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| 1 | Generation of new glutinous rice by CRISPR/Cas9-targeted mutagenesis of the Waxy gene in elite rice varieties显示文摘In rice, amylose content(AC) is controlled by a single dominant Waxy gene. We used Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)/CRISPR-associated 9(Cas_9) to introduce a loss-of-function mutation into the Waxy gene in two widely cultivated elite japonica varieties. Our results show that mutations in the Waxy gene reduce AC and convert the rice into glutinous ones without affecting other desirable agronomic traits, offering an effective and easy strategy to improve glutinosity in elite varieties. Importantly, we successfully removed the transgenes from the progeny. Our study provides an example of generating improved crops with potential for commercialization, by editing a gene of interest directly in elite crop varieties. | Jinshan Zhang Hui Zhang Jose Ramón Botella Jian-Kang Zhu | 2018 | Journal of Integrative Plant Biology2018，60，5： | 49 |
| 2 | HMGA蛋白在恶性外周神经鞘膜肿瘤和滑膜肉瘤中的表达显示文摘 | Hui P Li N Johnson C 黄文斌(摘译) 陈洁宇(摘译) 周晓军(审校) | 2005 | 临床与实验病理学杂志2005，21，6： | 4 |
| 3 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 4 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 5 | A major outbreak of severe acute respiratory syndrome in Hong Kong显示文摘 | LEE N HUI D WU A | 2003 | N Engl J Med2003，348，20： | 2 |
| 6 | Response of nanocomposite pyroelectric detectors 显示文摘 | CHEN Y CHAN W L H HUI N M | 1998 | Sensors and Actuators A1998，69，1： | 2 |
| 7 | Noor Grafting of sodium carboxymethylcellulose (CMC) with glycidyl methacrylate and development of UV curable coatings from CMC-g-GMA induced by cationic photoinitiators显示文摘 | Lin Ong Hui Kumar R N Rozman H D | 2005 | Carbohydrate Polymers2005，59，1： | 1 |
| 8 | Size distributions of maternal and fetal DNA in maternal plasma显示文摘 | Chan K C ZhangJ Hui A B Wong N Lau T K Leung T N | 2004 | Clin Chem2004，50，： | 1 |
| 9 | A major outbreak of severe acute respiratory syndrome in Hong Kong显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，348，： | 1 |
| 10 | Fibrovascular proliferation and retinal detachment after intravitreal injection of activated macrophages in the rabbit eye显示文摘 | Hui YN Goodnight R Sorgente N | 1989 | Am J Ophthalmol1989，108，： | 1 |
| 11 | Prevalence of Malnutrition and Risk Factors in Geriatric Patients of a Convalescent and Rehabilitation Hospital显示文摘 | Shum N C Hui W W Chu F C | 2005 | Hong kong Med J2005，11，4： | 1 |
| 12 | Is gastric lymphoepithelioma- like carcinoma a special subtype of EBV-associated gastric carcinoma? New insight based on clinicopathological features and EBV genome polymorphisms 显示文摘 | Cheng N Hui DY Liu Y | 2014 | Gastric Cancer2014，18，2： | 1 |
| 13 | Cross Entropy Method for Networks Estimation显示文摘 | Hui K P Bean N Kraetzl M | 2005 | Annals of Operations Research2005，134，： | 1 |
| 14 | A major outbreak of severe acute respiratory syndrome in Hong Kong 显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，7，： | 1 |
| 15 | Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，14，： | 1 |
| 16 | A major outbreak of severe acute respiratory syndrome in Hong Kong显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，348，20： | 1 |
| 17 | Breast cancer following augmentation mammaplasty with polyacrylamide hydrogel (PAAG) injection显示文摘 | CHENG N X LIU L G HUI L | 2009 | Aesthetic Plast Surg2009，33，4： | 1 |
| 18 | Cartilage repair:2013 Asian update显示文摘 | Hui JH Goyal D Nakamura N | 2013 | Arthroscopy2013，29，12： | 1 |
| 19 | 3-D mapping of regional soil hydraulic characteristics through establishment of pedo-transter functions显示文摘 | Mei D Hui H Christoph N | 2012 | Disaster Advances2012，5，4： | 1 |
| 20 | A propective intervention study on higher-dose oseltamivir treatment in adults hospi- talized with influenza a and B infections显示文摘 | Lee N Hui DS Zuo Z | 2013 | Clin Infect Dis2013，57，11： | 1 |
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