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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 3 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 4 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 5 | P6 aeupoint injec- tion reduce postoperative nausea and vomiting显示文摘 | Shyr M H Hsu J C Wu Y W Hui Y L Tan P P | 1990 | Ma Tsui Hsueh Tsa Chi Anaesthesiol Sinica1990，28，6： | 1 |
| 6 | Forward-se- cure multisignature and blind signature schemes显示文摘 | Chow S S M Hui L C K Yiu S M | 2005 | Applied Mathematics and Computation2005，168，： | 1 |
| 7 | Measuring customer satisfaction of FM service in housing sector:A structural equation model approach显示文摘 | HUI E C M ZHENG X | | 0，，5： | 1 |
| 8 | Molecular analysis of hypoxanthine phosphoribosyltransferase gene deletions induced by alpha- and X- radiation in human lymphoblastoid cells显示文摘 | Bao C Y Ma A H Evans H H Horng M F Mencl J Hui T E Sedwick W D | 1995 | Mutation Research1995，326，： | 1 |
| 9 | Effective-Medium for Weakly Nonlinear Composites显示文摘 | Bergman D J Hui P M | 1988 | Phys Rev B1988，38，10： | 1 |
| 10 | Synthesis of diosgenyl gracillin and related saponins显示文摘 | LI C LIU M Z HUI Y Z | 1998 | Carbohydrate Research1998，306，： | 1 |
| 11 | Wind turbulence characteristics study at the Stonecutters Bridge site: Part I-Mean wind and turbulence intensities显示文摘 | HUI M C H LARSEN A XIANG H F | 2009 | Journal of Wind Engineering and Industrial Aerodynamics2009，97，1： | 1 |
| 12 | Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell careinoma 显示文摘 | Li Z J Mack S C Mak T H Angers S Taylor M D Hui C C | 2014 | Oncogene2014，33，： | 1 |
| 13 | Mining a web citation database for document clustering 显示文摘 | HE Y HUI S C FONG A C M | 2002 | Applied Artificial Intelligence2002，16，： | 1 |
| 14 | A study of commuting patterns of new town residents in Hong Kong显示文摘 | Hui C M Manfred C M | 2005 | Habitat International2005，，29： | 1 |
| 15 | Cytot oxicity,he-molysis,and acute in viwot oxicity of dendri mers basedon melamine candidate vehicles for drug delivery显示文摘 | HUI T C NEER M F SIME E | 2004 | Journal of the American Chemical Society2004，126，10： | 1 |
| 16 | Cellular automaton models of traffic flow along a highway containing a junction显示文摘 | BENJAMIN S C JOHNSON N F HUI P M | 1996 | J phys A1996，29，： | 1 |
| 17 | Analytic approach to co-evolving dynamics in complex networks: dissatisfied adaptive snow- drift game 显示文摘 | Gr ser O Xu C Hui P M | 2011 | New J Phys2011，13，08： | 1 |
| 18 | Rotating Bending Fatigue Properties of Two Hardening Steels After Nitriding Treatment显示文摘 | Zhou C Wang M Q Hui W J | 2013 | Materials and Design2013，46，： | 1 |
| 19 | Core-shell Fe3O4@SiO2 nanoparticles synthesized with well-dispersed hydrophilic Fe3O4 seeds显示文摘 | Hui C Shen C M Tian J F | | 0，，02： | 1 |
| 20 | Comparison of FEM and BEM for interactive object simulation显示文摘 | TANG Y M ZHON A F HUI K C | 2006 | Computer Aided Design2006，38，8： | 1 |
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