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| 1 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 2 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 3 | Adrenal masses:characterization with delayed contrast-enhanced CT 显示文摘 | Boland GWL Hahn PF Pena C | 1997 | Radiology1997，202，： | 2 |
| 4 | Flavivirus Genome Organization, Expression, and Replication显示文摘 | T J Chambers C S Hahn R Galler C M Rice | 1990 | Annual Review of Microbiology1990，，： | 2 |
| 5 | Flavivirus Genome Organization, Expression, and Replication显示文摘 | T J Chambers C S Hahn R Galler C M Rice | 1990 | Annual Review of Microbiology1990，，： | 2 |
| 6 | A study on comparison of optimization performances between immune algorithm and other heuristic algorithms 显示文摘 | Sung C J Jang Hyun Kyo Hahn Song Yop | 1998 | IEEE Trans on Magnetics1998，34，5： | 2 |
| 7 | Frequent somatic mutations and homozygous of the P16(MTS1) gene in pancreatic adenocarcinoma显示文摘 | Hahn SA da Costa LT | 1994 | Nat Genet1994，8，： | 1 |
| 8 | Dendritic cells stimuInted with actinobacilus actinomycetemcomitans elicit rapid gamma interferon responses by natural killer cells显示文摘 | KIKUCHI T HAHN C L TANAKA S | 2004 | Infection and Immunity2004，72，9： | 1 |
| 9 | Emergence of new project teams from open source software developer networks: Impact of prior collaboration ties 显示文摘 | Hahn J Moon J Y Zhang C | 2008 | Information Systems Research2008，19，3： | 1 |
| 10 | Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways显示文摘 | Lowin B Hahne M Mattmann C | 1994 | Nature1994，370，6491： | 1 |
| 11 | Effect of loading parameters on the fatigue behavior of impact damaged composite laminates 显示文摘 | Milan M Hahn H T Greg P C | 1999 | Composites Science and Technology1999，59，14： | 1 |
| 12 | Head injuries in children under 36 months of age:demography and outcome显示文摘 | Hahn YS Chyung C Barthel MJ | | 0，，01： | 1 |
| 13 | PAK signaling regulates oxidant-dependent NF-κB activation by flow显示文摘 | Orr AW Hahn C Blackman B R | | 0，，06： | 1 |
| 14 | Characterization of the inhibition of hepatitis C virus entry by in vitro-generated and patient-derived oxidized low-density lipoprotein显示文摘 | Westhaus S Bankwitz D Ernst S Rohrmann K Wappler I AgnéC Luchtefeld M Schieffer B Sarrazin C Manns M P Pietschmann T Ciesek S von Hahn T | 2013 | Hepatology2013，57，5： | 1 |
| 15 | Comprehensive Identification of Proteins from MALDI Imaging显示文摘 | Stefan K. Maier Hannes Hahne Amin Moghaddas Gholami Benjamin Balluff Stephan Meding Cédrik Schoene Axel K. Walch Bernhard Kuster | 2013 | Molecular & Cellular Proteomics2013，，10： | 1 |
| 16 | The effect of cop- per and cadmium on 65 - zinc absorption in zinc - defi- cient and zinc supplemented rats 显示文摘 | Evans G W Grace C I and Hahn C | 1974 | Bioinorg Chem1974，3，11： | 1 |
| 17 | Rules for making human tumor cells 显示文摘 | HAHN W C WEINBERG R A | 2002 | N Engl J Med2002，347，20： | 1 |
| 18 | Flavivirus genome organization expression and replication显示文摘 | Chambers T J Hahn C S Galler R | 1990 | Annu Rev Microbiol1990，44，： | 1 |
| 19 | Size separation of circulatory DNA in maternal plasma permits ready detection of fetal DNA polymorphisms显示文摘 | Li Y Zimmermann B Rusterholz C Kang A Holzgreve W Hahn S | 2004 | Clin Chem2004，50，： | 1 |
| 20 | Linking purchasing to corporate competitive strategy显示文摘 | Kim K Y Hahn C K | 1992 | International Journal of Purchasing and Materials Management1992，18，4： | 1 |
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