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| 1 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 2 | Carotid intima-media thickness:an index for subclinical atherosclerosis in type 1 diabetes显示文摘 | Abdelghaffar S EI Amir M EI Hadidi A | 2006 | Trop Pediatr2006，52，1： | 1 |
| 3 | The effects of diclofenac on cryo-indueed miosis 显示文摘 | al Salem M Hadidi H Alwash R | 1996 | Int Ophthalmol1996，20，： | 1 |
| 4 | Carotid intimamedia thickness: an index for subclinical atherosclerosis in type 1 diabetes显示文摘 | Abdelghaffar S El Amir M El Hadidi A | 2006 | J Trop Pediatr2006，52，1： | 1 |
| 5 | Transverse cracking of concrete bridge decks : state-of-the-art 显示文摘 | HADIDI R SAADEGHVAZIRI M A | 2005 | Journal of Bridge Engineering2005，10，： | 1 |
| 6 | Sensitive detection of potato spindle tuber viroid using RT-PCR and identification of variant naturally infecting pepino plants显示文摘 | Shanloul A M Hadidi A Zhu S F | 1997 | Can J Plant Phathol1997，19，： | 1 |
| 7 | Recon-struction plate fixation of subtrochanteric femoral fractures in children显示文摘 | El-Sayed M Abulsaad M Hadidi M | 2007 | Acta Orthop Belg2007，73，4： | 1 |
| 8 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 9 | Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men显示文摘 | E1 Hadidy el HM Ghonaim M E1 Gawad S | 2011 | BMC Endocr Disord2011，1115，： | 1 |
| 10 | Sensitive detection of potato spindle tuber and temperate fruit tree viroids by reverse transcription-polymerase chain reaction- probe capture hybridization显示文摘 | SHAMLOUL A M HADIDI A | 1999 | J Virol Methods1999，，80： | 1 |
| 11 | Early elective cesarean delivery before 36 weeks vs late spontaneous delivery in infants with gastroschisis显示文摘 | Hadidi A Subotic U Goeppl M | | 0，，： | 1 |
| 12 | Performance evaluation and benchmarking for main- tenance decision making units at petrochemical corpo- ration using a DEA model 显示文摘 | ASSAF S A HADIDI L A HASSANAIN M A | 2015 | International Journal of Advanced Manufacturing Technology2015，76，9： | 1 |
| 13 | Linear recursive state estimators under uncertain observations显示文摘 | HADIDI M SCHWARTZ S | 1979 | IEEE Trans Auto Cont1979，24，： | 1 |
| 14 | Polyarthritis with chondronecrosis associated with osteonecrosis, panniculitis and pancreatitis显示文摘 | Mustafa KN Hadidy A Shoumaf M | 2010 | Rheumatol Int2010，30，9： | 1 |
| 15 | Detection of potato leafroll andstraw berry mild yellow-edge luteo virus by RT-PCR 显示文摘 | Hadidi A Montasser M S Levy L | 1993 | PlantDisease1993，77，6： | 1 |
| 16 | Linear recursive state estimators under uncertain observations显示文摘 | Hadidi M T Schwartz S C | 1979 | IEEE Transactions on Automatic Control1979，24，6： | 1 |
| 17 | Accuracy of single versus combined use of ultrasonography or computed tomo- graphy in the localization of parathyroid adenoma显示文摘 | Younes N A Hadidi A M Mahafzah W S | 2008 | Saudi Med J2008，29，2： | 1 |
| 18 | An approach to the ehemosystematics of the zygophyllaceae显示文摘 | N A M Saleh M N El -Hadidi | 1977 | Biochemical Systematics and Ecology1977，5，2： | 1 |
| 19 | Simple and rapid preparation of infected plant tissue extracts for PCR amplification of virus,viroid,and MLO nucleic acids显示文摘 | Levy L Lee I M Hadidi A | 1994 | J Virol Methods1994，49，： | 1 |
| 20 | A low-power,small-size 10-bit successive-approximation ADC显示文摘 | BANIHASHEMI M HADIDI K KHOEI A | 2005 | IEICE Trans Fundamentals2005，88，4： | 1 |
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