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	题名	作者	年代	出处	被引量
1	Genome survey uncovers the secrets of sex and lifestyle in caterpillar fungus显示文摘The caterpillar fungus Ophiocordyceps sinensis (best known as Cordyceps sinensis) mummifies ghost moth larvae exclusively in Tibetan Plateau alpine ecosystems. Touted as 'Himalayan Viagra', the fungus is highly prized due to its medical benefits and dwindling supplies. Attempts to culture the sexual fruiting-body have failed and the huge market demand has led to severe devastation of local ecosystems and to the fungus heading towards extinction. By genome sequencing, we establish that unlike related insect pathogens O. sinensis contains two compatible mating-type genes in its genome and is self-fertile, i.e. homothallic. However, sexual processes are only initiated under native environmental conditions. O. sinensis resembles biotrophic plant pathogens in having a genome shaped by retrotransposon-driven expansions. The resulting changes in gene content suggest that O. sinensis has a biphasic pathogenic mechanism beginning with stealth pathogenesis in early host instars. O. sinensis is the first psychrophilic fungus sequenced and is adapted to extreme cold with putative antifreeze proteins and mechanisms for increasing lipid accumulation and fatty acid unsaturation. We hypothesize that for the inbreeding O. sinensis the massive proliferation of retrotransposons provides a tradeoff between the advantages of increased genetic variation independent of sexual recombination and deletion of genes dispensable for its specialized pathogenic lifestyle.	HU Xiao ZHANG YongJie XIAO GuoHua ZHENG Peng XIA YongLiang ZHANG XingYu ST LEGER Raymond J LIU XingZhong WANG ChengShu	2013	Chinese Science Bulletin2013，58，23：	26
2	醌氧化还原酶1抑制剂双香豆素促进HBV X蛋白降解进而抑制cccDNA转录的机制研究显示文摘【据Journal of Hepatology2021年3月报道】题:醌氧化还原酶1抑制剂双香豆素促进HBV X蛋白降解进而抑制ccc DNA转录的机制研究(作者Cheng ST等)HBV ccc DNA在肝细胞核内持续稳定的存在,被认为是HBV感染慢性化、抗病毒治疗无法彻底清除以及停药后肝炎复发的最主要原因。HBV X蛋白(HBx)对HBV ccc DNA的转录过程发挥关键作用;促进HBx降解,则可能抑制ccc DNA转录。因此,开发靶向HBx的小分子化合物是达到'ccc DNA沉默清除'这一重要目标的可能途径。	陈娟黄爱龙 CHENG ST HU JL REN JH	2021	临床肝胆病杂志2021，37，4：	12
3	Differential gene expression by Metarhizium anisopliae growing in root exudate and host(Manduca sexta)cuticle or hemolymph reveals mechanisms of physiological adaptation显示文摘	Wang C S Hu G St Leger R J	2005	Fungal Genetics and Biology2005，42，：	1
4	Control anc eradication of syphilis in Chi- na显示文摘	Hu CK Ge Y Chen ST	1964	I3ejing Sci Conference1964，，16：	1
5	Immigrant Chinese Student s' Use of Silence in the Language Arts Classroom: Perceptions, Reflections, and Actions显示文摘	HU Y ST ACEY FE LL- E ISENKRAFT	2003	Teaching & Learning2003，，17：	1
6	Influence of local fracture energy distribution onmaximum fracture load of three-point-bending notched concrete beams 显示文摘	Yang ST Hu XZ Wu ZM	2011	Engineering Fracture Mechanics2011，78，：	1
7	Uncertainties of optical parameters and their propagations in an analytical ocean color inversion algorithm显示文摘	Lee Z P Arnone R Hu C M st al	2010	Applied Optics2010，49，3：	1
8	Treatment of a human breast cancer xenograft with an adenovirus vector containing an interferon gene results in rapid regression due to viral oneolysis and gene therapy 显示文摘	Zhang JF Hu C Geng Y st al	1996	Proc Natl Acad Sci U S A1996，93，9：	1
9	Researh progress of Noroviruses 显示文摘	Hu XF Diao YH Qi ST	2007	Port Health Control2007，12，6：	1
10	Short stay pyeloplasty: variables affecting pain and length of stay显示文摘	Chamie K Tanaka ST Hu B	2008	J Urol2008，179，4：	1
11	Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects显示文摘	HIDEO YASUDA PETER ST YUEN XUZHEN HU	2006	Kidney Int2006，69，9：	1
12	Cerebral hemispherectomy in pediatric patients with epilepsy: comparison of three tech- niques by pathological substrate in 115 patients 显示文摘	Cook SW Nguyen ST Hu B	2004	J Neuro- surg2004，100，2：	1
13	Genome variation of human papillomavirus types:phylogenetic and medical implications 显示文摘	Bernard HU Calleja-Macias IE Dunn ST	2006	Int J Cancer2006，118，5：	1
14	An inducible fusaric acid tripartiteefflux pump contributes to the fusaric acid resistance in stenotroph-omonas maltophilia显示文摘	Hu RM Liao ST Huang CC	2002	Plos One^2002，7，51：	1
15	Genome variation of human papillomavirus types:phylogenetic and medical implications显示文摘	Bernard HU Calleja-Macias IE Dunn ST		0，，5：	1
16	Field studies using a recombinant mycoinsecticide (Metarhizium anisopliae) reveal that it is rhizosphere competent 显示文摘	Hu G St Leger R J	2002	Applied and Environmental Microbiology2002，68，：	1
17	Location of the mandibular canal and the topography of its neurovascular structures 显示文摘	Kim ST Hu KS Song WC	2009	J Craniofac Surg2009，20，3：	1
18	Control and eradication of syphilis in China 显示文摘	Hu CK Ge Y Chen ST	1964	Beijing Sci Conf1964，10，：	1
19	Rapid identification of the Mycobacterium tuberculosis complex by combining the ESAT-6/CFP-10 immunochromatographic assay and smear morphology显示文摘	Shen GH Chiou CS Hu ST	2011	J Clin Microbiol2011，49，3：	1
20	Soluble E-cadherin is a valid prognostie marker in gastric carcinoma显示文摘	Chan AO Lam SK Chu KM Lam CM Kwok E Leung SY Yuen ST Law SY Hui WM Lai KC Wong CY Hu HC Lai CL Wong J		0，，：	1

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