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| 1 | 一种缓冲回填材料的筛选及其特性:西班牙实例(英文)显示文摘介绍了西班牙在高放废物深地质处置中用于缓冲回填材料的泥岩的筛选及其特性的研究成果,这项研究在西班牙核废料管理委员会资助下进行,始于 20 世纪 80 年代,且在开始阶段主要是开展泥岩沉积层及黏土供应商的筛选工作。黏土这些特性与标准已被国际社会广泛接受,但进一步的研究主要涉及到泥岩的矿物纯度、持水特性、可塑性、低渗透性、较高的膨胀压力和热导性。经初步研究,确定两种膨润土沉积层被选中,并在实验室中对其特性进行了研究,主要包括:热–水–力特性的确定、预加热和温度的影响以及石英添加剂的作用。由于膨润土具有较高的膨胀性以及低渗透性,因而必须对传统的试验技术进行改进,并设计出新的试验设备。最终确定Cortijo de Archidona(Almería)选为西班牙膨润土的供应区,其开采的膨润土已在近期结束的数个研究课题中得到了应用。无论是从矿物学、热学、水力学、力学和地质化学,还是从可变性等方面看来,该区膨润土的特性都是最好的;另外,处置库中膨润土的变化特征在实验室以及现场都已经作了相应的研究。 | Villar María Victoria Astudillo Julio Huertas Fernando | 2006 | 岩石力学与工程学报2006，25，4： | 6 |
| 2 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 3 | Toll‐Like Receptors and Cytokines are Upregulated during H elicobacter pylori Infection in Children显示文摘 | Hugo Lagunes‐Servin Javier Torres Carmen Maldonado‐Bernal Martha Pérez‐Rodríguez Sara Huerta‐Yépez Armando Madrazo de la Garza Leopoldo Mu?oz‐Pérez Lourdes Flores‐Luna Guillermo Ramón‐García Margarita Camorlinga‐Ponce | 2013 | Helicobacter2013，，6： | 2 |
| 4 | An elastic plastic damage formulation for concrete:application to elementary tests and comparison with an isotropic damage model 显示文摘 | JASON L HUERTA A PIJAUDIER-CABOT G | 2006 | Computer Methods in Applied Mechanics and Engineering2006，195，： | 1 |
| 5 | Detect Runways in Complex Airport Scenes显示文摘 | Huertas A Cole W Nevatia R | 1990 | Computer Vision Graphics and Image Processing1990，24，2： | 1 |
| 6 | COPD:a multifactorial systemic disease显示文摘 | Huertas A Palange P | 2011 | Ther Adv Respir Dis2011，5，3： | 1 |
| 7 | Reduced risk of colorectal cancer among long-term users of aspirin and nonsteroidal anti-inflammatory drugs显示文摘 | Garcia-Rodriguez L A Huerta A Ivarez C | 2001 | Epidemiology2001，12，1： | 1 |
| 8 | Circulating haemopoietic and endothelial progenitor cells are decreased in COPD显示文摘 | Palange P Testa U Huertas A | 2006 | Eur Respir J2006，27，3： | 1 |
| 9 | Geochemistry of iron and manganese in soils and sediments of a mangrove sys- tem, Island ofPai Matos (Cananeia -SP, Brazil)显示文摘 | Otero X L Ferreira T O Huerta M A | 2009 | Geoderma2009，148，： | 1 |
| 10 | Detecting runways in complex airport scenes 显示文摘 | Huertas A Cole W Nevatia R | 1990 | Computer Vision Graphics and Image Processing1990，51，2： | 1 |
| 11 | Detecting Runways in Complex Airport Scenes 显示文摘 | Huertas A Cole W Nevatia R | 1990 | CVGIP1990，51，2： | 1 |
| 12 | Upper and lower bounds in limit analysis: Adaptive meshing strategies and discontinuous loading显示文摘 | MUNOZ J J BONET J HUERTA A | 2009 | International Journal for Numerical Methods in Engineering2009，77，4： | 1 |
| 13 | Decentral- ized sliding mode block control of multimachine pow- er systems显示文摘 | Huerta H Loukianov A G Canedo J M | 2010 | International Journal of Electrical Power Energy Systems2010，32，1： | 1 |
| 14 | Detection of intensity changes with suhpixel accuracy using laplacian of Gaussian masks 显示文摘 | HUERTAS A MEDIONI G | 1986 | IEEE Transactions on Pattern Analysis and Machine Intelligence1986，8，5： | 1 |
| 15 | Detecting Buildings in Aerial Images 显示文摘 | Huertas A Nevatia R | 1988 | Computer Vision Graphics and Image Processing1988，41，2： | 1 |
| 16 | Landing hazard detection with stereo vision and shadow analysis显示文摘 | MATTHIES L HUERTAS A CHENG Yang | 2007 | Planetary and Space Science2007，12，7： | 1 |
| 17 | Structure, composition and electrical properties of YSZ films deposited by ultrasonic spray pyrolysis显示文摘 | RAMIREZ E B HUANOSTA A SEBASTIAN J P HUERTA L ORTIZ A ALONSO J C | 2007 | Journal of Materials Science2007，42，3： | 1 |
| 18 | Reduced risk of colorectal cancer among long-term users of aspirin and nonsteroidal anti-inflammatory drugs显示文摘 | GARCIA R L HUERTA A C | 2001 | Epidemiology2001，12，： | 1 |
| 19 | Pilot scale lactic acidfermentation of shrimp wastes for chitinrecovery 显示文摘 | Cira L A Huerta S Hall G M | 2002 | Process Biochemistry2002，37，： | 1 |
| 20 | Leptin and regula- tory T lymphocytes in idiopathic pulmonary arterial hy- pertension显示文摘 | Huertas A Tu L Gambaryan N | 2012 | Eur Respir J2012，40，4： | 1 |
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