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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Inhibition of human hepatocar- cinoma cell proliferation by mammalian and fish gona- dotropin-releasing hormones 显示文摘 | PATI D HABIBI H R | 1995 | Endocrinology1995，136，1： | 1 |
| 3 | TEM investigation of precipitation phenomena occurring in PH15-5 alloy显示文摘 | Habibi H R Servant C | 1993 | Acta Metal Mater1993，41，5： | 1 |
| 4 | The effects of social media based brand communities on brand community markers, val- ue creation practices, brand trust and brand loyalty显示文摘 | Laroche M Habibi M R Richard M | 2012 | Computers in Human Behavior2012，28，5： | 1 |
| 5 | Isolation and structure of D-xylans from pericarp seeds of Opuntia ficus-indica prickly pear fruits 显示文摘 | HABIBI Y MAHROUZ M V1GNON M R | 2002 | Carbohydrate Research2002，337，17： | 1 |
| 6 | Expression profiles of three types of GnRH during sex-change in the protandrous cinnamon clownfish, Arnphiprion melanopus:effects of exogenous GnRHs 显示文摘 | Kim N N Shi H S Habibi H R | 2012 | Compar-ative Biochemistry and Physiology B-Biochemistry & Molecular Biology2012，161，2： | 1 |
| 7 | Delayed hemolytic transfusion reaction in sickle cell disease patients: evidence of an emerging syndrome with suicidal red blood cell death显示文摘 | Chadehech P Habibi A Nzouakou R | 2009 | Transfusion2009，49，9： | 1 |
| 8 | Arabinan-rich polysaccharides isolated and characterized from the endosperm of the seed of Opuntia fwusindica prickly pear fruits 显示文摘 | HABIBI Y MAHROUZ M VIGNON M R | 2005 | Carbohydrate Polymers2005，60，3： | 1 |
| 9 | Security and Privacy Analysis of Song-Mitchell RFID Authentication Protocol 显示文摘 | Habibi M H Aref M R | 2013 | Wireless PersonalCommunications2013，69，4： | 1 |
| 10 | Effect of electrical potential on the electro- demulsifieation oil oily sludge 显示文摘 | Elektorowicz M Habibi S Chifrina R | 2006 | Journal of Colloid and Interface Science2006，295，： | 1 |
| 11 | Optimization of cellouronie acid synthesis by TEMPO-mediated oxidation of cellulose III from sugar beet pulp显示文摘 | Habibi Y Vignon M R | 2007 | Cellulose2007，15，1： | 1 |
| 12 | Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment 显示文摘 | WHALEY-CONNELL A HABIBI J NISTALA R | 2008 | Hy- pertension2008，51，2： | 1 |
| 13 | Functional relationship between receptor binding and biological activity for analogs of mammalian and salmon gonadotropin-releasing hormones in the pituitary of goldfish(Carassius auratus)显示文摘 | Habibi H R Marchant T A Nabornink C S | 1989 | Biol Reprod1989，40，： | 1 |
| 14 | The effect of ageing upon the mi- crostructure and mechanical properties of type 15-5 PH stainless steel 显示文摘 | Habibi Bajguirani H R | 2002 | Materials Science and Engineering2002，338，： | 1 |
| 15 | Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat显示文摘 | WHALEY-CONNELL AI HABIBI J NISTALA R | 2012 | Regul Pept2012，176，13： | 1 |
| 16 | The effects of social media based brand communities on brand com- munity markers, value creation practices, brand trust and brand loyalty 显示文摘 | LAROCHE M HABIBI M R RICHARD M O | 2012 | Computers in Human Behavior2012，28，5： | 1 |
| 17 | Fuel characterization and co-pyrolysis kinetics of biomass and fossil fuels显示文摘 | MASNADI M S HABIBI R KOPYSCINSKI J | 2014 | Fuel2014，117，： | 1 |
| 18 | Functional sig- nificance of nuclear estrogen receptor subtypes in the liver of goldfish 显示文摘 | NELSON E R HABIBI H R CHOI C Y | 2010 | Endocrinology2010，151，4： | 1 |
| 19 | Renin inhibition attenuates insulin resistance, oxidative stress and pancreatic remodeling in the transgenic Ren2 rat显示文摘 | Habibi J Whaley - Connel A Hayden M R | 2008 | Endocrinology2008，149，： | 1 |
| 20 | Pulmonary hypertension and cnr pulmonale during severe acute chest syndrome in sickle cell disease显示文摘 | MEKONTSO DESSAP A LEON R HABIBI A | 2008 | Am J Respir Crit Care Med2008，177，6： | 1 |
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