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| 1 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | Chestnut and hazel propagation by leafy summer euttings显示文摘 | Ponehia G Howard B H | 1988 | Aeta Hortieulturae1988，227，： | 1 |
| 4 | The apparent, of polyphenol oxidase and phloridzin in the production of apple rooting cofactors显示文摘 | Bassuk N L Hunter L D Howard B H | 1981 | J Hort Sci1981，56，4： | 1 |
| 5 | Wound healing dressings and drug delivery systems: A review显示文摘 | Joshua S B Kerr H M Howard N E S | 2008 | J Pharma- ceutical Sci2008，97，8： | 1 |
| 6 | Formation of polycyclic arom atic hydrocarbons and their growth to soot: A review of chemical reaction pathways显示文摘 | Richter H Howard J B | 2000 | Progress in Energy and Combustion Science2000，26，46： | 1 |
| 7 | Methanol conversion for the production of hydrogen 显示文摘 | Taylor C E Howard B H Myers C R | 2007 | Industrial & Engineering Chemistry Research2007，，： | 1 |
| 8 | Irradiated nude rat model for orthotopic human lung cancers显示文摘 | Howard R Chu H Zeligman B | 1991 | Cancer research1991，51，12： | 1 |
| 9 | Rapid Devolatilization and Hydrogasification of Bimmlnous Coal 显示文摘 | Anthony D B Howard J B Hottel H C | 1976 | Fuel1976，55，2： | 1 |
| 10 | The apparent of polyphenol oxidase and phlorizin in the production of apple rooting factors显示文摘 | Bassuk N L Hunter L D Howard B H | 1981 | J Hort Sci1981，56，4： | 1 |
| 11 | Formation of polycyclic aromatic hydrocarbons and their growth to soot-A review of chemical reaction pathways显示文摘 | RICHTER H HOWARD J B | 2000 | Progress in Energy and Combustion Science2000，26，456： | 1 |
| 12 | Fish kills linked to a toxic ambushpredator dinoflagellate:distribution and environmental conditions显示文摘 | Burkholder J M Howard B G Jr Cecil W H | 1995 | Mar Ecol Prog Set1995，124，： | 1 |
| 13 | Diabetes and cardiovascular disease显示文摘 | Resnick H E Howard B V | 2002 | Annu Rev Med2002，53，2： | 1 |
| 14 | Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency:support for an endothelium-dependent mechanism显示文摘 | CARR A N HOWARD B W YANG H T | 2006 | Cardiouasc Res2006，69，4： | 1 |
| 15 | Acquiring design knowledge through design decision justification 显示文摘 | Garcia A C B Howard H C | 1992 | Artificial Intelligence for Engineering Design Analysis and Manufacturing1992，6，1： | 1 |
| 16 | Evaluation of Oil Produced from the Microwave Retorting of Australian Shales显示文摘 | Douglas H B Howard K W | 1996 | Fuel1996，75，3： | 1 |
| 17 | Formation of polycyclic aromatic hydrocarbons and their growth to soot-A review of chemical reaction pathways显示文摘 | RICHTER H HOWARD J B | 2000 | Progress in Energy and Combustion Science2000，26，： | 1 |
| 18 | Efficacy of systemic administration ofSDF - 1 in a model of vascular insufficiency : support for an endothelium- dependentmechanism 显示文摘 | Carr A N Howard B W Yang H T | 2006 | Cardiovasc Res2006，69，4： | 1 |
| 19 | Expression of the peptide transporter hPepT1 in human colon:a potential route for colonic protein nitrogen and drug absorption 显示文摘 | Ford D Howard A Hirst B H | 2003 | Histochem Cell Biol2003，119，1： | 1 |
| 20 | Experimental and computational prediction of the hydrogen transport prop- erties of Pd4 S 显示文摘 | Morreale B D Howard B H Iyoha O | 2001 | Ind Eng Chem Res2001，46，： | 1 |
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