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| 1 | Brain-derived neurotropic factor and GABAergic transmission in neurodegeneration and neuroregeneration显示文摘Neurotoxicity induced by stress,radiation,chemicals,or metabolic diseases,is commonly associated with excitotoxicity,oxidative stress,and neuroinflammation.The pathological process of neurotoxicity induces neuronal death,interrupts synaptic plasticity in the brain,and is similar to that of diverse neurodegenerative diseases.Animal models of neurotoxicity have revealed that clinical symptoms and brain lesions can recover over time via neuroregenerative processes.Specifically,brain-derived neurotropic factor(BDNF) and gamma-aminobutyric acid(GABA)-ergic transmission are related to both neurodegeneration and neuroregeneration.This review summarizes the accumulating evidences that suggest a pathogenic role of BDNF and GABAergic transmission,their underlying mechanisms,and the relationship between BDNF and GABA in neurodegeneration and neuroregeneration.This review will provide a comprehensive overview of the underlying mechanisms of neuroregeneration that may help in developing potential strategies for pharmacotherapeutic approaches to treat neurotoxicity and neurodegenerative disease. | Jinwook Kim Sueun Lee Sohi Kang Sung-Ho Kim Jong-Choon Kim Miyoung Yang Changjong Moon | 2017 | Neural Regeneration Research2017，12，10： | 8 |
| 2 | Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression显示文摘Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages.To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation.Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation.We also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor.Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.Sodium butyrate pretreatment reversed these changes.These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval No.KIRAMS16-0002)on December 30,2016. | Hae June Lee Yeonghoon Son Minyoung Lee Changjong Moon Sung Ho Kim In Sik Shin Miyoung Yang Sangwoo Bae Joong Sun Kim | 2019 | Neural Regeneration Research2019，14，9： | 7 |
| 3 | Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial显示文摘 | Yi-Long Wu Caicun Zhou Cheng-Ping Hu Jifeng Feng Shun Lu Yunchao Huang Wei Li Mei Hou Jian Hua Shi Kye Young Lee Chong-Rui Xu Dan Massey Miyoung Kim Yang Shi Sarayut L Geater | 2014 | Lancet Oncology2014，，2： | 3 |
| 4 | Anti-inflammatory Effects of Sanguisorbae Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice显示文摘Objective:To investigate the anti-inflammatory effects of Sanguisorbae Radix on contact dermatitis(CD).Methods:Mice were sensitized by painting 30μL of 1-fluoro-2,4-dinitrofluorobenzene(DNFB)onto each ear for 3 days.Four days later,mice were challenged by painting with 50μL of DNFB onto the shaved dorsum every 2 days.Sanguisorbae Radix methanol extract(MESR)was applied onto the shaved dorsum every 2 days.The effects of MESR on skin thickness,skin weights,histopathological changes,skin lesions and cytokine production in DNFB-induced CD mice were investigated,as well as its effects on body weights and spleen/body weight ratio.Results:Topical application of MESR effectively inhibited enlargement of skin thickness and weight(P<0.05).MESR treatment also inhibited hyperplasia,spongiosis and immune cell infiltration induced by DNFB in inflamed tissues and improved lesions on dorsum skin in CD mice.Moreover,treatment with MESR suppressed the increase in the levels of tumor necrosis factor α(TNF-α,P<0.01)and interferonγ(IFN-γ,P<0.05),respectively.Finally,MESR had no effect on body weight gain or spleen/body weight ratio.Conclusion:These data suggest that MESR acts as an anti-inflammatory agent that decreases the production of TNF-α and IFN-γ,resulting in reductions of skin lesions and histopathological changes in inflamed skin tissues. | Suzy Jo Junghyun Ryu Hanna Kim Miyoung Kim Mi Heon Ryu Hyungwoo Kim Su-ln Cho | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 2 |
| 5 | Arabidopsis SAP5 functions as a positive regulator of stress responses and exhibits E3 ubiquitin ligase activity显示文摘 | Miyoung K Mohamed F Haggag A | | 0，，： | 1 |
| 6 | Formation of hydroxyapa- Lite within porous TiO2 layer by micro - arc oxidation coupled with eleetrophoretie deposition显示文摘 | Dong - Yoon Kim Miyoung Kim Hyoun - Ee Kim Young - Hag Koh Hae - Won Kim Jun - Hyeog Jang | 2009 | Aeta Biomaterialia2009，5，： | 1 |
| 7 | Measuring Experience Economy Concepts:Tourism Applications显示文摘 | Haemoon Oh Ann Marie Fiore Miyoung Jeoung | 2007 | Journal of Travel Research2007，，11： | 1 |
| 8 | Understanding travelers' adoption of hotel reservation web sites 显示文摘 | Cristian Morosan Miyoung Jeong | 2006 | Information and Communication Technologies in Tourism2006，80，10： | 1 |
| 9 | ChIP-Seq:A method for global identification of regulatory elements in the genome显示文摘 | Debasish R Miyoung H Michael S | 2010 | Curr Protocols Mol Biol2010，21，： | 1 |
| 10 | Estab- lishment of a routine model for radiation-induced bone loss using micro-computed tomography in adult C3H/HeN mice 显示文摘 | Jin-Hee Lee Hae-June Lee Miyoung Yang | 2013 | LabAnimRes2013，29，1： | 1 |
| 11 | Achieving Excellence in Teacher Workforee and Equity in Learning Opportunities in South Korea显示文摘 | NAM-HWA KANG MIYOUNG HONG AKIBA LETENDRE | 2008 | Educational Researcher2008，7，4： | 1 |
| 12 | A Signature-Based Data Security Technique for Energy-Efficient Data Aggregation in Wireless Sensor Networks显示文摘 | Min Yoon Miyoung Jang Hyeong-II Kim | 2014 | International Journal of Distributed Sensor Networks2014，2014，： | 1 |
| 13 | Characteristic finite element methods for diffusion epidemic models withage-structured populations显示文摘 | KIM Miyoung PARK Eunjae | 1981 | Ann Mat Pura Appl1981，97，： | 1 |
| 14 | Developing a wetland type classification system in the Republic of Korea 显示文摘 | Kim Kwigon Park Miyoung Choi Heesun | 2006 | Landscape and Ecological Engineering2006，，2： | 1 |
| 15 | The Brain Activity Map Project and the Challenge of Functional Connectomics显示文摘 | A. Paul Alivisatos Miyoung Chun George M. Church Ralph J. Greenspan Michael L. Roukes Rafael Yuste | 2012 | Neuron2012，，6： | 1 |
| 16 | Factors affecting the self-directed learning of students at clinical practice course for advanced practice nurse显示文摘 | Miyoung K Seong Y P | 2011 | Asian Nursing Research2011，5，1： | 1 |
| 17 | Measuring Experience Economy Concepts:Tourism Applications显示文摘 | Ann Marie Fiore Miyoung Jeoung | 2007 | Journal of Travel Research2007，46，： | 1 |
| 18 | Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial显示文摘 | Yi-Long Wu Caicun Zhou Cheng-Ping Hu Jifeng Feng Shun Lu Yunchao Huang Wei Li Mei Hou Jian Hua Shi Kye Young Lee Chong-Rui Xu Dan Massey Miyoung Kim Yang Shi Sarayut L Geater | 2014 | Lancet Oncology2014，，2： | 1 |
| 19 | Reliability and validity of the korean version of belongingness scale-clinical placement experience (BS-CPE)显示文摘 | Miyoung K Dukyoo J | 2012 | Asian Nursing Research2012，6，4： | 1 |
| 20 | Measuring Experience Economy Concepts : Tourism Applications 显示文摘 | Haemoon Oh Ann Marie Fiore Miyoung Jeoung | 2007 | Journal of Travel Research2007，，46： | 1 |
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