 0.001, respectively), while positively correlated with IL-23, IL-17, and MCP-1. We classified the patients according to sonar findings into four groups. Group Ⅰa with bright hepatomegaly and included 14 patients. Group Ⅰb with perihepatic fibrosis and included 11 patients. Group Ⅰc with liver cirrhosis and included 11 patients. Group Ⅰd with he patocellular carcinoma (HCC) and included 14 patients. Vitamin D and active vitamin D were shown to be lower in cirrhotic patients and much lower in patients with HCC, and this difference was highly significant (P = 0.0001). IL-17 and-23 and MCP-1 were higher in advanced liver disease) and the differences were highly significant (P = 0.0001).CONCLUSION:Whether the deficiency of vitamin D is related to HCV-induced chronic liver disease or predisposing factor for higher viral load is a matter of debate. | Noha M El Husseiny Hala M Fahmy Waleed A Mohamed Hisham H Amin | 2012 | World Journal of Hepatology2012，4，8： | 12 |
| 2 | Isotopic abundances of water of crystallization of gypsum from the Miocene evaporite formation, Carpathian Foredeep, Poland 显示文摘 | HALAS S KROUSE H R | 1982 | Geochimica et Cosmochimica Acta1982，46，2： | 1 |
| 3 | Three-dimensional echocardiography in the evaluation of global and regional function in patients with recent myocardial infarction: a comparison with magnetic resonance imaging 显示文摘 | Thorstensen A Dalen H Hala P | 2013 | Echocardiography2013，30，6： | 1 |
| 4 | Mild zinc deficiency and undemutrition during the prenatal and postnatal periods in rats: effects on weight, food consumption, and brain catecholamine concentrations显示文摘 | HALAS E S WALLWORK J C SANDSTEAD H H | 1982 | Journal of Nutrition1982，112，： | 1 |
| 5 | Plasmonic Nanoshell Arrays Combine Surface-Enhanced Vibrational Spectroscopies on a Single Substrate显示文摘 | Wang H Kundu J Halas N J | 2007 | Angew Chem Int Ed2007，46，： | 1 |
| 6 | Three-dimensional echocardiography in the evaluation of global and regional function in patients with recent myocardial infarction: a comparison with magnetic resonance imaging 显示文摘 | Thorstensen A Dalen H Hala P | 2013 | Echocardiography2013，30，6： | 1 |
| 7 | A Cellular Trojan Horse for delivery ofther apeutic nanoparticles into tumors显示文摘 | Choi M R Stanton - Maxey K J Stanley J K Levin C S Bardhan R Akin D Badve S Sturgis J Robinson J P Bashir B Halas H J and Clare S E | 2007 | Nano Letters2007，7，12： | 1 |
| 8 | Phenylpropanoids from leaves of Juniperus phoenicea 显示文摘 | Xing C L Hala N E Charles D H | 1997 | Phytochemistry1997，45，8： | 1 |
| 9 | Expression oF the vascular endothelial growth actor (VEGF) gene in epithelial ovarian canc- er: an approach to anti-VEGF therapy显示文摘 | Hala K Watanabe Y Nakai H | 2011 | Anticancer Res2011，31，2： | 1 |
| 10 | Cloning and Characterization of Ginkgo biloba levopimaradiene synthase, which catalyzes the first committed step in ginkgolides biosynthesis 显示文摘 | Hala G Schepmann Pang J H | 2001 | Arch Biochem Biophys2001，392，2： | 1 |
| 11 | Giant peritoneal loose body in the pelvic ('avity : repo,l of a ease显示文摘 | Nomura H Hala F Yasoshima T e! al | 2003 | Surg Today2003，33，10： | 1 |
| 12 | Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control显示文摘 | Eman A El-ghoroury Hala M Raslan Ehsan A Badawy Gamila S El-Saaid Mervat H Agybi Ibrahem Siam Sohair I Salem | 2009 | Blood Coagulation & Fibrinolysis2009，，4： | 1 |
| 13 | Expression of vascular endothelial growth factor in experimental choroidal neovascularization 显示文摘 | Ishibashi T Hala Y Yoshikawa H Nakagawa K Sueishi K Inomata H | 1997 | Graefe Arch Clin Exp Ophthalmol1997，235，3： | 1 |
| 14 | New rapid validated HPTLC method for the determination of galanthamine in Amaryllidaceae plant extracts显示文摘 | AMINA H SOAD M HALA M | 2008 | Phytochemical Analysis2008，19，4： | 1 |
| 15 | Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy 显示文摘 | Gobin A M Lee M H Halas N J | 2007 | Nano Lett2007，7，7： | 1 |
| 16 | Nanosphere arrays with controlled Sub-10-nm gaps as surfaceenhanced Raman spectroscopy substrates 显示文摘 | Wang H Levin C S Halas N J | 2005 | Journal of the American Chemical Society2005，127，14： | 1 |
| 17 | Nanosphere arrays with controlled sub-10-nm gaps as surfaceenhanced Raman spectroscopy substrates显示文摘 | Wang H Levin C S Halas N J | | 0，，43： | 1 |
| 18 | JAK2 V617F mutation detection; laboratory comparison of two kits using RFLP and qPCR显示文摘 | Shammaa D Bazarbachi A Halas H | 2010 | Genetic testing and molecular biomarkers ?2010，14，1： | 1 |
| 19 | Three-dimensional echocardiography in the evaluation of global and regional function in patients with recent myocardial infarction: a comparison with magnetic resonance imaging 显示文摘 | Thorstensen A Dalen H Hala P | 2013 | Echocardiography2013，30，6： | 1 |
| 20 | 显示文摘 | Wang H Kundu J Halas N J | 2007 | Angew Chem Int Ed2007，46，47： | 1 |
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