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| 1 | Applications of Wavelet Analysis in Differential Propagation Phase Shift Data De-noising显示文摘Using numerical simulation data of the forward differential propagation shift(ΦDP) of polarimetric radar, the principle and performing steps of noise reduction by wavelet analysis are introduced in detail. Profiting from the multiscale analysis, various types of noises can be identified according to their characteristics in different scales, and suppressed in different resolutions by a penalty threshold strategy through which a fixed threshold value is applied, a default threshold strategy through which the threshold value is determined by the noise intensity, or a ΦDPpenalty threshold strategy through which a special value is designed for ΦDPde-noising. Then, a hard- or soft-threshold function, depending on the de-noising purpose, is selected to reconstruct the signal. Combining the three noise suppression strategies and the two signal reconstruction functions, and without loss of generality, two schemes are presented to verify the de-noising effect by dbN wavelets:(1) the penalty threshold strategy with the soft threshold function scheme(PSS);(2) the ΦDPpenalty threshold strategy with the soft threshold function scheme(PPSS). Furthermore, the wavelet de-noising is compared with the mean, median, Kalman, and finite impulse response(FIR) methods with simulation data and two actual cases. The results suggest that both of the two schemes perform well, especially when ΦDPdata are simultaneously polluted by various scales and types of noises. A slight difference is that the PSS method can retain more detail, and the PPSS can smooth the signal more successfully. | HU Zhiqun LIU Liping | 2014 | Advances in Atmospheric Sciences2014，31，4： | 17 |
| 2 | Pm21 from Haynaldia villosa Encodes a CC-NBS- LRR Protein Conferring Powdery Mildew Resistance in Wheat显示文摘 | Liping Xing Ping Hu Jiaqian Liu Kamil Witek Shuang Zhou Jiefei Xu Weihao Zhou Li Gao Zhenpu Huang Ruiqi Zhang Xiue Wang Peidu Chen Haiyan Wang Jonathan D.G. Jones Miroslava Karafiatova Jan Vrana Jan Baros Jaroslav Dolezel Yuanchun Tian Yufeng Wu Aizhong Cao | 2018 | Molecular Plant2018，11，6： | 16 |
| 3 | Spatial variations of macrozoobenthos and sediment nutrients in Lake Yangcheng: Emphasis on effect of pen culture of Chinese mitten crab显示文摘We determined the effect of Chinese mitten crab(CMC) pen culture on the quantified spatial distribution of the macrozoobenthic community and sediment nutrients in Lake Yangcheng.Redundancy analysis indicated that water temperature, macrophyte occurrence, sediment type, and crab culture were the main environmental factors that influence the spatiotemporal macrozoobenthic distribution. Macrozoobenthic assemblages in the lake were characterized by eutrophic indicator species. In the most polluted estuaries, the abundance and diversity indices of the whole community and abundance of chironomids and oligochaetes were significantly depressed, and sediment carbon(C) and phosphorus(P) were significantly enhanced compared with those in the western, middle(MB), and eastern basin(EB). Crab culture in this lake had significant effects on the species composition of the macrozoobenthic community in one of three CMC culture pens(CP), and generally depressed the abundance of most chironomid and oligochaete species. Significantly increased diversity, evenness, sediment carbon and nitrogen content, and sediment C:P ratio in the CP were found compared with those in the three basins.However, no conspicuous difference in sediment P content between the CP and the two basins of MB and EB was detected. Our results showed that the enhanced diversity and evenness of macrozoobenthos might be associated with the joint effect of macrophyte planting and crab predation, and macrophyte planting may modify the effects of CMC culture by leading to disproportional accumulation of C and N in the sediment relative to P in the CP of the lake. | Liping Chen Ying Zhang Qigen Liu Zhongjun Hu Yuejuan Sun Ziran Peng Lijing Chen | 2015 | Journal of Environmental Sciences2015，27，11： | 15 |
| 4 | Review of organic and inorganic pollutants removal by biochar and biochar-based composites显示文摘Biochar(BC)has exhibited a great potential to remove water contaminants due to its wide availability of raw materials,high surface area,developed pore structure,and low cost.However,the application of BC for water remediation has many limita-tions.Driven by the intense desire of overcoming unfavorable factors,a growing number of researchers have carried out to produce BC-based composite materials,which not only improved the physicochemical properties of BC,but also obtained a new composite material which combined the advantages of BC and other materials.This article reviewed previous researches on BC and BC-based composite materials,and discussed in terms of the preparation methods,the physicochemical properties,the performance of contaminant removal,and underlying adsorption mechanisms.Then the recent research progress in the removal of inorganic and organic contaminants by BC and BC-based materials was also systematically reviewed.Although BC-based composite materials have shown high performance in inorganic or organic pollutants removal,the potential risks(such as stability and biological toxicity)still need to be noticed and further study.At the end of this review,future prospects for the synthesis and application of BC and BC-based materials were proposed.This review will help the new researchers systematically understand the research progress of BC and BC-based composite materials in environmental remediation. | Liping Liang Fenfen Xi Weishou Tan Xu Meng Baowei Hu Xiangke Wang | 2021 | Biochar2021，3，3： | 13 |
| 5 | Recent Progress in Dual-Polarization Radar Research and Applications in China显示文摘Dual-polarization(dual-pol)radar can measure additional parameters that provide more microphysical information of precipitation systems than those provided by conventional Doppler radar.The dual-pol parameters have been successfully utilized to investigate precipitation microphysics and improve radar quantitative precipitation estimation(QPE).The recent progress in dual-pol radar research and applications in China is summarized in four aspects.Firstly,the characteristics of several representative dual-pol radars are reviewed.Various approaches have been developed for radar data quality control,including calibration,attenuation correction,calculation of specific differential phase shift,and identification and removal of non-meteorological echoes.Using dual-pol radar measurements,the microphysical characteristics derived from raindrop size distribution retrieval,hydrometeor classification,and QPE is better understood in China.The limited number of studies in China that have sought to use dual-pol radar data to validate the microphysical parameterization and initialization of numerical models and assimilate dual-pol data into numerical models are summarized.The challenges of applying dual-pol data in numerical models and emerging technologies that may make significant impacts on the field of radar meteorology are discussed. | Kun ZHAO Hao HUANG Mingjun WANG Wen-Chau LEE Gang CHEN Long WEN Jing WEN Guifu ZHANG Ming XUE Zhengwei YANG Liping LIU Chong WU Zhiqun HU Sheng CHEN | 2019 | Advances in Atmospheric Sciences2019，36，9： | 12 |
| 6 | Synthesis of Large-Area, Few-Layer Graphene on Iron Foil by Chemical Vapor Deposition显示文摘我们表明一个简单、可控制的方法综合大区域,由优化化学蒸汽免职(CVD ) 的铁底层上的很少层 graphene 用甲烷和氢的混合物的方法。基于 Fe-C 阶段图的分析,为 Fe 表面上的 graphene 的成功的合成的一个合适的过程被设计。适当温度和冷却过程被发现在高度水晶的很少层 graphene 的合成很重要。基于 Graphene 的地效果晶体管(联邦货物税) 设备用产生很少层 graphene 被制作,并且与 3001150 cm2/ 的提取活动性显示出好质量(V 敢椠 ?? 敤瑢吗? | Yunzhou Xue Bin Wu Yunlong Guo Liping Huang Lang Jiang Jianyi Chen Dechao Geng Yunqi Liu Wenping Hu Gui Yu | 2011 | Nano Research2011，4，12： | 7 |
| 7 | Initial gut microbiota structure affects sensitivity to DSS-induced colitis in a mouse model显示文摘The dextran sulfate sodium (DSS)-induced colitis model is a widely applied mouse model, but controversial results have been obtained from experiments using the same mouse strain under the same conditions. Because the gut microbiota play an important role in DSS-induced colitis, it is essential to evaluate the influence of the initial gut microbiota in this model. Here, we identified significant variations in the initial gut microbiota of different batches of mice and found that the initial intestinal microbiota had a profound influence on DSS-induced colitis. We performed three independent trials using the same C57BL/6J mouse model with DSS treatment and used high-throughput 16S rRNA gene sequencing to analyze the gut microbiota. We found that the structure and composition of the gut microbiota in mice with severe colitis, as compared with mice with milder colon damage, had unique features, such as an increase in Akkermansia bacteria and a decrease in Barnesiella spp. Moreover, these varied gut bacteria in the different trials also showed different responses to DSS treatment. Our work suggests that, in studies using mouse models, the gut microbiota must be considered when examining mechanisms of diseases, to ensure that comparable results are obtained. | Min Li Yanqiu Wu Yingxin Hu Liping Zhao Chenhong Zhang | 2018 | Science China(Life Sciences)2018，61，7： | 6 |
| 8 | miR-486 sustains NF-KB activity by disrupting multiple NF-KB-negative feedback loops显示文摘 | Libing Song Chuyong Lin Hul Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2013 | Cell Research2013，23，2： | 6 |
| 9 | A capability matching and ontology reasoning method for high precision OGC web service discovery显示文摘Finding the right spatially aware web service in a heterogeneous distributed environment using criteria such as service type,version,time,space,and scale has become a challenge in the integration of geospatial information services.A new method for retrieving Open Geospatial Consortium(OGC)Web Service(OWS)that deals with this challenge using page crawling,link detection,service capability matching,and ontology reasoning,is described in this paper.Its major components are distributed OWS,the OWS search engine,the OWS ontology generator,the ontology-based OWS catalog service,and the ontology-based multi-protocol OWS client.Experimental results show that the execution time of this proposed method equals only 0.26 of that of Nutch’s method.In addition,the precision is much higher.Moreover,this proposed method can carry out complex OWS reasoning-based queries.It is being used successfully for the Antarctica multi-protocol OWS portal of the Geo-Information Web Service Portal of the Polar. | Nengcheng Chen Zeqiang Chen Chuli Hu Liping Di | 2011 | International Journal of Digital Earth2011，4，6： | 6 |
| 10 | Characterization of a Putative New Semi-Dominant Reduced Height Gene, Rht_NM9, in Wheat(Triticum aestivum L.)显示文摘Plant height is an important agronomic trait in cereal crops, and can affect both plant architecture and grain yield. New dwarfing genes are required for improving the genetic diversity of wheat. In this study, a novel dwarf mutant, NM9, was created by treating seeds of the wheat variety NAU9918 with ethyl methanesulfonate(EMS). NM9 showed obvious phenotypic changes, which were distinct from those caused by other dwarfing genes, especially the reduced plant height, increased effective tiller number, and elongated spike and grain length. The reduced plant height in NM9 was attributable to a semi-dominant dwarfing gene Rht_NM9, which was flanked by two closely linked SNP markers, SNP34 and SNP41, covering an 8.86-Mb region on the chromosome arm 2AS. The results of gibberellic acid(GA) sensitivity evaluation, comparative genomics analysis and allelism test indicated that Rht_NM9 was neither allelic to Rht7 and Rht21 nor homoeoallelic to Rht8, so Rht_NM9 was proposed to be a new dwarfing locus on the homoeologous group 2 chromosomes of wheat. Rht_NM9has a negative effect on plant height and positive effects on effective tiller number and grain size, thus, Rht_NM9 could be used for elucidating the mechanisms underlying plant architecture and grain development. | Yuan Lu Liping Xing Shujuan Xing Ping Hu Chaofan Cui Mingyi Zhang Jin Xiao Haiyan Wang Ruiqi Zhang Xiue Wang Peidu Chen Aizhong Cao | 2015 | Journal of Genetics and Genomics2015，42，12： | 6 |
| 11 | NECK LEAF 1, a GATA type transcription factor, modulates organogenesis by regulating the expression of multiple regulatory genes during reproductive development in rice显示文摘在 monocot 米饭种类 Oryza sativa L. ,最惹人注目的词法过程之一在繁殖开发期间是有上面的 internodes (合众国际社) 的顺序的延伸的圆锥花序开发的同时发生。阐明内在的分子的机制,我们克隆米饭基因颈叶 1 (NL1 ) ,什么时候变异,它在 flowering 时间,有簇叶丛生的苞的更小的圆锥花序和反常合众国际社延伸模式导致延期。NL1 基因与一个单个锌手指领域,和它的抄本编码一个 GATA 类型抄写因素在苞 primordia 主要被检测,它通常在野类型的植物堕落。在转基因的植物的 NL1 的 Overexpression 经常产生严重生长延迟,不太植物的 phytomers 和更小的叶子,建议 NL1 起在器官区别的一个重要作用。PLASTOCHRON1 (PLA1 ) 的新奇变异的等位基因,知道在调整叶开始起一个关键作用的基因,在这研究被识别。基因分析表明了在 nl1 和 pla1 之间的一个相互作用,与 PLA1 在上游的代理的 NL1。表示水平和 PLA1 的空间模式被发现在 nl1 被改变变异。而且, flowering, Hd3a 和 OsMADS1 的二个管理者的表示,也在 nl1 异种被影响。根据这些调查结果,我们建议 NL1 是通过在米饭在繁殖开发期间调整 PLA1 和另外的规章的基因的表示调制并且协调 organogenesis 的一个内在的因素。 | Liping Wang Hengfu Yin Qian Qian Jun Yang Chaofeng Huang Xiaohe Hu Da Luo | 2009 | Cell Research2009，19，5： | 6 |
| 12 | Study on cosmogenic activation in germanium detectors for future tonne-scale CDEX experiment显示文摘A study on cosmogenic activation in germanium was carried out to evaluate the cosmogenic background level of natural and ^(70)Ge depleted germanium detectors. The production rates of long-lived radionuclides were calculated with Geant4 and CRY.Results were validated by comparing the simulated and experimental spectra of CDEX-1B detector. Based on the validated codes, the cosmogenic background level was predicted for further tonne-scale CDEX experiment. The suppression of cosmogenic background level could be achieved by underground germanium crystal growth and high-purity germanium detector fabrication to reach the sensitivity requirement for direct detection of dark matter. With the low cosmogenic background, new physics channels,such as solar neutrino research and neutrinoless double-beta decay experiments, were opened and the corresponding simulations and evaluations were carried out. | JingLu Ma Qian Yue ShinTed Lin Henry Tsz-King Wong JinWei Hu LiPing Jia Hao Jiang Jin Li ShuKui Liu ZhongZhi Liu Hao Ma WeiYou Tang Yang Tian Li Wang Qing Wang Yi Wang LiTao Yang Zhi Zeng | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 5 |
| 13 | Achievements in cancer research supported by National Natural Science Foundation of China显示文摘For the past two decades,great achievements have been made in cancer research of China and the majority of them were supported by the National Natural Science Foundation of China(NSFC).In this article,we reviewed the funding history of NSFC including the number of proposals,the amount of grants,distribution of supported program categories during the period of 1987 to 2012 and the representative achievements made by continuous support of NSFC.Also,the impacts of NSFC support on discipline development and talent fostering were analyzed.From 1987 to 2012,a total of 8738 proposals related to cancer research were funded by NSFC.The percentages of the Research Program,Talent-Training Program,and the Research Environment Program were 61.19%,36.32%,and 2.49%,respectively.Under the support of NSFC,cancer research in China has achieved a significantly rapid and balanced development in both disciplines and scientist resources. | HONG Wei LI Cui ZHANG LiPing XU YanYing ZHANG Jun HU Hai DONG ErDan | 2013 | Chinese Science Bulletin2013，58，1： | 5 |
| 14 | Speciation and thermal transformation of sulfur forms in high-sulfur coal and its utilization in coal-blending coking process:A review显示文摘The utilization of high-sulfur coal is becoming more urgent due to the excessive utilization of low-sulfur,high-quality coal resources,and sulfur removal from high-sulfur coal is the most important issue.This paper reviews the speciation,forms and distribution of sulfur in coal,the sulfur removal from raw coal,the thermal transformation of sulfur during coal pyrolysis,and the sulfur regulation during coal-blending coking of high organic-sulfur coals.It was suggested that the proper characterization of sulfur in coal cannot be obtained only by either chemical method or instrumental characterization,which raises the need of a combination of current or newly adopted characterization methods.Different from the removal of inorganic sulfur from coal,the organic sulfur can only be partly removed by chemical technologies;and the coal structure and property,particularly high-sulfur coking coals which have caking ability,may be altered and affected by the pretreatment processes.Based on the interactions among the sulfur radicals,sulfur-containing and hydrogen-containing fragments during coal pyrolysis and the reactions with minerals or nascent char,regulating the sulfur transformation behavior in the process of thermal conversion is the most effective way to utilize high organic-sulfur coals in the coke-making industry.An in-situ regulation approach of sulfur transformation during coal-blending coking has been suggested.That is,the high volatile coals with an appropriate releasing temperature range of CH4 overlapping well with that of H2 S from high organic-sulfur coals is blended with high organic-sulfur coals,and the C–S/C–C bonds in some sulfur forms are catalytically broken and immediately hydrogenated by the hydrogencontaining radicals generated from high volatile coals.Wherein,the effect of mass transfer on sulfur regulation during the coking process should be considered for the larger-scale coking tests through optimizing the ratios of different coals in the coal blend. | Yanfeng Shen Yongfeng Hu Meijun Wang Weiren Bao Liping Chang Kechang Xie | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 5 |
| 15 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 16 | Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain显示文摘Peripheral nerve injury could lead to chronic neuropathic pain.Understanding transcriptional changes induced by nerve injury could provide fundamental insights into the complex pathogenesis of neuropathic pain.Gene expression profiles of dorsal root ganglia(DRG)in neuropathic pain condition have been studied.However,little is known about transcriptomic changes in individual DRG neurons after peripheral nerve injury. | Kaikai Wang Sashuang Wang Yan Chen Dan Wu Xinyu Hu Yingjin Lu Liping Wang Lan Bao Changlin Li Xu Zhang | 2021 | Cell Research2021，31，8： | 5 |
| 17 | Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus显示文摘The coordinated utilization of nitrogen(N)and phosphorus(P)is vital for plants to maintain nutrient balance and achieve optimal growth.Previously,we revealed a mechanism by which nitrate induces genes for phosphate utilization;this mechanism depends on NRT1.1B-facilitated degradation of cytoplasmic SPX4,which in turn promotes cytoplasmic-nuclear shuttling of PHR2,the central transcription factor of phosphate signaling,and triggers the nitrate-induced phosphate response(NIPR)and N-P coordinated utilization in rice.In this study,we unveiled a fine-tuning mechanism of NIPR in the nucleus regulated by Highly Induced by Nitrate Gene 1(HINGE1,also known as RLI1),a MYB-transcription factor closely related to PHR2.RLI1/HINGE1,which is transcriptionally activated by PHR2 under nitrate induction,can directly activate the expression of phosphate starvation-induced genes.More importantly,RLI1/HINGE1 competes with PHR2 for binding to its repressor proteins in the nucleus(SPX proteins),and consequently releases PHR2 to further enhance phosphate response.Therefore,RLI1/HINGE1 amplifies the phosphate response in the nucleus downstream of the cytoplasmic SPX4-PHR2 cascade,thereby enabling fine-tuning of N-P balance when nitrate supply is sufficient. | Zhihua Zhang Zhao Li Wei Wang Zhimin Jiang Liping Guo Xiaohan Wang Yangwen Qian Xiahe Huang Yongqiang Liu Xiujie Liu Yahong Liu Aifu Li Yu Yan Junpeng Xie Shouyun Cao Stanislav Kopriva Legong Li Fanjiang Kong Baohui Liu Yingchun Wang Bin Hu Chengcai Chu | 2021 | Molecular Plant2021，14，3： | 4 |
| 18 | Polyelectrolytes/α-Fe_(2)O_(3) modification of carbon cloth anode for dealing with food wastewater in microbial fuel cell显示文摘In this paper,the layer-by-layer assembled polydimethyl diallyl ammonium chloride(PDADMAC),poly sodium-p-styrene sulfonate(PSS)and α-Fe_(2)O_(3) modified carbon cloth(CC),nitric acid activated CC,blank CC were used as anodes in two-chamber microbial fuel cell(MFC)for dealing with food wastewater.The electricity production of microbial fuel cell increased dramatically after modification of the anode.When four double layers of PDADMAC and PSS and one layer α-Fe_(2)O_(3) was assembled on CC(CC/(PDADMAC/PSS)4/α-Fe_(2)O_(3)),the highest current 0.48 mA and the highest power density 0.285 W/m2 were obtained.The electrode process of CC/(PDADMAC/PSS)4/α-Fe_(2)O_(3) anode in MFC was controlled by the electron production step,while the blank CC anode was an electron diversion-controlled process.The high electricity production of nitric acid treated CC anode in MFC was due to the amino group after activation,which made microbes easy to anchor on the anode surface.The effect of polyelectrolytes and α-Fe_(2)O_(3) on the performance improvement of MFC was due to both physical and chemical properties of the anode surface. | Meicong Wang Zinuo Wang Fei Hu Liping Fan Xuejun Zhang | 2020 | Carbon Resources Conversion2020，3，1： | 4 |
| 19 | Promotion of Mn Doped Co/CNTs Catalysts for CO Hydrogenation to Light Olefins显示文摘与各种各样的内容, Mn 被介绍进支持的碳 nanotubes ( CNT )钴催化剂和获得的 Mn-Co/CNTs 催化剂被调查让公司加氢点亮链烯并且由 N2 吸附描绘了,X光检查衍射( XRD ),X光检查光电子系列( XPS ), H2 温度规划了减小( TPR ),公司温度规划了解吸附作用( TPD )和传播电子显微镜( TEM )。结果显示到支持 CNTs 的公司催化剂的 Mn (0.3 wt%) 的小数量的增加显著地增加了 C2C4 石蜡的选择并且减少 CH4 的选择。与到钴催化剂的 Mn 的进一步的增加,然而, CH4 选择与 C5+ 选择的增加一起显然减少了。与 unpromoted 催化剂相比,支持 Mn 的钴催化剂增加了 C2C4/C20C40 臼齿的比率。 | Liping Tang Chengli Song Xiaolong Yang Mengli Li Bin Hu | 2013 | Chinese Journal of Chemistry2013，31，6： | 4 |
| 20 | Therapeutic siRNA:state of the art显示文摘RNA interference(RNAi)is an ancient biological mechanism used to defend against external invasion.It theoretically can silence any disease-related genes in a sequence-specific manner,making small interfering RNA(siRNA)a promising therapeutic modality.After a two-decade journey from its discovery,two approvals of siRNA therapeutics,ONPATTRO®(patisiran)and GIVLAARI™(givosiran),have been achieved by Alnylam Pharmaceuticals.Reviewing the long-term pharmaceutical history of human beings,siRNA therapy currently has set up an extraordinary milestone,as it has already changed and will continue to change the treatment and management of human diseases.It can be administered quarterly,even twice-yearly,to achieve therapeutic effects,which is not the case for small molecules and antibodies.The drug development process was extremely hard,aiming to surmount complex obstacles,such as how to efficiently and safely deliver siRNAs to desired tissues and cells and how to enhance the performance of siRNAs with respect to their activity,stability,specificity and potential off-target effects.In this review,the evolution of siRNA chemical modifications and their biomedical performance are comprehensively reviewed.All clinically explored and commercialized siRNA delivery platforms,including the GalNAc(N-acetylgalactosamine)–siRNA conjugate,and their fundamental design principles are thoroughly discussed.The latest progress in siRNA therapeutic development is also summarized.This review provides a comprehensive view and roadmap for general readers working in the field. | Bo Hu Liping Zhong Yuhua Weng Ling Peng Yuanyu Huang Yongxiang Zhao Xing-Jie Liang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
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