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| 1 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 2 | Geochemistry of oils and condensates, K Field, offshore Taiwan: a case study in migration fractiona显示文摘 | Dzou L I P Houghes W B | 1993 | Organic Geochemistry1993，20，： | 1 |
| 3 | Isolation of cDNA encoding a newly identified major allergenic protein of rye-grass poUen显示文摘 | Singh MB Hough T Theerakulpisut P | 1991 | Proc Natl Acad Sci USA1991，88，4： | 1 |
| 4 | 3-monochloropropane-1,2-diol (3-MCPD) in soy sauces and similar products available from retail outlets in the UK 显示文摘 | Macarthur R Crews C Davies A Brereton P Hough P Harvey D | 2000 | Food Additives and Contaminants2000，17，11： | 1 |
| 5 | Middle ear electromagnetic semi - implantable hearing device : resuhs of the phase II SOUNDTEC direct system clinical trial 显示文摘 | Hough J V Matthews P Wood M W | 2002 | Otol Neurotol2002，23，6： | 1 |
| 6 | The preparation of 4,6- dichloro-4,6-deoxy-6'-chlorodeoxy -fl-D-galactose sucrose and the conversion of chlorinated derivation into anhydrides显示文摘 | HOUGH L PHADNIS S P TARELLI E | 1975 | Carbohydrate Research1975，44，1： | 1 |
| 7 | Mapping of CD24 and homologous sequences to multiple chromosomal loci显示文摘 | ROSTEN P M SEXTON T L | 1994 | Genomics1994，22，1： | 1 |
| 8 | Survey of 3- monochloropropane- 1,2-diol (3-MCPD) in selected food groups, 1999 - 2000显示文摘 | CREWS C HOUGH P BRERETON P | 2002 | Food Addit Contam2002，19，1： | 1 |
| 9 | Differentiation of mouse embryonic stem cells after RNA interference-mediated silencing of OCT4 and Nanog显示文摘 | Hough S R Clements I Welch P J | 2006 | Stem Cells2006，24，： | 1 |
| 10 | Methode and means for recognizing complex patterns 显示文摘 | Hough P V C | 1962 | United States Patent1962，，12： | 1 |
| 11 | Method and means for recognizing complex patterns显示文摘 | Hough P V C | 1962 | Patent1962，30，1： | 1 |
| 12 | Derivatives of 13 - D - frucbfuranosyl a - D - galactopyranoside 显示文摘 | Fairc bugh P H Hough L Richardson A C | 1975 | Carbohydrate Rsereh1975，，： | 1 |
| 13 | Quantitation of the main constituents of some authentic grape - seed oils of different origin 显示文摘 | CREWS C HOUGH P GODWARD J | 2006 | Journal of Agricultural and Food Chemistry2006，54，17： | 1 |
| 14 | Study of the main constituents of some authentic walnut oils 显示文摘 | Crews C Hough P Godward J | 2005 | Journal of Agricultural and Food Chemistry2005，53，12： | 1 |
| 15 | Phase Transitions and Functionality of Enzymes and Yeasts in Dehydrated Matrices显示文摘 | Mazzobre M F Hough G and Buera M P | 2003 | Food Science and Technology Intemafional2003，6，9： | 1 |
| 16 | Differentiation of mouse embryonic stem cells after RNA interference-mediated silencing of Oct-4 and Nanog 显示文摘 | HOUGH S R CLEMENTS I WELCH P J | 2006 | Stem Cells2006，24，： | 1 |
| 17 | Survey of 3-monochloropropane-1, 2-diol (3-MCPD) in selected food groups, 1999- 2000 显示文摘 | Crews C Hough P Brereton P | 2002 | Food Addit Contain2002，19，1： | 1 |
| 18 | Survey of 3-monochloropropane- 1,2-diol ( 3-MCPD ) in selected food groups, 1999-2000 显示文摘 | Crews C Hough P Brereton P | 2002 | Food Addit Contam2002，19，1： | 1 |
| 19 | Differentiation of mouse embryonic stem cells after RNA silencing of OCT4 and Nanog 显示文摘 | Hough S R Clements I Welch P J and Wiederholt K A | 2006 | Stem Cells2006，24，： | 1 |
| 20 | Study of the main constituents of some authentic walnut oils显示文摘 | Crews C Hough P Godward J | 2005 | Journal of Agricultural and Food Chemistry2005，53，12： | 1 |
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