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| 1 | Radiation therapy for portal venous invasion by hepatocellular carcinoma显示文摘AIM: To clarify the efficacy and safety of three-dimensional conformal radiotherapy (3-D CRT) for this disease and to specify patient subgroups suitable for this treatment.METHODS: Fifty-two patients with HCC received PVI-targeted radiation therapy from January 1995 through December 2003. Portal venous invasion (PVI) was found in the second or lower order branches of the portal vein in 6 patients, in the first branch in 24 patients and in the main trunk in 22 patients. Child classifications of liver function before radiation therapy were A, B, and C for 19, 24 and 2 patients, respectively. All patients received three-dimensional conformal radiotherapy with a total dose ranging from 39 to 60 Gy (57.0 Gy in average).RESULTS: Overall survival rates at 1, 2, 3, 4, and 5 years were 45.1%, 25.3%, 15.2%, 10.1%, and 5.1%, respectively. Univariate analysis revealed that Child status, the number of tumor foci, tumor type,transcatheter arterial embolization (TAE) after radiation therapy were statistically significant prognostic factors.Multivariate analysis showed that the number of tumor foci and TAE after radiation therapy were statistically significant.CONCLUSION: The results of this study strongly suggest the efficacy of 3-D CRT as treatment for PVI in HCC. 3-D CRT is recommended in combination with postradiation TAE for PVI of HCC with 5 tumor foci or less in the liver and with Child A liver function. | Keiichi Nakagawa Hideomi Yamashita Kenshiro Shiraishi Naoki Nakamura Masao Tago Hiroshi Igaki Yoshio Hosoi Shuichiro Shiina Masao Omata Masatoshi Makuuchi Kuni Ohtomo | 2005 | World Journal of Gastroenterology2005，11，46： | 14 |
| 2 | Prevention of esophageal strictures after endoscopic submucosal dissection显示文摘Endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) have recently been accepted as less invasive methods for treating patients with early esophageal cancers such as squamous cell carcinoma and dysplasia of Barrett's esophagus.However,the large defects in the esophageal mucosa often cause severe esophageal strictures,which dramatically reduce the patient's quality of life.Although preventive endoscopic balloon dilatation can reduce dysphagia and the frequency of dilatation,other approaches are necessary to prevent esophageal strictures after ESD.This review describes several strategies for preventing esophageal strictures after ESD,with a particular focus on anti-inflammatory and tissue engineering approaches.The local injection of triamcinolone acetonide and other systemic steroid therapies are frequently used to prevent esophageal strictures after ESD.Tissue engineering approaches for preventing esophageal strictures have recently been applied in basic research studies.Scaffolds with temporary stents have been applied in five cases,and this technique has been shown to be safe and is anticipated to prevent esophageal strictures.Fabricated autologous oral mucosal epithelial cell sheets to cover the defective mucosa similarly to how commercially available skin products fabricated from epidermal cells are used for skin defects or in cases of intractable ulcers.Fabricated autologous oralmucosal-epithelial cell sheets have already been shown to be safe. | Shinichiro Kobayashi Nobuo Kanai Takeshi Ohki Ryo Takagi Naoyuki Yamaguchi Hajime Isomoto Yoshiyuki Kasai Takahiro Hosoi Kazuhiko Nakao Susumu Eguchi Masakazu Yamamoto Masayuki Yamato Teruo Okano | 2014 | World Journal of Gastroenterology2014，20，41： | 12 |
| 3 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 4 | Detection of human osteosarcoma associated antigen ( s ) by monoclonal antibodies 显示文摘 | Hosoi S Nakamura T Higashi S | 1982 | Cancer Res1982，42，： | 4 |
| 5 | Ca^(2+)及cAMP调控的神经递质与激素释放显示文摘神经递质和激素的释放受胞内诸多信号通路的调控。这两种内源物质的释放都由依赖于Ca2+浓度的快速引发机制介导,相对于其他介导因素,[Ca2+]占主导地位。神经递质和激素释放的调控大多是通过调节释放小泡数量实现的。尽管在处于静息状态的神经末梢中,释放小泡的数量相对恒定,但当释放小泡被胞吐作用“消耗”后,其再生速度受调控作用介导而发生改变,从而导致小泡数量“稳中有变”的动态调控过程。这一动态调控作用表明了“消耗”与“再生”之间的平衡机制。 | 艾尔温·尼尔 Nobutake Hosoi Takeshi Sakaba 方守狮(组稿) | 2006 | 自然杂志2006，28，5： | 3 |
| 6 | Comparison of Surgical Results of D2 Versus D3 Gastrectomy (Para-Aortic Lymph Node Dissection) for Advanced Gastric Carcinoma: A Multi-Institutional Study显示文摘 | Chikara Kunisaki Hirotoshi Akiyama Masato Nomura Goro Matsuda Yuichi Otsuka Hidetaka Ono Yutaka Nagahori Hideo Hosoi Masazumi Takahashi Fumihiko Kito Hiroshi Shimada | 2006 | Annals of Surgical Oncology2006，，5： | 2 |
| 7 | Isolated ileal perforation due to cytomegalovirus reactivation during management of terbinafine hypersensitivity显示文摘We report a case of 71-year-old man who developed a hypersensitivity syndrome associated with terbinafine. He was placed on terbinafine (250 mg/d) for the treatment of tinea pedis due to diabetes mellitus. Following the treatment with terbinafine, he developed druginduced hypersensitivity syndrome (DIHS). Systemic corticosteroid led to transient improvement of his clinical manifestations. Three months after disease onset, he presented with panperitonitis due to ileal perforation, and underwent an emergency operation. The affected ileum was resected and ileostomy was performed in the terminal ileum. Cytomegalovirus (CMV)-specific IgG antibodies were significantly increased, high-titer CMV antigenemia was detected, and pathological examination of the resected ileum confirmed CMV infection. Based onthese observations, we strongly recommend that physicians monitor reactivation of the family of herpesvirus other than herpesvirus 6, to manage DIHS properly. | Soichi Sano Hiroki Ueno Keiko Yamagami Yosuke Yakushiji Yoshihiro Isaka Isao Kawasaki Masashi Takemura Takeshi Inoue Masayuki Hosoi | 2010 | World Journal of Gastroenterology2010，16，26： | 2 |
| 8 | Thymic hyperplasia inpatientswith Graves disease:Identification of thyrotropin receptors in human thymus显示文摘 | Murakami M Hosoi Y Negishi T | 1996 | J Clin Invest1996，98，10： | 1 |
| 9 | Association of bone mineral density with a polymorphism of the peroxisome proliferator-activated receptor gamma gene :PPARgamma expression in osteoblasts显示文摘 | Ogawa S Urano T Hosoi T | 1999 | Biochem Biophys Res Commun1999，260，1： | 1 |
| 10 | Changes in fecal microflora induced by incubation of mice with Bacillus subtilis (natto) spores are dependent upon dietary components显示文摘 | Hosoi T Ametani A Kiuchi K | 1999 | Canadian journal of microbiology1999，45，： | 1 |
| 11 | PI3K-Akt inactivation induced CHOP expression in endoplasmic retieulum-stressed cells 显示文摘 | Hyoda K Hosoi T Horie N | 2006 | Bioehem Biophys Res Commun2006，340，1： | 1 |
| 12 | Inhibition of leptin induced IL-1beta expression by glucocorticoids in the brain显示文摘 | Hosoi T Okuma Y Wada S | 2003 | Brain Res2003，969，： | 1 |
| 13 | Rapamycin causes poorly reversible inhibition of roTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells 显示文摘 | Hosoi H Dilling MB Shikata T | 1999 | Cancer Res1999，59，4： | 1 |
| 14 | Immobilization- induced and crowded environment - induced stress delay barrier recovery in murine skin 显示文摘 | Denda M Tsuchiya T Hosoi J | 1998 | Br J Dermatol1998，138，5： | 1 |
| 15 | Air-stable n-channel organic field-effect transistors based on N,N'-bis (4-trifluoromethylbenzyl) perylene-3,4,9,10-tetracarboxylic diimide显示文摘 | HOSOI Y TSUNAMI D ISHII H | | 0，，1： | 1 |
| 16 | Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy显示文摘 | Hirota K Hara T Hosoi S | 2005 | J Anesth2005，19，1： | 1 |
| 17 | The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma显示文摘 | Komuro Y Watanabe T Hosoi Y | 2002 | Cancer2002，95，6： | 1 |
| 18 | Inhibition of Leptin-induced IL1beta expression by glucocorticoids in the brain显示文摘 | Hosoi T Okuma Y Wada S | 2003 | Brain Res2003，969，： | 1 |
| 19 | Rapid flow injection analysis method for successive determination of ammonia,nitrite,and nitrate in water by gas-phase chemiluminescence显示文摘 | Toyoaki Aoki Shinji Fukuda Yasuo Hosoi | 1997 | Anal Chimica Acta1997，，349： | 1 |
| 20 | Association of bone mineral density with polymorphism of the estrogen receptor gene显示文摘 | Kobayashi S Inoue S Hosoi T | | 0，，： | 1 |
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