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| 1 | Current and future applications of in vitro magnetic resonance spectroscopy in hepatobiliary disease显示文摘原子磁性的回声光谱学允许细胞的生物化学和新陈代谢的学习,在整个身体在活体内并且在更高的磁场力量在试管内。因为这种技术非侵略、非选择,磁性的回声光谱学方法论广泛地在生物化学和药被使用了。房间,身体液体和纸巾的在试管内磁性的回声光谱学研究在医药生物化学被使用了调查 pathophysiological 过程,更最近,这种技术被医生使用了决定疾病畸形在活体内。这个加亮的话题说明在试管内的潜力在学习肝胆管系统的磁性的回声光谱学。在恶意、非恶意的肝疾病和胆汁作文的学习的磁性的回声光谱学学习的在试管内质子和磷的角色被讨论,特别地与关联词在活体内的参考整个身体的磁性的回声光谱学应用。在摘要,磁性的回声光谱学技术能在到内在的 pathophysiological 过程的疾病严厉和指针上提供非侵略的生物化学的信息。磁性的回声光谱学为疾病简历标记,以及估计的治疗学的反应作为一个屏蔽工具保持潜在的诺言。 | I Jane Cox Amar Sharif Jeremy FL Cobbold Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，30： | 10 |
| 2 | Ultraviolet A Enhances Cathepsin L Expression and Activity via JNK Pathway in Human Dermal Fibroblasts显示文摘 | Qing-Fang Xu Yue Zheng Jian Chen Xin-Ya Xu Zi-Jian Gong Yun-Fen Huang Chun Lu Howard I Maibach Wei Lai | 2016 | Chinese Medical Journal2016，，23： | 3 |
| 3 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 4 | Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature显示文摘Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals,including solid organ transplant recipients,but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy,and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis,and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis. | Shugo Mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 5 | Improved Technique for the Routine Determination of Tritiated Water in Aqueous Samples显示文摘 | Warwick P E Croudace I W Howard A G | 1999 | Anal Chim Acta1999，382，： | 2 |
| 6 | An examination of methods of assessing interacting surface cracks by comparison with experimental data显示文摘 | Leek T H Howard I C | 1996 | Int J Pres & Piping1996，68，： | 1 |
| 7 | The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in typel diabetes显示文摘 | B C Bergman D Howard I E Schauer | 2013 | Journal of Clinical Endocrinology&Metabolism2013，98，1： | 1 |
| 8 | The effects of complexation with hydrogenated phos-pholipid on the transport of salicylic acid, diclofenac andindomethacin across snake stratum comeum 显示文摘 | BHATTACHAR S N HOWARD R J TOMOO I | 1992 | Int J Pharm1992，79，： | 1 |
| 9 | Structure and binding in small neutral and cationic boron cluster 显示文摘 | RAY A K HOWARD I A KANAL K M | 1992 | Phys Rev B1992，45，14： | 1 |
| 10 | Computer simulation of the impact performance of a wire rope safety fence显示文摘 | Bateman M B Howard I C Johnson A R | | 0，，1： | 1 |
| 11 | Skin aging: effect on transepidermal water loss, stratum corneum hydration, skin surface pH, and casual sebum content 显示文摘 | Wilhelm Klaus-P Cua Anastasia B Maibach Howard I | 1991 | Archives of dermatology1991，127，12： | 1 |
| 12 | Finite element analysis of high contact ratio spur gears in mesh显示文摘 | WANG Jiande Howard I | 2003 | Journal of Tdbology2003，127，： | 1 |
| 13 | Sorption Isotherm-Sequential Extraction Analysis of Heavy Metal Retention in Landfill Liners显示文摘 | SALIM I A MILLER C J HOWARD J L | 1996 | Soil Science Society of America Journal1996，60，1： | 1 |
| 14 | Lumboperitoneal shunts 显示文摘 | Howard M Eisenberg Robin I | 1994 | Neurosurg1994，35，10： | 1 |
| 15 | Development and validation of a finite element model for hotrolling using ABAQUS/STANDARD显示文摘 | MUKHOPADHYAY A HOWARD I C SELLARS C M | 2004 | Materials Scienceand Technology2004，20，： | 1 |
| 16 | Measurement and prediction of doformation in plane strain compression tests of AA5182显示文摘 | Boldetti C Pinna C Howard I C | 2006 | Materials Science and Technology2006，22，11： | 1 |
| 17 | Finite dement analysis of non - local effects in ductile fracture 显示文摘 | HOWARD I C Li Z H | 2000 | Fatigue & Fracture of Engineering Materials & Structures2000，23，10： | 1 |
| 18 | Glyeine transporter GLYT1 is essential for glycine-mediated protection of human intestinal epithelial cells against oxidative damage 显示文摘 | Howard A Tahir I Javed S | 2010 | J Physiol2010，588，6： | 1 |
| 19 | A Comparison of Eleven Static Heuristics for Mapping a Class of Independent Tasks onto Heterogeneous Distributed Computing Systems显示文摘 | Tracy D Braun Howard Jay Siegel Noah Beck Ladislau L B?l?ni Muthucumaru Maheswaran Albert I Reuther James P Robertson Mitchell D Theys Bin Yao Debra Hensgen Richard F Freund | 2001 | Journal of Parallel and Distributed Computing2001，，6： | 1 |
| 20 | Functional characterization of ERplS, a new endoplasmic reticulum-located thioredoxin superfamily member显示文摘 | Alanen H I Williamson R A Howard M J | 2003 | J Biol Chem2003，278，28： | 1 |
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