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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017，27，2： | 6 |
| 3 | Modified ZehnerSchlunder models for stagnant thermal conductivity of porous media 显示文摘 | Hsu C T Cheng P Wong K W | 1994 | Int J Heat Mass Transfer1994，37，17： | 2 |
| 4 | A lumped-parameter model for stagnant thermal conductivity of spatially periodic porous media 显示文摘 | Hsu C T Cheng P Wong K W | 1995 | J Heat Transfer1995，177，： | 2 |
| 5 | The study of supercritical carbon dioxide extraction for Ganoderma lucidum显示文摘 | Hsu R C Lin B H Chen C W | 2001 | Ind Eng Chem Res2001，40，： | 2 |
| 6 | Mineralization and biodegradability enhancement of low level p-nitrophenol in water using Fenton's reagent显示文摘 | Eakalak K Roger B W Hsu T M | 2005 | Journal of Environmental Engineering2005，131，2： | 1 |
| 7 | Sliding mode control for uncertain nonlinear systems with multiple inputs containing sector nonlinearities and deadzones 显示文摘 | Hsu K C Wang W Y Lin P Z | 2004 | IEEE Trans on Systems Man and Cybernetics-Part B: Cybernetics2004，34，1： | 1 |
| 8 | Effect of hydrostatic pressure on the molecular conformation of tilapia (Orechromis niloticus) myosin显示文摘 | KO W C JAO C L HSU K C | 2003 | Journal of Food Science2003，68，4： | 1 |
| 9 | 显示文摘 | Chen L C Hsu C Y Lan W H | 2003 | Solid-State Electronics2003，47，： | 1 |
| 10 | Micro--injection Molding with the Infrared Assisted Mold Heating System显示文摘 | Yu M C Young W B Hsu P M | 2007 | Material Science and Engineering A2007，，： | 1 |
| 11 | Formation oftitaninm silicides Ti5Si3 and TiSi2 by self-propagating combustion synthesis显示文摘 | YEH C L CHEN W H HSU C C | 2007 | J Alloy Compd2007，432，： | 1 |
| 12 | Genetic analysis of organ fusion in Arabidopsis thaliana显示文摘 | LOLLE S J HSU W PRUITT R E | 1998 | Genetics1998，149，2： | 1 |
| 13 | Design of large-sale time-delayed systems with dead-zone input via variable structure control显示文摘 | SHYU K K LIU W J HSU K C | 2005 | Automatica2005，41，7： | 1 |
| 14 | Characterizations and models for the thermal growth of a motorized high speed spindle 显示文摘 | Chen J S Hsu W Y | 2003 | International Journal of Machine Tools & Manufacture2003，，43： | 1 |
| 15 | Effects of homogenization treatment on recrystallization behavior and dispersoid distribution in an Al-Zn-Mg-Sc-Zr alloy显示文摘 | WU L M WANG W H HSU Y F | 2008 | Journal of Alloys and Compounds2008，456，12： | 1 |
| 16 | P6 aeupoint injec- tion reduce postoperative nausea and vomiting显示文摘 | Shyr M H Hsu J C Wu Y W Hui Y L Tan P P | 1990 | Ma Tsui Hsueh Tsa Chi Anaesthesiol Sinica1990，28，6： | 1 |
| 17 | A comparison of methods for multi-class support vector machines显示文摘 | HSU C W LIN C J | 2002 | IEEE Transactions on Neural Networks2002，13，2： | 1 |
| 18 | Differentially transcribed genes in skeletal muscle of Duroc and Taoyuan pigs显示文摘 | Lin C S Hsu C W | 2005 | Journal of Animal Sci- ence2005，83，9： | 1 |
| 19 | Accuracy enhancement of five-axis CNC machines through real-time error compensation显示文摘 | Lei W T Hsu Y Y | 2003 | International Journal of Machine Tools and Manufacture2003，43，9： | 1 |
| 20 | A comparison of methods for multi-class support vector machines 显示文摘 | Hsu C W Lin C J | 2002 | IEEE Transactions on Neural Networks2002，3，13： | 1 |
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