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| 1 | Safety of the long-term use of proton pump inhibitors显示文摘The proton pump inhibitors (PPIs) as a class are remarkably safe and effective for persons with peptic ulcer disorders. Serious adverse events are extremely rare for PPIs, with case reports of interstitial nephritis with omeprazole, hepatitis with omeprazole and lansoprazole, and disputed visual disturbances with pantoprazole and omeprazole. PPI use is associated with the development of fundic gland polyps (FGP); stopping PPIs is associated with regression of FGP. In the absence of Helicobacter pylori infection, the long-term use of PPIs has not been convincingly proven to cause or be associated with the progression of pre-existing chronic gastritis or gastric atrophy or intestinal metaplasia. Mild/modest hypergastrinemia is a physiological response to the reduction in gastric acid secretion due to any cause. The long-term use of PPIs has not been convincingly proven to cause enterochromaff in-like cell hyperplasia or carcinoid tumors. PPIs increase the risk of community acquired pneumonia, but not of hospital acquired (nosocomial) pneumonia. There is no data to support particular care in prescribing PPI therapy due to concerns about risk of hip fracture with the long-termuse of PPIs. Long-term use of PPIs does not lead to vitamin B12 def iciencies, except possibly in the elderly, or in persons with Zollinger-Ellison Syndrome who are on high doses of PPI for prolonged periods of time. There is no convincingly proven data that PPIs increase the risk of Clostridium difficile-associated diarrhea in persons in the community. The discontinuation of PPIs may result in rebound symptoms requiring further and even continuous PPI use for suppression of symptoms. As with all medications, the key is to use PPIs only when clearly indicated, and to reassess continued use so that long-term therapy is used judiciously. Thus, in summary, the PPIs are a safe class of medications to use longterm in persons in whom there is a clear need for the maintenance of extensive acid inhibition. | Alan BR Thomson Michel D Sauve Narmin Kassam Holly Kamitakahara | 2010 | World Journal of Gastroenterology2010，16，19： | 20 |
| 2 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 3 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 4 | Morphological changes in the skin and wool fibres of Merino sheep infused with mouse epidermal growth factor 显示文摘 | Hollis D E Chapman R E Panaretto B A | 1983 | Aust J Biol Sci1983，36，4： | 1 |
| 5 | A double-blind, place-bocontmlledo randomized phase Ⅲ trial of gemcitabine ( G ) plus bevacizumab(B) versus gemcitabine plus placebo (P)in patients (pts) with advanced pancreatic cancer ( PC ) : A preliminary analysis of Cancer and Leukemia Group B(CALGB) 显示文摘 | Kindler HL Niedzwiecki D Hollis D | 2007 | J Clin Oncol2007，25，18： | 1 |
| 6 | Phase Ⅲ study of irinotecan/5FU/LV (FOLFIRI)or oxaliplatin/5FU/LV (FOLFOX)-+-cetuximab for pa- tients with untreated metastatic adenocarcinoma ofthe colon or rectum (MCRC): CALGB 80203 pre- liminary results显示文摘 | VENOOK A NIEDZWIECKI D HOLLIS D | 2006 | Journal of Clinical Oncology2006，24，18： | 1 |
| 7 | Audits as a corporate governance mechanism: evidence from the German market 显示文摘 | Hollis A Terry D W | 2003 | Journal of In- ternational Accounting Research2003，，2： | 1 |
| 8 | Factors associated with the develop- ment of brain metastases : analysis of 975 patients with early stage nons- mall cell lung cancer显示文摘 | Hubbs JL Boyd JA Hollis D | 2010 | Cancer2010，116，21： | 1 |
| 9 | Irinotecan plus fluorouracil/leucovorin(IFL) versus fluorouracil/leucovorin alone(FL) in stage Ⅲ colon cancer(intergroup trial CALGB C89803)显示文摘 | Saltz LB Niedzwiecki D Hollis D | 2004 | Proc Am Soc Clin Oncol2004，，： | 1 |
| 10 | Hepatic arterial Infusion versus systemic therapy for hepatic metastases from colorectal cancer:a randomized trial of efficacy,quality of life,and molecular markers (CALGB 9481)显示文摘 | Kemeny N Niedzwiecki D Hollis DR | 2006 | J Clin Oncol2006，24，9： | 1 |
| 11 | Spectroscopic properties of Er3 + and Tm3 +in tellurite glasses显示文摘 | McDongall J Hollis D B Payne M J P | 1996 | Phys Chem Glasses1996，37，25： | 1 |
| 12 | Hopf bifurcation to limit cycles in fluid film bearings 显示文摘 | Hollis P Taylor D L | 1986 | ASME Journal of Tribology1986，108，2： | 1 |
| 13 | Minimally invasive lumbar fusion 显示文摘 | Foley K T Holly L T Schwender J D | 2003 | Spine2003，15，： | 1 |
| 14 | A prospective trail of the feasibility of thoracoscopy in the staging of esophageal cancer:preliminary result of cancer and leukemia group显示文摘 | Krasna MJ Reed C Hollis D | 2001 | Ann Thorac Surg2001，71，： | 1 |
| 15 | Minimal- ly invasive transforaminal lumbar interbody fusion (TLIF): technical feasibility and initial results 显示文摘 | Schwender J D Holly L T Rouben D P | 2005 | J Spinal Disord Tech2005，，18： | 1 |
| 16 | Radiation - induced narrowing of the tracheobronchial tree : An in - depth analysis 显示文摘 | Kelsey CR Kahn D Hollis DR | 2006 | Lung Cancer2006，52，： | 1 |
| 17 | Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis显示文摘 | Arjmandi B H Alekel L Hollis BW Amin D Stacewicz-Sapuntzalis M Guo P Kukreja S C | 1996 | Nutr1996，126，1： | 1 |
| 18 | Phase III trail of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781显示文摘 | Joel E Reed CE Hollis D | 2008 | Journal of Clinical Oncology2008，26，7： | 1 |
| 19 | Promotion of megakaryocyte progenitor expansion and differentiation by the c-MPL ligand thrombopoietin 显示文摘 | Kaushansky K Lok S Holly R D | 1994 | Nature1994，369，6481： | 1 |
| 20 | Activities of caspofungin,intraconazole,posacon azole,ravuconazole,voriconazole,and amphoteri cin B against 448 recent clinical isolates of filamentous fungi显示文摘 | Diekema D J Messer S A Hollis R J | 2003 | Journal of Clinical Microbiology2003，41，8： | 1 |
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