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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Classification of gastric neuroendocrine tumors and its clinicopathologic significance显示文摘ClassificationofgastricneuroendocrinetumorsanditsclinicopathologicsignificanceYUJiYao1,WANGLuPing2,MENGYuHong1,HUMeng1,WA... | Yu, JY Wang, LP Meng, YH Hu, M Wang, JL Bordi, C | 1998 | World Journal of Gastroenterology1998，4，2： | 5 |
| 3 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 4 | Effect of fiber pretreatment condition on the interfacial strength and mechanical properties of wood fiber/PP composites显示文摘 | Wu J S Yu D M Chan C M | 2000 | J Appl Polym Sci2000，76，7： | 2 |
| 5 | Durable Asphalt Pavements Are Self Healing显示文摘The traffic volume and the number of heavy vehicles are growing continuously. Considering the continuous traffic flow and the limited time available for road maintenance,it is very important to design a durable pavement system. Asphalt pavements with a healing capability are believed to be very useful since they can extend the pavement service life thanks to rest periods and hot summers. In order to design durable asphalt pavements,research in understanding and upgrading the self-healing capability of bituminous materials in time is of major importance. The self healing capability of bituminous mastic was evaluated in this research with a direct tension healing test. In the test program,different healing times,crack status and modifications were applied. The results indicate that elastic recovery and flow capacity are important factors for the self healing capability of bituminous materials at different crack phases as simulated with the direct tension test. | QIU J VAN DE VEN M F C WU S P YU J Y MOLENAAR A A A | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 6 | Properties of lead-free solder alloys with rare earth element additions显示文摘 | WU C M L YU D Q LAW C M T WANG L | 2004 | Materials Science and Engineering2004，44，1： | 2 |
| 7 | Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes显示文摘The term 'neurodevelopmental disorder' broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions. | MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 8 | Fine mapping of a C-terminal linear epitope highly conserved among the major envelope gly coprotein E2 (gpS1 to gp54) of different pestiviruses显示文摘 | Yu M Wang L F Shiell B J Morrissy C J Westbury H A | 1996 | Virology1996，222，： | 1 |
| 9 | Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest 显示文摘 | LU M KWAN T YU C | 2005 | J Biol Chem2005，280，8： | 1 |
| 10 | Faminial risk of hepatocelluarear cinoma among chronic hepatitis B carriers and their relatives显示文摘 | Yu M W Chang H C LiawYF | 2000 | J Natl Cancer Inst2000，92，14： | 1 |
| 11 | Micro--injection Molding with the Infrared Assisted Mold Heating System显示文摘 | Yu M C Young W B Hsu P M | 2007 | Material Science and Engineering A2007，，： | 1 |
| 12 | Uniform Metal Nanotube Arrays by Multistep Template Replication and Electrodeposition显示文摘 | Yu Y X Wang R M | 2004 | Adv Mater2004，16，17： | 1 |
| 13 | Polyamide thin film composite membrane prepared from m-phenylenediamine and m-phenylenediamine-5-sulfonic acid 显示文摘 | Zhou Y Yu S C Liu M H | 2006 | Journal of Membrane Science2006，270，12： | 1 |
| 14 | The relationship between coronary ar tery disease and abnormal glucose regulation in China: the China Heart Survey显示文摘 | Hu D Y Pan C Y Yu J M | 2006 | Eur Heart J2006，27，21： | 1 |
| 15 | Effect of iron on the gasification of Victorian brown coal with steam: enhancement of hydrogen production显示文摘 | Yu J Tian F Chow M C | 2006 | Fuel2006，85，2： | 1 |
| 16 | Productivity growth of Taiwan's major domestic airports in the presence of aircraft noise 显示文摘 | Yu M M Hsu S H Chang C C and Lee D H | 2008 | Transportation Research Part E2008，44，3： | 1 |
| 17 | Research on the additional stress and deformation in the soil of compo-site pile foundation under vertically uniform loads显示文摘 | Yu C Za J M Liu S Y | 2005 | Advances in Deep Foundations(GSP132)2005，，157： | 1 |
| 18 | Degradation of azo dye procion red by photocatalytic oxidation 显示文摘 | So C Cheng M Yu J | 2002 | Chemosphere2002，46，6： | 1 |
| 19 | A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging 显示文摘 | YU C M ZHANG Q FUNG J W | 2005 | J Am Coll Cardiol2005，45，5： | 1 |
| 20 | Effects of sand burial on the survival, growth and biomass allocation in semi-shrub Hedysarum lacre seedlings显示文摘 | Zhang C Y Yu F H Dong M | 2002 | Acta Bat Sin2002，44，3： | 1 |
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