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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | 心血管疾病病死率与血清25-羟基维生素D浓度相关性研究显示文摘目的研究心衰死亡、心血管疾病死亡和过早死亡与血清25-羟基维生素D[25(OH)D]浓度的相关性。方法在第3次美国健康和营养调查中,1988~1994年为基线数据,纳入35岁以上参与者13 131名(男性6130名,女性7 001名),随访至2000年12月31日。结果随访8年期间,共有3 266人死亡(24.9%),其中心衰死亡101人,心血管疾病死亡1 451人,早死1 066人。心衰死亡者中有37%血清25(OH)D水平低于20ng/mL,非心衰死亡者为26%(P<0.001)。多元Cox模型显示,血清25(OH)D水平低于20ng/mL的心衰死亡风险是超过30ng/mL的2.06倍(95%CI:1.01~4.25)(P<0.001),过早死亡风险为1.40倍(95%CI:1.17~1.68;P<0.001);血清25(OH)D浓度20~29ng/mL的过早死亡风险是超过30ng/mL的1.11倍(95%CI:0.93~1.33)。结论血清25(OH)D水平不足的成年人死于心血管病、心衰和过早死亡的风险较高。 | 刘隆健 魏敏 陈明 Shelley R Hankins Ana E.Nùez Robert A Watson Perry J Weinstock Craig J.Newschaffer Howard J Eisen 邹强 杨书 陈卫中 | 2013 | 成都医学院学报2013，8，2： | 6 |
| 3 | phenomena of scintillation noise in radar-tracking system显示文摘 | Dunn J H Howard D D king A M | 1959 | Proceedings of IRE1959，47，5： | 1 |
| 4 | Chronic sub-clinical inflammation as part of the insulin resistance syn-drome:the insulin restance atherosclerosis study(IRSA)显示文摘 | Festa A D Agostion R J R Howard G | 2000 | Circulation2000，102，： | 1 |
| 5 | Identification of solar sources of major geomagnetic storms between 1996 and 2000显示文摘 | Zhang J Dere K P Howard R A | 2003 | Astrophysical Jouranal2003，582，1： | 1 |
| 6 | Direct observation of behaviour of Au nanoclusters on TiO2(110) at elevated temperatures显示文摘 | MITCHELL C E J HOWARD A CARGEN M EGDLL R G | 2001 | Surface Science2001，490，： | 1 |
| 7 | Sand transport model of barchan dune equilibrium显示文摘 | Howard A D Morton J B Gad-el-Hak M | 1978 | Sedimentology1978，25，： | 1 |
| 8 | Research strategies for safety evaluation of nanomaterials, Part IV : Risk assessment of nanopartlcles显示文摘 | TSUJI J S MAYNARD A D HOWARD C P | 2006 | Toxicological Sciences2006，89，1： | 1 |
| 9 | The prevalence of amtibiotic resistance in Haremophilus in fluenzae in wales显示文摘 | HOWARD A J WILLMAS H M | 1988 | Antimicrob Chemother1988，21，： | 1 |
| 10 | Improvement in survival and clinical benefit with gemeltabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial 显示文摘 | Howard A Burriz III Malcolm J | 1997 | J Clin Oneol1997，15，： | 1 |
| 11 | Clinical application of vorieonazole concentrations in the treatment of invasive aspergillosis显示文摘 | HOWARD A HOFFMAN J SHETH A | 2008 | Ann Pharmacother2008，42，12： | 1 |
| 12 | Use of organic carbon and loss - on - ignition to estimate soil organic matter in different soil types and horizons显示文摘 | Howard P J A Howard D M | 1990 | Biology and Fertility of soils1990，9，： | 1 |
| 13 | Early diagenetic re-crystallization of Holocene (<3000 years old) peritidal dolo-mites ? Ambergris Cay, Belize显示文摘 | Gregg J M Howard S A Mazzullo S J | 1992 | Sedimentology?1992，39，1： | 1 |
| 14 | Estradiol and tamoxifen stimulate LAM-assoeiated angiomyolipoma cell growtb and activate both genomic and nongenomic signaling pathways 显示文摘 | Yu J Astrinidis A Howard S | 2004 | Am J Physiol Lung Cell Mol Physiol2004，286，： | 1 |
| 15 | Leptin prevents the fall in plasma osteocalcin during starvation in male mice显示文摘 | Goldstone A P Howard J K Lord G M | 2002 | Biochem Biophys Res Commun2002，295，2： | 1 |
| 16 | Overproduction of recombinant proteins in plants显示文摘 | EGELKROUT E RAJAN V HOWARD J A | 2012 | Plant Sci2012，184，3： | 1 |
| 17 | Gsx2 eontruls region- specific aetivatiml of neural stem cells and injmT-imluced neurogenesis in the aduh subventrieular zone显示文摘 | L6pez-Juarez A Howard J Ulhan K | 2013 | Gem-s Dev2013，27，11： | 1 |
| 18 | Growth characteristics of the human nasal septum 显示文摘 | Van Loosen J Van Zanten G A Howard C V | 1996 | Rhinology1996，34，2： | 1 |
| 19 | Ziprasidone : a novel antipsychotic agent with a unique human receptor binding profile显示文摘 | SCHMIDT A W LEBEL L A HOWARD H R J R | 2001 | Eur J Pharmacol2001，425，3： | 1 |
| 20 | The Arabidopsis ribonuclease gene RNS1 is tightly controlled in response to phosphate limitation显示文摘 | BARIOLA P A HOWARD C J TAYLOR C B | 1994 | The Plant Journal1994，6，5： | 1 |
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