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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients显示文摘Pathogenic human coronavirus infections,such as severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERS-CoV),cause high morbidity and mortality[1,2].Recently,a severe pneumonia-associated respiratory syndrome caused by a new coronavirus(SARS-CoV-2)was reported in December 2019 in the city of Wuhan,Hubei province,China[3-5],which was also named as pneumonia-associated respiratory syndrome(PARS)[6]and can cause coronavirus disease 2019(COVID-19)to seriously endanger human health. | Yonggang Zhou Binqing Fu Xiaohu Zheng Dongsheng Wang Changcheng Zhao Yingjie Qi Rui Sun Zhigang Tian Xiaoling Xu Haiming Wei | 2020 | National Science Review2020，7，6： | 54 |
| 3 | Permian Alkaline Granites in Central Inner Mongolia and Their Geodynamic Significance显示文摘Alkaline granites (Rb-Sr ages 276-286 Ma)occurring in the Bayan Ul-East Ujimqin belt at the southern margin of the Siberian plate originated in a tensional tectonic environment about 60 Ma earlier than the Late Devonian to Early Carboniferous collision between the Siberian and Sino-Korean plates. They belong to post-orogenic A-type granites and may be used as an indicator of the end of the orogeny. At the northern margin of the Sino-Korean plate, however, only late-orogenic calc-alkaline granites occurred during the late Caboniferous-Permian, and alkaline syenites did not appear until the Late Triassic. The asymmetric magmatism at the margins of the two neighbouring plates might be controlled by the differences in size and mass of the two plates. | Hong Dawei, Huang Huaizeng, Lithosphere Research Center, Chinese Academy of Geological Sciences, BeijingXiao Yijun, Institute of Geology, Chinese Academy of Geological Sciences, BeijingXu Haiming,Institute of Mineral Deposits, Chinese Academy of Geological Sciences, Beijingand Jin M anyuanTianjin Geological Academy, Ministry of Metallurgical Industry, Tianjin Fei Zhenbi | 1995 | Acta Geologica Sinica(English Edition)1995，69，1： | 40 |
| 4 | FH 17 cells in human recurrent pregnancy loss and ~re-eclampsia显示文摘 | Binqing Fu | 2014 | Cellular & Molecular Immunology2014，11，6： | 36 |
| 5 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 6 | Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘 | Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao | 2017 | Frontiers of Medicine2017，11，4： | 37 |
| 7 | Plasmonic nanostructure design and characterization via Deep Learning显示文摘Nanophotonics,the field that merges photonics and nanotechnology,has in recent years revolutionized the field of optics by enabling the manipulation of light–matter interactions with subwavelength structures.However,despite the many advances in this field,the design,fabrication and characterization has remained widely an iterative process in which the designer guesses a structure and solves the Maxwell’s equations for it.In contrast,the inverse problem,i.e.,obtaining a geometry for a desired electromagnetic response,remains a challenging and time-consuming task within the boundaries of very specific assumptions.Here,we experimentally demonstrate that a novel Deep Neural Network trained with thousands of synthetic experiments is not only able to retrieve subwavelength dimensions from solely farfield measurements but is also capable of directly addressing the inverse problem.Our approach allows the rapid design and characterization of metasurface-based optical elements as well as optimal nanostructures for targeted chemicals and biomolecules,which are critical for sensing,imaging and integrated spectroscopy applications. | Itzik Malkiel Michael Mrejen Achiya Nagler Uri Arieli Lior Wolf Haim Suchowski | 2018 | Light(Science & Applications)2018，7，1： | 25 |
| 8 | Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway显示文摘Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of doxorubicin(DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant and anti-apoptotic capacities. Our present study aimed to investigate the effect of matrine on DOX-induced cardiotoxicity and try to unearth the underlying mechanisms. Mice were exposed with DOX to generate DOX-induced cardiotoxicity or normal saline as control. H9 C2 cells were used to verify the effect of matrine in vitro.DOX injection triggered increased generation of reactive oxygen species(ROS) and excessive cardiomyocyte apoptosis, which were significantly mitigated by matrine. Mechanistically, we found that matrine ameliorated DOX-induced uncoupling protein 2(UCP2) downregulation, and UCP2 inhibition bygenipin could blunt the protective effect of matrine on DOX-induced oxidative stress and cardiomyocyte apoptosis. Besides, 50-AMP-activated protein kinase α2(Ampkα2) deficiency inhibited matrine-mediated UCP2 preservation and abolished the beneficial effect of matrine in mice. Besides, we observed that matrine incubation alleviated DOX-induced H9 C2 cells apoptosis and oxidative stress level via activating AMPKα/UCP2, which were blunted by either AMPKα or UCP2 inhibition with genetic or pharmacological methods. Matrine attenuated oxidative stress and cardiomyocyte apoptosis in DOX-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway, and it might be a promising therapeutic agent for the treatment of DOX-induced cardiotoxicity. | Can Hu Xin Zhang Wenying Wei Ning Zhang Haiming Wu Zhenguo Ma Lingli Li Wei Deng Qizhu Tang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 25 |
| 9 | Mechanism of sperm capacitation and the acrosome reaction: role of protein kinases显示文摘哺乳动物的精子必须经历一系列生物化学、生理的修正,一起叫的 capacitation,在在 acrosome 反应(AR ) 以前的女繁殖的道。尽管蛋白质 kinases 被显示在 capacitation 和 AR 期间涉及细胞内部的 Ca 2+ 的规定,这些修正的机制很好没被描绘。在现在的评论,我们总结一些涉及 capacitation 的发信号的事件。在 capacitation 过程期间, phosphatidyl-inositol-3-kinase (PI3K ) 是经由一个蛋白质 kinase A (PKA ) 依赖者的 phosphorylated/activated 由蛋白质 kinase C α 的串联,和 downregulated;(PKCα) 。PKCα在 capacitation 的开始是活跃的,导致 PI3K inactivation。在 capacitation 期间, PKCα象 PP1γ 一样; 2 被 PKA 依赖的机制降级,允许 PI3K 的激活。PKA 的激活主要在 capacitation 期间取决于酸式碳酸盐依赖者生产的周期的腺苷 monophosphate (营地) 可溶的 adenylyl cyclase。PKA 的这激活在肌动朊聚合导致增加,必需品为 hyperactivated 活动性的发展处理,它为成功的授精是必要的。肌动朊聚合被果仁 2 以二个方法调停:首先,果仁 2 为 phospholipase D (PLD ) 激活,和秒充当一个余因子,作为绑并且禁止象 gelsolin 那样的切断肌动朊的蛋白质的一个分子。gelsolin 的酷氨酸 phosphorylation 为它的 inactivation 也在由 Src 家庭 kinase (SFK ) 的 capacitation 期间是重要的。在 AR 以前, gelsolin 被免除果仁 2 并且经历 dephosphorylation/activation,导致 AR,导致快 F 肌动朊 depolymerization。 | Debby Ickowicz Maya Finkelstein Haim Breitbart | 2012 | Asian Journal of Andrology2012，14，6： | 17 |
| 10 | Decidual natural killer cells and the immune microenvironment at the maternal-fetal interface显示文摘During early pregnancy,an orchestrated evolutionary maternal adaption toward tolerance of the semiallogeneic fetus is required to ensure decidualization and early embryo development.Remodeling of the immune system involves natural killer cells(NKs),macrophages,T cells and dendritic cells(DCs) altering the microenvironment in the deciduas.In particular,a unique population of NK cells with a CD56^(bright)CD16^- phenotype in the decidua has been proposed to play a key role in the maternal adaptation to pregnancy.However,there is a tendency for pregnancy immunology to reflect transplantation immunology regarding the assumption that the maternal immune system should be suppressed.This tendency is misleading.We discuss how the immune system is formed in early deciduas and the interactions between maternal NK cells and fetal growth.We propose that the maternal immune response must not be fully suppressed and is even necessary for the local response of uterine NK cells. | Binqing Fu Haiming Wei | 2016 | Science China(Life Sciences)2016，59，12： | 15 |
| 11 | 6–100 GHz research progress and challenges from a channel perspective for fifth generation(5G)and future wireless communication显示文摘Radio frequency is a valuable resource for wireless communication systems. The high-frequency band from 6 GHz up to 100 GHz, where continuous and broad spectra exist, is promising to meet the high spectrum requirement of fifth generation(5G) mobile communication systems by 2020. To date, many groups from academia and industry have contributed to devising approaches to allocate and utilize frequency resources from 6 GHz to 100 GHz for 5G and future wireless communication systems. In this paper, we present global efforts to allocate potential frequency bands and field trial progress from 6 GHz to 100 GHz for 5G. From a channel perspective, we summarize research progress and challenges, including channel measurement platforms and channel parameter analysis, both of which are important to extract the inherent channel characteristics and use a high-frequency band for 5G and future wireless communication systems. | Jianhua ZHANG Pan TANG Lei TIAN Zhixue HU Tan WANG Haiming WANG | 2017 | Science China(Information Sciences)2017，60，8： | 14 |
| 12 | YAGG:Ce transparent ceramics with high luminous efficiency for solid-state lighting application显示文摘A series of Y2.985Al5–xGaxO12:0.015Ce(YAGG:Ce,x=0,1,2,3,4,5)transparent ceramics were prepared via a solid-state reaction method.Two-step sintering technique was proved to be an effective approach to prepare functional ceramics with high Ga concentration,and Y3Ga5O12(YGG)transparent ceramic was successfully prepared for the first time.According to the variation of Al/Ga ratio,regulation of band structure and luminescence properties of YAGG:Ce transparent ceramics were effectively investigated.When Ga substitutes Al sites,the tetrahedral site is more favorable compared to the octahedral site for Ga to occupy according to the first-principle calculation.A continuous blue shift of the emission from 565 to 515 nm was achieved as Ga was gradually introduced into Y3Al5O12:Ce matrix.High quality green light was obtained by coupling the YAGG:Ce ceramics with commercial blue InGaN chips.Transparent luminescence ceramics accomplished in this work can be quite prospective for high power LED application. | Hui HUA Shaowei FENG Zhongyu OUYANG Hezhu SHAO Haiming QIN Hui DING Qiping DU Zhijun ZHANG Jun JIANG Haochuan JIANG | 2019 | Journal of Advanced Ceramics2019，8，3： | 13 |
| 13 | Efficiency and Inheritance of Targeted Mutagenesis in Maize Using CRISPR-Cas9显示文摘CRISPR/Cas(clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins) is an adaptive immune system in bacteria and archaea to defend against invasion from foreign DNA fragments. Recently, it has been developed as a powerful targeted genome editing tool for a wide variety of species. However, its application in maize has only been tested with transiently expressed somatic cells or with a limited number of stable transgenic T0 plants. The exact efficiency and specificity of the CRISPR/Cas system in the highly complex maize genome has not been documented yet. Here we report an extensive study of the well-studied type II CRISPR-Cas9 system for targeted genome editing in maize, with the codon-optimized Cas9 protein and the short non-coding guide RNA generated through a functional maize U6 sn RNA promoter. Targeted gene mutagenesis was detected for 90 loci by maize protoplast assay, with an average cleavage efficiency of 10.67%. Stable knockout transformants for maize phytoene synthase gene(PSY1) were obtained. Mutations occurred in germ cells can be stably inherited to the next generation. Moreover, no off-target effect was detected at the computationally predicted putative off-target loci. No significant difference between the transcriptomes of the Cas9 expressed and non-expressed lines was detected. Our results confirmed that the CRISPR-Cas9 could be successfully applied as a robust targeted genome editing system in maize. | Jinjie Zhu Ning Song Silong Sun Weilong Yang Haiming Zhao Weibin Song Jinsheng Lai | 2016 | Journal of Genetics and Genomics2016，43，1： | 12 |
| 14 | A new perturbation algorithm and enhancing security of SFLASH signature scheme显示文摘This paper introduces the concept of noise factor and noise operation, and constructs a noise group. We present a new perturbation algorithm for enhancing security of multivariate public key cryptosystems (MPKCs). European Consortium SFLASH which derives from Matsumoto-Imai scheme is a fast signature scheme intended for low cost smart cards. It was broken with the differential cryptanalysis by Dubois et al. in 2007. Taking Matsumoto-Imai system as an example, security analysis shows that the new algorithm can powerfully demolish its potential mathematical properties of the public key, and effectively avoid differential cryptanalysis without lowering the effciency of the original algorithm. | WANG HouZhen ZHANG HuanGuo GUAN HaiMing HAN HaiQing | 2010 | Science China(Information Sciences)2010，53，4： | 12 |
| 15 | Radio Propagation and Wireless Coverage of LSAA-Based 5G Millimeter-Wave Mobile Communication Systems显示文摘Millimeter-wave(mm Wave) communications will be used in fifth-generation(5G) mobile communication systems, but they experience severe path loss and have high sensitivity to physical objects, leading to smaller cell radii and complicated network architectures. A coverage extension scheme using large-scale antenna arrays(LSAAs) has been suggested and theoretically proven to be cost-efficient in combination with ultradense small cell networks. To analyze and optimize the LSAA-based network deployments, a comprehensive survey of recent advances in statistical mmWave channel modeling is first presented in terms of channel parameter estimation, large-scale path loss models, and small-scale cluster models. Next, the measurement and modeling results at two 5G candidate mmWave bands(e.g., 28 GHz and 39 GHz) are reviewed and compared in several outdoor scenarios of interest, where the propagation characteristics make crucial contributions to wireless network designs. Finally, the coverage behaviors of systems employing a large number of antenna arrays are discussed, as well as some implications on future mmWave cellular network designs. | Haiming Wang Peize Zhang Jing Li Xiaohu You | 2019 | China Communications2019，16，5： | 12 |
| 16 | Immunotherapeutical Potential of Mycobacterium Vaccae on M. Tuberculosis Infection in Mice显示文摘Tuberculosis remains the worldwide infectious disease. To identify the therapeutic potential of M. vaccae in treating tuberculosis,M. vaccae was injected into Mycobacterium tuberculosis(M. tuberculosis) infected mice. The optimal dose of M. vaccae(22.5 μg/mouse) treated mice showed lower pathological change index,spleen weight index,lung weight index and vital M. tuberculosis count than those of the untreated group. Treatment with M. vaccae enhanced the percentages of CD3+ and CD4+ T cells,IFN-γ+CD4+ T cells,innate immune cells including NK cells,NK1.1+ T cells and γδ T cells,and reduced the percentage of IL-4+CD4+ T cells. Therefore,M. vaccae could protect the mice from M. tuberculosis infection and improved mouse innate and adaptive cell-mediated immunity,suggesting that M. vaccae is a potential immunotherapeutic agent in pulmonary tuberculosis. | Lijun Xu Yanyan Wang Xiaodong Zheng Xiangdong Gui Lifeng Tao Haiming Wei | 2009 | Cellular & Molecular Immunology2009，6，1： | 11 |
| 17 | The Involvement of Heat Shock Proteins in Murine Liver Regeneration显示文摘Partial hepatectomy (PHx) in mammals is a very common experimental model to investigate the process of liver regeneration. The surgery itself could give birth to a series of stresses, such as the temporary raise of body temperature and the ischaemia-reperfusion injury. Heat shock proteins (HSPs) were a family of stress-inducible proteins involved in maintaining cell homeostasis and regulating the immune system. In our study, we intended to investigate the expression and role of HSPs in liver regeneration. Using RT-PCR and Western blotting, we determined the expression in regenerating liver of HSP27, HSP60, HSP70 and HSP90 in mRNA level and protein level, respectively, with mice treated with sham operation as controls. We also used quercertin as an inhibitior of HSPs to explore their effects on liver regeneration. We found that hepatic expression of HSPs increased at the early phase of liver regeneration and declined to the constitutively low level later. Moreover, quercetin pretreatment delayed the progress of liver regeneration in mice via inhibition of HSPs. The results indicated that HSPs played an important role in liver regeneration. | Qing Shi Zhongjun Dong Haiming Wei | 2007 | Cellular & Molecular Immunology2007，4，1： | 10 |
| 18 | Erucic acid from Isatis indigotica Fort. suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-kB and p38 MAPK pathway显示文摘Isatis indigotica Fort.(Ban-Lan-Gen)is an herbal medicine prescribed for influenza treatment.However,its active components and mode of action remain mostly unknown.In the present study,erucic acid was isolated from Isatis indigotica Fort.,and subsequently its underlying mechanism against influenza A virus(IAV)infection was investigated in vitro and in vivo.Our results demonstrated that erucic acid exhibited broad-spectrum antiviral activity against IAV resulting from reduction of viral polymerase transcription activity.Erucic acid was found to exert inhibitory effects on IAV or viral(v)RNA-induced pro-inflam-matory mediators as well as interferons(IFNs).The molecular mechanism by which erucic acid with antiviral and anti-inflammatory properties was attributed to inactivation of NF-kB and p38 MAPK signaling.Furthermore,the NF-kB and p38 MAPK inhibitory effect of erucic acid led to diminishing the transcriptional activity of interferon-stimulated gene factor 3(ISGF-3),and thereby reducing IAV-triggered pro-inflammatory response amplification in IFN-β-sensitized cells.Additionally,IAV-or vRNA-triggered apoptosis of alveolar epithelial A549 cells was prevented by erucic acid.In vivo,erucic acid administration consistently displayed decreased lung viral load and viral antigens expression.Meanwhile,erucic acid markedly reduced CD8+cytotoxic T lymphocyte(CTL)recruitment,pro-apoptotic signaling,hyperactivity of multiple signaling pathways,and exacerbated immune inflammation in the lung,which resulted in decreased lung injury and mortality in mice with a mouse-adapted A/FM/1/47-MA(H1N1)strain infection.Our findings provided a mechanistic basis for the action of erucic acid against IAV-mediated inflammation and injury,suggesting that erucic acid may have a therapeutic potential in the treatment of influenza. | Xiaoli Liang Yuan Huang Xiping Pan Yanbing Hao Xiaowei Chen Haiming Jiang Jing Li Beixian Zhou Zifeng Yang | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 10 |
| 19 | High-performance PVDF-HFP based gel polymer electrolyte with a safe solvent in Li metal polymer battery显示文摘Poly(vinylidenefluoride-co-hexafluoropropylene)(PVDF-HFP)based gel polymer electrolytes are widely studied owing to their electrochemical stability and high dielectric constant.However,most gel polymer electrolytes show unsatisfied safety and interface compatibility due to excessive absorption of volatile and flammable liquid solvents.Herein,by using a safe solvent(N-methyl-2-pyrrolidone)with higher boiling(203℃)and flash points(95℃),we initiatively fabricate a flexible PVDF-HFP based gel polymer electrolyte.The obtained gel polymer electrolyte demonstrates a high ionic conductivity of 7.24×10^−4 S cm−1,an electrochemical window of 5.2 V,and a high lithium transference number of 0.57.As a result,the synthesized polymer electrolyte exhibits a capacity retention of 70%after 500 cycles at 0.5 C,and a discharge capacity of 86 mAh g−1 even at a high current rate of 10 C for LiFePO4 based Li metal batteries.Moreover,a stable Li plating/stripping for more than 500 h is achieved under 0.1 mAh at both room temperature and 70℃.Our results indicate that the PVDF-HFP polymer electrolyte is promising for manufacturing safe and high-performance Li metal polymer batteries. | Jing Jie Yulong Liu Lina Cong Bohao Zhang Wei Lu Xinming Zhang Jun Liu Haiming Xie Liqun Sun | 2020 | Journal of Energy Chemistry2020，29，10： | 10 |
| 20 | IEEE 802.11aj(45GHz):A New Very High Throughput Millimeter-Wave WLAN System显示文摘This paper presents an overview of a new very high throughput millimeterwave WLAN system operating at 45 GHz band. We begin by reviewing standards process of IEEE 802.11aj(45GHz). Then the frequency spectrum allocation at 45 GHz band is introduced. Next, the channel measurement and mod-eling is given. Specifically, the millimeter-wave MIMO for physical layer enhancement is given in detail. | WANG Haiming HONG Wei CHEN Jixin SUN Bo PENG Xiaoming | 2014 | China Communications2014，11，6： | 10 |
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