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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Redefining prognostic factors for breast cancer:YB 1 is a stronger predictor of relapse and disease specific survival than estrogen receptor or HER 2 across all tumor subtype显示文摘 | Habibi G Leung S Law JH | 2008 | Breast Cancer Res2008，10，5： | 1 |
| 3 | Occurrence distribution and relative incidence of mosaic viruses infecting field-grown squash in Tehran Province, Iran显示文摘 | Farhangi S H Mosahebi G Habibi M K Okhowai S M | 2004 | Agricultural and Biological Sciences2004，69，4： | 1 |
| 4 | l)irect renin inhibition improves systemic insulin resistance and skeletal muscle glucose tram- port in a transgenic rodent model of tissue renin overexpression显示文摘 | G Habibi J Whaley-Connell AT | 2009 | En- docrinology2009，150，6： | 1 |
| 5 | Impact of radiation models in CFD simulations of steam cracking furnaces 显示文摘 | HABIBI A MERCI B HEYNDERICKX G J | 2007 | Computers & Chemical Engineering2007，31，11： | 1 |
| 6 | Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer providing a potential target for therapy 显示文摘 | Stratford AL Habibi G Astanehe A | 2007 | Breast Cancer Res2007，9，5： | 1 |
| 7 | Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression显示文摘 | Lastra G Habibi J Whaley-Connell AT | 2009 | Endocrinology2009，150，6： | 1 |
| 8 | Neural network control of air-to-fuel ratio in a bi-fuel engine显示文摘 | GNANAM G HABIBI S R BURTON R T | 2006 | IEEE Trans Syst Man Cybern C2006，36，5： | 1 |
| 9 | Oxidative stress contributes to pulmonary hypertension in the transgenic (mren2) 27 rat 显示文摘 | DeMarco V G Habibi J Whaley-Connell A T | 2008 | Am J Physiol Heart Circ Physiol2008，294，6： | 1 |
| 10 | The role of avian influenza,Newcastle commercial broiler farms of Iran显示文摘 | Hadipour M M Habibi G H Golchin P | | 0，，02： | 1 |
| 11 | The assessment of affected factors on cytomegalovirus and rubella virus prevalence in females in Hamadan, Iran 显示文摘 | Sabouri Ghannad M Roshanaei G Habibi H | 2014 | Aeta Med Iran2014，2，4： | 1 |
| 12 | The role of avian influenza,Newcastle disease and infectious bronchitis viruses during the respiratory disease outbreak in commercial broiler farms of Iran显示文摘 | Hadipour M M Habibi G H Golchin P | | 0，，02： | 1 |
| 13 | Effect of different con- centrations of ginger root powder and its essential oil on growth performance, serum metabolites and antioxidant status in broiler chicks under heat stress 显示文摘 | Habibi R Sadeghi G Karimi A | 2014 | British Poultry Science2014，55，2： | 1 |
| 14 | Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression 显示文摘 | Lastra G Habibi J Whaley-Connell AT | 2009 | Endocrinology2009，150，： | 1 |
| 15 | Inner-loop control for electro-mechanical (EMA) flight surface actuation systems显示文摘 | Habibi S Roach J Luecke G | 2008 | ASME Journal of Dynamic Systems Measurement and Control2008，130，： | 1 |
| 16 | Impact of radiationmodels in CFD simulations of steam cracking furnaces显示文摘 | Habibi A Merci B Heynderickx G J | 2007 | Computers and Chemical Engineering2007，31，： | 1 |
| 17 | Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 ( YB-1 ) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy 显示文摘 | Stratford AL Habibi G Astanehe A | 2007 | Breast Cancer Res2007，9，5： | 1 |
| 18 | TEM investigation of precipitation phenomena occurring in PH 15-5 alloy显示文摘 | HABIBI BAJGUIRANI H R SERVANT C CIZERON G | 1993 | Acta Metallurgica et Materialia1993，41，5： | 1 |
| 19 | TEM investigation of precipitation phenomena occurring in PH15-5 alloy显示文摘 | HABIBI BAJGUIRANI H R SERVANT C CIZERON G | 1993 | Acta Metal Mater1993，41，5： | 1 |
| 20 | Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 ( YB-1 ) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy 显示文摘 | Stratford AL Habibi G Astauehe A | 2007 | Breast Cancer Res2007，9，5： | 1 |
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