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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model显示文摘Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors(SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescribed antidepressants, the potential of SSRIs to impair bone healing may adversely affect millions of patients' ability to heal after sustaining trauma. Here, we investigate the effect of the SSRI sertraline on bone healing through pre-treatment with(10 mg·kg^(-1) sertraline in drinking water, n = 26) or without(control, n = 30) SSRI followed by the creation of a 5-mm calvarial defect. Animals were randomized into three surgical groups:(a) empty/sham,(b) implanted with a DermaMatrix scaffold soak-loaded with sterile PBS or(c) DermaMatrix soak-loaded with542.5 ng BMP2. SSRI exposure continued until sacrifice in the exposed groups at 4 weeks after surgery. Sertraline exposure resulted in decreased bone healing with significant decreases in trabecular thickness, trabecular number and osteoclast dysfunction while significantly increasing mature collagen fiber formation. These findings indicate that sertraline exposure can impair bone wound healing through disruption of bone repair and regeneration while promoting or defaulting to scar formation within the defect site. | R.Nicole Howie Samuel Herberg Emily Durham Zachary Grey Grace Bennfors Mohammed Elsalanty Amanda C.LaRue William D.Hill James J.Cray | 2018 | International Journal of Oral Science2018，10，4： | 5 |
| 3 | 怀孕母猪的高纤维日粮可增加经济效益显示文摘一项经济分析显示,怀孕母猪饲喂高纤维日粮,每头110天饲养成本比饲喂玉米大豆日粮高3.3美元。但是,采食高纤维日粮的母猪的每窝断奶仔猪数较高,经济收益超过饲养成本的增加。 | 孙占田 刘志敏 Michael Howie | 1999 | 国外畜牧学(饲料)1999，，4： | 3 |
| 4 | Papillomavirus E6 proteins显示文摘 | Heather L. Howie Rachel A. Katzenellenbogen Denise A. Galloway | 2008 | Virology2008，，2： | 2 |
| 5 | 碱化处理可提高谷物的营养价值显示文摘碱化处理可提高谷物的营养价值MichaelHowie著张倩摘译王加启校用氢氧化钠处理谷物可以达到提高产奶量和乳蛋白含量、减少瘤胃酸中毒和继发性蹄炎的目的。碱化处理不是一个新概念,美国和苏格兰早就开始了此项研究。80年代中期英国部分地区开始使用此项技术... | Michael Howie 张倩 | 1998 | 国外畜牧科技1998，25，3： | 2 |
| 6 | The Hedgehog Signalling Pathway in the Gastrointestinal Tract: Implications for Development, Homeostasis, and Disease显示文摘 | Charlie Lees Sarah Howie R. Balfour Sartor Jack Satsangi | 2005 | Gastroenterology2005，，5： | 2 |
| 7 | The role of megalin(LRP-2/GP330) during development显示文摘 | Fisher CE Howie SE | 2006 | Dev Biol2006，296，2： | 1 |
| 8 | Maternal Nutritional History Predicts Obesity in Adult Offspring Independent of Postnatal Diet 显示文摘 | Howie GJ Slobeda DM Kamal T | 2009 | J Physiol2009，587，4： | 1 |
| 9 | Psychopathology in female juvenile offenders显示文摘 | Dixon A Howie P Starling J | 2004 | J Child Psychol Psychiatry2004，45，6： | 1 |
| 10 | Idempotent Generators in Finite Full Transformation Semigroups显示文摘 | Howie J M | | 0，，： | 1 |
| 11 | Finite element modelling of the pelvis:inclusion of muscular and ligamentous boundary conditions显示文摘 | Phillips AT Pankaj P Howie CR | 2007 | Med Eng Phys2007，29，7： | 1 |
| 12 | Behaviour in children with neurofibromatosis type 1: cognition, executive function, attention, emotion, and social competence显示文摘 | Lehtonen A Howie E Trump D | 2013 | Dev Med Child Neurol2013，55，2： | 1 |
| 13 | Primary human osteoblasts grow into porous tantalum and maintain an osteoblastic phenotype显示文摘 | Welldon KJ Atkins GJ Howie DW | 2008 | J Biomed Mater Res A2008，84，3： | 1 |
| 14 | Idempotent Rank in Finite Full Transformation Semigroups显示文摘 | Howie J M McFadden R B | | 0，，： | 1 |
| 15 | Extrathymic T cell differentiation in the human intestine early in life显示文摘 | Howie D Spencer J Delord D | 1998 | J Immunol1998，161，11： | 1 |
| 16 | On factorisations and generators in transformation semigroup显示文摘 | AYIK GtAYIK H HOWIE J M | 2005 | Semigroup Forum2005，70，2： | 1 |
| 17 | Ameasure of perceived health in evaluationg general practice:the Nottingham Health rofile显示文摘 | PORTER AM HOWIE JG | 1991 | Fam Pract1991，8，3： | 1 |
| 18 | Microstructure of poly (vinyl alcohol) hydrogels produced by freeze/thaw cycling 显示文摘 | Willcox P J Howie D W Schmidt-Rohr K et ol | 1999 | J Polym Sci Part B: Polym Phys1999，37，24： | 1 |
| 19 | Treatment of humeral shaft fractures with the Seidel intramedullary nail显示文摘 | Bain Gi Sandow Mj Howie DW | 1996 | J Surg1996，66，： | 1 |
| 20 | Purification of acidic glutathione S-transferases from human lung, placenta and erythrocyte and the development of a specific radioimmunoassay for their measurement显示文摘 | Howie AF Hayes JD Beckett GJ | 1988 | Clin Chim Acta1988，177，： | 1 |
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