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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Removal of mixed heavy metal ions in wastewater by zeolite 4A and residual products from recycled coal fly ash 显示文摘 | Hui K S Chao C Y H Kot S C | 2005 | Journal of Hazardous Materials2005，127，13： | 1 |
| 4 | Size distributions of maternal and fetal DNA in maternal plasma显示文摘 | Chan K C ZhangJ Hui A B Wong N Lau T K Leung T N | 2004 | Clin Chem2004，50，： | 1 |
| 5 | Stonecutters Bridge-Durability,Maintenance and Safety Considerations显示文摘 | Michael C H Hui Chris K P Wong | 2009 | Structure and Infrastructure Engineering2009，5，3： | 1 |
| 6 | Forward-se- cure multisignature and blind signature schemes显示文摘 | Chow S S M Hui L C K Yiu S M | 2005 | Applied Mathematics and Computation2005，168，： | 1 |
| 7 | Refinery planning under uncertainty 显示文摘 | Li W K Hui C W Li P Li A X | 2004 | Industrial & Engineering Chemistry Research2004，43，21： | 1 |
| 8 | Constructive Conflict in China:Cooperative Conflict as a Bridge between East and West 显示文摘 | Tjosvold D Hui C Law K S | 2001 | Journal of World Business2001，36，2： | 1 |
| 9 | Quantitative analysis and prognostic implication of SARS coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome 显示文摘 | Ng E K Hui D S Chan K C | 2003 | Clin Chem2003，49，12： | 1 |
| 10 | Effects of step - change of synthesis temperature on synthesis of zeolite 4A from coal fly ash 显示文摘 | HUI K S CHAO C Y H | 2006 | Microporous and Mesoporous Materials2006，88，2： | 1 |
| 11 | Analysis and Spectral characteristics of a spread-spectrum technique for conducted EMI suppression显示文摘 | Tse K K Chung H Hui S Y R So H C | 2000 | IEEE Trans on Power Electronics2000，15，： | 1 |
| 12 | Chemical contamination of the East River(Dongjiang) and its implication on sustainable development in thePearl River Deltal显示文摘 | Ho K C Hui K C C | 2001 | Environment International2001，26，56： | 1 |
| 13 | Removal of mixed heavy metal ionsin wastewater by zeolite 4A and residual products from recycledcoal fly ash显示文摘 | Hui K Chao C Kot SC | 2005 | J Hazard Mater2005，127，13： | 1 |
| 14 | Cryptanalysis of Harn digital multisignature scheme with distinguished signing authorities显示文摘 | Li Z C Hui L C K Chow K P | 2000 | Electronics Letters2000，36，4： | 1 |
| 15 | Total-site scheduling for better energy utilization显示文摘 | Cheung K Y Hui C W | 2004 | Journal of Cleaner Production2004，12，2： | 1 |
| 16 | Removal of mixed heavy metal ions in waste water by zeolite 4A and residual products from recycled coal fly ash显示文摘 | Hui K S Chao C Y H Kot S C | | Journal of Hazardous Materials0，127，123： | 1 |
| 17 | Short-term site-wide maintenance scheduling显示文摘 | Cheung K Y Hui C W Sakamoto H | 2004 | Computers and Chemical Engineering2004，28，12： | 1 |
| 18 | Removal of mixed heavy metal ions in wastewater by zeolite 4A and residual products from recycled coal fly ash 显示文摘 | Hui K S Chao C Y H Kot S C | 2005 | Journal of Hazardous Materials2005，127，13： | 1 |
| 19 | Comparison of FEM and BEM for interactive object simulation显示文摘 | TANG Y M ZHON A F HUI K C | 2006 | Computer Aided Design2006，38，8： | 1 |
| 20 | A Structural Equation Model of the Effects of Negative Affectivity, Leader - Member Exchange, and Perceived Job Mobility on Inrole and Extra - role Performance: A Chinese Case显示文摘 | Hui C Law K S Chen Z X | 1999 | Organizational Behavior and Human Decision Processes1999，77，1： | 1 |
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