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| 1 | Microglia in depression:current perspectives显示文摘Major depressive disorder(MDD)is a prevalent psychiatric disease that involves malfunctions of different cell types in the brain.Accumulating studies started to reveal that microglia,the primary resident immune cells,play an important role in the development and progression of depression.Microglia respond to stress-triggered neuroinflammation,and through the release of proinflammatory cytokines and their metabolic products,microglia may modulate the function of neurons and astrocytes to regulate depression.In this review,we focused on the role of microglia in the etiology of depression.We discussed the dynamic states of microglia;the correlative and causal evidence of microglial abnormalities in depression;possible mechanisms of how microglia sense depression-related stress and modulate depression state;and how antidepressive therapies affect microglia.Understanding the role of microglia in depression may shed light on developing new treatment strategies to fight against this devastating mental illness. | Xiaoning Jia Zhihua Gao Hailan Hu | 2021 | Science China(Life Sciences)2021，64，6： | 25 |
| 2 | Clinical implications of hedgehog signaling pathway inhibitors显示文摘Hedgehog was first described in Drosophila melanogaster by the Nobel laureates Eric Wieschaus and Christiane Nüsslein-Volhard. The hedgehog (Hh) pathway is a major regulator of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and carcinogenesis. The first link of Hh signaling to cancer was established through studies of a rare familial disease, Gorlin syndrome, in 1996. Follow-up studies revealed activation of this pathway in basal cell carcinoma, medulloblastoma and, leukemia as well as in gastrointestinal, lung, ovarian, breast, and prostate cancer. Targeted inhibition of Hh signaling is now believed to be effective in the treatment and prevention of human cancer. The discovery and synthesis of specific inhibitors for this pathway are even more exciting. In this review, we summarize major advances in the understanding of Hh signaling pathway activation in human cancer, mouse models for studying Hh- mediated carcinogenesis, the roles of Hh signaling in tumor development and metastasis, antagonists for Hh signaling and their clinical implications. | Hailan Liu Dongsheng Gu Jingwu Xie | 2011 | Chinese Journal of Cancer2011，30，1： | 11 |
| 3 | miR164c and miR168a regulate seed vigor in rice^∞显示文摘Micro RNAs(miRNAs)are key regulators of gene expression in many important biological processes of plants.However,few miRNAs have been shown to regulate seed vigor.Here,we conducted microarray assays to analyze miRNA expression levels in seeds of the rice(Oryza sativa L.)cultivar ZR02.Results showed significant differences in the expression of 11 miRNAs between artificially aged and untreated control seeds.Among these,osa-miR164c was transcriptionally upregulated,while osamiR168 a was downregulated in artificially aged seeds;this was verified by quantitative real-time PCR analysis.Under the same aging condition,osa-miR164c overexpression in OE164c transgenic seeds and osa-miR168a silencing in MIM168a transgenic seeds of the rice cultivar Kasalath led to lower germination rates,whereas osa-miR164c silencing Rin MIM164c and osa-miR168a overexpression in OE168a resulted in higher seed germination rates compared with wild-type seeds.Meanwhile,changes in cytomembrane permeability of seeds and in the expression level of osa-miR164c target genes(OsPM27 and OsPSK5)and osamiR168a target genes(OsAGO1 and OsPTR2)under aging conditions coincided with changes in seed vigor induced by osa-miR164c and osa-miR168 a.Thus,genetic manipulation of miRNAs has important implications in the development of crop cultivars with high vigor and extended life span of seeds. | Yan Zhou Shiqi Zhou Liping Wang Duo Wu Hailan Cheng Xu Du Dandan Mao Chunlai Zhang Xiaocheng Jiang | 2020 | Journal of Integrative Plant Biology2020，62，4： | 7 |
| 4 | Leaky modes and the first arrivals in cased boreholes with poorly bonded conditions显示文摘The generation mechanism of the first arrivals in the cased boreholes for the poorly bonded conditions is investigated. Based on the analyses of the Riemann surface structure of the characteristic function, the dispersion features, excitation spectra and contributions of modes excited in the cased boreholes with different cementing types are studied. The phase velocity dispersion studies of leaky modes show that high-order modes form 'plateau' regions with one approximate velocity denoted by v separated by their cutoff frequencies, in which the phase velocity changes little with a considerable frequency range, while the group velocity keeps a relatively constant high value. Usually, the operation frequency range of a specific cementing evaluation acoustic logging tool is covered by such a 'plateau' region. Mode excitation and contribution analyses show that the first arrivals in the cased boreholes for the poorly bonded conditions are the contributions from leaky modes, where the traveling velocity of the first arrivals processed by slowness time coherence(STC) method is equal to the approximated velocity v. Analyses on generation of leaky modes in the cased boreholes supplement the understanding of the generation mechanism of the first arrivals. | XiuMei Zhang XiuMing Wang HaiLan Zhang | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，2： | 7 |
| 5 | Numerical simulation and processoptimization for producing large-sized castings显示文摘3-Dvelocity and temperature fields of mold filling and solidification processes of large-sized castingswere calculated,and the efficiency and accuracy of numerical calculation were studied.The mold filling andsolidification processes of large-sized stainless steel,iron and aluminum alloy castings were simulated by using ofnew scheme;their casting processes were optimized,and then applied to produce castings. | Wang Junqing Sun Xun Guan Yang Wang Penghua Li Hailan Bai Limei Sun Xinzhi | 2008 | China Foundry2008，5，3： | 6 |
| 6 | Recent progress on mechanisms of human cognition and brain disorders显示文摘Human cognition plays a crucial role in our daily life.It enables us to perceive a constant influx of inputs,to memorize the scenarios,and to reason or decide their outcomes(Thagard,2005).Abnormal cognitive function,which is usually involved in neurological and mental diseases,such as chronic pain,mood disorders,autism,dementia,often seriously deteriorates individuals’life quality and brings inexhaustible social problems. | Fang Fang Hailan Hu | 2021 | Science China(Life Sciences)2021，64，6： | 5 |
| 7 | Ubiquitous Learning Environment as a Solution to Education Problem显示文摘Ubiquitous learning means the intelligent learning environment that enables people to learn using any terminal at any place and at any time no matter what the contents may be.This is different from the existing method of learning the information through the internet or studying at specific place,such as school or library,and so on.People do not need to go to specific place at specific time to access the information that they want,but the learning information finds its way to people,which is the biggest difference from the existing method. Ubiquitous learning aims to solve current problems of education in more creative and learner-oriented way by creating an education environment where learners can learn with any terminal anytime and anywhere without regard to contents.The presentation this time would help promote the understanding of the Ubiquitous and explore the ubiquitous education environment that is capable of solving overall problems of education.In addition,it will propose a direction of ubiquitous learning scenario and the change in the educational environment. | ZHAO Hailan Jung-Hwan Park | 2006 | 开放教育研究2006，12，4： | 5 |
| 8 | Computational neuroscience:a frontier of the 21^st century显示文摘THEORY IN NEUROSCIENCE The human brain is a biological organ,weighing about three pounds or 1.4 kg,that determines our behaviors,thoughts,emotions and consciousness.Although comprising only 2%of the total body weight,the brain consumes about 20%of the oxygen entering the body.With the expensive energy demand,the brain enables us to perceive and act upon the external world,as well as reflect on our internal thoughts and feelings. | Xiao-Jing Wang Hailan Hu Chengcheng Huang Henry Kennedy Chengyu Tony Li Nikos Logothetis Zhong-Lin Lu Qingming Luo Mu-ming Poo Doris Tsao Si Wu Zhaohui Wu Xu Zhang Douglas Zhou | 2020 | National Science Review2020，7，9： | 4 |
| 9 | Novel MSX1 variants identified in families with nonsyndromic oligodontia显示文摘The goal of this study was to identify MSX1 gene variants in multiple Chinese families with nonsyndromic oligodontia and analyse the functional influence of these variants.Whole-exome sequencing(WES)and Sanger sequencing were performed to identify the causal gene variants in five families with nonsyndromic oligodontia,and a series of bioinformatics databases were used for variant confirmation and functional prediction.Phenotypic characterization of the members of these families was described,and an in vitro analysis was performed for functional evaluation.Five novel MSX1 heterozygous variants were identified:three missense variants[c.662A>C(p.Q221P),c.670C>T(p.R224C),and c.809C>T(p.S270L)],one nonsense variant[c.364G>T(p.G122*)],and one frameshift variant[c.277delG(p.A93Rfs*67)].Preliminary in vitro studies demonstrated that the subcellular localization of MSX1 was abnormal with the p.Q221P,p.R224C,p.G122*,and p.A93Rfs*67 variants compared to the wild type.Three variants(p.Q221P,p.G122*,and p.A93Rfs*67)were classified as pathogenic or likely pathogenic,while p.S270L and p.R224C were of uncertain significance in the current data.Moreover,we summarized and analysed the MSX1-related tooth agenesis positions and found that the type and variant locus were not related to the severity of tooth loss.Our results expand the variant spectrum of nonsyndromic oligodontia and provide valuable information for genetic counselling. | Jinglei Zheng Miao Yu Haochen Liu Tao Cai Hailan Feng Yang Liu Dong Han | 2021 | International Journal of Oral Science2021，13，1： | 4 |
| 10 | Brain's neural switch for social dominance in animals显示文摘Animals perform social behaviors during their lives to survive and reproduce. As one of the most robust and fundamental social behaviors, social dominance determines individual's behavioral displays, priority access to food, mate,territory or other resources, and impacts on its physical and mental health. In human society, socioeconomic status (SES)is a major predictor of physical and mental outcomes, even when the participants have equal access to health care. A Norwegian scientist Thorleif Schjelderup-Ebbe first scientifically described dominance behaviors when he | Hong Zhu Hailan Hu | 2018 | Science China(Life Sciences)2018，61，1： | 4 |
| 11 | Illuminating the Activated Brain: Emerging Activity-Dependent Tools to Capture and Control Functional Neural Circuits显示文摘Immediate-early genes(IEGs) have long been used to visualize neural activations induced by sensory and behavioral stimuli. Recent advances in imaging techniques have made it possible to use endogenous IEG signals to visualize and discriminate neural ensembles activated by multiple stimuli, and to map whole-brain-scale neural activation at single-neuron resolution. In addition, a collection of IEG-dependent molecular tools has been developed that can be used to complement the labeling of endogenous IEG genes and, especially, to manipulate activated neural ensembles in order to reveal the circuits and mechanisms underlying different behaviors. Here, we review these techniques and tools in terms of their utility in studying functional neural circuits. In addition, we provide an experimental strategy to measure the signal-to-noise ratio of IEG-dependent molecular tools, for evaluating their suitability for investigating relevant circuits and behaviors. | Qiye He Jihua Wang Hailan Hu | 2019 | Neuroscience Bulletin2019，35，3： | 4 |
| 12 | Special α-limit points and unilateral γ-limit points for graph maps显示文摘Let G be a graph and f:G → G be a continuous map.Denote by P(f),R(f),SA(f) and U Γ(f) the sets of periodic points,recurrent points,special α-limit points and unilateral γ-limit points of f,respectively.In this paper,we show that R(f)SA(f) = U Γ(f)∪P(f)■. | SUN TaiXiang XI HongJian LIANG HaiLan | 2011 | Science China Mathematics2011，54，9： | 3 |
| 13 | An element by element spectral element method for elastic wave modeling显示文摘光谱联合优点的元素方法光谱有限元素方法的有那些的方法,在在复杂媒介模仿有弹性的波浪方程提供一个有效工具。基于从 elastodynamic 方程弱,为 Legendre 的数学明确的表达光谱元素方法被介绍。一个元素上的波浪地是用高顺序的 Lagrange 插值的 discretized,并且在元素上的集成被完成在 Gauss-Lobotto-Legendre 集成规则之上基于。这导致导致一个极大地简化的算法的一个斜集体矩阵。另外,由元素例子的元素被恨到在我们的方法到减少记忆尺寸并且改进计算效率。最后,一些数字例子被恨示威光谱精确性和效率。因为有限元素的联合,策划,包括免费表面边界和强壮的异质并且一光谱算法。 | LIN Weijun WANG Xiuming ZHANG Hailan | 2006 | Progress in Natural Science:Materials International2006，16，1： | 3 |
| 14 | Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling显示文摘The link of hedgehog (Hh) signaling activation to human cancer and synthesis of a variety of Hh signaling inhibitors raise great expectation that inhibiting Hh signaling may be effective in human cancer treatment. Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein. However, its poor solubility, acid sensitivity, and weak potency relative to other Hh antagonists prevent the clinical development of Cyc as a therapeutic agent. Here, we report properties of cyclopamine tartrate salt (CycT) and its activities in Hh signaling-mediated cancer in vitro and in vivo. Unlike Cyc, CycT is water soluble (5-10 mg/mL). The median lethal dose (LD50) of CycT was 62.5 mg/kg body weight compared to 43.5 mg/kg for Cyc, and the plasma half-life (T1/2) of CycT was not significantly different from that of Cyc. We showed that CycT had a higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC50 = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). We also tested the antitumor effectiveness of these Hh inhibitors using two mouse models of basal cell carcinomas (K14cre:Ptch1neo/neo and K14cre:SmoM2YFP). After topical application of CycT or Cyc daily for 21 days, we found that all CycT-treated mice had tumor shrinkage and decreased expression of Hh target genes. Taken together, we found that CycT is an effective inhibitor of Hh signaling-mediated carcinogenesis. | Qipeng Fan Dongsheng Gu Miao He Hailan Liu Tao Sheng Guorui Xie Ching-xin Li Xiaoli Zhang Brandon Wainwright Arash Garrossian Massoud Garrossian Dale Gardner Jingwu Xie | 2011 | Chinese Journal of Cancer2011，30，7： | 3 |
| 15 | An acoustic imaging system of migration technique used in borehole显示文摘以便检测 casing 地上凿穿的损坏,有一个二维的超声的数组的一个声学的成像方法被介绍。数组的每个元素独立地在超声的波浪下面射出,所有元素收到的回响被取样并且在地面表面上传给一台计算机,动态移植方法在此被用来形成一 2 或在地上凿穿的状况的 3-dimensional 图象。数字模拟和实验被进行与在数组使用的元素的一个小数字表明高成像精确性。自从在传统的分阶段执行的数组成像使用的延期电路,系统不在这个系统被需要,并且所有数据进程能在地上凿穿在一个扎根的系统,复杂性和系统的卷被完成可以显著地被简化,它对地上凿穿仪器批评。 | LIN Weijun WU Nan SUN Jian ZHANG Hailan | 2008 | Chinese Journal of Acoustics2008，27，3： | 3 |
| 16 | Fusion Visual Attention and Low-Level Features in Images for Region of Interest Extraction显示文摘 | CHEN Zailiang ZOU Beiji GAO Xu SHEN Hailan ZHANG Xiaoyun | 2013 | Chinese Journal of Electronics2013，22，2： | 3 |
| 17 | Efficacy of percutaneous ethanol injection in the adjuvant treatment of hepatocellular carcinoma after TACE显示文摘在 transcatheter 以后在肝细胞癌(HCC ) 的辅佐疗法评估经皮的乙醇注射(PEI ) 的功效的目的动脉的 chemoembolization (不作声) 由进步(TTP ) 的时间的主要终点。学习人口与不能实行的 HCC (中国分类系统 IIA/IIB ) 由 73 个连续病人组成了的方法。在他们之中, 22 个病人被对待与不作声并且 PEI (试验性的组) ,和剩余的 51 与仅仅被对待不作声(控制组) ,然后进行的时间(TTP ) 和这二个组的全面幸存(OS ) 被分析。结果中部的 TTP 是 10 个月[95% 信心间隔(CI ) , 7.9 12.1 个月] 在试验性的组和 6 个月(95% CI, 4.7 7.3 个月) 在控制组。第 3-month,6-mon,并且 1 年的前进免费幸存(PFS ) 率是分别地 77.3% , 63.6% ,和 48.1% 在试验性的组,并且 76.5% , 42.15% ,和 24.8% 在控制组。试验性的组的 TTP 比控制组的显著地长(P <
0.05 ) 。中部的幸存时期是 17 个月[95% 信心间隔(CI ) , 11 23 个月] 试验性的组和 12 个月(95% CI, 10 14 个月) 控制组(P >
0.05 ) 。结论与单身者相比不作声,联合不作声, PEI 能显然推迟疾病进步并且延长 HCC 病人的幸存。 | Mingzhi Hao Hailan Lin Youhong Shen Linan Tang Ruoyuan Yan Jianxiong Zheng Ojzhong Chen Jing Chen Zhougui Wu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 2 |
| 18 | A numerical investigation of the acoustic mode waves in a deviated borehole penetrating a transversely isotropic formation显示文摘A 2.5-dimensional method in frequency wave-number domain is developed to investigate the mode waves in a deviated borehole penetrating a transversely isotropic formation. The phase velocity dispersion characteristics of the fast and slow flexural mode waves excited by a dipole source are computed accurately at various deviation angles for both hard and soft formations. The sensitivities of the flexural mode waves to all elastic constants in a transversely isotropic formation are calculated. Numerical results show that, for a soft formation, the fast flexural mode wave is dominated by c66 at high deviation angles and low frequencies, while the slow flexural mode wave is dominated by c44 at the same conditions. Waveforms in time domain are also presented to support the conclusions. | LIU Le LIN WeiJun ZHANG HaiLan WANG XiuMing | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，8： | 2 |
| 19 | The electromyographic activity of masseter and anterior temporalis during orofacial symptoms induced by experimental occlusal highspot 显示文摘 | Li Jian Jiang Ting Feng Hailan | 2008 | J Oral Rehabil2008，35，2： | 1 |
| 20 | Injectable tissue-engineered bone composed of human adipose-derived stromal cellsand platelet-rich plasma显示文摘 | Yunsong Li Yongsheng Zhou Hailan Feng | 2008 | Biomaterials2008，29，23： | 1 |
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