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| 1 | Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets显示文摘 | Hommes D W Peppelenbosch M P van Deventer S J | 2003 | Gut2003，52，1： | 14 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management显示文摘 | A. Dignass G. Van Assche J.O. Lindsay M. Lémann J. S?derholm J.F. Colombel S. Danese A. D’Hoore M. Gassull F. Gomollón D.W. Hommes P. Michetti C. O’Morain T. ?resland A. Windsor E.F. Stange S.P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 4 | Changing Crohn’s disease management: Need for new goals and indices to prevent disability and improve quality of life显示文摘 | Daniel Hommes Jean-Frédéric Colombel Paul Emery Marco Greco William J. Sandborn | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 5 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 6 | Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets显示文摘 | Hommes D Peppelenbosch M van Deventer S | 2003 | Gut2003，52，1： | 1 |
| 7 | Stealth PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system 显示文摘 | Bazile D Prud' Homme C Bassoulet MT | 1995 | J Pharm Sci1995，84，4： | 1 |
| 8 | Reliable Real-Time Solution of Parameterized Partial Differential Equations:Reduced-basis Output Bound显示文摘 | Prud'homme C Rovas D V Veroy K | 2002 | Journal of Fluids Engineering2002，124，： | 1 |
| 9 | Critical appraisal ofthe current practice in murine TNBS-induced colitis显示文摘 | te VeIde A A Verstege M I Hommes D W | 2006 | Inflamm Bowel Dis2006，12，10： | 1 |
| 10 | Sensitivity of maximal aerobic power to training is genotype-dependent 显示文摘 | Prud'homme D Bouchard C Leblanc C | 1984 | Med Sei Sports Exerc1984，16，5： | 1 |
| 11 | Preparation and characterizationof alginate microspheres containing a model antigen显示文摘 | LEMOINE D WAUTERS F BOUCHEND'HOMME S | 1998 | Int J Pharm1998，176，： | 1 |
| 12 | Infliximab treatment for Crohn's disease:one -year experience in a Dutch academic hospital显示文摘 | Hommes D W van de Heisteeg B H van der Spek M | 2002 | Inflamm Bowel Dis2002，8，： | 1 |
| 13 | Measuring, explaining and addressingpatent quality issues in China显示文摘 | Prud'Homme D | 2013 | Mpra Paper2013，，58： | 1 |
| 14 | Association of physical activity and bone: influence of vitamin D receptor genotype 显示文摘 | Blancher C Giguere Y Prud'homme D | 2002 | Med Sci Sports Exert2002，34，1： | 1 |
| 15 | Stealth Me PEG-PLA nanoparticles avoid uptake by the monomuclear phagocyte system显示文摘 | Bazille D Prud'homme C Bassoullet MT | 1995 | J Pharm Sci1995，84，1995： | 1 |
| 16 | Functionalized single graphene sheets derived from splitting graphite oxide 显示文摘 | Schniepp H C Li J L McAllister M J Sai H Herrera Alonso M Adamson D H Prud'Homme R K Car R Saville D A Aksay I A | 2006 | J Phys Chem B2006，110，17： | 1 |
| 17 | Structure and Rheology Studies of Poly(oxycthylene-oxypropylene-oxyethylene) Aqueous Solution显示文摘 | Prud'homme R K Wu G Schneider D K | 1996 | Langmuir1996，12，20： | 1 |
| 18 | Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease显示文摘 | Hommes D van-den-Blink B Plasse T | 2002 | Gastroenterol2002，122，1： | 1 |
| 19 | Effect of the detraining status on high-fat diet induced fat accumulation in the adipose tissue and liver in female rats显示文摘 | Yasari S Dufresne E Prud'homme D | | 0，，2： | 1 |
| 20 | Preparation and characterization of alginate microspheres containing a modelantigen 显示文摘 | Lemoine D Wauters F Bouchend's homme S | 1998 | Int J Pharm1998，176，1： | 1 |
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